Tag: pubmed

J Am Dent Assoc. 2025 Mar 7:S0002-8177(25)00091-1. doi: 10.1016/j.adaj.2025.01.007. Online ahead of print.

ABSTRACT

BACKGROUND: The authors investigated, via a web-based survey, the perceptions of general dentists in the United States regarding endodontists restoring endodontically treated teeth (ETT).

METHODS: A 15-question survey was distributed to American Dental Association members. Participants were asked to rate their comfort with various scenarios. In the control scenario, an endodontist placed restorations without prior discussion with the general dentist. In the experimental scenario, an endodontist trained in endorestorative procedures, having previously discussed their intentions, placed the restorations. Data were analyzed using descriptive statistics, Fisher exact test, McNemar test, and false discovery rate adjustment (P_adj).

RESULTS: The response rate was 48% (N = 544). General dentists were significantly more likely to accept the experimental scenario than the control scenario for post space creation (88.1% vs 84.2%; P_adj = .026), post placement (66.7% vs 52.2%; P_adj = 3.35e-13), and core placement (68.2% vs 55.1%; P_adj = 2.28e-12). Overall, 69% (374) supported endodontists placing restorations after discussion with referring general dentists, 12.9% (70) disagreed, and 18.4% (100) were undecided. Opponents (67) cited lack of trust (64%) and billing preferences (18%). Undecided general dentists (83) identified residency training (28%), case portfolios (16%), and individualized discussions (13%) as factors likely to increase acceptance. More recent graduates, female practitioners, those practicing at community clinics, in rural or urban areas, and in the South or West were significantly more comfortable with endodontists placing restorations (P_adj < .05).

CONCLUSIONS: General dentists broadly supported endodontists restoring ETT if they were trained in endorestorative procedures and after prior discussion.

PRACTICAL IMPLICATIONS: Endodontists should communicate their intent to restore ETT with general dentists to facilitate interdisciplinary collaboration.

PMID:40057857 | DOI:10.1016/j.adaj.2025.01.007

J Am Dent Assoc. 2025 Mar 6:S0002-8177(25)00088-1. doi: 10.1016/j.adaj.2025.01.006. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of this study was to assess the feasibility of screening at-risk adult dental patients for abnormal blood glucose levels by means of using a chairside finger-stick test that measures glycated hemoglobin (HbA_1c) levels.

METHODS: A total of 260 high-risk adult patients, as classified by the American Diabetes Association and Centers for Disease Control and Prevention Prediabetes Risk Test, with no history of diabetes received a chairside HbA_1c finger-stick test. Descriptive statistics and χ² and Fisher exact tests were used to examine associations of HbA_1c levels with risk scores and study participants’ characteristics.

RESULTS: Results of chairside testing indicated that 34.2% had undiagnosed prediabetes and 6.6% had undiagnosed diabetes. Results of the postprocedure questionnaire showed high levels of acceptance and satisfaction with the testing. At 6 months after testing, 64.6% of patients with dysglycemia had consulted their primary care provider for follow-up.

CONCLUSIONS: Dental care professionals are in a unique position to collaborate with physicians and other health care providers in the identification of undiagnosed prediabetes and diabetes. Targeted chairside diabetes testing in the oral health care setting for high-risk patients is a viable public health primary preventive measure.

PRACTICAL IMPLICATIONS: Screening is pivotal for the early detection, prevention, and management of diabetes, and the dental care setting, where chairside testing is a viable strategy, may be an important venue in confronting the diabetes epidemic.

PMID:40057856 | DOI:10.1016/j.adaj.2025.01.006

Orv Hetil. 2025 Mar 9;166(10):377-384. doi: 10.1556/650.2025.33243. Print 2025 Mar 9.

