Tag: pubmed

J Caring Sci. 2025 Sep 8;14(3):173-181. doi: 10.34172/jcs.025.33640. eCollection 2025 Sep.

ABSTRACT

INTRODUCTION: Colorectal cancer (CRC), as a leading cause of cancer-related morbidity and mortality worldwide, often requires surgical interventions such as colostomy, which can substantially affect patients’ health-related quality of life. The presence of a colostomy adversely affects deferent aspects of patient’s life. The aim of this study is to compare the health-related quality of life in patients with and without a colostomy.

METHODS: In this comparative cross-sectional study, 256 patients with CRC were included through convenience sampling, comprising 127 patients with a colostomy (49.6%) and 129 without a colostomy (50.4%). The data collection tools included the demographic information form and the shortened form of the health-related quality of life questionnaire (SF-36). Statistical analyses were performed using IBM SPSS Statistics version 13, including descriptive statistics, independent samples t-tests, general linear modeling, and multiple regression analyses. Results: In this study, the health-related quality of life score (range: 0-100) was 43.03±17.08 in patients with a colostomy and 51.38±15.57 in those without a colostomy. Also, there was a statistically significant difference in physical functioning, role limitation due to physical health, role limitation due to emotional problems and health-related quality of life in people with and without colostomies (P<0.05). Finally, in sex stratified exploratory analyses, differences were evident among women but not among men.

CONCLUSION: This study demonstrates that patients with CRC, particularly those with a colostomy, experience significantly lower health-related quality of life. The findings emphasize the importance of early and targeted interventions to improve physical and psychosocial well-being in this population. Greater attention should be given to the needs of patients with colostomy in both hospital and community care settings to enhance their overall quality of life.

PMID:41200699 | PMC:PMC12586898 | DOI:10.34172/jcs.025.33640

Health Serv Insights. 2025 Nov 4;18:11786329251388775. doi: 10.1177/11786329251388775. eCollection 2025.

ABSTRACT

INTRODUCTION: The need for tailored services for individuals with young-onset dementia (YOD) is well established. Specialised services exist but regional disparities may hinder timely and appropriate care and support. Yet, a comprehensive overview of such services is currently lacking.

OBJECTIVE: To examine regional disparities in the delivery, access and management of YOD-specialised services in the Netherlands, revealing service gaps and opportunities for future development.

DESIGN: An exploratory cross-sectional survey (YOD self-scan) was developed and distributed to 39 Dutch healthcare organisations affiliated with a national YOD knowledge infrastructure, ensuring broad geographical representation.

METHODS: Quantitative and qualitative data were collected through open- and closed-ended questions between July and August 2023. Descriptive statistics and manifest content analyses were used to assess the delivery and management of YOD-specialised services in terms of utilisation, capacity, accessibility, variety and organisational factors.

RESULTS: A total of 1707 individuals with YOD utilised outpatient services, and 801 received permanent residential care. Service delivery and management varied across regions. Rural organisations reported shorter waiting times, more employees who had received specific YOD training, and higher day care utilisation per organisation. Urban organisations offered a broader range of services and more involvement of local governments. Most organisations (72.4%) reported service gaps, including limited day care options, inflexible residential services, and insufficient support for carers, especially children of individuals with YOD. Also, the need for more innovative services and improved coordination was identified.

CONCLUSIONS: YOD-specialised services are underutilised, likely due to unequal accessibility and regional disparities in the delivery and management of services. Addressing service gaps, expanding capacity, and enhancing knowledge exchange are important for equitable, high-quality care. These findings may inform future research and international efforts to improve equitable access and management of specialised dementia services.

PMID:41200695 | PMC:PMC12586858 | DOI:10.1177/11786329251388775

Indian J Community Med. 2025 Oct;50(Suppl 2):S213-S218. doi: 10.4103/ijcm.ijcm_72_24. Epub 2025 Apr 17.

ABSTRACT

BACKGROUND: City bus drivers are more prone to work-related musculoskeletal disorders (WRMSDs) due to the nature of their work, yet city bus drivers are the least studied population. The present study aims to assess WRMSDs in city bus drivers and to determine some factors related to them.

