J Thorac Cardiovasc Surg. 2026 Jun 26:S0022-5223(26)01040-8. doi: 10.1016/j.jtcvs.2026.05.012. Online ahead of print.
NO ABSTRACT
PMID:42363924 | DOI:10.1016/j.jtcvs.2026.05.012
Tag: pubmed
Appl Neuropsychol Adult. 2026 Jun 27:1-11. doi: 10.1080/23279095.2026.2691093. Online ahead of print.
ABSTRACT
The present study aims to examine the language impairments observed across various stages of Alzheimer’s Disease (AD) in Turkish-speaking individuals. The study involved 24 participants diagnosed with AD (12 women, 12 men; mean age = 82.00 ± 6.75) and a control group of 24 healthy adults (12 women, 12 men; mean age = 80.71 ± 8.61). All participants completed the Test Your Memory-Turkish (TYM-TR) and the Aphasia Language Assessment Test (ADD). Data analysis was conducted using SPSS 24 software with descriptive statistics, Spearman’s correlation coefficient, and the Mann-Whitney U test. Participants with AD scored lower on the TYM-TR and ADD than healthy participants. A strong positive correlation was observed between scores on the TYM-TR and ADD tests in both participant groups. The test scores decreased as AD stages progressed. This study provides a framework for SLTs to identify AD stages and tailor language interventions accordingly.
PMID:42363914 | DOI:10.1080/23279095.2026.2691093
Anesth Analg. 2026 Jun 25. doi: 10.1213/ANE.0000000000008155. Online ahead of print.
ABSTRACT
BACKGROUND: Spinal muscular atrophy (SMA) is a genetic disorder resulting in progressive muscle atrophy due to the degradation of motor neurons. There are limited data on anesthesia care for these patients, the incidence of anesthesia-related adverse events, and difficult intubations. The investigators aim to characterize patients with SMA who required anesthetics at a large quaternary pediatric hospital, describe the procedures being performed, report the incidence of severe anesthesia-related adverse events, and determine the incidence of difficult intubations. The investigators hypothesized that lumbar puncture for nusinersen administration would represent the most common procedure for which patients with SMA required anesthesia care.
METHODS: A retrospective chart review of anesthetics provided to SMA patients from June 1, 2012, to December 30, 2023. Data obtained included procedures performed, patient characteristics, perioperative care, anesthesia technique, and outcomes.
RESULTS: In total, 1804 procedures were performed for 175 patients with SMA. The majority of procedures (1423/1804, 78.9%) were for lumbar puncture for nusinersen administration; 234 of 1804 (13.0%) received general anesthesia with endotracheal tube placement; 22 of 1804 total cases (1.2%) or 22 of 234 (9.4%) of those with endotracheal tube placement met the definition of difficult intubation. There were no statistically significant associations between difficult intubation and SMA type, age, and presence of halo headframe (all P > .05). There were six severe anesthesia-related adverse events (0.33%). Of 1423 total procedures for lumbar punctures for nusinersen administration, 1254 of 1423 (88.1%) were performed with a natural airway (nasal canula, facemask, or home continuous positive airway pressure [CPAP] or biphasic positive airway pressure [BiPAP]) or pre-existing tracheostomy.
CONCLUSIONS: Lumbar puncture for nusinersen administration made up the vast majority of procedures for which patients with SMA presented for anesthesia care. The incidence of difficult intubation was 9.4%, and the incidence of anesthesia-related severe adverse events was 0.33%. These results indicate the need to focus research on the perioperative and airway-related risks for this evolving and medically complex population.
PMID:42363899 | DOI:10.1213/ANE.0000000000008155
J Am Soc Mass Spectrom. 2026 Jun 27. doi: 10.1021/jasms.6c00010. Online ahead of print.
