Tag: pubmed

J Strength Cond Res. 2025 Oct 30. doi: 10.1519/JSC.0000000000005279. Online ahead of print.

ABSTRACT

Tuncer, D, Altay, E, and Furuncu, B. Physical performance in young adult women with high femoral anteversion. J Strength Cond Res XX(X): 000-000, 2025-Women with high femoral anteversion (HFA) demonstrate significantly increased hip internal rotation and anteversion angles than controls, which may affect lower extremity biomechanics. This cross-sectional observational study aimed to evaluate the impact of HFA on physical performance in young adult women. Twenty-two women with HFA (age 21.36 ± 1.89 years) and 22 age-matched controls (age 22.23 ± 2.05 years) were assessed. Femoral anteversion was assessed using both the Craig test and goniometric measurements of hip internal and external rotation. Physical performance was evaluated using sit-and-reach flexibility test, hand-grip strength, back-leg-chest dynamometry, double- and single-leg horizontal jump tests, and 6-minute walk test. The HFA group exhibited significantly increased internal rotation and decreased external rotation ranges of motion, along with higher femoral anteversion angles as determined by the Craig test (p < 0.001). No statistically significant differences were found between groups for most physical performance measures (p > 0.05), although back-leg-chest strength tended to be lower in the HFA group (p = 0.05, moderate effect size). These findings suggest that despite marked anatomical differences, physical performance in young adult women with HFA is largely comparable with controls. Future research should investigate symptomatic individuals and the potential functional impact of higher anteversion angles.

PMID:41160019 | DOI:10.1519/JSC.0000000000005279

Cytotherapy. 2025 Sep 26:S1465-3249(25)00846-1. doi: 10.1016/j.jcyt.2025.09.008. Online ahead of print.

ABSTRACT

BACKGROUND AIMS: Induced pluripotent stem cells (iPSCs) are a promising cell-based therapy given their ability to differentiate into various cell types for therapeutic use. Although clinical trials using these cells have recently emerged, such trials are small, heterogenous in design, and examine a broad range of diseases. A systematic scoping review of published clinical studies and registered trials is needed to understand important aspects of study design and identify barriers to greater clinical adoption.

METHODS: A systematic search of published clinical studies was conducted in MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (1946 to January 29, 2025) and ongoing registered clinical trials in Clinical Trials.Gov and the World Health Organization International Clinical Trials Registry Platform (January 29, 2025). Descriptive statistics were used for data analysis. Meta-analysis was not performed given the small number and size of included studies.

RESULTS: We identified 10 published clinical studies and 22 ongoing registered trials utilizing iPSCs to treat a wide range of diseases, including cardiac conditions, ocular disorders, cancer, graft-versus-host disease, and as a source of platelets for transfusion. Published studies were mostly small (only 2 studies reported on more than 4 patients) and uncontrolled, with a total of 115 patients treated. While iPSC characterization was generally aligned with criteria established by the International Society for Stem Cell Research, considerable variability was observed in terms of study design, medical conditions examined, and cell source used for iPSC generation. Moreover, a broad range of iPSC-derived cell products were administered. Variability among studies and ongoing trials may complicate and delay our understanding of the safety and efficacy of iPSC-based therapies.

CONCLUSIONS: iPSCs are poised to have a significant impact on clinical care for patients with conditions such as cardiac disease, cancer, and ocular disorders. We anticipate a period of several more years before the safety and efficacy of iPSC-based therapies can be definitively determined. Standardized study protocols and adherence to iPSC-derived product characterization criteria could facilitate more accelerated approval of iPSC-based therapies.

PMID:41160002 | DOI:10.1016/j.jcyt.2025.09.008

J Nutr Educ Behav. 2025 Oct 28:S1499-4046(25)00427-0. doi: 10.1016/j.jneb.2025.09.004. Online ahead of print.

ABSTRACT

OBJECTIVE: To describe the intervention and research methods of the Teacher Education and Classroom Habits (TEACH) study, a social cognitive theory-based virtual nutrition intervention program for Montessori teachers to enhance teachers’ personal and classroom nutrition beliefs and behaviors.

