Tag: pubmed

Health Qual Life Outcomes. 2024 Nov 26;22(1):101. doi: 10.1186/s12955-024-02312-4.

ABSTRACT

BACKGROUND: Patient-reported outcome measures (PROMs) provide invaluable information on patients’ health outcomes and can be used to improve patient-related outcomes at the individual, organizational and policy levels. This systematic review aimed to a) identify contemporary applications and synthesize all evidence on the use of PROMs in these contexts and b) to determine characteristics of interventions associated with increased effectiveness.

METHODS: Five databases were searched for studies providing quantitative evidence of the impact of PROM interventions. Any study design was permitted. An overall benefit (worsening) in outcome was defined as a statistically significant improvement (deterioration) in either a PROM, patient-reported experience measure or clinical outcome. Study quality was assessed using the Effective Public Healthcare Panacea Project’s Quality Assessment Tool for Quantitative Studies. A narrative synthesis was conducted.

RESULTS: Seventy-six studies of the 11,121 articles identified met the inclusion criteria. At the individual level, 10 (43%) of 23 studies that fed back PROMs to the patient or healthcare provider showed an improvement in outcome. This percentage increased in studies which used PROMs to monitor disease symptoms and linked these to care-pathways: 17 (68%) of 25 studies using this mechanism showed an improvement. Ten (71%) of 14 studies using PROMs to screen for disease found a benefit. The monitoring and screening approach was most effective using PROMs covering cancer-related, depression and gastro-intestinal symptoms. Three studies found that the mere collection of PROMs resulted in improved outcomes. Another three studies used PROMs in decision aids and found improved decision quality. At the organizational/policy level, none of the 4 studies that used PROMs for benchmarking found a benefit. The three studies that used PROMs for in-depth performance analyses and 1 study in a plan-do-study-act (PDCA) cycle found an improvement in outcome. Studies employing disease-specific PROMs tended to observe improved outcomes more often. There are concerns regarding the validity of findings, as studies varied from weak to moderate quality.

CONCLUSIONS: The use of PROMs at the individual level has matured considerably. Monitoring/screening applications seem promising particularly for diseases for which treatment algorithms rely on the experienced symptom burden by patients. Organizational/policy-level application is in its infancy, and performance evaluation via in-depth analyses and PDCA-cycles may be useful. The findings of this review may aid stakeholders in the development and implementation of PROM-interventions which truly impact patient outcomes.

PMID:39593045 | DOI:10.1186/s12955-024-02312-4

Pediatr Rheumatol Online J. 2024 Nov 26;22(1):102. doi: 10.1186/s12969-024-01035-6.

ABSTRACT

BACKGROUND: To assess the psychosocial impact of moderate-severe juvenile idiopathic arthritis (JIA) on patients and their families, among those who had been treated with at least one anti-tumor necrosis factor (anti-TNF-α), according to routine clinical practice in Spain.

PATIENTS AND METHODS: A 24-month observational, multicentric, cross-sectional and retrospective study was performed. Children diagnosed with JIA were enrolled at three tertiary-care Spanish hospitals. The study included children treated with biologic disease-modifying antirheumatic drugs (bDMARD) who participated in a previous study, the ITACA, and who continued follow-up in these pediatric rheumatology units. Patient health-related quality of life (HRQoL) was assessed using the Pediatric Quality of Life Inventory (PedsQL™). Caregivers completed an interview to gather information about school attendance, their children’s participation in school and social activities, its impact on their jobs and social life and perceived psychosocial support. A descriptive statistical analysis of all the variables was performed. The Mann-Whitney-U test or Kruskall-Wallis H test were used to compare quantitative variables and Fisher’s exact tests was used for qualitative variables. Tests were two-tailed with a significance level of 5%. The data were analyzed using SPSS V18.0 statistical software.

RESULTS: One hundred and seven patients were included. Overall, patients were on inactive disease or low disease activity according to JADAS-71 score and had very low functional disability according to CHAQ score. Up to 94.4% of patients were receiving drug treatment, mainly with bDMARD in monotherapy (84.5%). Based on PedsQL, patients and parents referred a high HRQoL. School Functioning PedsQL domain achieved the lowest score. Work and social impact due to the child´s disease was greater for mothers than for fathers. The understanding of the disease was lower at school than in the with family and friends’ environments.

