Tag: pubmed

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2026 Mar 15;40(3):430-437. doi: 10.7507/1002-1892.202601049.

ABSTRACT

OBJECTIVE: To analyze the changing trends in the burden of gout disease attributable to high body mass index (BMI) and impaired kidney function in China from 1990 to 2023, and predict the burden of gout disease attributable to high BMI and impaired kidney function in China from 2024 to 2035, to provide a scientific basis for gout prevention and control.

METHODS: Based on the 2023 Global Burden of Disease (GBD) study data, this study analysed the characteristics of the burden of gout attributable to high BMI and impaired kidney function by gender and age group. It employed the Joinpoint regression model to examine trends in the age-standardized disability-adjusted life years (DALYs) rate and utilized the autoregressive integrated moving average (ARIMA) model to predict the disease burden trend from 2024 to 2035.

RESULTS: From 1990 to 2023, the age-standardized DALYs rate for gout attributable to high BMI in China increased (1990: 3.79 per 100 000, 95% UI: 2.15 per 100 000-6.24 per 100 000; 2023: 7.34 per 100 000, 95% UI: 4.22 per 100 000-11.39 per 100 000). Joinpoint analysis results showed that from 1990 to 2023, the age-standardized DALYs rate for gout attributable to high BMI in China exhibited an overall upward trend [average annual percent change (AAPC) for males=2.12%, 95% CI: 2.02%-2.22%; AAPC for females=1.92%, 95% CI: 1.79%-2.04%, both P<0.05]. For gout attributable to impaired kidney function, the age-standardized DALYs rate showed a slow overall increase in males, while the change in females was not significant (AAPC for males=0.36%, 95% CI: 0.27%-0.45%, P<0.05; AAPC for females=0.11%, 95% CI: -0.11%-0.33%). According to the ARIMA model predictions, by 2035, the age-standardized DALYs rates of gout attributable to high BMI in males and females and attributable to impaired kidney function in females were projected to stabilize at 10.85 per 100 000, 3.48 per 100 000, and 1.75 per 100 000, respectively. In contrast, the age-standardized DALYs rate of gout attributable to impaired kidney function in males was predicted to continue rising until 2035, reaching an estimated 5.98 per 100 000.

CONCLUSION: The disease burden of gout associated with high BMI and impaired kidney function continues to worsen in China. The age-standardized DALYs rate for gout attributable to impaired kidney function in males is projected to continue rising until 2035. Therefore, there is an urgent need to improve population-wide BMI management strategies and enhance medical support for patients with kidney diseases, with targeted interventions prioritized among specific groups such as middle-aged obese individuals and middle-aged and elderly patients with kidney diseases.

PMID:41839557 | DOI:10.7507/1002-1892.202601049

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2026 Mar 15;40(3):422-429. doi: 10.7507/1002-1892.202601010.

ABSTRACT

OBJECTIVE: To investigate the epidemiological features and changing trends of disease burden of spinal cord injury (SCI) in China from 1990 to 2023, conduct decomposition analysis of disease burden changes, and provide evidence for SCI prevention and control.

METHODS: Based on the 2023 Global Burden of Disease (GBD) study data, indicators including incidence and years lived with disability (YLDs) were used to analyze the status and changing trends of SCI disease burden in China from 1990 to 2023. The Gupta decomposition framework was applied to quantify the contributions of population growth, population aging, age-specific incidence rate changes, and disease severity changes to YLDs growth.

RESULTS: In 2023, the number of SCI incidence cases in China was 232 700 cases, representing a 43.6% increase compared to 1990. From 1990 to 2023, the age-standardized YLDs rate of SCI decreased, while the age-standardized incidence rate showed an overall upward trend: it increased year by year from 1990 to 2015, declined briefly after 2015, and rose again from 2020. The disease burden of SCI in males was higher than in females. The age distribution of disease burden showed a shift toward older age groups, with incidence rates increasing with age among middle-aged and elderly populations. Falls were the main cause of SCI in China. Compared with 1990, YLDs in males and females increased by 48.58% and 41.72% respectively in 2023. The proportions of male growth attributed to population growth, population aging, age-specific incidence rate changes, and disease severity changes were 22.79%, 22.69%, 34.99%, and -31.88%, while those for females were 23.82%, 26.30%, 21.99%, and -30.40%.

