Tag: pubmed

J Oral Facial Pain Headache. 2025 Jun;39(2):101-111. doi: 10.22514/jofph.2025.029. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: Temporomandibular disorder (TMD) is a prevalent condition associated with pain and dysfunction of the temporomandibular joint (TMJ) and surrounding structures. Sleep disturbances are common in TMD patients, yet the bidirectional causal relationship between specific sleep behaviors and TMD remains unclear. This study aimed to investigate this relationship using a two-sample Mendelian randomization (MR) approach.

METHODS: A bidirectional two-sample MR analysis was conducted using genome-wide association study (GWAS) summary statistics for seven sleep behaviors and TMD/TMD related pain (TMD-pain). Single nucleotide polymorphisms (SNPs) were used as instrumental variables. The analysis included data from the UK Biobank and FinnGen Consortium, focusing on individuals of European ancestry. Statistical methods included inverse variance weighting (IVW), MR-Egger regression and sensitivity analyses to ensure robust findings.

RESULTS: The analysis identified that genetically predicted “morning person” status reduced the risk of TMD (β: -0.173, p = 0.014), while longer sleep duration decreased the risk of TMD-pain (β: -0.382, p = 0.015). In reverse MR analysis, TMD-pain increased the risk of insomnia, obstructive sleep apnea (OSA) and sleep disorders (p < 0.05). No significant associations were found between other sleep behaviors and TMD or TMD-pain.

CONCLUSIONS: This study demonstrates a bidirectional relationship between sleep behaviors and TMD. Being a morning person and having longer sleep duration protect against TMD and TMD-pain, respectively, while TMD-pain increases the risk of certain sleep disorders. These findings highlight the importance of addressing sleep issues in TMD management.

PMID:41070538 | DOI:10.22514/jofph.2025.029

J Oral Facial Pain Headache. 2025 Jun;39(2):48-65. doi: 10.22514/jofph.2025.025. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: Understanding the global prevalence and characteristics of a given health problem is essential for sizing its global and regional burden, estimating treatment needs, prioritizing healthcare services, and formulating targeted policies. This systematic review and meta-analysis aimed to estimate the global prevalence of temporomandibular disorders (TMDs) by gender, age, and continent, and the prevalence of specific categories such as myalgia, arthralgia, clicking/joint sounds, and limited mouth opening.

METHODS: A comprehensive search was conducted across three databases-PubMed, Scopus and Web of Science and supplemented by manual search up to June 2024. TMD diagnoses were based on the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) or Diagnostic Criteria for Temporomandibular Disorders (DC/TMD).

RESULTS: The database search yielded 15,628 records, from which 27 studies involving 20,971 subjects, including 6075 diagnosed with TMDs, were selected for final analysis. All meta-analyses utilized a random effects model. It is estimated that nearly a third of the global population (29.5%) suffers from TMDs. TMDs affected females at a significantly higher rate compared to males (36.7% versus 26.7%), representing a 1.75-fold greater likelihood among females. Prevalence among individuals under 18 years of age is 38.5%, compared to 34.1% in those 18 and older. TMDs are most prevalent in Europe (33.8%), followed by Asia (27.9%) and South America (27.3%); the lowest prevalence was in North America (19.4%). The most frequently reported signs and symptoms of TMDs are myalgia (37.2%), clicking/joint sounds (29.8%), and arthralgia (16.8%), with limited mouth opening/locking being the least prevalent (8.1%).

CONCLUSIONS: TMDs represent a significant and largely unrecognized health burden. Although conducting further primary studies is urgent for confirmation, this current research underscores that TMDs might constitute a silent epidemic that has not garnered the urgent attention it deserves from healthcare providers, the local community, and researchers.

THE PROSPERO REGISTRATION: PROSPERO number is CRD42024583777.

PMID:41070533 | DOI:10.22514/jofph.2025.025

Turk Psikiyatri Derg. 2025;36:57. doi: 10.5080/u27671.

ABSTRACT

OBJECTIVE: The aim of this study was to compare cognitive flexibility and executive functions in adolescents diagnosed with social anxiety disorder (SAD) who have autistic traits with those who do not, and to investigate whether there is a significant difference compared to healthy controls.

METHOD: The study included 36 adolescents diagnosed with SAD and 36 healthy controls. All participants completed the Cognitive Flexibility Scale (CFS), and the Liebowitz Social Anxiety Scale was administered to the SAD group. Neuropsychological tests including the Stroop Test TBAG Form, the Wisconsin Card Sorting Test (WCST), Raven&rsquo;s Standard Progressive Matrices Test, and Visual-Auditory Digit Span Test-B were applied. Autistic traits were assessed using the Autism Spectrum Quotient-Adolescent&rsquo;s Version (AQ-Adolescent) and the Childhood Autism Rating Scale.