CONCLUSION: Most of the patients had a high HRQoL and had controlled disease activity, despite having a negative psychosocial impact on some of them and their families, mainly on school functioning. Children’s disease seems to involve greater work and psychosocial impacts for mothers than for fathers of children affected by JIA.

PMID:39593042 | DOI:10.1186/s12969-024-01035-6

BMC Musculoskelet Disord. 2024 Nov 26;25(1):965. doi: 10.1186/s12891-024-08108-3.

ABSTRACT

BACKGROUND: The anatomical structure of the elbow joint makes it vulnerable to contractures. While elbow arthroscopy minimizes soft tissue damage and enhances early rehabilitation, the optimal duration for postoperative Continuous Passive Motion (CPM) therapy is unclear. This retrospective study aims to establish the appropriate duration of CPM following arthroscopic elbow contracture release.

METHODS: We analyzed postoperative outcomes from patients undergoing CPM rehabilitation for 1, 3, or 5 months. Metrics such as ASES, VAS, DASH, MEPS scores, grip strength, and range of motion were assessed before surgery and at 1,3,6 and 12 months post-surgery.

RESULTS: Patients who received 3 or 5 months of CPM therapy showed statistically significant improvements in elbow flexion-extension, range of motion, and functional scores (ASES, VAS, DASH, MEPS) compared to the 1-month group (p < 0.05). However, no significant differences were observed between the 3- and 5-month groups.

CONCLUSIONS: A 3-month CPM period is effective for patients with higher functional demands, with no additional benefit from extending therapy to 5 months.

PMID:39593033 | DOI:10.1186/s12891-024-08108-3

BMC Public Health. 2024 Nov 26;24(1):3276. doi: 10.1186/s12889-024-20794-1.

ABSTRACT

BACKGROUND: The adverse selection theory speculates a high level of demand for health insurance by people with vulnerable health conditions. However, the COVID-19 pandemic changed the prevailing narratives and pattern of healthcare utilization in many African countries. This study estimated the effects of household member’s disability and presence of serious illness on the probability of National Hospital Insurance Fund (NHIF) subscription with the average treatment effect (ATE) and average treatment effect on the treated (ATET).

METHODS: The data were collected telephonically in 2020 using the sampling frame of the United Nations High Commission on Refugees (UNHCR). The respondents were refugees with active phone numbers who were registered by the UNHCR in Nairobi, Mombasa and Nakuru cities. A total of 2,438 completed the surveys. The data were analysed with Treatment Effects Probit regression model using the regression adjustment estimator.

RESULTS: The results showed that 24.89% of the respondents had health insurance. Also, 3.28%, 1.39% and 2.46%, respectively suffered from physical, cognitive and sensory disability, while 8.28% had some form of serious illness. The Probit regression results showed that probability of being health insured significantly increased (p < 0.05) with membership of community-based organizations (CBO), asset index, possession of bank savings account, residence in Nairobi and household size, while residence in Nakuru reduced it. The ATE for physical and cognitive disabilities were significant (p < 0.05) with 0.1100 and 0.1816, respectively, while that for serious illness was 0.1046 (p < 0.01). The ATET for physical disability and serious illness were also significant (p < 0.05) with 0.1251 and 0.0996, respectively.

CONCLUSION: It was concluded that efforts to facilitate NHIF subscriptions among the refugees should be channelled among people with disability and serious illness. In addition, there is the need to promote refugees’ welfare through employment that can induce formal savings and promote less reliance on informal borrowing. The operational mechanisms and differences in healthcare service distribution between the three cities should be considered along some salient interventions for health insurance subscription that are channelled through some CBOs.

PMID:39593027 | DOI:10.1186/s12889-024-20794-1

BMC Med Educ. 2024 Nov 26;24(1):1375. doi: 10.1186/s12909-024-06243-y.

ABSTRACT

BACKGROUND: Remedial teaching is a tailored educational approach dedicated to enhancing the academic performance of students facing challenges within the curriculum. By identifying and addressing specific learning difficulties, it provides essential support and guidance to bring students closer to expected standards while preventing future setbacks. We hypothesize that underperforming medical students who receive daily, tailored remediation will demonstrate significant improvement in their formative and summative assessment scores in biochemistry.