ABSTRACT

Bevezetés: A COVID–19-világjárvány előtt a digitális egészségügyi megoldások elterjedését szabályozási és stratégiai hiányosságok is akadályozták, a pandémia idején azonban a digitális eszközök gyors bevezetése szükségszerűvé vált. Ezen időszak után már rendelkezésre állnak a szabályozási feltételek Magyarországon is, amelyek a digitális egészségügyi megoldások használatát támogatják, ugyanakkor az alkalmazásuk iránti kényszer csökkent. Célkitűzés: Két országos reprezentatív lakossági kutatásunkban arra kerestük a választ, hogy a COVID–19-járvány milyen hatással volt a lakosság digitális egészségügyi megoldásokkal kapcsolatos használati szokásaira, attitűdjeire és igényeire. Módszerek: Két országos reprezentatív lakossági felmérés eredményeit hasonlítjuk össze. Az első felmérést 2021 októberében, a COVID–19-járvány idején végeztük 1500 fő telefonon történő megkérdezésével, míg a második felmérést 2024 februárjában 1000 fő online kérdőíves megkeresésével. Mind a két minta nem, kor, iskolai végzettség és településtípus szerint reprezentálja a magyar felnőtt lakosságot. Az adatgyűjtést mindkét felmérés esetében az Ipsos Zrt. végezte. Eredmények: A két lakossági felmérés eredményei alapján az internetes egészségügyi információkeresés gyakorisága és módja jelentős változásokon ment keresztül. Azok aránya, akik egyáltalán nem keresnek információt az interneten, tovább csökkent. Az egészségügyi célú internethasználat során a weboldalak népszerűsége nőtt, míg a blogok, a podcastok és a közösségi platformok iránti érdeklődés csökkent. A digitális egészséggel kapcsolatos lehetőségek ismertsége és használata szintén növekedett, különösen az online időpontfoglalás, az egészségügyi adatok megosztása és a közösségi média használata terén. Az ellátás hatékonyságával kapcsolatos pozitív vélemények enyhén csökkentek, míg a technológiai frusztrációval kapcsolatos aggodalmak enyhültek. Következtetés: A COVID–19-járvány elmúltával megjelentek a digitális egészségüggyel kapcsolatos szabályozások, a lakosság körében pedig megszokottá vált a digitális egészségügyi technológiák használata. A digitális technológiák ismertsége és használata szignifikánsan növekedett, különösen az online időpontfoglalás, az e-recept és a viselhető eszközök esetében. A digitális eszközök használatának potenciális hátrányai iránti aggodalmak mérséklődtek, míg az előnyök iránti elvárások nem változtak jelentősen, ami reálisabb megítélést jelez. A páciensek digitalizációs igénye mára az ellátás szerves részévé vált, támogatva a tudatosabb, aktívabb szerepvállalást a gyógyulási folyamatban. Orv Hetil. 2025; 166(10): 377–384.

PMID:40057836 | DOI:10.1556/650.2025.33243

Exp Hematol Oncol. 2025 Mar 8;14(1):32. doi: 10.1186/s40164-025-00622-x.

ABSTRACT

Cancer remains the leading cause of mortality worldwide, and the emergence of drug resistance has made the identification of new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct of glycolysis with limited ATP-producing capacity, has recently gained recognition as a critical signaling molecule. It plays a key role not only in cancer cell metabolism but also in shaping the tumor microenvironment (TME). Histone lysine lactylation, a newly identified post-translational modification, has been shown to influence a range of cellular processes in cancer. Current research focuses on the mechanisms and functions of histone lactylation in cancer, including its role in gene expression regulation, signal transduction, and protein synthesis. However, despite these advancements, there are still plenty of barriers in the quest to unravel the mechanisms of lactylation modification. The emergence of single-cell and spatial transcriptomics may offer valuable insights for selecting targets. This review provides a comprehensive summary of the mechanisms and the applications of lactylation modification in clinical settings. Through a detailed analysis, we identify the key challenges and limitations that exist in the current research landscape. These insights lay the groundwork for future studies by highlighting promising research directions.

PMID:40057816 | DOI:10.1186/s40164-025-00622-x

Arthritis Res Ther. 2025 Mar 8;27(1):54. doi: 10.1186/s13075-025-03522-x.