RESULTS: There was no statistically significant difference in CFS scores between the social anxiety disorder and control groups. The SAD group showed poorer performance in the subdomains of the WCST. Additionally, in all subtestes of the Stroop test, the SAD group took significantly longer to complete the test. The AQ-Adolescent scores were significantly higher in the SAD group compared to the controls. In 25% (n=9) of the cases, autistic traits were above the cutoff. There were no significant difference in neuropsychological test results between the groups who have and do not have autistic traits within the case group. A weak negative correlation was found between the Liebowitz total and avoidance subscale scores and the AQ-imagination and attention to detail scores, while no correlation was found between the Liebowitz dimensions and CFS scores.

CONCLUSION: This is the among the first studies to examine autistic traits and executive functions among adolescents with SAD. While no difference was found in cognitive flexibility scale scores between the SAD and control groups, the SAD group showed poorer performance in tests measuring other executive functions. However, this difference was not significantly influenced by the presence of autistic traits.

PMID:41070518 | DOI:10.5080/u27671

BMC Public Health. 2025 Oct 9;25(1):3426. doi: 10.1186/s12889-025-24643-7.

ABSTRACT

BACKGROUND: Childhood malnutrition remains a public health concern in Rwanda, with stunting rates at 33%, underweight at 8%, and wasting at 1%. These rates are particularly high in rural areas. As primary caregivers, women play a central role in child nutrition, their financial inclusion may significantly influence child health outcomes. This study investigated the relationship between women’s financial inclusion and the nutritional status of children aged under five in Rulindo District, Rwanda.

METHODS: A cross-sectional study was conducted in February 2024 among 315 women with children aged under 5 years. Financial inclusion data were collected using structured questionnaire. Children’s nutritional status was assessed using anthropometric tools. WHO Anthro software, and SPSS version 25.0 were used to analyze the collected data. Bivariate and binary logistic regression analyses were conducted to identify associations between financial inclusion variables and child nutrition outcomes.

RESULTS: Among children, 29.5% were stunted, 7.6% underweight, and 4.1% wasted. Bivariate analysis showed significant associations between financial practices (saving for future use and microfinance membership) and child nutritional status. Women who saved for the future were significantly less likely to have stunted children (p = 0.008) or wasted (p = 0.028). Additionally, microfinance membership was associated with a lower prevalence of stunting (p = 0.07), but a higher risk of underweight (p = 0.035). Logistic regression confirmed the association: women with stable income had children with lower odds of stunting (Adjusted Odds Ratio [AOR] = 4.039, p = 0.022), and those in microfinance groups were less likely to have stunted children (AOR = 2.587, p = 0.009), but more likely to report underweight (Crude Odd Ratio [COR] = 4.711, p = 0.029). Saving behavior was protective in the crude model, though it was not statistically significant in the adjusted model.

CONCLUSION: Women’s financial inclusion is positively associated with improved child nutritional outcomes, particularly regarding stunting and wasting. However, financial literacy and targeted support are needed to ensure that economic tools translate into measurable health benefits. Integrated strategies addressing both financial capacity and nutrition education are essential for long-term child health improvement.

PMID:41068771 | DOI:10.1186/s12889-025-24643-7

BMC Public Health. 2025 Oct 9;25(1):3422. doi: 10.1186/s12889-025-24292-w.

NO ABSTRACT

PMID:41068756 | DOI:10.1186/s12889-025-24292-w

Infect Agent Cancer. 2025 Oct 9;20(1):69. doi: 10.1186/s13027-025-00699-3.

ABSTRACT

BACKGROUND: Methylation of host genes is promising for the triage of women with high-risk human papillomavirus (HR-HPV) infections. This study aimed to validate the potential value of Glycophorin C (GYPC) methylation (GYPC^m) in the early detection of cervical cancer.

METHODS: We recruited HR-HPV-positive women at the hospital outpatient clinic between August and December 2023, using cytology triage. The remaining exfoliated cervical cells were subjected to GYPC^m testing. A total of 549 cases were finally included for analysis: 156 cervicitis, 303 cervical intraepithelial neoplasia (CIN)1, 49 CIN2, 37 CIN3, and 4 CC.

RESULTS: The difference of GYPC^m ΔCp values between CIN1 and CIN2 was statistically significant in the pathology results of 549 participants (P < 0.001). The optimal threshold value of GYPC^m for detecting CIN2 + was 6.35. The GYPC^m adjusted ORs for CIN2 + and CIN3 + were 31.23 (95%CI: 16.53-58.99) and 34.68 (95%CI: 11.90-101.11), respectively. In all individuals, the sensitivity of GYPC^m for CIN2 + and CIN3 + was consistent with that of cytology (CIN2 + 83.3%; CIN3 + 90.2%), with higher specificity than that of cytology (CIN2 + 85.8 vs. 29.4%; CIN3 + 79.7 vs. 28.7%, all P < 0.001). The sensitivity and negative predictive value (NPV) of HPV16/18 combined GYPC^m for CIN3 + were not statistically different from those of HPV combined with cytology (sensitivity 95.1 vs. 97.6%, P = 0.317; NPV 99.4 vs. 99.0%, P = 0.613). The net reclassification improvement for HPV16/18 combined GYPC^m and its combined cytology to classify CIN2 + vs. < CIN2 was 48.8% (95%CI: 39.7-57.9%, P < 0.001), with a relative colposcopy referral rate of 50.1% (95%CI: 45.5-54.7%).

