Tag: pubmed

Eur J Med Res. 2024 Dec 31;29(1):639. doi: 10.1186/s40001-024-02242-3.

ABSTRACT

BACKGROUND: There are limited and controversial findings concerning ovulation induction using intrauterine and intramuscular human chorionic gonadotropin (hCG) injection compared to intramuscular hCG alone. The study aimed to examine the impact of intrauterine hCG injection, which is used to induce ovulation, on the efficacy of the intrauterine insemination (IUI) technique in patients with unexplained infertility.

METHODS: A randomized controlled clinical trial was conducted involving 80 subjects with unexplained primary infertility at the infertility clinic of Al-Zahra Hospital in northwest Iran. Patients were randomly allocated into two groups: control and intervention. Both groups received initial treatment with letrozole and Recombinant follicle-stimulating hormone (r-FSH). After confirmation of at least one follicle measuring 18 mm or larger through ultrasonography, in the control group, two ampoules of 5000 units of hCG were administered intramuscularly. The intervention group received 500 units of hCG diluted in 0.5 cc of normal saline and was injected into the uterine cavity along with the two intramuscular ampoules. Primary outcomes were clinical and chemical pregnancy rates and the secondary outcome was any adverse pregnancy outcomes. Multiple logistic regression analysis was used to estimate crude and adjusted odds ratios (AORs) of the pregnancy rates with 95% confidence intervals (CIs).

RESULTS: No significant differences were found between the two groups regarding baseline characteristics (p > 0.05). Chemical and clinical pregnancy rates in the control and intervention groups were (32.5 vs. 40%) (32.5% vs. 35%), respectively. In the final analysis after adjusting the potential confounders, intrauterine and intramuscular hCG injection increased the likelihood of chemical pregnancy by 1.39 times AOR = 1.42 (1.31-4.12; p = 0.036), and clinical pregnancy by AOR = 1.25 (1.03-3.74; p = 0.048) compared to intramuscular hCG alone. There were no statistical differences regarding adverse pregnancy outcomes between the study groups (p value > 0.05).

CONCLUSIONS: It seems that ovulation induction through intrauterine and intramuscular hCG injection increased the odds of both chemical and clinical pregnancy rates compared with intramuscular hCG alone. Multicenter clinical trials and meta-analysis studies are needed for decision making in clinical settings.

PMID:39741322 | DOI:10.1186/s40001-024-02242-3

J Orthop Surg Res. 2024 Dec 31;19(1):898. doi: 10.1186/s13018-024-05367-7.

ABSTRACT

OBJECTIVE: This study aims to explore the predictive value of endplate morphology and pedicle screw bone quality score on screw loosening after single-level lumbar spinal fusion surgery.

METHODS: A retrospective analysis was conducted on the clinical data of 207 patients who underwent single-level lumbar spinal fusion (34 in the screw loosening group and 173 in the non-screw loosening group). Univariate analysis and binary logistic regression model analysis were performed using SPSS 27.0. MedCalc 23 was used to plot the receiver operating characteristic (ROC) curve to evaluate diagnostic efficacy.

RESULTS: Through comparative analysis of clinical data, we found statistically significant differences between the two groups in terms of endplate morphology, lumbar CT values, and PBQ scores(P<0.05). The results of the binary logistic regression analysis indicated that endplate morphology (OR = 17.088, 95% CI: 3.886-75.142; p < 0.001) and PBQ score (OR = 3.347, 95% CI: 1.473-7.603; p = 0.004) are independent risk factors for screw loosening after single-level lumbar spinal fusion surgery. The ROC analysis showed that the area under the curve (AUC) for endplate morphology was 0.731 (95% confidence interval [CI]: 0.665-0.790), with the optimal threshold representing irregular endplate morphology (sensitivity: 94.1%, specificity: 52.0%). The AUC for the PBQ score was 0.791 (95% CI: 0.729-0.844), with an optimal threshold of 3.198 (sensitivity: 91.2%, specificity: 61.8%). Furthermore, the predictive model constructed using both endplate morphology and PBQ score had an AUC of 0.870 (95% confidence interval: 0.817-0.913), with a maximum Youden index of 0.668, yielding a diagnostic sensitivity of 88.2% and specificity of 78.6%.

CONCLUSION: Endplate morphology and pedicle screw bone quality score have significant reference value for diagnosing screw loosening after single-level lumbar spinal fusion surgery.