CONCLUSION: From 1990 to 2023, population aging made a substantial contribution to the growth of SCI disease burden in China. The primary factor driving the growth of SCI disease burden differed by gender. Clinical interventions that mitigate disease severity represent a key strategy for addressing the rapid growth of SCI disease burden.

PMID:41839556 | DOI:10.7507/1002-1892.202601010

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2026 Mar 15;40(3):414-421. doi: 10.7507/1002-1892.202601044.

ABSTRACT

OBJECTIVE: To analyze the changing trends and attributable risk factors of low back pain disease burden in Chinese population from 1990 to 2023, and to predict the related disease burden of low back pain in 2030.

METHODS: Based on the 2023 Global Burden of Disease (GBD) study database, the incidence, prevalence, years lived with disability (YLDs), and characteristics and trends of risk factors among Chinese individuals with low back pain from 1990 to 2023 were analyzed, the age and gender differences in disease burden were assessed, and the disease burden in 2030 was jointly predicted by autoregressive integrated moving average model and age-period-cohort model.

RESULTS: From 1990 to 2023, the number of incident cases, the number of prevalent cases, and YLDs in Chinese low back pain population showed an upward trend, from 29.989 1 million cases, 68.636 3 million cases, and 7.732 4 million person-years to 41.383 6 million cases, 95.324 0 million cases, and 10.635 9 million person-years, respectively. The incidence rate, prevalence rate, and YLDs rate increased from 2 543.31 per 100 000, 5 820.89 per 100 000, and 655.77 per 100 000 to 2 892.65 per 100 000, 6 663.01 per 100 000, and 743.43 per 100 000 respectively. However, the age-standardized incidence rate, age-standardized prevalence rate, and age-standardized YLDs rate showed a downward trend, from 2 859.73 per 100 000, 6 636.60 per 100 000, and 740.83 per 100 000 to 2 164.80 per 100 000, 4 929.78 per 100 000, and 551.92 per 100 000, respectively. The burden of low back pain in women was significantly higher than that in men and increased with age (peak at 50 to 59 years old). Attribution analysis showed that smoking, occupational factors, and high body mass index (BMI) were the main factors leading to the increase of YLDs, and there was a gender difference. The tow model showed that the age-standardized incidence rate, the age-standardized prevalence rate, and the age-standardized YLDs rate for low back pain would decrease year by year from 2023 to 2030.

CONCLUSION: The disease burden of low back pain in China shows that from 1990 to 2023, the burden of low back pain in the Chinese population has been increasing year by year. Smoking, occupational factors, and high BMI are the main risk factors. Interventions targeting these controllable risk factors are crucial for reducing the disease burden. It is expected that by 2030, the disease burden of low back pain is expected to decrease, although the absolute burden will remain high. Greater attention should be paid to the middle-aged and elderly population, especially the female population, who bear a heavier disease burden. Targeted interventions, such as weight control and smoking cessation management, should be actively implemented against these controllable risk factors.

PMID:41839555 | DOI:10.7507/1002-1892.202601044

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2026 Mar 15;40(3):405-413. doi: 10.7507/1002-1892.202601124.

ABSTRACT

OBJECTIVE: Based on the data from the 2023 Global Burden of Disease (GBD) study, the changing trends of the disease burden of neck pain and its demographic characteristics in China from 1990 to 2023 was systematically evaluated, in order to provide evidence for the formulation of neck pain prevention and control strategies.

METHODS: Data on the incidence, prevalence, years lived with disability (YLDs), and their age-standardized rates of neck pain in China were extracted from the GBD 2023 database. A descriptive analysis was conducted by stratifying data by gender and age. The Joinpoint regression model was used to analyze the temporal trends of age-standardized incidence, prevalence, and YLDs rates, and the average annual percentage change (AAPC) was calculated.

RESULTS: From 1990 to 2023, the number of incident cases, prevalent cases, and YLDs of neck pain in China increased by 66.08%, 83.06%, and 80.49%, respectively, while the age-standardized rates showed relatively small fluctuations overall (rate of change<1.2%). The incidence, prevalence, and YLDs rates in females were higher than those in males, and the age-standardized YLDs rate in females showed a continuous upward trend (AAPC=0.067%, P<0.05). The disease burden of neck pain gradually increased with age, being most concentrated in middle-aged, elderly, and advanced-age populations. Joinpoint regression analysis revealed that the age-standardized incidence, prevalence, and YLDs rates exhibited multi-stage changes, with a common upward phase from 2005 to 2009 and a slight decline after 2021.