METHODS: A cross-sectional mixed-method study was conducted on 56 underperforming first-year medical undergraduates to assess the effect of targeted remediation on formative and summative assessments in Biochemistry. Training sessions included various remediation techniques over six months. Post-remediation feedback was collected to gather insights into students’ attitudes, perceptions, and the effectiveness of the methods in improving their understanding of the subject. Logistic regression analysis was employed to determine the most effective remediation for student performance. Benefits and weaknesses of remedial training approaches for future application as perceived by the students were derived through deductive thematic analysis of their feedback.

RESULTS: The mean marks, evaluated out of a maximum of 100, showed improvement from 29.86 ± 7.71 to 71.48 ± 10.19, with statistical significance (p < 0.001). From the students’ perspective, the most effective remediation method was grade incentives in formative assessments (odds ratio 6.19). Five major themes were identified: perceived barriers prior to remediation, positive outcomes and behavioral changes observed after remediation, and strengths and areas for improvement in remediation.

CONCLUSIONS: The study concludes that identifying underperformers in the early stages of the medical curriculum and providing them with tailored remediation can enhance their performance in exams. Grade incentives in formative assessments, mind maps, quizzes, quick revisions, and assignments were beneficial remedial tools. Targeted remediation proved advantageous for students in improving their academic skills, exam preparation, time management, and attitudes towards the subject.

PMID:39593026 | DOI:10.1186/s12909-024-06243-y

BMC Med Imaging. 2024 Nov 26;24(1):319. doi: 10.1186/s12880-024-01506-y.

ABSTRACT

BACKGROUND: This study aimed to perform a comprehensive morphometric analysis of the epiglottis using cone-beam computed tomography (CBCT) images, including the determination of epiglottis dimensions, the investigation of shape variations, and the assessment of their relationship with gender and age.

METHODS: A retrospective analysis was conducted on high-quality CBCT images from 100 patients, obtained using the NewTom 5G system. In CBCT images, epiglottis thicknesses (right, midline, left) and horizontal angle at three levels (suprahyoid, hyoid, infrahyoid) were measured in axial sections, while the length and vertical angle of epiglottis were measured in midsagittal view. Epiglottis shapes were identified through 3D visualization.

RESULTS: The midline epiglottis thicknesses were 4.68 mm at the suprahyoid level, 5.51 mm at the hyoid level, and 6.80 mm at the infrahyoid levels. Epiglottis thicknesses and length were statistically significantly greater in males. Of the 100 patients, 51 had a normal curvature, 41 had a flat epiglottis, and 8 had an omega epiglottis. The omega-shaped epiglottis was significantly longer compared to both the flat and normal curvature types (p = 0.011). There was a positive correlation between age and epiglottis thicknesses at the suprahyoid level and horizontal angles at three levels.

CONCLUSIONS: This study visualizes epiglottis morphology and uncovers significant morphometric differences. Males exhibit greater epiglottis thickness and length compared to females, while the omega-shaped epiglottis is notably longer than other types. These findings underscore the need for further investigation into the clinical relevance of these morphometric differences, particularly in improving airway management and refining approaches to swallowing function.

PMID:39593020 | DOI:10.1186/s12880-024-01506-y

BMC Health Serv Res. 2024 Nov 26;24(1):1469. doi: 10.1186/s12913-024-11936-7.

ABSTRACT

BACKGROUND: Healthcare use by High-Need High-Cost (HNHC) patients is believed to be modifiable through better coordination of care. To identify patients for care management, a hybrid approach is recommended that combines clinical assessment of need with model-based prediction of cost. Models that predict high healthcare costs persisting over time are relevant but scarce. We aimed to develop and validate two models predicting Persistent High-Cost (PHC) status upon hospital outpatient visit and hospital admission, respectively.

METHODS: We performed a retrospective cohort study using claims data from a national health insurer in the Netherlands-a regulated competitive health care system with universal coverage. We created two populations of adults based on their index event in 2016: a first hospital outpatient visit (i.e., outpatient population) or hospital admission (i.e., hospital admission population). Both were divided in a development (January-June) and validation (July-December) cohort. Our outcome of interest, PHC status, was defined as belonging to the top 10% of total annual healthcare costs for three consecutive years after the index event. Predictors were predefined based on an earlier systematic review and collected in the year prior to the index event. Predictor effects were quantified through logistic multivariable regression analysis. To increase usability, we also developed smaller models containing the lowest number of predictors while maintaining comparable performance. This was based on relative predictor importance (Wald χ2). Model performance was evaluated by means of discrimination (C-statistic) and calibration (plots).