METHODS AND MATERIALS: The present cross-sectional study was conducted among bus drivers belonging to three bus depots of the city bus service. A simple random sampling was done to select the estimated sample size of 383 bus drivers. Data were collected by interview method using a self-designed questionnaire. The musculoskeletal disorders were assessed using the Cornell Musculoskeletal Discomfort Questionnaire. Univariate and multivariate analyses were done using Stata 17.

RESULTS: More than half of the bus drivers (202 (52.74%)) had WRMSDs, with 157 (40.99%) bus drivers having lower back discomfort. On univariate analysis, it was found that duration of driving ≥20 years (P = 0.007); driving distance ≥ 150 km (P = 0.001); waist-hip ratio ≥ 0.9 (P = 0.004); and self-perceived workstation factors such as seat adjustability (P = 0.04), seat comfortableness (P = 0.01), and body contour of the seat (P = 0.02); and congestion on the bus route (P = 0.05) were significantly related to musculoskeletal disorders. However, on multivariate logistic regression, driving distance ≥150 km per day, seat uncomfortableness, and lack of body contour of the seat were found to be statistically significant independent factors related to WRMSDs.

CONCLUSION: As the daily driving distance, seat uncomfortableness, and lack of body contour of the seat were statistically significantly related to WRMSDs, it is recommended that all the buses be retrofitted with proper ergonomically designed driver’s seats, and the daily average driving distance should be reduced.

PMID:41200692 | PMC:PMC12588123 | DOI:10.4103/ijcm.ijcm_72_24

Indian J Community Med. 2025 Oct;50(Suppl 2):S173-S179. doi: 10.4103/ijcm.ijcm_753_23. Epub 2025 Feb 21.

ABSTRACT

BACKGROUND AND OBJECTIVES: Postnatal morbidities if present adversely affect the health of the mother and baby, these being more in women residing in urban slums. The utilization of antenatal and postnatal care may act as factors to help curb these morbidities. Hence, this study was planned to estimate the prevalence of self-reported postpartum morbidity and its determinants among women aged 18-49 years and find the association between utilization of antenatal care and postnatal care received and morbidities reported.

MATERIALS AND METHODS: This was a cross-sectional study in the urban slums of Bhubaneswar over two years including 210 consenting postnatal women in the age group of 18-49 years using a two-stage stratified cluster sampling technique. A semi-structured pretested questionnaire was used for data collection which was entered into a Microsoft Excel sheet and analyzed using SPSS software. Multinomial logistic regression was used to ascertain independent association and a P value of < 0.05 was considered to be statistically significant.

RESULTS: The prevalence of self-reported postnatal morbidities was found to be 57.62%. Occupation of the spouse, number of ANCs received, and laboratory investigations conducted during the antenatal period were found to be statistically significant. The illiteracy of the study participant and the occupation of the spouse were found as statistically significant in the multinomial logistic regression model.

CONCLUSION: The postnatal morbidities were found to be high which reemphasises the importance of antenatal and postnatal care. Some ANC variables were found to contribute to the postnatal morbidities which when addressed timely can help curb these morbidities.

PMID:41200686 | PMC:PMC12588127 | DOI:10.4103/ijcm.ijcm_753_23

Indian J Community Med. 2025 Oct;50(Suppl 2):S228-S234. doi: 10.4103/ijcm.ijcm_86_24. Epub 2025 Feb 27.

ABSTRACT

BACKGROUND: The mankind has been fighting the pandemic of COVID-19 for the last few years and vaccines came in as a real game changer by the end of 2020. World’s biggest COVID-19 vaccination drive was started in India on January 16, 2021. A year later, vaccines were introduced for the adolescent population. The concern over Adverse Events Following Immunization (AEFI) surfaced and dampened vaccine uptake with increasing fear and misinformation toward vaccination. AEFI is any untoward medical occurrence that follows immunization, and not necessarily have a causal relationship with the usage of the vaccine. Although technical and toll-free numbers are available for the reporting of the AEFI, there is a high chance of under-reporting of the same. There were only very limited number of studies assessing the AEFI after Covaxin vaccination in the adolescent age group and hence this study was performed to assess the adverse reaction following immunization and the factors associated with it among the adolescent age group. Further, this study assessed perception, and ideas regarding acceptance of COVID-19 vaccination services among adolescent beneficiaries.