CONCLUSION: The increase in the absolute burden of neck pain in China is mainly driven by population aging. Priority should be given to focusing on female, middle-aged, and elderly populations, and early intervention should be strengthened to reduce long-term disability burden.

PMID:41839554 | DOI:10.7507/1002-1892.202601124

Acta Med Philipp. 2026 Jan 30;60(2):66-72. doi: 10.47895/amp.vi0.11821. eCollection 2026.

ABSTRACT

BACKGROUND AND OBJECTIVE: Humans need constant interaction for a better well-being. It is advisable to actively participate socially to acquire psychological support and elicit satisfaction. In fact, social participation is a key driver of life satisfaction among the elderly. This study aims to describe social participation and life satisfaction among employees of a premier university in Manila, Philippines and infer their relationship through activity theory.

METHODS: Seventy-one participants ages fifty years and older as of June 30, 2020 representing various employee categories participated in the online survey: a) faculty; b) research extension and professional staff; and c) administrative staff. Ten key informant interviews (KIIs) were likewise conducted to determine their opinions and perceptions on social participation in campus.

RESULTS: Social media usage and “malling” ranked the highest, contributing to 76% and 48% of the activities for indoor and outdoor activities, respectively. In terms of membership, professional organizations comprised 69%. On the other hand, 68% of organization members were elected officers. The relationship between social participation and life satisfaction were observable as indicated by the high rate of social participation and low percentage of participants who reported life dissatisfaction (4%).

CONCLUSIONS: High levels of social participation in terms of indoor and outdoor activities; membership including activeness in organizations; as well as positions held in organizations may indicate high levels of life satisfaction. Further research on a large sample size may explore statistical analysis on the longitudinal effects of social participation and life satisfaction.

PMID:41835905 | PMC:PMC12982903 | DOI:10.47895/amp.vi0.11821

Acta Med Philipp. 2026 Jan 30;60(2):22-32. doi: 10.47895/amp.vi0.11548. eCollection 2026.

ABSTRACT

BACKGROUND AND OBJECTIVES: Clinical pathways (CPs) ensure adherence to heart failure (HF) management guidelines. To optimize quality care in a low resource setting, an evidence-based care pathway for the management of acute HF was implemented at the emergency department (ED) of the Philippine General Hospital (PGH), the designated national tertiary hospital and referral center. This study aimed to describe the characteristics of adults with acute HF admitted at the ED and evaluate the quality of care they received, measured using physician adherence to the hospital’s acute heart failure CP.

METHODS: This was a retrospective, descriptive cohort study. We reviewed the inpatient charts of all adult patients with acute HF admitted to the ED of the PGH and referred to the Division of Cardiovascular Medicine between December 1, 2022 and May 31, 2023. Quality of care was assessed based on adherence to quality indicators adapted from routine and conditional order sets detailed in the pathway. Descriptive statistics was utilized to describe patient characteristics, quality of care, and outcomes.

RESULTS: Two hundred thirty-six (236) patients were included, with a mean age of 51.8 years. Majority were male (53.4%); hypertension (61.4%) and ischemic heart disease (53.8%) were the most common comorbidities, and infection the most common precipitant of decompensation (60.6%). There were optimal adherence rates to routine orders, which included referrals to Internal Medicine and Cardiology, baseline vital signs monitoring, fluid intake and output monitoring, chest radiograph, complete blood count, blood urea nitrogen, sodium, potassium, prothrombin time, partial thromboplastin time, arterial blood gas, urinalysis, and N-terminal pro b-type natriuretic peptide. Conditional orders, such as oxygen support, focused echocardiography, thyroid-stimulating hormone, and the use of vasopressors, diuretics, and venous thromboembolism prophylactic agents, were optimally performed when warranted. However, we noted suboptimal adherence to certain resource-intensive conditional orders, such as hourly monitoring of urine output (61.4%), hooking to cardiac monitor (53.8%), and performance of 12-lead ECG within 10 minutes (56.8%). Further, only 43.9% of patients were referred to the intensive care unit. Troponin I, calcium, magnesium, and albumin were ordered in excess.

CONCLUSION: Overall adherence rate of physicians to the hospital’s Acute Heart Failure Pathway was satisfactory. Work is needed to improve adherence to hourly urine output monitoring, consistent hooking to cardiac monitor, and timely performance of 12-lead ECG – an effort that begins with expanding in-hospital diagnostic equipment and human resource supply. We recommend continuous pathway implementation with periodic evaluation and stakeholder feedback to further improve quality of care.