RESULTS: In the outpatient development cohort (n = 135,558), 2.2% of patients (n = 3,016) was PHC. In the hospital admission development cohort (n = 24,805), this was 5.8% (n = 1,451). Both full models included 27 predictors, while their smaller counterparts had 10 (outpatient model) and 11 predictors (hospital admission model). In the outpatient validation cohort (n = 84,009) and hospital admission validation cohort (n = 20,768), discrimination was good for full models (C-statistics 0.75; 0.74) and smaller models (C-statistics 0.70; 0.73), while calibration plots indicated that models were well-calibrated.

CONCLUSIONS: We developed and validated two models predicting PHC status that demonstrate good discrimination and calibration. Both models are suitable for integration into electronic health records to aid a hybrid case-finding strategy for HNHC care management.

PMID:39593019 | DOI:10.1186/s12913-024-11936-7

BMC Pregnancy Childbirth. 2024 Nov 26;24(1):790. doi: 10.1186/s12884-024-06989-9.

ABSTRACT

BACKGROUND: Antenatal care (ANC) plays a crucial role in reducing maternal fatalities and morbidities through early detection and management of pregnancy-related complications and ensures the proper referral in the level of care. Various variables facilitate a pregnant woman’s ability to schedule enough ANC visits. This research sought to identify factors contributing to Tanzanian pregnant women receiving adequate antenatal care.

METHODS: The study used data from the 2015-16 TDHS-MIS. We analysed a total of 6924 included in the analysis. The outcome variable was adequate ANC, and we assessed different predictors on how they influence good antenatal care attendance. Bivariate (chi-square) and multivariate logistic regression were conducted at the statistical significance of p < 0.05.

RESULTS: 3438 (49.7%) had inadequate ANC visits. Determinants for antenatal attendance included giving birth outside health facility (aOR = 0.77, 95%CI = 0.62-0.95, p-value = 0.02) are less likely to complete all the ANC, mothers who book early for ANC (aOR = 5.79, 95%CI = 4.56-7.35, p-value < 0.001) were more likely to achieve the recommended visits, parity of 2 to 4 (aOR = 0.63, 95%CI = 0.48-0.81, p-value < 0.001), and five and above (aOR = 0.48, 95%CI = 0.35-0.68, p-value < 0.001) showed a decreased odd to complete adequate ANC, the use of the Internet (aOR = 1.62, 95%CI = 1.08-2.42, p-value = 0.02) were two times more likely to attend the required visits, pregnant mothers who experienced sexual violence from partners (aOR = 0.70, 95%CI = 0.52-0.94, p-value = 0.02) were less likely to complete the adequate visit, and the use of the mobile telephone for health-related issues (aOR = 1.476, 95%CI = 1.02-2.14, p-value = 0.04) slightly increase the chance of attending adequate visits.

CONCLUSION: This study identified determinants influencing ANC visits. ANC booking, using the Internet, and mobile phones enhance the likelihood of completing recommended ANC visits while higher parity and experiencing partner-related sexual violence decrease these chances. These findings show a need for addressing wealth inequality, geographical barriers, the impact of intimate partner violence, encouraging internet access for health information, and health promotion for early ANC booking to improve the uptake of ANC services.

PMID:39593016 | DOI:10.1186/s12884-024-06989-9

BMC Pregnancy Childbirth. 2024 Nov 26;24(1):788. doi: 10.1186/s12884-024-06997-9.

ABSTRACT

BACKGROUND: Placental accreta spectrum (PAS) disorder with bladder involvement is found to be associated with severe maternal and neonatal morbidity.When planning surgery or other treatments, a diagnosis and assessment of the invasiveness of placenta accreta spectrum disorder with bladder involvement are crucial.The detection of the depth of villi invasion can be accomplished with both MRI and US.The advent of three-dimensional Crystal Vue provides details additional information for scanning abnorma issue.

PURPOSE: Our goal was to compare and assess the diagnostic accuracy of 2D US combined with the 3D Crystal Vue and MRI in case of placenta accreta spectrum (PAS) involving the bladder.

