Tag: pubmed

J Intellect Disabil Res. 2024 Nov 29. doi: 10.1111/jir.13200. Online ahead of print.

ABSTRACT

BACKGROUND: The 22q11.2 deletion syndrome (22q11.2DS) entails intellectual disabilities and higher risk of psychotic disorders. Neurocognitive deficits predict real-life functioning of schizophrenic patients. We investigated real-life functioning in 22q11.2DS, aiming at defining how neurocognitive profile and psychopathological variables impact on psychotic patients’ social functioning.

METHODS: We recruited 63 patients with schizophrenia (SCZ, N = 63), 44 with 22q11.2DS (DEL, N = 44) and 19 with 22q11.2DS and psychosis (DEL-SCZ, N = 19), all matched for age, sex and neurocognitive profile; we administered the Positive and Negative Syndrome Scale (PANSS), the Brief Negative Symptom Scale (BNSS), the Specific Levels of Functioning (SLoF) scale and the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). We implemented descriptive analyses, MANCOVA and linear regression statistics.

RESULTS: The DEL-SCZ and the SCZ groups showed similar levels in Interpersonal Relationships (p = 0.093) and Social Acceptability subscales (p = 0.283). The DEL group scored higher on the Interpersonal Relationships subscale compared with the SCZ group (p = 0.001). The groups scored similarly on the other SLoF subscales. Both BNSS total score (beta = -0.343; p = 0.004) and BNSS asociality (beta = -0.487; p = 0.038) significantly predicted the Interpersonal Relationships variable in the groups with psychosis (SCZ and DEL-SCZ).

DISCUSSION AND CONCLUSIONS: Individuals with 22q11.2DS display a similar real-life functioning to patients with chronic schizophrenia. Social functioning impairments are typical of psychosis regardless of the genetic condition and highly predicted by negative symptoms like asociality. The 22q11.2DS represents a reliable biological model to study vulnerability to psychosis and its consequences on patients’ real-life and social functioning.

PMID:39614621 | DOI:10.1111/jir.13200

Hand (N Y). 2024 Nov 29:15589447241300713. doi: 10.1177/15589447241300713. Online ahead of print.

ABSTRACT

BACKGROUND: The recent trend in administering postoperative oral corticosteroids has proven effective in alleviating pain and improving surgical outcomes for hand and upper extremity procedures. However, concerns persist regarding potential infection risks despite a lack of supporting evidence in the current literature. We propose that a 6-day regimen of low-dose postoperative oral corticosteroids is safe and does not increase the likelihood of surgical site infections (SSIs) in adult upper extremity surgeries.

METHODS: A retrospective study of all adult patients who underwent clean, upper extremity surgery, including both soft tissue and hardware implantation cases, between November 2021 and November 2023, performed at a single institution were included in the study. Primary outcome measures were diagnosis of SSI by 14 days and 30 days. Categorical variables were compared using χ² tests, and continuous variables were compared using Wilcoxon rank-sum tests. A P value less than .05 was considered statistically significant.

RESULTS: A total of 813 cases were included for analysis-196 received a 6-day course of postoperative oral steroids (methylprednisolone) and 617 did not. Both groups had similar SSI rates of 4.1% and 3.1%, respectively, with no statistical differences between the groups at any postoperative time. Subgroup analysis of patients diagnosed with an SSI identified no statistically different demographic factors or medical comorbidities when comparing patients who received postoperative oral corticosteroids versus those who did not.

CONCLUSIONS: Low-dose, postoperative oral steroid use following adult upper extremity surgery is safe and does not increase the risk of SSI. Further investigations with prospective studies on postoperative oral corticosteroids would prove advantageous.

PMID:39614609 | DOI:10.1177/15589447241300713

Mov Disord Clin Pract. 2024 Nov 29. doi: 10.1002/mdc3.14285. Online ahead of print.

ABSTRACT

BACKGROUND: Transcranial direct current stimulation (tDCS) over the supplementary motor area (SMA) has shown promise in Tourette syndrome (TS), but previous studies were limited in size and stimulation duration.

OBJECTIVE: The aim was to explore the efficacy and safety of multiple sessions of cathodal tDCS over the bilateral SMA on tic severity in TS.

METHODS: A double-blind, randomized, sham-controlled trial 1 mA cathodal tDCS over bilateral SMA was performed in participants with TS older than 16 years. The intervention involved two 20-min periods of stimulation with either sham or active tDCS per day, over 5 consecutive days, during which participants actively suppressed tics. Tic severity was measured using the Yale Global Tic Severity Scale Total Tic Severity (YGTSS-TTS, primary outcome) score at baseline, day 5 (visit 5), and 1 week later (visit 6). Questionnaires focusing on comorbidities were performed at baseline and visit 6.

