Tag: pubmed

J Pediatr Orthop B. 2026 Jun 2. doi: 10.1097/BPB.0000000000001358. Online ahead of print.

ABSTRACT

This study compares the outcomes of tension-band plates (TBP) correction of angular deformities in patients with Hurler and Morquoio syndromes mucopolysaccharidoses (MPS) to those with idiopathic etiologies. A retrospective analysis of patients aged less than 18 at a single institution who received TBP between 2005 and 2017 for valgus angular deformities was conducted. Inclusion criteria were patients with complete data and MPS or idiopathic etiology. Femoral and tibial deformities were evaluated independently. Postsurgical X-rays were reported at 6-month intervals. Statistical significance was determined by Mann-Whitney and χ2 tests. Twenty-nine patients were included: Hurler syndrome (8), Morquio syndrome (1), and idiopathic (20). Femoral TBP corrections at 1 year were 4.9° (MPS) and 11.2° (idiopathic); total degrees of correction were 7.3° (MPS) and 8.9° (idiopathic). Tibial TBP corrections at 1 year were 5.8° (MPS) and 5.4° (idiopathic); total degrees of correction were 9.1° (MPS) and 6.0° (idiopathic). The average correction rates for femoral TBPs were 4.3°/year (MPS) and 7.3°/year (idiopathic), and tibial TBPs were 4.5°/year (MPS) and 4.6°/year (idiopathic). Full correction was achieved in four of nine (44.4%) MPS patients and 14 of 20 (70%) idiopathic patients, as well as 9 of 22 (40.9%) MPS limbs and 20 of 38 (52.6%) idiopathic limbs. There were no statistically significant differences between groups or by gender. MPS patients with femoral and tibial TBPs experienced comparable correction rates to idiopathic patients, although idiopathic patients corrected slightly faster, consistent with prior literature. This demonstrates that TBP is an effective growth modulation technique for MPS patients despite morphological differences.

PMID:42228852 | DOI:10.1097/BPB.0000000000001358

J Pediatr Orthop B. 2026 Jun 3. doi: 10.1097/BPB.0000000000001357. Online ahead of print.

ABSTRACT

Ponseti treatment of congenital clubfoot utilizes foot abduction bracing to prevent recurrence. In unilateral clubfoot, families have expressed concern about inducing deformity in the uninvolved leg. This study evaluated rotational profiles of uninvolved legs in children with unilateral clubfoot. We retrospectively reviewed 78 children (mean age: 9.5 ± 3.4 years) with unilateral idiopathic clubfoot treated by Ponseti method at a single institution from 2008 to 2025. Motion capture kinematics evaluated hip, tibial, ankle rotation, and foot progression angle (FPA). Physical exam evaluated bimalleolar axis, hip rotation, and thigh-foot angle (TFA). Pedobarographic data evaluated FPA and foot loading. Results compared to normative cohorts of typically developing children using unpaired t-tests (P < 0.05). The uninvolved side demonstrated more kinematic internal ankle rotation (3.9 ± 7.3 vs. 0.9 ± 5.6°; P = 0.0004), more kinematic external hip rotation (-4.4 ± 9.6 vs. 1.2 ± 6.8°; P = 0.0001), less hip internal rotation on exam (47.4 ± 13.2 vs. 57.6 ± 12.3°; P = 0.0001) and more external bimalleolar axis (-19.0 ± 6.8 vs. -16.0 ± 5.9°; P = 0.0091). There was no difference in TFA or FPA. Pedobarographic analysis showed no foot loading or FPA impact. The uninvolved limb in unilateral clubfoot develops statistically significant external hip rotation and increased external bimalleolar axis compared to normative controls, though kinematic tibial internal rotation was not significantly different. However, there was no significant impact on TFA, FPA, or foot loading, indicating that these differences are clinically insignificant. Awareness of these changes is helpful for counseling and reassuring families. This is a level III retrospective case-control study.

PMID:42228848 | DOI:10.1097/BPB.0000000000001357

J Strength Cond Res. 2026 Jun 3. doi: 10.1519/JSC.0000000000005508. Online ahead of print.