PMID:39741319 | DOI:10.1186/s13018-024-05367-7

BMC Oral Health. 2024 Dec 31;24(1):1574. doi: 10.1186/s12903-024-05377-1.

ABSTRACT

OBJECTIVE: Based on the critical role of implant length and placement timing in treatment success, this study aimed to compare clinical outcomes (implant failure, marginal bone loss, biological and mechanical complications) between short implants (4-8 mm) versus long implants (≥ 8 mm) with sinus floor elevation, and between delayed versus immediate placement of long implants in the posterior maxilla.

METHODS: This network meta-analysis was prospectively registered in the PROSPERO database (CRD42023495027). Adhering to PRISMA-NMA guidelines, we systematically reviewed eligible studies from January 2014 to November 2024 was conducted across major databases, such as the Cochrane Library, PubMed, Embase, Scopus and Web of Science. The main focus of this NMA was to determine the rate of implant failure, as well as to assess marginal bone loss and the occurrence of biological and mechanical complications related to the implants.

RESULTS: Data from 17 studies, involving 1,076 patients and 1,751 implants, was collected and examined. Long implants have lower failure rates (OR = 1.26; 95% CI = 0.53, 3.00) and short dental implants showed a trend towards lower biological (OR = 0.47; 95% CI = 0.19, 1.18) and mechanical (OR = 0.94; 95% CI = 0.45, 1.94) complications rates, although this trend was not statistically significant. Additionally, compared to longer implants, short implants resulted in a significant reduction in marginal bone loss, regardless of whether long implants were immediately (MD=-0.17; 95%CI: -0.29, -0.05) or delayed (MD = 0.35; 95%CI: 0.05, 0.64) placed following sinus floor elevation. The analysis of cumulative ranking probabilities revealed that delayed placement of long implants with SFE demonstrated the highest efficacy in reducing implant failure (73.9%). SIs were found to excel in reducing marginal bone loss (88.7%) and biological complications (88.2%%), while short implants with SFE proved to be the most effective in preventing mechanical complications (66.0%%).

CONCLUSION: Short implants achieved comparable clinical outcomes to long implants with sinus floor elevation in posterior maxilla with limited vertical bone height. Given the limitations of the network meta-analysis and included studies, treatment selection should be individualized based on specific patient conditions.

PMID:39741292 | DOI:10.1186/s12903-024-05377-1

J Orthop Surg Res. 2024 Dec 31;19(1):896. doi: 10.1186/s13018-024-05339-x.

ABSTRACT

BACKGROUND: Anterior cervical corpectomy and fusion (ACCF) is a standard surgical procedure for cervical spondylosis with spinal cord compression (CSWSCC), especially in patients with intensity on T2-weighted imaging high signal (T2WIHS). The titanium mesh cage (TMC) utilized in this procedure is essential in stabilizing the spine; however, the optimal slotting width of the TMC remains unclear.

OBJECTIVE: This study aimed to investigate the impact of TMC slotting width on the clinical and radiological outcomes of ACCF in patients with spinal cord compression type cervical spondylosis with intensity on T2WIHS (CST2WIHS).

METHODS: We retrospectively analyzed 69 patients who underwent single-level ACCF between December 2010 and October 2021. The patients were divided into narrower (< 2 mm) and wider (> 2 mm) groups based on the slotting width of the TMC. The Neck Disability Index (NDI) and Japanese Orthopedic Association (JOA) scores were used to assess clinical outcomes. Radiological outcomes included cervical lordosis (CL), functional spinal unit (FSU) height, transverse decompression range (TDR), spinal canal area (SCA), TMC alignment, and subsidence and fusion rates.

RESULTS: Patients in both groups exhibited significant postoperative improvement in NDI and JOA scores (P < 0.05). Radiologically, patients in the wider slotting group exhibited better decompression, evidenced by a larger TDR (P < 0.01) and smaller postoperative SCA (P < 0.01) than the narrow group. Regarding CL, FSU height, TMC alignment, subsidence, or fusion rates, the groups did not differ significantly. Although statistically non-significant, patients in the wider group exhibited a trend towards improvement in spinal cord signal intensity than those in the narrower group.

CONCLUSION: The study demonstrated that a wider TMC slotting width offers superior decompression and may improve postoperative spinal cord signal; it does not compromise spinal stability or fusion outcomes. These findings indicate that slotting width should be carefully considered in ACCF procedures to optimize decompression and spinal cord recovery.