CONCLUSION: GYPC^m has a higher CIN2 + OR and higher specificity and positive predictive value than cytology in HR-HPV-positive women and is a potential molecular biomarker for triaging HR-HPV (+) to detect cervical (pre)cancer.

PMID:41068755 | DOI:10.1186/s13027-025-00699-3

BMC Med Educ. 2025 Oct 9;25(1):1384. doi: 10.1186/s12909-025-08003-y.

ABSTRACT

BACKGROUND: Academic burnout is a significant concern for dental students, often resulting from prolonged stress and a lack of support in the learning environment. This study investigates academic burnout among dental students, focusing on its relationship with their perceptions of the quality of the learning environment and the mediating role of dental environmental stress.

METHODS: In this cross-sectional study, 300 undergraduate dental students were recruited using a convenience sampling method in Isfahan, Iran, in 2022. Data were collected online via WhatsApp and Telegram platforms. In addition to demographic data, the Burnout Clinical Subtype Questionnaire, the Dental School Learning Environment Survey, and the Dental Environmental Stress Questionnaire were employed. Structural equation modeling was conducted using the Partial Least Squares approach to analyze the relationships among variables (p < 0.05).

RESULTS: The study indicated moderate levels of academic burnout (2.61/5), perceived quality of the learning environment (2.92/5), and dental environmental stress (2.80/4). The quality of the learning environment accounted for 2.8% of the variance in the dental environmental stress. The combined quality of the learning environment and dental stress accounted for 22.1% of the variance in academic burnout. Statistically significant relationships were found between the quality of the learning environment and dental environmental stress (p = 0.001), the quality of the learning environment and academic burnout (p = 0.026), and dental environmental stress and academic burnout (p < 0.001). Furthermore, dental environmental stress significantly mediated the relationship between the quality of the learning environment and academic burnout (p = 0.003).

CONCLUSIONS: The results highlighted the pivotal role of the learning environment in shaping dental students’ academic experiences, particularly concerning stress and burnout. Considering the mediating role of dental environmental stress, the findings emphasize the need for supportive, well-structured, and engaging learning environments.

PMID:41068734 | DOI:10.1186/s12909-025-08003-y

Int J Equity Health. 2025 Oct 9;24(1):263. doi: 10.1186/s12939-025-02493-4.

ABSTRACT

BACKGROUND: During the covid-19 pandemic, despite sexual and reproductive health (SRH) services being considered essential, in Brazil, only 55% of abortion services remained in operation. This restriction of access could lead to an increase in unplanned pregnancies, unsafe abortion practices, and, consequently, an increase in the maternal mortality rate. In addition to the difficulty of consolidating information for monitoring and evaluating SRH services. In this scenario, postabortion contraception (PAC) during hospital admission is essential, especially with the postabortion use of long-acting reversible methods (LARC), such as intrauterine devices (IUDs), since they are effective, economical, safe and with immediate contraception.

OBJECTIVE: To evaluate postabortion contraceptive methods, mainly LARC, during hospital admission after spontaneous abortion and legal termination of pregnancy and their associated factors through the abortion surveillance network.

METHODS: a cross-sectional study with women of any age admitted for spontaneous abortions or legal interruption procedures at the Women’s Hospital at State University of Campinas (UNICAMP), Brazil, between July 2017 and November 2022. The study was approved by the Research Ethics Committee from UNICAMP. The dependent variable was IUD insertion. The independent variables were clinical, sociodemographic characteristics, vulnerable groups and period of hospitalization (pre-pandemic: until 10/03/2020; pandemic: from 11/03/2020). For statistical analysis, Cochran-Armitage trend tests and an adjusted logistic regression model were used, with the significance of the coefficients evaluated by the p-value, obtained through the Wald statistics associated with each parameter, as well as the confidence interval.