METHODOLOGY: A mixed methods study was conducted at AIIMS Bhubaneswar for adolescent beneficiaries aged 15-18 years between January 3^rd and March 31^st, 2022. A prospective longitudinal study was conducted with a sample size of 250. Study participants were selected by simple random sampling from the beneficiary list in CoWin app. Ten beneficiaries per day were selected for the telephonic interview regarding AEFI, 7 to 10 days following immunization. Data were collected using the tool based on the document for toxicity grading in healthy volunteers in preventive vaccine trials given by the US FDA. In-depth interview was conducted among adolescent beneficiaries using predesigned interview schedule. Analysis was performed using SPSS version 25.0 and Anthropac software for quantitative and qualitative data, respectively.

RESULTS: AEFI was assessed after first dose among participants, among which 84 (36.52%) had some kind of AEFI. Pain at the injection site was the most common AEFI reported. One-third participants (32.1%) had developed only one AEFI. More than one AEFI was reported in 10 participants. Among the 50 participants followed up in their second dose, 10 (20.83%) developed any AEFI in our study. Five participants reported having AEFI in the first and second doses. There was no statistical difference in the number of AEFI reported after the first and second doses. Majority of the adolescents seemed self-motivated to avail COVID-19 vaccine. According to the beneficiaries, vaccination certificate was the felt need to enter schools and sit for exams.

CONCLUSION: Covaxin (BBV152) has good safety profile among adolescent age group. The AEFI reported are less in comparison with other mRNA vaccines as well. Although AEFI is common after BBV152 among adolescent, majority are mild in nature. Still, further studies with larger cohort are warranted to study the long-term effects of vaccination as well. It’s encouraging that the adolescents were optimistic about availing vaccine.

PMID:41200685 | PMC:PMC12588121 | DOI:10.4103/ijcm.ijcm_86_24

Clin Oral Implants Res. 2025 Nov 6. doi: 10.1111/clr.70071. Online ahead of print.

ABSTRACT

AIM: To compare the clinical performance of two sandblasted, large-grit, acid-etched implant surfaces regarding changes in radiographic marginal bone level (MBL) 12 months after loading.

MATERIALS AND METHODS: In this randomized, split-mouth, dual-center clinical trial, each patient received one test (modified hydrophilic surface) implant and one control (conventional surface) implant. The primary endpoint was the change in MBL measured 12 months after loading. Secondary outcomes included the assessment of soft tissue wound healing index (WHI), adverse events, implant stability quotient (ISQ), peri-implant soft tissue parameters (probing pocket depth, bleeding on probing, keratinized mucosa width), and oral health-related quality of life (OHRQoL) measured with the Oral Health Impact Profile-14 (OHIP-14). Generalized linear models, paired Student’s t-tests, and Wilcoxon tests were employed for data analysis.

RESULTS: The study included 68 subjects (136 implants). No statistically significant differences were found between groups for any of the clinical outcomes measured. The mean change in MBL from loading to 12 months was 0.04 mm (SD = 0.39) for the modified hydrophilic implants and 0.07 mm (SD = 0.22) for the conventional implants (p = 0.658), with no significant differences between the groups.

CONCLUSIONS: Over a 12-month period of functional loading, both implant surfaces demonstrated comparable performance regarding peri-implant bone stability, safety, and clinical outcomes. Although a small but statistically significant difference between groups was observed in MBL changes from baseline to 12 months (MD = 0.15 mm), no significant differences were found in MBL changes from loading to 12 months (primary outcome), ISQ, soft tissue healing, or peri-implant health.

PMID:41199413 | DOI:10.1111/clr.70071

Br J Nutr. 2025 Nov 7:1-46. doi: 10.1017/S0007114525105400. Online ahead of print.