ABSTRACT
Drug-induced phospholipidosis is a common side effect of the pharmacological treatment. Although mostly reversible, it can lead to deleterious consequences, including inflammation and fibrosis. While it can be readily detected in tissue biopsies or cell cultures, biomarkers that can be measured noninvasively remain scarce. We used a panel of four compounds known to induce phospholipidosis to investigate three primary target tissues as potential new biomarkers. Using mass spectrometry imaging, followed by analysis with prediction models and feature-wise statistical analysis, we identified over 150 mass/charge features correlated with DIPL in general or in specific tissues, many of which yielded database hits in the LipidMaps DB in molecule classes linked to DIPL before. Our data set provides a foundation for annotating reliable biomarkers in blood and urine.
PMID:42363896 | DOI:10.1021/jasms.6c00010
J Child Adolesc Psychiatr Nurs. 2026 Aug;39(3):e70062. doi: 10.1111/jcap.70062.
ABSTRACT
PURPOSE: This study aimed to determine the effects of a cognitive-behavioral therapy (CBT)-based psychoeducation program (the Social Media Addiction Reduction Psychoeducation Program (SMARPP), on university students’ social media addiction and self-control.
METHOD: The study used pre-test, post-test, and follow-up method with university students. Ninety-five students took part. Data were collected using a general information form, the Social Media Addiction Scale (SMAS), and the Short Self-Control Scale (SSCS). The data were analyzed using basic statistics such as number, percentage, average, and standard deviation, as well as independent sample t-tests and variance analysis.
RESULTS: The average age of the experimental group was 20.39 ± 1.81years, and that of the control group was 20.16 ± 2.09 years. In the experimental group, students’ SMAS total scores and subdimension scores (occupation, mood regulation, conflict, and repetition) decreased significantly. Their total SSCS scores went up significantly (p < 0.05). In the control group, there were no significant changes in the scores (p > 0.05).
CONCLUSION: The SMARPP effectively reduced university students’social media addiction and increased their self-control. In this regard, it is recommended that mental health nurses and psychological counselors working in schools apply the SMARPP.
PMID:42363867 | DOI:10.1111/jcap.70062
Future Oncol. 2026 Jun 27:1-9. doi: 10.1080/14796694.2026.2687697. Online ahead of print.
ABSTRACT
INTRODUCTION: Given the underrepresentation of adults aged ≥75 years with extensive-stage small-cell lung cancer (ES-SCLC) in clinical trials, we compared first-line chemoimmunotherapy versus chemotherapy in this population.
METHODS: This retrospective study enrolled 88 patients aged ≥75 years with ES-SCLC treated with either chemotherapy alone (n = 42) or chemoimmunotherapy (n = 46). The primary endpoint was overall survival (OS). Secondary endpoints included progression-free survival (PFS) and safety. Multivariable Cox regression and stabilized inverse probability of treatment weighting (IPTW) analyses were performed to reduce confounding.
RESULTS: Median OS and PFS were 14.3 (95% CI: 11.6-22.5) and 6.6 in the chemotherapy group and 16.9 (95% CI: 12.7-NA) and 7.6 months in the chemoimmunotherapy group, respectively (HR: 0.90, 95% CI: 0.51-1.58, p = 0.71; HR: 0.75, 95% CI: 0.43-1.29, p = 0.30, respectively). Multivariate analysis identified smoking status as an independent predictor of OS (HR: 2.10, 95% CI: 1.01-4.38, p = 0.048).
CONCLUSION: Among patients aged ≥75 years with ES-SCLC, chemoimmunotherapy was associated with numerically longer OS compared with chemotherapy alone, although this difference did not reach statistical significance.
PMID:42363803 | DOI:10.1080/14796694.2026.2687697
J Int Med Res. 2026 Jun;54(6):3000605261462010. doi: 10.1177/03000605261462010. Epub 2026 Jun 27.