MATERIALS AND METHODS: 111 pregnancy patients between May 2019 and November 2023 at the First Affiliated Hospital of Anhui Medical University whether or not they had placenta previa were included in the study if they were diagnosed of having placenta increta (PI) or placenta percreta (PP).Both US and MRI were used to evaluate the pregnant women.Total 53 pregnant women were ultimately included in our analysis.53 patients were split into groups with and without bladder involvement. They underwent 2D US,3D Crystal Vue, and MRI.The visual features of every subject were noted. Next, we analyzed the fundamental information, associated medical history, pregnancy outcomes, and different US and MRI signals between the two groups. To determine the potential contributing factors of PAS complicated with bladder involvement, a univariate analysis was performed. A multivariable logistic regression analysis was performed to identify US and MRI findings predictive of bladder involvement in placenta accreta spectrum.

RESULTS: Multiple logistic regression analysis found that the bridging vessels (OR, 31.76,95% CI, 1.64-614.31,p = 0.022) and the tramline sign “fully” obliterated on Crystal Vue feature (OR, 68.92;95%CI,6.76-702.35,p < 0.001) were independently associated with an increased likelihood of bladder involvement. These findings when combined allowed for the prediction of bladder involvement with an 88.2% sensitivity, a 94.4% specificity, and an AUC of 0.933 (95% CI,0.829-0.983, p = 0.001). The results of the MRI logistic regression analysis were as follows: the three independent risk factors for bladder involvement were: Placental bulge (OR,57.99,95%CI,3.89-835.80,p = 0.003),Bladder wall interruption (OR,11.93, 95%CI, 1.60-88.85, p = 0.016), and Bladder vessel sign (OR, 9.75,95%CI, 1.43-66.21, p = 0.020).The joint diagnosis showed a sensitivity of 94.1% and specificity of 83.3%.The area under the curve was 0.942(95%CI,0.841-0.988). Regarding projected bladder involvement, there were no statistically significant differences between MRI and 2D integrated 3D Crystal Vue imaging.

CONCLUSION: Both 2D coupled 3D Crystal Vue imaging and MRI are highly effective for predicting bladder invasion.Ultrasound is preferred over MRI because it is more convenient and more affordable.Among them, the tramline sign “fully” obliterated on 3D Crystal Vue was a new and reliable US sign for detecting bladder involvement.

PMID:39593009 | DOI:10.1186/s12884-024-06997-9

BMC Health Serv Res. 2024 Nov 27;24(1):1478. doi: 10.1186/s12913-024-11996-9.

ABSTRACT

BACKGROUND: Patient satisfaction is a crucial indicator of healthcare quality, influencing outcomes and providing insights for improvement. This study aims to assess patient satisfaction levels, and associated factors, and identify areas for enhancement at Remera Rukoma District Hospital (RRDH) in Rwanda, where such data was previously lacking.

METHODS: A cross-sectional study using a mixed approach of data collection was conducted, involving 384 participants (164 inpatients, 220 outpatients). Quantitative surveys and qualitative interviews were employed. Patient satisfaction was categorized as Very Satisfied (> 70%), Satisfied (50-69.9%), or Not Satisfied (≤ 49.9%). Data analysis included descriptive statistics, bivariate logistic regression, and thematic analysis of qualitative data.

RESULTS: The study comprised 37.8% male and 62.2% female participants. Overall, 52.6% were highly satisfied, 29% satisfied, and 18% not satisfied. Among outpatients, 35.9% were dissatisfied with cashier services, and 46.9% with pharmacy wait times. Inpatients showed 74.4% satisfaction with the admission process, but 69.5% reported delayed test result feedback. Educational level significantly influenced satisfaction, with uneducated participants showing lower odds of satisfaction compared to university-educated ones (cOR = 0.409, 95% CI: 0.186-0.897, p = 0.026). Qualitative findings highlighted issues with wait times, communication, and service consistency.

CONCLUSIONS: While overall satisfaction at RRDH was positive, the study identified areas needing improvement, particularly in communication, wait times, and service delays. Education level was significantly associated with satisfaction level. Addressing these factors, beyond operational efficiency, may significantly impact patient satisfaction. Enhancing communication, managing expectations, and optimizing service delivery are crucial for maintaining satisfaction and improving service quality.

PMID:39593008 | DOI:10.1186/s12913-024-11996-9