ABSTRACT

PURPOSE: Quercetagetin, a flavonoid derived from the natural herb Flos eriocauli, is used in traditional Chinese medicine for its fire-purging (anti-inflammation) and wind-expelling (pain-alleviating) properties. However, its potential effects concerning rheumatoid arthritis (RA) remain underexplored. This study was designed to elucidate the potential associations between Quercetagetin and RA, establishing the therapeutic potential of Quercetagetin and related mechanisms in RA treatment.

METHODS: Network pharmacology was conducted to decipher related targets and signaling pathways between Quercetagetin and RA. In vitro assays were then conducted to explore the effects of Quercetagetin on osteoclast cell behaviors and corresponding signaling pathways. In vivo study further validated the therapeutic effect of Quercetagetin in collagen antibody-induced arthritis (CAIA) mice.

RESULTS: The network pharmacological analysis indicated an intimate correlation of Quercetagetin with RA-related inflammatory osteolysis treatment. Pertaining to biological validations, 2 µM of Quercetagetin successfully inhibited LPS-driven osteoclast differentiation and function. qPCR assay and Western blot analyses denoted parallel changes in osteoclastic marker genes and proteins. Further mechanism study uncovered the effect of Quercetagetin in stimulating the Nrf2/Keap1 signaling pathway and moderating the Pten/AKT/Nfatc1 axis in osteoclasts. In vivo study revealed 40 mg/kg Quercetagetin every day could significantly relief joint destruction in CAIA mice.

CONCLUSIONS: Our study presents Quercetagetin ‘s therapeutic potential in treating RA, outlining its effects and potential mechanisms in suppressing LPS-induced osteoclast activity, and alleviating inflammatory bone destruction in CAIA model, thereby laying the groundwork for further translational research on Quercetagetin and Flos eriocauli in RA treatment.

PMID:40057805 | DOI:10.1186/s13075-025-03522-x

BMC Nurs. 2025 Mar 8;24(1):262. doi: 10.1186/s12912-025-02924-1.

ABSTRACT

BACKGROUND: Nursing internship play a crucial role in cultivating nursing students. However, nursing interns often face challenges of career anxiety, which can have negative impacts on their professional development and work quality. Therefore, understanding the factors influencing career anxiety among nursing interns is important.

OBJECTIVES: The purpose of this study was to investigate the serial multiple mediating effect of perceived stress and self-control in the relationship between neuroticism and career anxiety among nursing interns in China.

DESIGN: A cross-sectional study.

METHODS: A total of 499 nursing interns from five tertiary hospitals in Xi’an, China, participated. Neuroticism, perceived stress, self-control, and career anxiety among nursing interns were assessed. Serial mediation analysis was conducted using the PROCESS Macro in SPSS. Statistical analyses included descriptive analysis, t-tests, ANOVA, Pearson correlation, and regression with bootstrapping.

RESULTS: (1)Career anxiety was significantly and positively correlated with neuroticism (r = 0.384, p < 0.001) and perceived stress (r = 0.460, p < 0.001), and negatively correlated with self-control (r = -0.570, p < 0.001). (2) Neuroticism positively predicted perceived stress (β = 0.385, p < 0.001). Both perceived stress and neuroticism, negatively predicted self-control (β = -0.237; β = -0.355, p < 0.001). Self-control negatively predicted career anxiety (β = -0.401, p < 0.001), while neuroticism and perceived stress positively predicted it (β = 0.149; β = 0.173, p < 0.001). (3) In the model of neuroticism → perceived stress → self-control → career anxiety, the total indirect effect was 0.216. The mediating effect of perceived stress accounted for 18.1% of the total effect (0.066), while self-control accounted for 26.0% (0.095). The serial mediation effect of perceived stress and self-control contributed 15.1% (0.055) to the total effect.