ABSTRACT

Mukandi, I, Turner, A, Bishop, C, Beato, M. Neuromuscular and subjective recovery responses to day and night fixtures during congested and noncongested microcycles in professional soccer players. J Strength Cond Res XX(X): 000-000, 2026-This study investigated and compared the impact of day and night fixtures during congested and noncongested microcycles on countermovement jump (CMJ) performance and subjective self-reported measures 40 hours postcompetitive match play in professional soccer players. Twenty-eight players completed CMJ baseline assessment during preseason. Assessment 40 hours postmatch was limited to players who played ≥60 minutes. Baseline measures for subjective self-reported measures were collected 24 hours prematch. Congested microcycles were classified as 3-5 days between fixtures and noncongested microcycles ≥7 days between fixtures. Across all 4 fixture contexts, significant reductions (p < 0.05) with small-to-moderate effects (δ = -0.47 to 0.30) were observed for all CMJ metrics, except for eccentric mean force that showed nonsignificant, trivial effects for congested microcycles and night fixtures. Statistically significant reductions in sleep quality, mood, muscle soreness, and a composite score of all 3 measures were observed for both congested and noncongested microcycles as well as day fixtures (p < 0.05) (δ = -0.59 to 0.11). For night fixtures, nonsignificant changes were observed for sleep quality and mood. No significant differences were observed between day and night fixtures as well as congested and noncongested microcycles for all CMJ metrics. For subjective self-reported measures, significant trivial to small differences with a bias toward night fixtures were observed for muscle soreness, mood, and composite score. No significant differences were observed among the global positioning system metrics between congested and noncongested microcycles. Significant differences were observed between high-speed running and sprint distance between day and night fixtures with a bias toward day fixtures, while nonsignificant differences were found for total distance, distance per minute, accelerations, and decelerations. Monitoring both objective and subjective self-reported measures provides a holistic approach to understanding player fatigue and recovery, allowing for informed decision making in congested periods.

PMID:42228843 | DOI:10.1519/JSC.0000000000005508

Turk Arch Pediatr. 2026 May 21;61(6):531-542. doi: 10.65717/TurkArchPediatr.2026.25353.

ABSTRACT

OBJECTIVE: The aim of the study was to compare the key clinical features and course of SARS-CoV-2 infection between the local population of the Ternopil region and internally displaced persons (IDPs), to analyze the quality of life in both participant groups, and to determine the frequency and symptoms of long COVID.

METHODS: A cross-sectional study was conducted involving children with confirmed COVID-19 from September 2022 to May 2024. Clinical symptoms, COVID-19 severity, 25(OH)D and zinc levels, long COVID symptoms, and quality of life were compared between internally displaced and local populations using structured questionnaires and medical records.

RESULTS: A total of 299 children with COVID-19 were included, consisting of 29 IDPs and 270 local population. Gastrointestinal symptoms were significantly more common among IDPs (P<.0001), while respiratory symptoms and severe fatigue predominated in the local population (P < .0001 and P=.0229, respectively). The IDPs experienced a more severe course of COVID-19 (P=.0141) and had a longer duration of hospital stay (P < .0001). Serum zinc levels were significantly lower in IDPs compared to local population (P=.0229). Assessment of quality of life demonstrated higher total, physical, psychosocial, and school functioning scores among IDPs, indicating a statistically better perceived health status. The overall frequency of long COVID did not differ between groups; however, its distribution varied by age: it was significantly higher in IDPs under 6 years (P=.0062), whereas among children ≥6 years, it was more common in the local population (P=.0092). Age-specific differences in long COVID symptom patterns were also observed between IDPs and local children.

CONCLUSION: This study highlights the need to consider the impact of war, displacement, and chronic stress on the clinical presentation, timeliness of seeking care, and symptom reporting among children with COVID-19. Future efforts should focus on improving access to healthcare, health education, nutritional, and psychosocial support for displaced children to mitigate the combined negative effects of COVID-19 and war.

PMID:42228823 | DOI:10.65717/TurkArchPediatr.2026.25353

Turk Arch Pediatr. 2026 May 21;61(6):495-501. doi: 10.65717/TurkArchPediatr.2026.25440.

ABSTRACT

OBJECTIVE: This study aimed to evaluate the indications and clinical and microbiological outcomes of tigecycline use in pediatric patients and to analyze the factors associated with treatment success and mortality.

METHODS: The patients receiving tigecycline antibiotic therapy at a tertiary university hospital over a 12-year period were evaluated.