ABSTRACT

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious disease and increasingly prevalent in children. MASLD is associated with health consequences such as type 2 diabetes, and cardiovascular disease. While, vitamin E is a potent antioxidant that has been proposed to improve liver function and cardiometabolic health including liver markers, lipid profile, glycemic control, and anthropometric measurements. A comprehensive search was conducted up to March 2025. Data on anthropometric measures, liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT)), glycemic indices (fasting blood sugar (FBS), insulin, homeostatic model assessment for insulin resistance (HOMA-IR)), lipid profiles (total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)), and serum vitamin E levels were extracted. Statistical analyses were performed using a random-effects model. Eleven RCTs involving 665 participants were included in this study. Vitamin E significantly reduced ALT (weighted mean difference (WMD)= -5.23 U/L;95% confidence interval (CI): -7.72, -2.75; P< 0.001) and AST (WMD= -3.00 U/L;95% CI: -4.59, -1.41; P< 0.001), reflecting improved liver function. It also decreased TC (WMD= -5.77 mg/dL;95% CI: -11.46, -0.09; P= 0.04) and HOMA-IR (WMD= -0.82;95% CI: -1.28, -0.37; P< 0.001), while significantly increasing serum vitamin E levels (WMD= 9.16 mg/L;95%CI: 3.29, 15.03; P=0.002). No significant changes were observed in the BMI, GGT, FBS, insulin, LDL, HDL, or TG levels. Vitamin E supplementation in pediatric MASLD appears to favorably influence key liver enzymes such as ALT, AST and certain metabolic factors including TC, and HOMA-IR levels, supporting its potential role as adjunctive therapy.

PMID:41199412 | DOI:10.1017/S0007114525105400

J Forensic Sci. 2025 Nov 6. doi: 10.1111/1556-4029.70214. Online ahead of print.

ABSTRACT

The hypothesis of fingerprint individuality continues to be debated due to limited empirical verification, impacting the scientific foundation of fingerprint identification. This study proposed a quantitative model for fingerprint individuality and investigated the three-dimensional (3D) distribution of minutiae. This model considered the position and direction of minutiae as 3D feature variables. We extracted 3D feature data from 56,812,114 known fingerprints based on the automatic fingerprint identification system (AFIS). Following data calibration, translation, and error correction, we statistically analyzed the distribution density of minutiae. We developed the algorithm to calculate the individuality score of a single fingerprint through the individuality model. The experimental results showed that the minutiae distribution followed distinct patterns. The distribution density of minutiae exhibited symmetry between corresponding fingers on left/right hands. Significant variations in minutiae distribution density and central point distribution were observed across the five pattern types (whorl, left loop, right loop, arch, accidental). Minutiae with different directions exhibited symmetry along the Y-axis in both positional and quantitative distribution. Minutiae within diagonally opposite angular ranges showed similar distribution trends. The individuality scores were robust to distinguish different fingerprints. We preliminarily applied the individuality score to provide a basis for modifying the AFIS scoring mechanism, and we found that the individuality score of same-source fingerprints was greater than that of close nonmatches (CNMs). This work provides novel insights into fingerprint individuality and establishes a statistical foundation for refining AFIS scoring mechanisms and likelihood-ratio evidence evaluation frameworks.

PMID:41199411 | DOI:10.1111/1556-4029.70214

BMC Glob Public Health. 2025 Nov 7;3(1):99. doi: 10.1186/s44263-025-00219-w.

ABSTRACT

BACKGROUND: Stigma is a deleterious force that is associated with poor health outcomes among people with HIV (PWH). The Finding Respect and Ending Stigma around HIV (FRESH) intervention is designed to combat HIV and related stigmas about PWH and their care providers. To evaluate the effects of the Spanish-language FRESH in the Dominican Republic, our team conducted a pilot trial, informed by the stepped-wedge model, at two HIV clinics to ascertain signals of potential value for PWH.

