Tag: pubmed

J Esthet Restor Dent. 2024 Jul 17. doi: 10.1111/jerd.13283. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate the in vitro influence of prior silane application on the microshear bond strength (μSBS) of Scotchbond Universal Plus to glass ceramic.

MATERIALS AND METHODS: Thirty blocks of lithium disilicate ceramic were etched with hydrofluoric acid for 20 s and distributed into Group 1 (no silane and no adhesive), Group 2 (adhesive), Group 3 (silane + adhesive). Three cylinders of resin cement were made on each ceramic block. Five blocks (n = 15 cylinders) were subjected to the μSBS test after 24 h, and the other five blocks (n = 15 cylinders) were tested after 6 months of water storage.

RESULTS: According to two-way ANOVA, followed by Tukey’s test, the means of μSBS (MPa), denoted by different letters, show significant differences (p < 0.05): after 24 h-Group 1 (31.7)^B, Group 2 (43.3)^A, and Group 3 (31.3)^B; after 6 months-Group 1 (14.8)^B, Group 2 (33.6)^A, and Group 3 (30.3)^A. After 6 months of storage, there was a significant decrease in μSBS for Groups 1 and 2, along with an increase in adhesive failures across all groups.

CONCLUSIONS: Prior application of silane did not increase the μSBS between Scotchbond Universal Plus and ceramic, and there was degradation at the bond interface over time.

CLINICAL SIGNIFICANCE: Prior application of a silane agent is not necessary when using Scotchbond Universal Plus for bonding to glass ceramics. Regardless of the prior application of silane, there is degradation at the bond interface over time.

PMID:39016071 | DOI:10.1111/jerd.13283

Int Endod J. 2024 Jul 17. doi: 10.1111/iej.14114. Online ahead of print.

ABSTRACT

INTRODUCTION: In endodontics, the number of umbrella reviews has increased significantly over the last few years, but there is no evidence that they were methodologically sound. The aim of the current study was to appraise the methodological quality of umbrella reviews in endodontics, and to identify possible predictive factors associated with methodological quality.

METHODS: Umbrella reviews published in the discipline of endodontics until December 2023 were included. The methodological quality of the reviews was evaluated using a checklist consisting of 11 items. Each item in the checklist was evaluated by two independent assessors who assigned a score of ‘1’ if it was fully addressed, ‘0.5’ if it was partially ddressed, and ‘0’ if it was not addressed. Bootstrapped multiple linear regression analysis was used to examine the association between the total scores awarded and five predictor variables (a priori protocol registration, year of publication, number of authors, journal impact factor (IF) and continent of the corresponding author). The statistical significance level was set as 5%.

RESULTS: A total of 27 reviews were included. Ninety-six per cent of the reviews adequately reported: eligibility criteria for selecting the reviews, details of the reviews, techniques for assessing the risk of bias or methodological quality of the individual systematic reviews they included. Only 30% of the reviews adequately managed overlapping primary studies within individual systematic reviews. Among the five predictors analysed, a priori protocol registration and journals with IFs were associated with significantly greater total methodological quality scores.

DISCUSSION: Several methodological shortcomings in the umbrella reviews published within the field of endodontics were revealed. Umbrella reviews published in journals with IFs and those with protocols registered a priori had significantly superior methodological quality scores.

CONCLUSION: In endodontics, authors intending to publish umbrella reviews should consider the limitations revealed in this study and follow the appropriate rules to ensure their reviews comply with the highest standards and provide accurate and dependable information and conclusions.

PMID:39016048 | DOI:10.1111/iej.14114

Cannabis Cannabinoid Res. 2024 Jul 17. doi: 10.1089/can.2023.0253. Online ahead of print.