RESULTS: During the study period, tigecycline was used in 66 patients. The median age of the patients was 11 years (range: 2 months to 18 years), and 40 (60.6%) were male. While 53% of the patients received empirical treatment, 46.9% received targeted therapy. The majority of patients (81.8%) received tigecycline for “off-label” indications, with bacteremia being the most common “off-label” indication. Microbiological and clinical success rates were 77.1% and 66.7%, respectively. While clinical success did not differ significantly between empiric and targeted therapy groups (P=.22), microbiological success was significantly higher in the targeted therapy group (P=.02). No statistically significant differences were observed between indication types. However, mortality was higher in patients with bacteremia who were treated with tigecycline compared with the non-bacteremic group (P=.007). Tigecycline was combined with other antibiotics in all patients. No serious adverse events requiring discontinuation of tigecycline treatment or dose revision were observed during follow-up.

CONCLUSIONS: This study suggests that tigecycline, due to its broad spectrum of antibacterial activity, may be an important option in children in combination with other antibiotics in the absence of alternative options or in the absence of response to treatment.

PMID:42228818 | DOI:10.65717/TurkArchPediatr.2026.25440

Transplantation. 2026 Jun 2. doi: 10.1097/TP.0000000000005770. Online ahead of print.

NO ABSTRACT

PMID:42228811 | DOI:10.1097/TP.0000000000005770

PLoS One. 2026 Jun 2;21(6):e0348881. doi: 10.1371/journal.pone.0348881. eCollection 2026.

ABSTRACT

This study investigates the structural, optical, morphological, magnetic, and photocatalytic properties of Fe3O4/TiO2 nanocomposites (FeT NCs), synthesized through a modified sol-gel method for the photodegradation of Reactive Yellow 145 (RY145). Characterization of FeT NCs (PL, XRD, FTIR, VSM, DRUV-Vis, DLS, Zeta potential, XPS, BET, SEM, TEM, TGA) revealed that Fe3O4 incorporation into TiO2 enhances charge separation, suppresses electron-hole recombination through Ti-O-Fe linkages, and improves photocatalytic efficiency. The calcined 0.025FeT3 exhibited high crystallinity with dominant anatase TiO2 and no rutile transition. SEM and TEM revealed a core-shell morphology with Fe3O4 cores encapsulated by TiO2, while aggregation was minimized by synthesis conditions. Optimal photocatalytic performance (84.51% % RY145 removal at neutral pH) was achieved using 1 mg mL-1 0.025FeT3 following pseudo-first-order kinetics. The Langmuir-Hinshelwood model yielded rate and equilibrium constants of 2.80 mg.L-1 min-1 and 2.42 L mg-1, respectively. Mechanistic and scavenging experiments indicated that photogenerated holes and •OH radicals dominated the degradation process. The FeT catalyst maintained high stability over six cycles. Magnetic measurements showed soft magnetic behavior with low coercivity and remanence, favoring easy recovery. The reduced bandgap (2.62 eV) facilitated visible-light activation, while BET analysis confirmed a mesoporous structure with high surface area. XPS verified the oxidation states of Fe and Ti, and HPLC confirmed RY145 decomposition via azo bond cleavage and oxidation to carboxylic acids, demonstrating efficient and sustainable photocatalytic activity. 0.025FeT3 demonstrated efficient, stable, and magnetically retrievable photocatalytic activity under visible light, highlighting its potential for sustainable treatment of textile wastewater. To optimize the batch experimental data, a novel ML-driven predictive framework was tested to model and map the relationships between the selected optimization parameters (FeT contents, FeT dose, reaction time), to predict RY145 photodegradation efficiency, and to identify the optimal operating window for improved photocatalytic performance (using three regression measures R2, MAE, and RMSE). The CNN models outperformed with a predicted accuracy and R2 value of 0.91. Based on the results, ML-based evaluation outperformed manual optimization and traditional statistical methods, delivering a more efficient and reliable way for process optimization.

PMID:42228765 | DOI:10.1371/journal.pone.0348881

Acta Otolaryngol. 2026 Jun 2:1-7. doi: 10.1080/00016489.2026.2677603. Online ahead of print.

ABSTRACT

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect multiple organ systems. While cochlear and otolith involvement has been investigated, the impact on semicircular canal-mediated vestibulo-ocular reflex (VOR) function remains unclear.

AIMS/OBJECTIVES: To evaluate canal-specific, high-frequency VOR function in women with PCOS using the video head impulse test (vHIT) and compare findings with healthy controls.