DESIGN: This 12-week study will employ a cluster-randomized control design with a delayed intervention for the control group.

SETTING: Montessori schools across the US with early childhood programs.

PARTICIPANTS: Early childhood teachers will be recruited from approximately 29 Montessori schools across the US and randomized at the school level.

INTERVENTION: The TEACH study will provide culturally focused nutrition education for Montessori teachers over 6 weeks, consisting of 4 program components, including an interactive online platform, live virtual education sessions, a Montessori-based nutrition curriculum, and parent education handouts.

MAIN OUTCOME MEASURES: Using validated survey measures, changes in teachers’ nutrition knowledge, nutrition self-efficacy, nutrition teaching self-efficacy, cultural competence, classroom eating behaviors, classroom food practices, nutrition teaching practices, and teacher-parent communication will be assessed at 3 timepoints (i.e., baseline, week 6, and week 12).

ANALYSIS: Stepwise linear regressions will be used to assess relationships between baseline variables. Multilevel modeling will be used to determine the impact of the intervention. Statistical significance set at P ≤ 0.05.

PMID:41159997 | DOI:10.1016/j.jneb.2025.09.004

J Hand Surg Am. 2025 Oct 28:S0363-5023(25)00473-3. doi: 10.1016/j.jhsa.2025.08.017. Online ahead of print.

ABSTRACT

PURPOSE: Open reduction and internal fixation (ORIF) of distal humerus fractures (DHFs) has nearly identical work relative value unit (wRVU) compensation compared with distal radius fractures (DRFs). The purpose of this study was to compare perioperative work effort, surgical times, complications, and the frequency of postoperative follow-up care for ORIF DRF and DHF cases.

METHODS: All isolated cases of ORIF DHF and intra-articular DRF in adult patients between 2010 and 2024 from a single, large health care system were reviewed. Baseline demographics, surgical characteristics, complications/reoperations, and postoperative visits/communication were recorded. Work relative value units per minute of surgery (wRVU/min) were calculated for each case relative to their current procedural terminology (CPT) codes and assigned wRVUs: (1) CPT 24545: ORIF extra-articular DHF (13.15 wRVU), (2) CPT 24546: ORIF intra-articular DHF (14.91wRVU), (3) CPT 25608: ORIF intra-articular DRF, two fragments (11.07 wRVU), and (4) CPT 25609: ORIF intra-articular DRF, ≥3 fragments (14.38 wRVU). A 1:1 matched cohort was constructed to make comparisons between groups.

RESULTS: A total of 75 DHF and 74 DRF cases were included. Baseline demographics were similar. Distal humerus fractures had significantly longer mean surgical times (183 minutes) compared with DRFs (92 minutes). Distal humerus fracture cases had a mean wRVU/min of 0.093/min compared with DRF (0.154/min), and this difference was statistically significant. Distal humerus fracture cases also demonstrated significantly higher complication/reoperation rates (23% and 21%) compared with DRFs (6.8% and 6.8%). Both groups had similar frequencies of postoperative visits (mean = 3.0), and ORIF DHF cases had significantly more postoperative phone calls (mean = 2.6) compared with DRF cases (mean = 1.0).

CONCLUSIONS: Considering the longer surgical times and complication rates, upper-extremity surgeons are not proportionally compensated from a wRVU perspective for DHF management compared with DRFs.

CLINICAL RELEVANCE: These data should be used in future analyses and advocacy efforts related to wRVU adjustments for DHFs.

PMID:41159988 | DOI:10.1016/j.jhsa.2025.08.017

Microbiol Resour Announc. 2025 Oct 29:e0017425. doi: 10.1128/mra.00174-25. Online ahead of print.

ABSTRACT

We report an updated draft genome sequence of Streptomyces sp. isolate H28, a melanin-producing bacterium recovered from the sediments of Meycauayan River, Philippines. The improvement in sequencing methodology is reflected in the reported statistics. The new sequence data is highly useful for future exploration given the melanogenesis of the bacterium.

PMID:41159971 | DOI:10.1128/mra.00174-25

Eur J Psychotraumatol. 2025 Dec;16(1):2571252. doi: 10.1080/20008066.2025.2571252. Epub 2025 Oct 29.