PMID:39741291 | DOI:10.1186/s13018-024-05339-x

BMC Gastroenterol. 2024 Dec 31;24(1):482. doi: 10.1186/s12876-024-03574-4.

ABSTRACT

BACKGROUND: Percutaneous Endoscopic Gastrostomy (PEG) tube insertion, a routine procedure for long-term enteral nutrition, serves as a crucial intervention for patients who are incapable of tolerating oral intake or meeting adequate nutritional requirements. PEG tube placement carries complications like bleeding and infection. Impact of PEG tubes on the 30-day and long-term mortality in HIV patients is unknown. Despite the ongoing utilization of PEG tubes in HIV patients, a comprehensive exploration of its outcomes is yet to be explored. We intended to study the impact of HIV positive status on post-PEG mortality and review other PEG tube related complications.

METHODS: Our study comprised a total of 639 PEG tubes placed on 461 unique patients, from which 85 patients (n = 18%) were HIV positive. We reviewed all these PEG tube patients at our institution and compared their complications and mortality outcome between the two groups of HIV positive as against HIV negative.

RESULTS: Our findings reveal a statistically significant increase (p-value 0.001) in post-PEG insertion site bleeding in the HIV group (15.3%) compared to the non-HIV group (4.5%). This difference occurred despite no notable variations in laboratory parameters such as platelet count and (international normalized ratio), as well as similar usage of anticoagulant or antiplatelet medications between the two groups. Notably, the 1-year mortality rate in the HIV group stands at 37.6% (p < 0.001), contrasting sharply with the non-HIV group’s rate of 17.8%.

CONCLUSION: This study underscores the need for heightened vigilance and tailored management strategies when considering PEG tube procedures in the context of HIV, given the observed elevated bleeding risks and increased 1-year mortality rates in this patient population. Further research is warranted to elucidate the underlying factors contributing to these outcomes, facilitating the development of targeted interventions to optimize the care of HIV patients undergoing PEG placement.

PMID:39741264 | DOI:10.1186/s12876-024-03574-4

BMC Psychiatry. 2024 Dec 31;24(1):962. doi: 10.1186/s12888-024-06434-3.

ABSTRACT

BACKGROUND: Major depressive disorder (MDD) is a highly prevalent mental disorder with devastating consequences that often first manifest during adolescence. Anhedonia has emerged as one of the most promising symptoms of adolescent MDD, which means a longer time to remission， fewer depression-free days, and also increased risk of suicide ideas or actions. Research has shown that at least two-thirds of depressed adolescents have significant sleep-onset or sleep-maintenance problems. However, the association between sleep disorder and anhedonia, and the potential mediators are less understood.

METHODS: This is a cross-sectional study that includes 200 adolescents suffered from MDD between the ages of 12-17. We use Spearman’s test to explore the relationship among main variables. To evaluate the mediating effects of stress, we applied regression models and used bootstrap method to validate the significance of effects.

RESULTS: Significant correlation exists among sleep disorder, stress, and anhedonia (P<0.05).The direct effect of sleep disorder on anhedonia was 0.214 (95% CI: 1.5235, 6.2073), while the total effect was 0.295 (95% CI: 2.9683, 7.6924). The indirect effect of sleep disorder on anhedonia mediated by stress was 0.081 (95% CI: 0.5842, 2.5268). Robustness of the regression analysis results has been verified by bootstrap test.

CONCLUSIONS: Our finding suggested a positive correlation between sleep disturbance and anhedonia in adMDD. Stress partially mediated the relationship between sleep disorder and anhedonia. Due to the deleterious effects of anhedonia on depressed adolescents, these findings provide impetus to investigate further the causal relationship between sleep problems and anhedonia.

TRIAL REGISTRATION: ChiCTR2200060176(Registration Date: 21/05/2022).

PMID:39741263 | DOI:10.1186/s12888-024-06434-3

BMC Oral Health. 2024 Dec 31;24(1):1577. doi: 10.1186/s12903-024-05379-z.

ABSTRACT

BACKGROUND: Orthodontic treatment involves manipulation of tooth position that can temporarily lead to occlusal interferences capable of inducing bruxism. The objectives of this study were to determine the self-reported incidence of bruxism and its association with factors such as facial type, divergence, skeletal and dental malocclusions in orthodontic patients.