PMID:41835902 | PMC:PMC12982906 | DOI:10.47895/amp.vi0.11548

Acta Med Philipp. 2026 Jan 30;60(2):59-65. doi: 10.47895/amp.vi0.10060. eCollection 2026.

ABSTRACT

BACKGROUND AND OBJECTIVE: Severe Acute Respiratory Syndrome – Coronavirus-2 (SARS-CoV-2) was initially known to affect the respiratory system and has been reported to also involve the cardiovascular system leading to myocardial damage. Remdesivir is one of the approved treatments for COVID-19, wherein viral replication is inhibited by terminating the RNA transcription prematurely. According to studies, the primary electrocardiographic effect of remdesivir in COVID-19 patients are sinus bradycardia and QT prolongation. The use of electrocardiogram (ECG) is an essential diagnostic tool in assessing the electrical conditions of the heart. The objective of this study is to describe the electrocardiographic profile of adult patients with COVID-19 who were given remdesivir and admitted in the University of the Philippines-Philippine General Hospital (UP-PGH). To this date, this is the only study done locally identifying the electrocardiographic profiles of adult patients with COVID-19 who were given remdesivir.

METHODS: This was a retrospective descriptive study involving adult patients with COVID-19 who were given remdesivir and admitted in UP-PGH from June 2021 to June 2022. Demographic profiles and 12-lead ECG done during the hospital admission were gathered. Descriptive statistics was used to summarize the clinical characteristics and the electrocardiographic findings of the patients.

RESULTS: There were 412 confirmed COVID-19 patients who were given remdesivir (mean age 56 years old; female 52%) included in this study. The most common comorbidities were hypertension, diabetes mellitus, and stroke. Majority of the patients had severe (58%) to critical (22%) COVID-19 infection. Most of the patients had sinus rhythm (94%), normal rate (72%), and normal axis (93%). The most common baseline ECG findings were non-specific ST-T wave changes (42%). Some patients had atrioventricular blocks (3.4%), bundle branch blocks (3.6%), prolonged QT interval (1.9%). Among those with repeat 12-L ECG (136 patients) during admission, ECG changes observed were sinus bradycardia (6%), prolonged QT interval (4%), and both (1.5%).

CONCLUSION: Based on this retrospective review, which to our knowledge is the only study done locally investigating the effects of remdesivir on ECG of adult Filipino patients with COVID-19 infection, majority of the patients had sinus rhythm, normal rate, and axis. The most common ECG finding was non-specific ST-T wave changes. This study demonstrated a low incidence of adverse ECG changes that would preclude the administration of remdesivir when indicated. These include sinus bradycardia and QT interval prolongation which did not require further interventions. ECG remains to be useful, low-cost noninvasive tool that can help monitor electrophysiologic adverse events of remdesivir.

PMID:41835901 | PMC:PMC12982897 | DOI:10.47895/amp.vi0.10060

Front Psychol. 2026 Feb 26;17:1791041. doi: 10.3389/fpsyg.2026.1791041. eCollection 2026.

ABSTRACT

BACKGROUND: Earthquakes are frequently associated with elevated levels of psychological trauma, particularly among vulnerable groups. In this context, understanding the conceptual pathways and relational processes through which individuals cope becomes an important focus for research.

OBJECTIVE: This study investigates the serial mediation role of life engagement and coping humor in the link between psychological resilience and trauma among physical education and sport teachers affected by the earthquake, aiming to clarify how individual and psychosocial resources contribute to post-trauma adaptation.

METHODS: The study was conducted with 689 physical education and sport teachers affected by the earthquake. Data were collected using the Brief Resilience Scale (BRS), the Life Engagement Scale (LES), the Coping Humor Scale (CHS), and the Post Earthquake Trauma Level Determination Scale (PETLDS). Statistical analyses were performed with SPSS v22. The relationships among the variables were examined using Pearson correlation and regression analyses, and serial mediation associations were tested using the PROCESS Macro v3.5 (Model 6) with 5,000 bootstrap samples.

RESULTS: Psychological resilience was negatively associated with post-earthquake trauma in the serial mediation model (β = -0.736, p = 0.030). Life engagement and coping humor were associated with this relationship through statistically significant indirect pathways, as indicated by bootstrap confidence intervals that did not include zero [a1b1 = -0.110, 95% CI (-0.231, -0.018); a2b2 = -0.077, 95% CI (-0.183, -0.004); a1d1b2 = -0.033, 95% CI (-0.082, -0.003)]. These findings indicate that resilience, life engagement, and coping humor are related through theoretically consistent indirect associations within the proposed serial mediation framework.