ABSTRACT

Background: Forced displacement is globally increasing, with children and adolescents being particularly affected. Exposure to armed conflict, the flight itself and challenges of settling in new environments put them at risk of experiencing potentially traumatic events and developing mental health problems, such as post-traumatic stress disorder (PTSD) and depression. Still, limited information is available regarding the traumatic experiences, psychological stress and treatment goals of treatment-seeking refugee children and adolescents.Methods: This cross-sectional study evaluated data from refugee minors seeking treatment at an Outpatient Health Care Center for Refugee Children in Germany. The standard diagnostic procedure included assessing sociodemographic characteristics, traumatic experiences before, during and after flight and mental health problems, including the diagnosis of PTSD and depression. Treatment goals were also examined.Results: From October 2016 to December 2023, a total of 716 refugee minors participated in the study. They were on average 15.13 years old, 56.3% of the sample were unaccompanied, and 72.1% were male. Most participants were from Afghanistan and Syria. Repeated interpersonal violence was frequently experienced in the home country (65.5%), during flight (59.3%), and in Germany (13.7%). The majority of children and adolescents fulfilled the diagnostic criteria of PTSD (57.8%), and the prevalence of depressive episodes was 44.2%, with a comorbidity rate of 35.9%. The majority of refugee minors identified specific treatment goals, particularly for reducing trauma-related symptoms such as negative thoughts, sleep issues, and nightmares.Conclusions: Our findings provide novel data on the mental health problems, pre-, peri- and post-migration traumatic experiences and treatment expectations in a treatment-seeking sample of refugee minors. The findings highlight the importance of developing trauma-focused interventions and improving clinicians’ skills to address effects of complex, potentially ongoing, traumatic experiences and to tailor treatment to personal treatment goals. This is essential for providing high quality care for refugee minors.

PMID:41159958 | DOI:10.1080/20008066.2025.2571252

Eur J Public Health. 2025 Oct 29:ckaf175. doi: 10.1093/eurpub/ckaf175. Online ahead of print.

ABSTRACT

Dental and periodontal infections can lead to serious systemic complications through bacterial dissemination. While global awareness of these risks is increasing, data on the incidence and outcomes of such complications remain limited. This study aims to quantify the incidence of serious extraoral infectious complications associated with dental infectious foci, using dental procedures as markers of active oral infection, in the Czech Republic between 2010 and 2022. A retrospective analysis was conducted using data from the National Register of Reimbursed Health Services. Patients who underwent invasive dental procedures indicating active dental/periodontal infection and were hospitalized for severe infectious conditions within 7 days were identified. This temporal criterion captured both cases where dental procedures preceded systemic spread and cases where dental foci were identified during workup for serious infections. Descriptive statistics and linear regression analysed incidence rates and temporal trends. Among 15 098 093 dental procedures over 13 years, annual hospitalizations for associated infectious complications ranged from 855 to 1252 cases. Overall incidence was 12.82 per 100 000 population annually. Oral region complications (cellulitis, abscesses, osteomyelitis) were most common (9.48 per 100 000), followed by systemic complications (sepsis and endocarditis) (2.89 per 100 000). Significant increasing trends were observed for jaw periostitis (P = .006), endocarditis (P < .001), and central nervous system abscesses (P = .027), while acute sinusitis declined (P < .001). This population-based analysis reveals a substantial incidence of serious infectious complications associated with dental infectious foci, with concerning increasing trends in potentially life-threatening conditions. These findings emphasize the importance of preventive dental care and early intervention strategies.

PMID:41159935 | DOI:10.1093/eurpub/ckaf175

Aging Male. 2025 Dec 11;28(1):2568729. doi: 10.1080/13685538.2025.2568729. Epub 2025 Oct 29.

ABSTRACT

OBJECTIVE: To systematically compare the efficacy and safety of medications in elderly with overactive bladder.

METHODS: Pubmed, Embase, Web of Science, and the Cochrane Register of Clinical Trials databases were systematically searched from database inception to July 25, 2023, and randomized, controlled, double-blind trials for overactive bladder in the elderly were screened according to the protocol. Data were analyzed using Stata17.0.