RESULTS: Twenty-four participants were randomly assigned (12 active, 12 sham; 8 women; median age: 26). We observed a significant effect of visit on YGTSS-TSS, but no significant effect of treatment or treatment × visit interaction emerged. In contrast, a statistically significant effect of the treatment × visit interaction was observed for the motor tic subscore, with significantly larger improvement in the active arm. Furthermore, we detected a significantly larger decrease in premonitory urge intensity at visit 6 after active stimulation. No effect was detected on severity of comorbidities.

CONCLUSIONS: This preliminary study suggests that bilateral tDCS over the SMA provides small, but significant benefits in reducing motor tic severity in TS.

PMID:39614604 | DOI:10.1002/mdc3.14285

Nurs Open. 2024 Dec;11(12):e70082. doi: 10.1002/nop2.70082.

ABSTRACT

BACKGROUND: Sound mathematical skills are paramount for effective nursing practice and patient safety.

OBJECTIVES: To explore the factors that influence nursing student anxiety when engaging with mathematics-related activities in nursing education.

DESIGN: A concurrent mixed methods employing cross-sectional online survey and focus group interviews.

SETTING: One undergraduate nursing course at an Australian university.

PARTICIPANTS: Bachelor of Nursing students from across academic years.

METHODS: An online survey comprising closed- and open-ended questions to assess mathematics anxiety and self-efficacy and associated factors affecting its application to practice. Focus group interviews to explore anxieties related to mathematics and students’ approaches to nursing mathematics. Quantitative data were analysed using descriptive statistics and qualitative data using inductive content analysis.

RESULTS: A total of 202 nursing students commenced the survey, of which 135 were fully completed, while 17 students participated in focus groups. Less than half were school leavers. Around three-quarters reported some level of fear of mathematics, while many lacked confidence, fear of making errors and/or harming patients and negative childhood experiences of mathematics. Survey items demonstrated extensive variation in perceptions.

CONCLUSIONS: The complexity and diversity of anxieties presents key challenges for nurse academics seeking to educate competent, safe students. Teaching approaches should be varied and consideration of having specialist mathematics teachers and learning psychologists on teaching teams to ensure student success.

REPORTING METHOD: This study is reported using Mixed Methods Reporting in Rehabilitation & Health Sciences (MMR-RHS).

PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution.

PMID:39614599 | DOI:10.1002/nop2.70082

Food Res Int. 2024 Nov;196:115097. doi: 10.1016/j.foodres.2024.115097. Epub 2024 Sep 15.

ABSTRACT

Chinese consumers are unfamiliar with the sensory attributes of wine and often pay more attention to the extrinsic attributes of wine that can most directly present information. Therefore, it is crucial to study consumer preferences for extrinsic attributes. This paper proposes a consumer segmentation method based on stratification and weighted clustering algorithm, leveraging data from an anonymous online survey (N = 3179). The AFR model is constructed based on the RFM model to segment wine consumers from the perspective of customer value. This model removes Monetary indicator and adds a new indicator Amount to eliminate multicollinearity caused by the Frequency and Monetary indicators of RFM model. In addition, factor analysis is used to assign weights to clustering indicators, addressing the problems of unequal weighting and strong correlation among the indicators. This allows for a simple, efficient, and precise segmentation of wine consumers at different levels. The method proposed in this article segments consumers into two layers and six categories: the potential layer includes product-oriented type, amorphous type, and cheap-fine type, while the mature layer comprises the rational type, reputation-price type and random type. This research will provide wine producers and distributors with a simple and efficient basis for production and marketing decision-making. Additionally, it can serve as a reference for consumer segmentation in food and other fields.

PMID:39614571 | DOI:10.1016/j.foodres.2024.115097

Food Res Int. 2024 Nov;196:115027. doi: 10.1016/j.foodres.2024.115027. Epub 2024 Sep 6.

ABSTRACT

Foodborne diseases are a global burden. Actions to fight this group of diseases are necessary, especially for the younger demographic, which consists of consumers, food handlers, and the future workforce of the food chain. To this end, outlining the food safety profile of the target audience is imperative. Thus, this study aimed to understand and evaluate the risk perception, knowledge, and food safety self-reported practices of individuals between 5th and 9th grades (10 to 14 years old, considering the normal teaching flow) of public schools in the Federal District – Brazil. Instruments by Batista et al. (2023) and Brazil (2013) were used to achieve the objectives. The study included 1,420 students aged 9 to 17 (women = 50.6 %; n = 719) with a mean age of 11.9 years (±1.7) enrolled in 25 schools. It was observed that a more significant proportion of students attributed very low and low risk of Foodborne Diseases to the foods produced and served in School Food Services. The presence of optimistic bias, low perception of lethality, average knowledge, risky practices, and the gap between unsafe food knowledge and safe food handling/consumption practices were also identified. Correlations were identified between social vulnerability and risk perception (positive) and self-reported practices (negative). The results show the urgency of considering these individuals to ensure food safety, considering their vulnerability, reality, and the tools at their disposal.