MATERIALS AND METHODS: 80 patients who underwent a minimum of six months of orthodontic treatment were surveyed using a validated self-reported bruxism questionnaire for the presence or absence of bruxism. Data regarding patients’ facial type, divergence, skeletal and dental malocclusions were measured and collected from the patients’ orthodontic records. Binomial logistic regression analysis was used to assess the association of these factors with bruxism.

RESULTS: About 45% of the orthodontic patients reported bruxism after the commencement of orthodontic treatment. The median age of the sample was 19.8 (17.7, 24.3) years and 60% of them were women. Binomial logistic regression analysis showed an insignificant association of gender and age with bruxism. When analyzing the association with facial type, divergence, skeletal and dental malocclusion no statistically significant association was found. However, patients with hypodivergent face [odds ratio (OR) = 2.4; 95% confidence interval (CI) = 0.7-8.5] and dental class III [OR = 4.0; 95% CI = 0.3-51.0] were more likely to report bruxism after the initiation of orthodontic treatment. A statistically significant association was found with jaw fatigue or soreness upon awakening (28.7%), clenching (27.5%) and grinding (25%) in the bruxism group (p-value ≤ 0.001). Teeth and gum soreness were also significantly associated with bruxism, affecting 25% of the orthodontic patients (p-value ≤ 0.001). On the contrary, nocturnal grinding (10%) and temporal headaches (21.3%) were negatively correlated with bruxism.

CONCLUSIONS: There is a risk of bruxism among orthodontic patients, with 45% of them reporting bruxism following the initiation of treatment. Patients with bruxism commonly reported jaw fatigue or soreness upon awakening, clenching, grinding, teeth and gum soreness. Factors such as facial type, facial divergence, skeletal and dental malocclusions have no impact on the onset of bruxism during orthodontic treatment.

PMID:39741259 | DOI:10.1186/s12903-024-05379-z

BMC Psychiatry. 2024 Dec 31;24(1):960. doi: 10.1186/s12888-024-06390-y.

ABSTRACT

BACKGROUND: Problematic Internet use (PIU) is a growing concern in modern society. There is a limitation of epidemiologic data related to PIU. This is due to a lack of consensus on the definition and variability of assessment tools of PIU. PIU has been linked to a range of negative outcomes including depression, anxiety, social isolation, and poor academic or work performance. Resident physicians are at risk of exhibiting problematic internet use due to the high stress of academic demands, social isolation, long working hours, busy schedules, and internet access. There is limited research on this topic and targeting resident physicians in Ethiopia. This study aimed to determine the PIU prevalence and associated factors among resident physicians in SPHMMC, Ethiopia.

METHODS: An institutional-based cross-sectional study was conducted from September 1, 2023, to November 25, 2023, at St. Paul’s Hospital Millennium Medical College (SPHMMC). This study included 417 physician residents who were selected using multistage sampling techniques, and Young’s Internet addiction test was used to assess PIU. To look for associations, logistic regression analysis, both binary and multivariable, was performed, and a p-value of < 0.05 was used to determine statistical significance.

RESULTS: 414 participants were included in this study, with a response rate of 99.3%. The prevalence of PIU was 46.6%, with a 95% CI of 41.7-51.6%. The multivariable logistic regression model revealed that using the Internet for five or more hours per day (AOR: 1.84, 95% CI = 1.14, 2.99), having less than 7 h of actual sleep per night (AOR: 2.16, 95% CI = 1.03, 4.53), and having depression (AOR: 7.98, 95% CI = 2.47, 25.78) were significantly positively associated with PIU. In addition, factors such as being married (AOR: 0.42, 95% CI = 0.19, 0.91) and residents of the obstetrics and gynecology department (AOR: 0.32, 95% CI = 0.13, 0.81) were negatively associated with PIU.

CONCLUSION: This study revealed high PIU use among resident physicians at SPHMMC. Factors such as using the Internet for five or more hours per day, having less than seven hours of actual sleep per night, and having depression were found to be risk factors for PIU. On the other hand, being married and residents of the obstetrics and gynecology department were protective factors. Thus, creating awareness among medical residents about healthy tech habits and involving policymakers to develop guidelines for healthy internet use and awareness campaigns to reduce the impact of PIU is recommended.

PMID:39741254 | DOI:10.1186/s12888-024-06390-y

BMC Pregnancy Childbirth. 2024 Dec 31;24(1):889. doi: 10.1186/s12884-024-06912-2.

ABSTRACT

OBJECTIVE: To study the implementation value of abdominal B-ultrasound combined with cervical cerclage in the prevention and treatment of recurrent late abortion.