CONCLUSION: Psychological resilience, life engagement, and coping humor were associated with individuals’ trauma experiences following the earthquake. The findings indicate that these factors constitute relevant psychosocial resources in post-disaster contexts; however, their potential implications should be interpreted cautiously, given the study’s cross-sectional design.

PMID:41835898 | PMC:PMC12979233 | DOI:10.3389/fpsyg.2026.1791041

Front Psychol. 2026 Feb 27;17:1748385. doi: 10.3389/fpsyg.2026.1748385. eCollection 2026.

ABSTRACT

INTRODUCTION: Social-Emotional Competence is regarded as a core ability necessary for individual development in the 21st century, playing a significant role in improving students’ academic performance and promoting social development. As key guides to student development, teachers play an important role in cultivating children’s social-emotional competence. This study aims to explore the impact of teacher care on students’ social-emotional competence and its underlying mechanism.

METHODS: A moderated mediation model was constructed based on the 2013-2014 data from the China Education Panel Survey (CEPS), the most recent nationally representative dataset available for this type of analysis. Using data on teacher care, teacher-student relationship, social-emotional competence, migration status, and relevant covariates, a total of 12,319 valid samples were analyzed through descriptive statistics, correlation analysis, mediation effect test, and moderated mediation analysis.

RESULTS: Teacher care positively predicted social-emotional competence, teacher-student relationship partially mediated the relationship between teacher care and social-emotional competence. Analysis of simple moderation effects suggests that students’ migration status moderated the relationship between teacher care and teacher-student relationship.

DISCUSSION: These findings highlight the critical role of enhancing teachers’ caring behaviors and fostering positive teacher-student relationships in improving adolescents’ social-emotional competence. This study holds significant practical implications for promoting the harmonious physical and mental health development of middle school students.

PMID:41835893 | PMC:PMC12982437 | DOI:10.3389/fpsyg.2026.1748385

Front Psychol. 2026 Feb 26;17:1656208. doi: 10.3389/fpsyg.2026.1656208. eCollection 2026.

ABSTRACT

INTRODUCTION: This randomized controlled trial aimed to compare the effects of HIIT-30S protocols (30 s work/30 s rest) and Tabata protocols (20 s work/10 s rest) protocols on physical fitness and cognitive function in sedentary college students.

METHODS: Eighty-four undergraduates (19.07 ± 0.76 years; 34 males and 60 females) were stratified into HIIT-30S, Tabata, or moderate-intensity training (MICT) groups and completed 24 supervised sessions over 8 weeks. Physical outcomes included an 800-m run (cardiorespiratory endurance), push-ups/sit-ups (muscular endurance), 50-m sprint (speed), the Sitting Reach Test (flexibility), and heart rate recovery (cardiovascular recovery ability). Cognitive assessments encompassed the WAIS-IV core cognition (general intelligence), letter-number sequencing test (working memory), time management questionnaire (TMQ), emotion regulation questionnaire (ERQ), reaction time testing, and a 12 weeks follow-up comprehensive cognition questionnaire. Statistical significance was set at P < 0.05.

RESULTS: HIIT-30S and Tabata outperformed MICT in all domains (P < 0.05). HIIT-30S elicited superior physical adaptations: 800-m run time decreased by -11.78 s, push-ups increased +9.29 reps, sit-ups increased +11.39 reps, 50-m sprint decreased -0.37 s, and HRR improved +12.66%. Tabata showed greater neurocognitive enhancements: WAIS-IV core cognition scores rose +10.47 points, letter-number sequencing scores rose +1.68 points, TMA scores rose +10.97 points, EMA scores rose +16.79 points, simple reaction time decreased -40.61 ms, choice reaction time decreased -65.15 ms, and Continuous Reaction time decreased -51.14 ms. At the 12-week follow-up, HIIT-30S maintained cognitive gains (+3.05%) with the greatest improvement compared to Tabata (+1.97%).

DISCUSSION: These findings indicate that the work-to-rest ratio is a key determinant of training effects, enabling protocol customization for specific individual fitness and cognitive aims.

PMID:41835882 | PMC:PMC12979124 | DOI:10.3389/fpsyg.2026.1656208