PMID:39614552 | DOI:10.1016/j.foodres.2024.115027

Food Res Int. 2024 Nov;196:115010. doi: 10.1016/j.foodres.2024.115010. Epub 2024 Sep 4.

ABSTRACT

Pesticide residues are identified as a significant food safety issue in Hami melons, and their rapid and accurate detection is deemed critical for ensuring public health. In response to the cumbersome procedures with existing chemical detection methods, this study explored the potential of identifying different pesticide residues in Hami melon by microfluorescence hyperspectral imaging (MF-HSI) technology combined with machine learning. By simulating the actual agricultural production, three pesticides, Beta-Cypermethrin, Difenoconazole, and Acetamiprid, were sprayed on Hami melons. The Hami melons with pesticide residues were collected as samples, from which spectral and image information were extracted. Competitive adaptive reweighted sampling (CARS), genetic algorithm (GA), and sequential projection algorithm (SPA) methods were used to extract characteristic wavelengths. Partial least squares discriminant analysis (PLS-DA), extreme learning machine (ELM), and k-nearest neighbor (KNN) classification models of the original spectra and characteristic wavelengths were established. 9 feature variables-Red (R), Green (G), Blue (B), Hue (H), Saturation (S), Value (V), Lightness (L), Red-Green axis (a) and Yellow-Blue axis (b) information was extracted by the color statistical method. 4 important color information of the image (G, B, V, L) were identified through Pearson correlation analysis, and the optimal feature wavelength was fused to enhance the identification accuracy of models. The results indicated that the SPA-PLS-DA model demonstrated the highest accuracy for the characteristic wavelength dataset, achieving accuracies of 89.35 % for the training set and 86.99 % for the testing set, which was better than the model established by the full wavelength dataset. Using the dataset that fuses feature wavelengths with 4 important image features, the SPA-PLS-DA model demonstrated superior performance, with recorded accuracy, precision, specificity, and sensitivity metrics on the testing set at 93.48 %, 93.81 %, 96.63 %, and 93.36 %, respectively. Consequently, MF-HSI technology combined with machine learning offers an approach to analyze pesticide residues in Hami melons accurately, and it provides a technical basis for detecting pesticide residues in other fruits and vegetables.

PMID:39614536 | DOI:10.1016/j.foodres.2024.115010

Am J Emerg Med. 2024 Nov 24;88:96-104. doi: 10.1016/j.ajem.2024.11.077. Online ahead of print.

ABSTRACT

BACKGROUND: Combat casualty care has advanced significantly with the implementation of evidence-based protocols designed to lower combat-related mortality. Over the last decade, two major urban conflicts in southern Israel have challenged the evolving military trauma system. This study aimed to assess differences in prehospital care and compare the outcomes of aeromedically evacuated casualties from the 2014 and 2023 conflicts.

METHODS: This retrospective registry-based cohort study utilized records from the Military Airborne Combat Evacuation Unit (MACEU) and the Israeli National Trauma Registry. Eligible patients evacuated by MACEU between 07.17.14 and 08.16.14 and between 10.27.23 and 03.17.24 were compared. Ground-evacuated casualties were excluded. Demographics, prehospital interventions, and clinical outcomes were compared.

RESULTS: During the 2014 conflict, 251 patients were evacuated alive, compared to 940 in 2023. Both conflicts involved mostly young males injured by explosions, with comparable injury distributions across body regions. The time from injury to hospital arrival decreased from 65 min (IQR 47-94) in 2014 to 60 min (IQR 47-180) in 2023 (d = 0.5, p < 0.001). The proportion of severely injured patients (ISS ≥ 16) increased from 18.3 % to 25.2 % (OR 1.5 [95 % CI 1.06-2.14], p = 0.03), and critically injured patients (ISS ≥ 25) from 7.6 % to 12.8 % (OR 1.79 [95 % CI 1.08-2.96], p = 0.03). Prehospital advanced airway interventions and tube thoracostomies decreased from 11.6 % to 6.0 % (OR 0.48 [95 % CI 0.30-0.76], p < 0.001) and from 7.0 % to 2.1 % (OR 0.28 [95 % CI 0.15-0.54], p < 0.001), respectively. Prehospital blood transfusions use increased from 6.6 % to 16.4 % (OR 2.78 [95 % CI 1.64-4.76], p < 0.001). In-hospital mortality rates remained stable (2.7 % vs. 2.5 %, OR 1.12 [95 % CI 0.44-2.81], p = 0.99). Although not statistically significant, lower mortality rates were recorded among the severely (13.0 % vs. 8.4 %, OR 0.61 [95 % CI 0.23-1.61, p = 0.48) and critically injured (26.3 % vs. 15.8 %, OR 0.53 [95 % CI 0.17-1.64], p = 0.32).