CONCLUSION: Neuroticism significantly predicts career anxiety, mediated by perceived stress and self-control. Higher neuroticism leads to increased stress, reduced self-control, and greater career anxiety. Interventions focusing on stress reduction and self-control enhancement may help mitigate career anxiety among nursing interns.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40057794 | DOI:10.1186/s12912-025-02924-1

BMC Palliat Care. 2025 Mar 8;24(1):59. doi: 10.1186/s12904-025-01697-3.

ABSTRACT

BACKGROUND: The negative impact of over-treatment in end-of-life individuals has led to attention to the value of death. Reassessing the attitude of death and dying can improve care and improve the quality of life. Therefore, the use of multidimensional tools to comprehensively assess the attitudes of individuals on dying and death, identify attitude tendencies and causes meaningful, and evaluate the effectiveness of the tools is an important prerequisite.

OBJECTIVES: We aimed to obtain MODDI-F-C through cross-cultural translation and to evaluate its psychometric characteristics among mainland China participants.

METHODS: In order to obtain MODDI-F-C, a cross-cultural translation of MODDI- F/eng was performed using the Brislin model. The items quality, factor structure, reliability and validity were assessed among 2105 participants from mainland China. The concurrent validity was assessed using the Chinese version of DAP-R for the first time.

RESULTS: MODDI-F-C consists of 27 items, and five common factors were identified through factor analysis, accounting for 56.79% of the overall variance.The total consistency coefficient was 0.949.The correlation coefficient between DAP-R-C-Z and the overall scale was 0.55 (p < 0.001), between DAP – R-C – Z and the subscale 0.37-0.56 (p < 0.001).Most of the methods used for psychometric evaluation meet acceptable criteria.

CONCLUSIONS: Our research has initially confirmed that MODDI-F-C is an effective tool to evaluate the fear dimension of death and dying attitude, which can identify individuals’ tendencies and causes related to dying and death. However, the acceptance dimension needs further assessment.

PMID:40057793 | DOI:10.1186/s12904-025-01697-3

AIDS Res Ther. 2025 Mar 8;22(1):31. doi: 10.1186/s12981-025-00726-8.

ABSTRACT

BACKGROUND: Vaccine acceptance among People Living with HIV (PLWH) is crucial for managing and mitigating the spread of infectious diseases, including Mpox. This systematic review and meta-analysis assess the rate of vaccine acceptance for Mpox among PLWH and identify factors influencing these rates.

METHODS: We searched major databases including PubMed, Embase, and Web of Science up to 30 August 2024 for observational studies involving PLWH that reported on mpox vaccine acceptance rates. A random-effects model was employed for the meta-analysis, utilizing R software version 4.4. Heterogeneity among the studies was quantified using the I² statistic, and the methodological quality of each study was assessed using a modified version of the Newcastle-Ottawa Scale.

RESULTS: Out of 1,123 articles identified, 17 studies met the inclusion criteria and included 7,248 participants. The pooled estimate of the Mpox vaccine acceptance rate was 61.1% (95% CI: 44.2-75.7%), with high heterogeneity (I² = 99%). Additionally, a pooled vaccine hesitancy prevalence was 13.2%, (95% CI: 2.4-48.6%), reflecting substantial variability and had high heterogeneity (I² = 98%).

CONCLUSION: This systematic review and meta-analysis reveal moderate Mpox vaccine acceptance and considerable hesitancy among PLWH. To further increase vaccine uptake and address any remaining hesitancy in this at-risk population, targeted public health strategies and ongoing research are necessary. Strengthening vaccine acceptance is critical to safeguarding PLWH against emerging infectious diseases such as Mpox.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40057788 | DOI:10.1186/s12981-025-00726-8

Syst Rev. 2025 Mar 8;14(1):57. doi: 10.1186/s13643-025-02760-z.