ABSTRACT
ObjectiveTo evaluate the efficacy of small-incision, point-by-point debridement combined with double-cannula negative-pressure irrigation and drainage in the treatment of granulomatous mastitis.MethodsThis single-center, retrospective matched cohort study included 118 patients with granulomatous mastitis who were treated at the Third People’s Hospital of Mianyang between January 2022 and December 2024. Patients with comparable clinical characteristics were matched in a 1:1 ratio and assigned to either the treatment or control group, with 59 patients in each group. Patients in the treatment group underwent small-incision, point-by-point debridement of necrotic tissue combined with double-cannula continuous negative-pressure irrigation and drainage, whereas those in the control group underwent conventional incision and drainage combined with negative-pressure drainage. Postoperative drainage volume, time to drain removal, frequency of dressing changes, wound healing time, primary healing rate, recurrence rate, and breast shape score were compared between the two groups.ResultsCompared with the control group, the treatment group had a significantly lower postoperative drainage volume, fewer dressing changes, shorter time to drain removal, and shorter wound healing time. The recurrence rate was significantly lower in the treatment group than in the control group (χ2 = 5.221, p < 0.05). The primary healing rate was significantly higher in the treatment group than in the control group (χ2 = 4.140, p < 0.05). In addition, breast shape scores were significantly higher in the treatment group. All between-group differences were statistically significant.ConclusionSmall-incision, point-by-point debridement combined with double-cannula negative-pressure irrigation and drainage may promote wound recovery, reduce recurrence, and better preserve breast appearance in selected patients with granulomatous mastitis requiring surgical treatment. Further prospective studies are warranted to confirm these findings.
PMID:42363797 | DOI:10.1177/03000605261462010
J Int Med Res. 2026 Jun;54(6):3000605261463829. doi: 10.1177/03000605261463829. Epub 2026 Jun 27.
ABSTRACT
ObjectiveTo compare outcomes between immediate intraoperative dexamethasone implantation and scheduled 1-month postoperative dexamethasone implantation in pseudophakic eyes undergoing vitrectomy for diabetic macular edema with secondary epiretinal membrane.MethodsThis retrospective comparative study included 80 pseudophakic eyes with diabetic macular edema and secondary epiretinal membrane. All eyes underwent 25-gauge vitrectomy with epiretinal membrane and internal limiting membrane peeling. The Immediate Group received dexamethasone implantation at the end of vitrectomy, and the Delayed Group received the first dexamethasone implant 1 month postoperatively. From month 3, both groups followed the same pro re nata retreatment protocol. Best-corrected visual acuity, central macular thickness, intraocular pressure, and dexamethasone injection frequency were assessed for 12 months.ResultsBoth groups showed improvement in best-corrected visual acuity and reduction in central macular thickness, but early recovery was faster in the Immediate Group. At 1 month, best-corrected visual acuity was 0.55 ± 0.08 versus 0.78 ± 0.11 logarithm of the minimum angle of resolution, and central macular thickness was 315.5 ± 28.6 versus 520.2 ± 35.4 μm, respectively (both P < 0.001). Mixed-effects models showed significant time effects and significant group × time interactions at earlier visits, supporting greater early improvement in the Immediate Group. At 12 months, best-corrected visual acuity remained better in the Immediate Group (0.36 ± 0.08 vs. 0.43 ± 0.10 logarithm of the minimum angle of resolution, P = 0.001). Although central macular thickness remained lower in the Immediate Group, the group × time interaction for central macular thickness was no longer significant, indicating that the anatomical advantage became less pronounced over time. The Immediate Group showed numerically fewer dexamethasone injections, but without statistical significance. Intraocular pressure elevation was controlled medically, and no serious ocular or systemic adverse events were documented.ConclusionImmediate intraoperative dexamethasone implantation was associated with faster early anatomical recovery and earlier visual improvement. The anatomical advantage became less pronounced over time, and the potential effect on retreatment burden requires confirmation in prospective randomized studies.
PMID:42363796 | DOI:10.1177/03000605261463829
J Int Med Res. 2026 Jun;54(6):3000605261463455. doi: 10.1177/03000605261463455. Epub 2026 Jun 27.