ABSTRACT

Background: Patients have been known to use cannabinoids for treating established chemotherapy-induced peripheral neuropathy (CIPN) based on anecdotal information and retrospective reports suggesting that such might be beneficial. In response, a double-blinded, placebo-controlled, randomized, pilot clinical trial was developed to evaluate whether resultant data would support a phase III trial for testing whether a cannabidiol (CBD) cream might improve CIPN. Methods: Forty patients with established CIPN were randomized, in a double-blinded manner, to topical CBD or a placebo cream. The study product was applied for 2 weeks, followed by a crossover for 2 weeks. Neuropathy was evaluated using the European Organization of Research and Treatment of Cancer (EORTC)-CIPN20, the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool, and the Global Impression of Change instruments. Side effects were recorded by symptom diaries. Results: The EORTC-CIPN20 scores were similar in the patients receiving CBD versus the placebo. Likewise, the toxicity scores were similar in patients who received the CBD versus the placebo. Conclusions: This pilot trial did not support that the studied CBD isolate cream improved painful established CIPN. It was well tolerated overall. Clinical Trial Registration Number: NCT05388058.

PMID:39016024 | DOI:10.1089/can.2023.0253

Int J Adolesc Med Health. 2024 Jul 18. doi: 10.1515/ijamh-2024-0073. Online ahead of print.

ABSTRACT

OBJECTIVES: The tools to measure knowledge, attitudes, and self-efficacy related to adolescent sexual and reproductive health have been developed, but with adolescent subjects over 15 years old and with specific topics. The needs and focus of SRH education in adolescents are different from those of young adults. This study aimed to develop a valid and reliable tool to measure adolescents’ knowledge, attitude, and self-efficacy regarding SRH.

METHODS: A total of 100 items were developed based on a literature search, focus group discussion, and expert panel encompassing three domains: knowledge, attitude, and self-efficacy. The Adolescent Sexual and Reproductive Health – Knowledge, Attitude, and Self-Efficacy Questionnaires (ASRH-KASeQ) then underwent a validation process that included content validity, face validity, and internal consistency reliability. This study was conducted on adolescents aged 12-15 years in secondary school in Yogyakarta, Indonesia. All statistical methods were analyzed using STATA software.

RESULTS: The average content validity (S-CVI/Ave) and face validity (S-FVI/Ave) for knowledge, attitude, and self-efficacy demonstrated good validity with scores of 0.93 and 0.94, 0.92 and 0.96, and 0.95 and 0.96, respectively. The internal consistency reliability using Cronbach’s alpha for the knowledge, attitude, and self-efficacy domains exceeded 0.6, with results of 0.7, 0.81, and 0.89, which were considered acceptable.

CONCLUSIONS: The final set of ASRH-KASeQ consisted of 100 items measuring knowledge (40 items), attitude (30 items), and self-efficacy (30 items) of adolescents SRH. ASRH-KASeQ was shown to be a reliable and valid tool for Indonesian adolescents, especially those aged 12-15 years.

PMID:39016023 | DOI:10.1515/ijamh-2024-0073

Future Microbiol. 2024;19(8):715-740. doi: 10.2217/fmb-2023-0279. Epub 2024 Jun 7.

ABSTRACT

Nontuberculous mycobacteria (NTM) are widespread environmental organisms found in both natural and man-made settings, such as building plumbing, water distribution networks and hospital water systems. Their ubiquitous presence increases the risk of transmission, leading to a wide range of human infections, particularly in immunocompromised individuals. NTM primarily spreads through environmental exposures, such as inhaling aerosolized particles, ingesting contaminated food and introducing it into wounds. Hospital-associated outbreaks have been linked to contaminated medical devices and water systems. Furthermore, the rising global incidence, prevalence and isolation rates highlight the urgency of addressing NTM infections. Gaining a thorough insight into the sources and epidemiology of NTM infection is crucial for devising novel strategies to prevent and manage NTM transmission and infections.

PMID:39015998 | DOI:10.2217/fmb-2023-0279

Analyst. 2024 Jul 17. doi: 10.1039/d4an00682h. Online ahead of print.