ABSTRACT

BACKGROUND: Double gloving is recommended for protecting surgical personnel from infections, but it is not a universal practice, especially in low- and middle-income countries where risk is very high. Evidence for double gloving is still only moderate, and for indicator double gloves, it is even rare. This systematic review and meta-analysis includes recent trials to analyse outcomes like glove perforations (inner/outer/matched/intraoperatively detected) and hand contamination rates for single versus double including indicator double-gloved conditions and identify factors to be considered for deciding double gloving.

METHOD: Six databases PubMed, EBESCO, Embase, CINAHL, Scopus, Web of Science, and CENTRAL were searched up to May 2024. The quality of included trials was assessed using Cochrane risk-of-bias tool (version 5.1.0). Heterogeneity among trials was estimated using the chi-squared (I²) test. RevMan 5.3 was used for meta-analysis and subgroup analysis. Odds ratio at 95% confidence interval was used as statistical measure to compare outcomes and calculate effect size. Publication bias was assessed through a funnel plot.

RESULT: A review of these total of 18 randomized controlled trials showed that deep/major/emergent surgeries, primary surgeons, and longer surgical duration are prone to have higher glove perforations. Impaired dexterity is not a constraint for double gloving and has no impact on glove perforations. Meta-analysis of outcomes suggests that double gloving (standard or indicator) provides significant protection against infections compared to single gloves in terms of reduced inner (OR = 0.2, 95% CI 0.14-0.31) and matched glove perforations (OR = 0.1, 95% Cl 0.07-0.13) and lower incidences of hand contamination (OR = 0.28, 95% Cl 0.14-0.54). Standard double gloves were more effective in reducing matched glove perforations than indicator double gloves. But for detecting glove perforations intraoperatively, only the indicator double glove (OR = 8.64, 95% Cl 4.78-15.61) was effective.

CONCLUSION: Double gloving is recommended over single gloving for better safety of surgical personnel and indicator gloves for better detection of perforations during surgery so that it can be changed timely, but it does not provide any additional protection. In the future, there should be high-quality trials for specific surgeries, surgical personnel, and different surgical durations taking into consideration the cost-effectiveness of indicator gloving over standard double gloving so that specific recommendations can be made.

PMID:40057774 | DOI:10.1186/s13643-025-02760-z

Alzheimers Res Ther. 2025 Mar 8;17(1):58. doi: 10.1186/s13195-025-01708-8.

ABSTRACT

BACKGROUND: The influence of duration of type 2 diabetes mellitus (T2DM) on the likelihood of developing new-onset dementia in post-stroke population is not well understood. Therefore, we aimed to clarify the relationship between the duration of T2DM and the risk of developing dementia in the post-stroke population.

METHODS: Leveraging the Korean National Health Insurance Database, this study included 118,790 individuals with a history of stroke but no previous dementia diagnosis. We classified diabetes status into five categories: normoglycemia, impaired fasting glucose (IFG), newly diagnosed T2DM, and established T2DM with durations of less than 5 years and 5 years or more. The primary endpoint was the incidence of all-cause dementia.

RESULTS: Among 118,790 participants (average age 64.26 ± 9.95 years, 48% male), 16.7% developed dementia during an average follow-up of 7.3 ± 2.3 years. Participants with a history of T2DM for less than five years at cohort entry had a 26.7% higher risk of developing all-cause dementia compared to those with normoglycemia. Those with T2DM for five years or longer had a 46.7% increased risk, with an adjusted hazard ratio (aHR) of 1.466 (95% confidence interval [CI], 1.408-1.527). Specifically, the risk of developing Alzheimer’s disease (AD) and vascular dementia (VaD) rose by 43.4% and 51.4%, respectively, for individuals with T2DM lasting more than five years (aHR 1.434, 95% CI 1.366-1.505; aHR 1.514, 95% CI 1.365-1.679, respectively).

CONCLUSIONS: Our findings demonstrated a significant association between an extended duration of T2DM and an increased risk of developing all-cause dementia, including AD and VaD in post-stroke population. These results emphasize proactive dementia prevention approaches in stroke survivors, particularly those with longstanding T2DM.

PMID:40057772 | DOI:10.1186/s13195-025-01708-8