RESULTS: In terms of reducing Micturitions, the interventions were ranked: trospium chloride (TRO), fesoterodine (FES) 4/8 mg, vibegron (VIB), mirabegron (MIR) 25/50 mg, tolterodine ER (TOL) 4 mg, placebo (PBO), of which only TOL showed no significant difference compared to placebo; Forsafety, the TEAE of TOL 4/8 mg had the highest incidence and was significantly different from others; MIR, VIB, and FES 4mg were well-tolerated regarding dry mouth and constipation; TOL 4 mg, FES 4/8 mg, and VIB showed a statistically increase from placebo for headache and FES 4/8mg and MIR 25 mg showed a statistically increase for dizziness.

CONCLUSIONS: TRO 60 mg has the best efficacy in reducing micturitions, but increases the incidence of dry mouth and constipation; VIB and MIR are well tolerated in dry mouth and constipation, but may increase the risk of headache or dizziness.

PMID:41159930 | DOI:10.1080/13685538.2025.2568729

J Health Organ Manag. 2025 Oct 30:1-19. doi: 10.1108/JHOM-10-2024-0416. Online ahead of print.

ABSTRACT

PURPOSE: To determine the relationship between nursing care satisfaction levels and nursing image perceptions of patients hospitalized in inpatient units of a university hospital.

DESIGN/METHODOLOGY/APPROACH: This is a descriptive, correlational and cross-sectional study. The study data were collected from 610 patients hospitalized in the inpatient units of a university hospital with the Introductory Information Form, Patient Perception of Hospital Experience with Nursing Care and the Nursing Image Scale. Descriptive analyses, independent groups t-test, one-way analysis of variance, Mann-Whitney U test, Kruskal-Wallis test and Spearman correlation analysis were employed in the analysis of the data.

FINDINGS: It was determined that the Nursing Image Scale scores differed statistically significantly according to the participants’ age, education level, state of thinking that they received quality nursing care and nursing image perception of the participants. It can be stated that the satisfaction of the patients participating in the study with the nursing care provided is high, and the nursing image they perceive is at a high level and positive. A positive and significant relationship was found between the participants’ nursing care satisfaction levels and their perceptions of nursing image (r = 0.502, p < 0.01).

ORIGINALITY/VALUE: The results of the study are very important in terms of showing the effect of the image of nursing not only in terms of the development of the profession but also on the perception of the care provided. It is recommended that health institutions and managers determine more strategies in this regard because it affects the preferability of their institutions and the satisfaction of the care provided.

PMID:41159922 | DOI:10.1108/JHOM-10-2024-0416

Expert Rev Proteomics. 2025 Oct 29. doi: 10.1080/14789450.2025.2580647. Online ahead of print.

ABSTRACT

INTRODUCTION: Recent advances in multi-omic technologies and computational tools have enabled comprehensive studies of cancer that integrate proteomics, genomics, transcriptomics, and metabolomics to improve disease understanding and outcomes.

AREAS COVERED: 1. Recent improvements in throughput and decreasing sample mass requirements have enabled deep analysis of hundreds of human samples in multi-omic studies, increasing the statistical rigor of these studies and facilitating comparisons across clinical and demographic categories.2. Despite advances in statistical modeling, machine learning, and pathway-aware analysis, the principal outcome from these observational studies remains correlational – strong statistical associations between omic features and clinical characteristics, including clinical outcomes.3. Demonstration of causal relationships requires multi-pronged mechanistic experiments involving techniques in molecular and cellular biology that are distinct from the analytical and computational skills needed to generate these datasets.Database used: National Library of Medicine PubMed database.

EXPERT OPINION: True clinical utility depends on the demonstration of causal relationships between candidate targets and the biomedical process of interest. Enhanced collaboration with molecular and cellular biologists skilled in the use of modern tools of genetic manipulation and engineered model systems is required to realize the full translational potential of even the most comprehensive multi-omic studies.

PMID:41159901 | DOI:10.1080/14789450.2025.2580647