CONCLUSION: Over the past decade, there has been a decline in prehospital airway interventions and thoracostomies, coupled with an increase in early blood transfusions. Despite greater injury severity, mortality rates have remained stable. Although not statistically significant, lower mortality rates were recorded among the severely and critically injured. These findings support the “less is more” approach in modern prehospital combat casualty care.

PMID:39612529 | DOI:10.1016/j.ajem.2024.11.077

J Plast Reconstr Aesthet Surg. 2024 Nov 14;100:104-111. doi: 10.1016/j.bjps.2024.11.014. Online ahead of print.

ABSTRACT

OBJECTIVE: To assess the association between nonsyndromic craniosynostosis (NSC) and academic achievement.

METHODS: Registry data were analyzed on demographic background, presence of craniosynostosis and other comorbidities, grades, and results on national standardized tests (NSTs) across primary and upper secondary school, as well as the presence of academic degrees. The analysis used regression modeling on a sample of N = 1110 individuals with NSC and a matched cohort of N = 10,654 individuals.

RESULTS: There was a significant negative association between NSC and NST scores in third grade for both mathematics (aOR 0.76, 95% CI 0.60-0.99, p = .020) and Swedish (aOR 0.69, 95% CI 0.54-0.89, p = .004). The association seemed to primarily be carried by females with NSC (aORs for the interaction term 0.26-0.45, all ps <.05). Further, a slightly stronger negative association was observed in individuals with psychiatric comorbidities (aOR 0.44, 95% CI 0.22-0.90, p = .025 for mathematics; aOR 0.45, 95% CI 0.21-0.98, p = .045 for Swedish). No statistically significant association was found between NSC and NST scores or grades in later school years, or with academic degrees.

CONCLUSIONS: There is evidence for a limited temporary negative association between NSC and academic achievement. A stronger negative association between NSC and academic achievement seems to be present in girls, and for individuals with psychiatric comorbidities. This has important implications for clinical management and provision of support in educational contexts.

PMID:39612517 | DOI:10.1016/j.bjps.2024.11.014

Health Promot Int. 2024 Dec 1;39(6):daae170. doi: 10.1093/heapro/daae170.

ABSTRACT

Disadvantaged adolescents, including those from lower socioeconomic status (SES) or geographically remote backgrounds, engage in higher rates of risk behaviours, including poor diet, alcohol and tobacco use. While digital interventions targeting lifestyle risk behaviours show potential, few studies have focused on their implementation and relevance for this population. This study conducted a process evaluation of ‘Health4Life’, a universal school-based digital program targeting multiple behaviours, among a sample of disadvantaged adolescents. Participants were from six schools classified as low SES (Index of Community Socio-educational Advantage percentile score ≤ 25%), and/or regional using the Australian Statistical Geography Standard. Self-reported student (n = 214) and teacher evaluations (n = 16) assessed Health4Life’s acceptability, with qualitative questions capturing areas for improvement. Teacher-reported implementation data (n = 16) measured intervention fidelity and feasibility. Quantitative data were analysed using descriptive statistics and open-ended responses were thematically analysed. Compared to the entire sample, this subset of students evaluated Health4Life less favourably (66% versus 75%), with fewer enjoying the stories (63% versus 75%) and planning to use the skills and information (60% versus 70%). Teacher evaluations were mostly positive and aligned closely with the entire sample. Fidelity data also indicated comparable levels of student engagement (~92% versus ~85%). Key themes for refinement included improving content relevance and technical execution to better resonate with disadvantaged adolescents. While teacher evaluations suggest Health4Life is a valuable program in low SES or regional contexts, students’ lower ratings indicate refinements are needed. Identified areas for improvement will guide co-designing the program’s adaptation to improve effectiveness and relevance for disadvantaged adolescents. Trial registration: The Health4Life trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12619000431123).

PMID:39612512 | DOI:10.1093/heapro/daae170