METHODS: Clinics were randomized to first and second receipt of the intervention; the intervention was delivered over 2 days. In-person tablet-based digital surveys, including validated measures of stigma and discrimination, were administered to PWH (2021-2022, N = 419) every 6 months aggregated to pre- and post-intervention periods for analysis. Analysis of variance (ANOVA) and general linear modelling were used to evaluate differences in stigma scores. All data collection occurred after an HIV clinic visit. Statistical analyses were performed using SPSS.

RESULTS: Mean age of participants was 33.86 (standard deviation [SD] = 9.14; range = 18-70); respondents predominantly identified as male (N = 396, 94.5%) and multiracial (N = 330, 90.5%). Significant differences were observed across time, with decreases from pre- to post-intervention in public stigma (mean [M] = 3.92, SD = 1.25 to M = 3.47, SD = 1.41, p < .001) and perceived sexual orientation discrimination (M = .23, SD = .27 to M = .10, SD = .18, p < .001). Significant differences between clinics were also evident, with higher scores in clinic A compared to clinic B in disclosure concerns (M = 4.31, SD = .84 vs. M = 3.68, SD = 1.26, p < .001), perceived sexual orientation discrimination (M = .17, SD = .22 vs. M = .12, SD = .22, p = .030), and perceived discrimination related to race/ethnicity (M = .11, SD = .19 vs. M = .05, SD = .15, p = .002). The viral suppression rate in these clinics improved between pre-intervention and post-intervention periods, from 78 to 82%, but did not reach statistical significance.

CONCLUSIONS: Substantive differences in clinics could have impacted the intervention’s delivery and impacts. While there were significant associations of intervention experience with reductions in some forms of stigma among PWH, results should be extended cautiously considering the small size of this pilot. Data collection procedures were feasible and acceptable, and evidence was found to warrant full-scale testing of the intervention.

TRIAL REGISTRATION: NCT04491539, https://clinicaltrials.gov/study/NCT04491539?cond=NCT04491539&rank=1.

PMID:41199402 | DOI:10.1186/s44263-025-00219-w

Equine Vet J. 2025 Nov 6. doi: 10.1111/evj.70114. Online ahead of print.

ABSTRACT

BACKGROUND: Assessment of equine metabolic and locomotory responses to quantified levels of physical exercise is needed to support the creation of tailored protocols for optimal training adaptation. The locomotory response to exercise in horses is not fully understood.

OBJECTIVES: To investigate the effect of a standardised exercise test (SET) on upper-body and limb kinematics and stride-to-stride variability in Standardbred Warmblood trotters.

STUDY DESIGN: Experimental repeated-measures field study.

METHODS: Thirteen Standardbred trotters, equipped with nine inertial measurement units (IMUs), performed an incremental SET on an oval track. Heart rate and lactate data were collected to identify internal workload. Two 30-s segments of jog on the straight (at the beginning and at the end of the SET) were used for statistical analysis of the effect of the SET on locomotion parameters.

RESULTS: Upper-body kinematics revealed a decrease in head and withers range of motion (ROM; -12.3 mm; p = 0.04 and -8.5 mm; p = 0.01, respectively). Front limb sagittal ROM (16.1°; p = 0.001) increased explained by increased maximal protraction and retraction (6.9°, p = 0.002 and 9.1°, p = 0.002, respectively). Stride-to-stride variability (i.e., coefficient of variation) was reduced for stride duration (-0.7%; p = 0.01), front limb sagittal ROM (-7.3%; p = 0.04), front limb maximal protraction (-6.9%; p = 0.01) and maximal retraction (-7.4%; p = 0.03). No effects were found on sagittal hindlimb angles and none of the absolute asymmetry parameters changed (p > 0.05).

MAIN LIMITATIONS: Horses were of different ages and training statuses, and full orthopaedic examinations were not performed.

CONCLUSIONS: Several kinematic parameters were affected by the SET. Head and withers ROM were reduced, while front limb sagittal ROM increased. Stride-to-stride variability showed a decrease. The results indicate that exercise in Standardbred trotters produces both a metabolic and locomotory response. Additionally, these findings highlight the efficacy of IMUs as a non-invasive tool for detecting exercise-induced changes in limb and upper-body kinematics.

PMID:41199399 | DOI:10.1111/evj.70114