ABSTRACT

Compared to animal cells, phenotypic characterization of single plant cells on microfluidic platforms is still rare. In this work, we collated population statistics on the morphological, biochemical, physical and electrical properties of Arabidopsis protoplasts under different external and internal conditions, using progressively improved microfluidic platforms. First, we analyzed the different effects of three phytohormones (auxin, cytokinin and gibberellin) on the primary cell wall (PCW) regeneration process using a microfluidic flow cytometry platform equipped with a single-channel fluorescence sensor. Second, we correlated the intracellular reactive oxygen species (ROS) level induced by heavy metal stress with the concurrent PCW regeneration process by using a dual-channel fluorescence sensor. Third, by integrating contraction channels, we were able to effectively discriminate variations in cell size while monitoring the intensity of intracellular ROS signaling. Fourth, by combining an electrical impedance electrode with the contraction channel, we analyzed the differences in electrical and mechanical properties of wild-type and mutant plant cells before and after primary cell wall regeneration. Overall, our work demonstrates the feasibility and sensitivity of microfluidic flow cytometry in high-throughput phenotyping of plant cells and provides a reference for assessing metabolic and physiological indicators of individual plant cells in multiple dimensions.

PMID:39015957 | DOI:10.1039/d4an00682h

J Oral Implantol. 2024 Jul 17. doi: 10.1563/aaid-joi-D-23-00096. Online ahead of print.

ABSTRACT

To assess and compare the precision and predictability of zygomatic implants in atrophic maxilla using conventional and dynamic navigation methods. This study was a randomized controlled clinical trial conducted in patients requiring zygomatic implant placements in the atrophic maxilla. Forty zygomatic implants were placed in systemically healthy individuals. Zygomatic implant placement was done using the freehand technique in the control group, and the test group involved implant placement using a dynamic navigation system, and the entry, apex, and angular deviations were evaluated. The mean deviations at the site of entry (2D) in the navigation system (2.531.42) as compared to the free hand (4.151.29) were statistically significant. The variation in the free-hand group was greater than the navigation method at the apex (3D)(p<0.05). The navigation method had a higher accuracy in angular deviation than the freehand method (4.02±1.80 and 12.67±2.11). Also, the accuracy was checked on the right and left sides in both the conventional and dynamic groups. The dynamic navigation technology had better predictability in terms of accuracy and precision, and it’s the need of the hour for clinicians to master this technology and thereby aid in better prognostic level of implant placements.

PMID:39015953 | DOI:10.1563/aaid-joi-D-23-00096

World J Clin Cases. 2024 Jul 16;12(20):4272-4288. doi: 10.12998/wjcc.v12.i20.4272.

ABSTRACT

BACKGROUND: Education, cognition, and intelligence are associated with cholelithiasis occurrence, yet which one has a prominent effect on cholelithiasis and which cardiometabolic risk factors mediate the causal relationship remain unelucidated.

AIM: To explore the causal associations between education, cognition, and intelligence and cholelithiasis, and the cardiometabolic risk factors that mediate the associations.

METHODS: Applying genome-wide association study summary statistics of primarily European individuals, we utilized two-sample multivariable Mendelian randomization to estimate the independent effects of education, intelligence, and cognition on cholelithiasis and cholecystitis (FinnGen study, 37041 and 11632 patients, respectively; n = 486484 participants) and performed two-step Mendelian randomization to evaluate 21 potential mediators and their mediating effects on the relationships between each exposure and cholelithiasis.

RESULTS: Inverse variance weighted Mendelian randomization results from the FinnGen consortium showed that genetically higher education, cognition, or intelligence were not independently associated with cholelithiasis and cholecystitis; when adjusted for cholelithiasis, higher education still presented an inverse effect on cholecystitis [odds ratio: 0.292 (95%CI: 0.171-0.501)], which could not be induced by cognition or intelligence. Five out of 21 cardiometabolic risk factors were perceived as mediators of the association between education and cholelithiasis, including body mass index (20.84%), body fat percentage (40.3%), waist circumference (44.4%), waist-to-hip ratio (32.9%), and time spent watching television (41.6%), while time spent watching television was also a mediator from cognition (20.4%) and intelligence to cholelithiasis (28.4%). All results were robust to sensitivity analyses.