ABSTRACT
ObjectiveHip and femur fractures in older adults are linked to high morbidity, mortality, and socioeconomic costs. This meta-analysis compares regional anesthesia and general anesthesia for these surgeries, focusing on perioperative safety and outcomes.MethodsFifteen studies (6829 participants) from 2009 to 2024 were analyzed. Primary outcomes included 30-day mortality, postoperative delirium, and cardiovascular events; secondary outcomes covered intraoperative blood loss, hospital stay, and pain. Pooled effect sizes were calculated using random-effects models with odds ratios and 95% confidence intervals. Heterogeneity was assessed using the I2 statistic. Risk of bias was evaluated with Risk of Bias 2.0 (randomized controlled trials) and Risk Of Bias In Nonrandomized Studies of Interventions (observational studies). Certainty of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation approach.ResultsPooled analysis showed no significant difference in 30-day mortality between regional anesthesia and general anesthesia (odds ratio = 0.89 (0.72-1.10), p = 0.28, I2 = 34%). Regional anesthesia was associated with significantly lower hypotension rates (odds ratio = 0.28 (0.18-0.43), p < 0.001, I2 = 52%). There was a nonsignificant trend toward lower postoperative delirium with regional anesthesia (odds ratio = 0.78 (0.60-1.01), p = 0.06, I2 = 46%). Pain management favored general anesthesia in one large trial (severe pain: 28.8% vs. 42.3%, p < 0.01), but other studies showed no difference. No significant differences were found in long-term mortality or functional recovery (p > 0.05 for all). Substantial heterogeneity (I2 > 50%) was noted for some outcomes because of variations in age, fracture type, and study design.ConclusionRegional anesthesia may offer perioperative benefits, including reduced hypotension and a possible (but not statistically confirmed) reduction in postoperative delirium. General anesthesia provides better early pain control in some patients and remains suitable for complex cases. Individualized anesthesia plans are recommended. Future research should prioritize standardized outcomes and larger trials.
PMID:42363795 | DOI:10.1177/03000605261463455
J Nurs Manag. 2026;2026(1):e3436144. doi: 10.1155/jonm/3436144.
ABSTRACT
BACKGROUND: Nurses in resource-limited settings like Jordan require strong leadership and clinical judgment. Job rotation is believed to improve adaptability and self-efficacy, but its effect on clinical decision-making is unclear.
PURPOSE: This study aimed to examine whether job rotation mediates the relationship between clinical leadership skills and clinical decision-making among nurses.
METHODS: A cross-sectional correlational study was conducted among 395 registered nurses employed in Jordanian governmental hospitals. Participants were recruited using a proportional random sampling technique. Data were collected using validated questionnaires assessing clinical leadership skills, job rotation, and clinical decision-making. Statistical analyses, including ANOVA and regression analysis, were performed to examine relationships among the study variables. Structural equation modeling (SEM) was additionally used to assess mediation effects.
FINDINGS: The results showed significant differences between clinical decision-making and gender, marital status, and educational level. Clinical leadership significantly predicted decision-making (β = 0.433, 95% CI [0.331, 0.535], t = 8.226, p < 0.001). In contrast, job rotation indicated no significant direct effect (β = 0.000, 95% CI [-0.052, 0.051], t = -0.010, p = 0.992) and did not mediate the relationship between leadership and decision-making (β = 0.008, 95% CI [-0.041, 0.057], t = 0.325, p = 0.745).
CONCLUSION: Leadership skills were significantly associated with nurses’ clinical decision-making, and leadership development may play a more substantial role in clinical decision-making than job rotation within this sample.
IMPLICATION FOR NURSING MANAGEMENT: Job rotation implementation has to be intentional, by putting real effort into structured training, mentoring, and embedding workplace learning into daily routines, which improves decision-making quality, increases professional confidence, and ultimately enhances patient outcomes.
PMID:42363792 | DOI:10.1155/jonm/3436144