MATERIAL AND METHODS: This single-center case-control study included 42 women with PCOS (Rotterdam criteria) and 35 age-matched controls. vHIT was performed using the Interacoustics EyeSeeCam system. Canal-specific VOR gains, asymmetry indices (LARP, RALP, lateral), and corrective saccade frequencies were analyzed.

RESULTS: After correction for multiple comparisons (Benjamini-Hochberg method), LARP asymmetry was the only parameter that remained statistically significant in PCOS (p = 0.002; p = 0.019). Unadjusted differences in left lateral and right posterior canal gains did not survive correction. Corrective saccade frequency did not differ between groups.

CONCLUSIONS AND SIGNIFICANCE: Women with PCOS exhibited subtle, canal-specific differences in high-frequency VOR function. However, these findings should be interpreted cautiously, and their clinical significance remains uncertain.

PMID:42228394 | DOI:10.1080/00016489.2026.2677603

Work. 2026 Jun 2:10519815261454977. doi: 10.1177/10519815261454977. Online ahead of print.

ABSTRACT

BackgroundA growing body of evidence suggests that a combination of physical, psychological, and environmental factors increases the likelihood of experiencing complaints related to the arm, neck, and/or shoulder (CANS), although the precise nature of these relationships and their potential long-term effects remain uncertain.ObjectiveTo synthesize evidence from prospective cohort studies investigating the risk factors associated with the development of CANS among workers who use computers.MethodsA systematic search was conducted in PubMed, ProQuest, Scopus, Cochrane Library, and Google Scholar to identify prospective cohort studies published between January 2010 and 2025. Eligible studies investigated risk factors of CANS among workers using computers, with a follow-up period of at least one year. Two reviewers independently screened studies, extracted data, and assessed methodological quality using the Newcastle-Ottawa Scale. Relative risks (RR) and 95% confidence intervals (CI) were pooled using a random-effects meta-analysis. Heterogeneity among studies was assessed using Cochran’s Q test and the I² statistic.ResultsTwo studies indicated a low risk of bias, while the remaining studies were assessed as having a moderate risk. For overall exposures, the correlation with the prevalence of CANS was the duration of using computers or mouse >4 h/day and BMI, with RR = 1.25 (95% CI: 1.08-1.44) and 1.05 (95% CI: 1.02-1.08), respectively.ConclusionProlonged computer use and higher body mass index were significant predictors of CANS, and the findings highlight the importance of ergonomic interventions and health promotion strategies to reduce work-related musculoskeletal complaints in sedentary occupational environments.

PMID:42228393 | DOI:10.1177/10519815261454977

NeuroRehabilitation. 2026 Jun 2:10538135261455053. doi: 10.1177/10538135261455053. Online ahead of print.

ABSTRACT

ObjectiveEvidence for structured group telerehabilitation in stroke is limited. We evaluated therapist-led group telerehabilitation effects on physical function, psychological well-being, and health-related quality of life (HRQoL) in patients with chronic stroke, and identified functional predictors of improvement.MethodsThirty-five patients with chronic stroke were randomized into the telerehabilitation exercise group, referred to as TEG, with eighteen participants, or the self-exercise rehabilitation group, referred to as SRG, with seventeen participants. Outcomes were assessed at baseline and post-intervention. Interaction effects between group and time were evaluated. Significance was set at p < .025 for primary outcomes, Berg Balance Scale (BBS) and Timed Up and Go Test (TUG). Functional predictors were examined via baseline-adjusted regression.ResultsBoth groups showed significant within-group improvements (p < .001). Interaction effects revealed statistically significant, though modest, gains in BBS and TUG in the TEG versus SRG. Lower-limb strength, fall efficacy, and depressive symptoms improved over time without significant between-group differences. HRQoL gains were meaningful, especially in the TEG. Regression confirmed group allocation independently predicted balance and mobility improvements (R² = 0.152 and 0.153), with no group effects for other measures.ConclusionReal-time, group-based telerehabilitation led by physical therapists serves as a clinically viable alternative that supports functional balance, mobility, and HRQoL in patients with chronic stroke. These findings demonstrate statistically significant improvements in functional outcomes compared with unsupervised exercise, suggesting that this structured remote approach, by providing superior functional benefits over unsupervised exercise, serves as a practical and accessible alternative to traditional facility-based rehabilitation is unavailable.

PMID:42228382 | DOI:10.1177/10538135261455053