CONCLUSION: Education, cognition, and intelligence all play crucial roles in the development of cholelithiasis, and several cardiometabolic mediators have been identified for prevention of cholelithiasis due to defects in each exposure.

PMID:39015929 | PMC:PMC11235540 | DOI:10.12998/wjcc.v12.i20.4272

World J Clin Cases. 2024 Jul 16;12(20):4289-4300. doi: 10.12998/wjcc.v12.i20.4289.

ABSTRACT

BACKGROUND: Stroke often results in significant respiratory dysfunction in patients. Respiratory muscle training (RMT) has been proposed as a rehabilitative intervention to address these challenges, but its effectiveness compared to routine training remains debated. This systematic review and meta-analysis aim to evaluate the effects of RMT on exercise tolerance, muscle strength, and pulmonary function in post-stroke patients.

AIM: To systematically assess the efficacy of RMT in improving exercise tolerance, respiratory muscle strength, and pulmonary function in patients recovering from a stroke, and to evaluate whether RMT offers a significant advantage over routine training modalities in enhancing these critical health outcomes in the post-stroke population.

METHODS: Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, a comprehensive search across PubMed, Embase, Web of Science, and the Cochrane Library was conducted on October 19, 2023, without temporal restrictions. Studies were selected based on the predefined inclusion and exclusion criteria focusing on various forms of RMT, control groups, and outcome measures [including forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), maximal voluntary ventilation (MVV), peak expiratory flow (PEF), maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and 6-min walking test (6MWT)]. Only randomized controlled trials (RCTs) were included. Data extraction and quality assessment were conducted independently by two reviewers using the Cochrane Collaboration’s risk of bias tool. Statistical analyses, including those using the fixed-effect and random-effects models, sensitivity analysis, and publication bias assessment, were performed using Review Manager software.

RESULTS: A total of 15 RCTs were included. Results indicated significant improvements in MIP (12.51 cmH₂O increase), MEP (6.24 cmH₂O increase), and various pulmonary function parameters (including FEV1, FVC, MVV, and PEF). A substantial increase in 6MWT distance (22.26 meters) was also noted. However, the heterogeneity among studies was variable, and no significant publication bias was detected.

CONCLUSION: RMT significantly enhances walking ability, respiratory muscle strength (MIP and MEP), and key pulmonary function parameters (FEV1, FVC, MVV, and PEF) in post-stroke patients. These findings support the incorporation of RMT into post-stroke rehabilitative protocols.

PMID:39015926 | PMC:PMC11235562 | DOI:10.12998/wjcc.v12.i20.4289

World J Clin Cases. 2024 Jul 16;12(20):4041-4047. doi: 10.12998/wjcc.v12.i20.4041.

ABSTRACT

BACKGROUND: Obstructive sleep apnea hypoventilation syndrome (OSAHS) in children is a sleep respiratory disorder characterized by a series of pathophysiologic changes. Statistics in recent years have demonstrated an increasing yearly incidence.

AIM: To investigate the risk factors for OSAHS in children and propose appropriate management measures.

METHODS: This study had a case-control study design. Altogether, 85 children with OSAHS comprised the case group, and healthy children of the same age and sex were matched at 1:1 as the control group. Basic information, including age, sex, height, weight and family history, and medical history data of all study participants were collected. Polysomnography was used to detect at least 8 h of nocturnal sleep. All participants were clinically examined for the presence of adenoids, enlarged tonsils, sinusitis, and rhinitis.

RESULTS: The analysis of variance revealed that the case group had a higher proportion of factors such as adenoid grading, tonsil indexing, sinusitis, and rhinitis than the control group.

CONCLUSION: A regression model was established, and glandular pattern grading, tonsil indexing, sinusitis, and pharyngitis were identified as independent risk factors affecting OSAHS development.

PMID:39015923 | PMC:PMC11235552 | DOI:10.12998/wjcc.v12.i20.4041