RESULTS: 675 women were hospitalized during the period, 547 for spontaneous abortions and 128 for legal termination. Of these, 499 (79%) had at least one vulnerable factor and 45.2% started PAC during hospital stay, as injectables (48.5%), oral contraceptive pills (34.8% ) and IUDs (13.4%). There was a trend towards increased use of IUDs before hospital discharge (p < 0.01), especially in hospitalizations that occurred during the pandemic period, in the most vulnerable groups (p < 0.01) and women with previous abortions (p < 0.05). The factors independently associated with a higher frequency of IUD insertion were presence of 3 or more vulnerability factors (coefficient 4.50; 95% confidence interval [CI] 1.12 to 7.88; p = 0.01); hospitalization during the pandemic period (coefficient 2.56; CI 1.14-3.99; p < 0.01) and the number of abortions (coefficient 0.61; CI 0.09-1.13; p = 0. 02).

CONCLUSION: Reducing access barriers to highly effective and long-acting contraceptives is an important step towards curbing the rates of unplanned pregnancies. Increasing rates of postabortion IUD use in vulnerable populations and in the context of the pandemic reinforce the importance of the epidemiological surveillance strategy in reducing exposure to preventable risks such as unsafe abortion and managing SRH policy strategies to reduce the maternal mortality rate.

PMID:41068730 | DOI:10.1186/s12939-025-02493-4

BMC Oral Health. 2025 Oct 9;25(1):1583. doi: 10.1186/s12903-025-06961-9.

ABSTRACT

OBJECTIVES: This randomized clinical trial aimed to evaluate the effect of calcium hydroxide-based, calcium silicate-based and epoxy resin-based root canal sealers on postoperative pain (PP) after a single session of non-surgical endodontic retreatment of the teeth with chronic apical periodontitis.

MATERIALS AND METHODS: Ninety-six participants who had teeth with previously root canal treatment, asymptomatic, a single root and single canal, chronic apical periodontitis, were included in the study and then were randomly allocated to one of three experimental groups. (n = 32 per group).An endodontic specialist performed same retreatment protocols in a single visit. Participants were asked to rate the intensity of PP on a visual analogue scale at 6, 12, 24, and 48 h, and 3, 4,5, 6, and 7 days, and to mark whether they had taken analgesic (400 mg Ibuprofen) during the same periods after retreatment. All statistical analyses were performed using a software program (IBM SPSS Statistics, Version 22), and the significance level was set at P < 0.05.

RESULTS: There was no significant difference between the groups in PP and analgesic intake at any of the time intervals evaluated(P > 0.05).A strong positive correlation was observed at 48 h and 96 h when the correlation between PP and analgesic intake was evaluated regardless of the type of root canal sealer. PP level was associated with age, gender, Periapical Index (PAI) score, and jaw type.(P < 0 0.05).

CONCLUSIONS: Epoxy resin, Calcium silicate, and calcium hydroxide-based root canal sealers resulted in statistically similar postoperative pain levels.

CLINICAL SIGNIFICANCE: Each of the epoxy resin, calcium silicate, and calcium hydroxide-based root canal filling materials could be used safely in patients when considering PP.

TRIAL REGISTRATION: ClinicalTrial.gov, NCT06803277, record date: 2025-01-17, retrospectively registered.

PMID:41068727 | DOI:10.1186/s12903-025-06961-9

BMC Pediatr. 2025 Oct 10;25(1):798. doi: 10.1186/s12887-025-05832-0.

ABSTRACT

BACKGROUND: Autism Spectrum Disorder (ASD) is characterized by physical, communication, and behavioral challenges that often require comprehensive interventions. This study aimed to evaluate the combined efficacy of physiotherapy, occupational and speech therapies in improving physical and behavioral outcomes among children with ASD.

MATERIALS AND METHODS: This assessor-blinded randomized clinical trial was conducted at Proyash (Institute of Special Education), Jashore, Bangladesh, involving seventy children with ASD. Outcomes were assessed using the modified SF-36 for physical status and GARS-3 for behavioral status at baseline and after six weeks of intervention. Data were analyzed using SPSS version 25.0, with descriptive statistics (median and IQR) and inferential tests (Mann-Whitney U and Wilcoxon signed-rank), maintaining a 95% confidence level.

RESULTS: The average age of participants was 10.66 ± 3.28 years in Group A and 9.17 ± 2.83 years in Group B. Group A had a higher BMI of 21.86 ± 7.96 kg/m² compared to 19.53 ± 4.85 kg/m² in Group B. Post-intervention analysis revealed significant improvements in both physical and behavioral outcomes. Between-group comparisons yielded p-values < 0.01 for both measures. Within-group analysis showed significant improvements in Group A (p < 0.01), whereas changes in Group B were not statistically significant.

CONCLUSION: The combined rehabilitation program demonstrated significant improvements in physical and behavioral outcomes and showing greater effectiveness overall. These findings emphasize the importance of customized rehabilitation approaches in enhancing both physical and behavioral health, particularly when tailored to specific participant profiles.

TRIAL REGISTRATION: CTRI/2024/07/070209 (Prospectively Registered).

PMID:41068726 | DOI:10.1186/s12887-025-05832-0