METHODS: From October 2020 to December 2023, 196 pregnant patients who had a history of late abortions at our institution were chosen. They were divided into groups based on the treatments used. In the observational team, 98 instances received abdominal B-ultrasound along with cervical cerclage, while 98 instances in the controlling team underwent traditional conservative treatment. Vaginal flora, inflammatory factor levels, labor outcomes, uterine artery parameters, and adverse effects were observed in both groups of pregnant women.

RESULTS: Comparing the detection of vaginal flora between the two groups, the difference was not statistically significant (P > 0.05); the detection values of WBC, neutrophil percentage and neutrophil absolute value in the observation group were lower than those in the control group (P < 0.05). The recurrent late abortion rate (4.08%) and premature delivery rate (16.33%) were lower than those of the control group, and the full-term delivery rate (79.59%) and total fetal survival rate (93.88%) were higher than those of the control group, and the difference was statistically significant (P < 0.05). The resistance index (RI) and pulsatility index (PI) of pregnant women with abortion were higher than those of live birth pregnant women. The RI and PI of group A (pregnant women with recurrent late abortion) at 7, 12, 24 and 32 weeks of gestation were also higher than those of group B (pregnant women without recurrent late abortion), and the difference was statistically significant (P < 0.05). At 7 weeks of gestation, there was no statistical difference between the observation and control groups in terms of RI and PI (P > 0.05)0.12 By 32 weeks of gestation, the RI and PI were lower in the observation group than in the control group (P < 0.05)0.13 In the observation group, the RI and PI were lower than in the control group (P < 0.05). The incidence of gestational hypertension, gestational diabetes mellitus, and eclampsia were significantly lower in the observation group compared to the control group (P < 0.05).

CONCLUSION: Abdominal ultrasound combined with cervical cerclage reduces the risk of miscarriage by improving the hemodynamic status of the uterus and placenta, and also optimizes the pregnancy environment by reducing the inflammatory response in the uterine cavity, which has important clinical applications in the prevention and treatment of late recurrent spontaneous abortion.

PMID:39741251 | DOI:10.1186/s12884-024-06912-2

Int J Emerg Med. 2024 Dec 31;17(1):204. doi: 10.1186/s12245-024-00798-9.

ABSTRACT

BACKGROUND: Elevated initial serum lactate (iSL) levels are frequently employed to assess trauma severity, but their predictive value for mortality and morbidity remains inconsistent. We evaluated the association of iSL with mortality and morbidity at Puerto Rico Trauma Hospital (PRTH).

METHODS: This IRB-approved retrospective study included trauma patients ≥ 18 years with iSL measured within the first 48 h of admission to PRTH (July 2014-June 2019). Patients were classified as normal (4.5-19.8 mg/dL) or elevated (≥ 19.9 mg/dL) iSL levels. Group comparisons were conducted using t-tests, Wilcoxon rank-sum tests, Pearson’s chi-squared, or Fisher’s exact tests. Associations were evaluated with regression and ROC analyses.

RESULTS: Among 536 patients, 54.3% had elevated iSL levels. Initially, elevated iSL was associated with in-hospital mortality (OR: 2.18, 95%CI: 1.36-3.51, p < 0.001), traumatic intensive care unit (TICU) admission (OR: 2.06, 95%CI: 1.46-2.92, p < 0.001), and need for mechanical ventilation (MV) (OR: 2.80, 95%CI: 1.97-3.98, p < 0.001). However, adjusted analyses showed no significant associations (Mortality-AOR: 1.72, 95%CI: 0.97-3.04, p = 0.06; TICU-AOR: 1.11, 95%CI: 0.71-1.75, p = 0.65; MV-AOR: 1.49, 95%CI: 0.89-2.49, p = 0.13). Both iSL (AUC: 0.59, 95%CI: 0.54-0.64) and ISS (AUC: 0.59, 95%CI: 0.54-0.64) demonstrated limited ability to predict mortality, with no statistically significant difference between them (p > 0.99). Patients with elevated iSL experienced prolonged hospital and TICU stays and severe injuries.

CONCLUSIONS: Elevated iSL levels may not independently predict mortality, TICU admission, or the need for MV in trauma patients. However, their rapid availability supports their use alongside other clinical markers to guide trauma care decision-making and improve trauma outcomes.

PMID:39741239 | DOI:10.1186/s12245-024-00798-9