Tag: pubmed

Adv Mater. 2025 May 6:e2502766. doi: 10.1002/adma.202502766. Online ahead of print.

ABSTRACT

To address the growing demand for energy and support the shift toward transportation electrification and intermittent renewable energy, there is an urgent need for low-cost, energy-dense electrical storage. Research on Li-ion electrode materials has predominantly focused on ordered materials with well-defined lithium diffusion channels, limiting cathode design to resource-constrained Ni- and Co-based oxides and lower-energy polyanion compounds. Recently, disordered rocksalts with lithium excess (DRX) have demonstrated high capacity and energy density when lithium excess and/or local ordering allow statistical percolation of lithium sites through the structure. This cation disorder can be induced by high temperature synthesis or mechanochemical synthesis methods for a broad range of compositions. DRX oxides and oxyfluorides containing Earth-abundant transition metals have been prepared using various synthesis routes, including solid-state, molten-salt, and sol-gel reactions. This review outlines DRX design principles and explains the effect of synthesis conditions on cation disorder and short-range cation ordering (SRO), which determines the cycling stability and rate capability. In addition, strategies to enhance Li transport and capacity retention with Mn-rich DRX possessing partial spinel-like ordering are discussed. Finally, the review considers the optimization of carbon and electrolyte in DRX materials and addresses key challenges and opportunities for commercializing DRX cathodes.

PMID:40326162 | DOI:10.1002/adma.202502766

J Texture Stud. 2025 Jun;56(3):e70019. doi: 10.1111/jtxs.70019.

ABSTRACT

This research focuses on the measurement of the modulus of elasticity as a key elasto-mechanical property for three Iranian rice varieties-Tarom Hashemi, Anbarbu, and Dom Siah-using macroscopic compression tests and Atomic Force Microscopy (AFM) at the microscopic scale. The results indicated that Anbarbu exhibited the highest modulus of elasticity, reaching 1656.940 MPa at the macroscopic level and 786.102 MPa at the microscopic level. These values represent measurements at different scales and should not be directly compared; instead, they reflect the structural resistance to deformation at each scale. Tarom Hashemi, in contrast, showed lower modulus values, with an average of 1466.263 MPa in macroscopic measurements and 697.630 MPa in microscopic measurements, indicating comparatively lower rigidity. The statistical t-test, conducted at a significance level of p < 0.05, confirmed significant differences between the macroscopic and microscopic measurements, emphasizing the importance of microscopic approaches for understanding detailed structural mechanics. These findings provide valuable insights for tailoring rice processing techniques by highlighting how the modulus of elasticity influences grain breakage and deformation, ultimately aiding in preserving grain quality during post-harvest handling and processing.

PMID:40326156 | DOI:10.1111/jtxs.70019

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025 Apr;33(2):557-564. doi: 10.19746/j.cnki.issn.1009-2137.2025.02.037.

ABSTRACT

OBJECTIVE: To analyze the efficacy and safety of decitabine-based myeloablative preconditioning regimen for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukemia (AML).

METHODS: The clinical characteristics and efficacy of 115 AML patients who underwent allo-HSCT at the First Medical Center of Chinese PLA General Hospital from August 2018 to August 2022 were retrospectively analyzed, including 37 patients treated with decitabine conditioning regimen (decitabine group) and 78 patients without decitabine conditioning regimen (non-decitabine group). The cumulative incidence of relapse (CIR), overall survival (OS), leukemia-free survival (LFS), non-relapse mortality (NRM) and graft versus host disease (GVHD) were analyzed.

RESULTS: For the patients in first complete remission (CR1) state before allo-HSCT, the 1-year relapse rates of decitabine group(22 cases) and non-decitabine group(69 cases) were 9.1% and 29.6%, respectively, the difference was statistically significant(P =0.042). The 1-year cumulative incidence of acute graft-versus-host disease (aGVHD) in decitabine group and non-decitabine group was 62.2% and 70.5%, respectively, and the 1-year cumulative incidence of chronic inhibitor-versus-host disease (cGVHD) was 18.9% and 14.1%, respectively, there were no significant differences in the incidence of aGVHD and cGVHD between the two groups (P >0.05). Of the 115 patients, there were no significantly differences in the 1-year CIR(21.7% vs 28.8%, P =0.866), NRM(10.9% vs 3.9%, P =0.203), OS(75.2% vs 83.8%, P =0.131) and LFS(74.6% vs 69.1%, P =0.912) between the decitabine group(37 cases) and the non-decitabine group(78 cases).

CONCLUSION: Decitabine-based conditioning regimen could reduce the relapse rate of AML CR1 patients with good safety.

PMID:40326134 | DOI:10.19746/j.cnki.issn.1009-2137.2025.02.037

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025 Apr;33(2):530-537. doi: 10.19746/j.cnki.issn.1009-2137.2025.02.033.

ABSTRACT

OBJECTIVE: To study the results, re-donation situation and characteristics of single-reagent reactive blood donors who were put into the reentry strategy in Wuhan area, explore the rationality and effectiveness of the current reentry strategy, and provide data support for the improvement of the reentry process of blood donors.

METHODS: From January 2020 to December 2023, blood donors who conform the reentry criteria and voluntarily applied for returning to Wuhan Blood Center were tested and the results were analyzed. According to the reentry strategy, serological testing and nucleic acid testing were carried out in parallel, serological testing was performed by ELISA with reagents from two different manufacturers, and the primary reactive samples were tested by double-well retest, and HBV/HCV/HIV nucleic acid detection was performed by RT-PCR with an individual donor test mode. Supplementary HBcAb testing was applied for HBV single reagent reactivity by chemiluminescence method. Supplementary TP-WB testing was applied for returning blood donors with repeated TP single reagent reactivity. If returning blood donors with HIV single reagent reactivity were repeated single reagent reactivity, the samples were sent to local CDC for confirmatory test.

RESULTS: 7 098 blood donors were qualified for reentry, 716 donors voluntarily applied for reentry, 436 donors successfully reentry, 251 donors entered the next round, 29 donors could not reentry. The reentry rates for the past four years were 66.67%（42/63）, 54.73%（81/148）, 60.71%（136/224） and 62.99%（177/281）, respectively. Up to December 31, 2023, 275 donors donated blood again, and the donation rates for past four years were 76.19%（32/42）, 72.84%（59/81）, 61.76%（84/136） and 56.50%（100/177）, respectively. After donating blood, 31 donors were disqualified again by blood screening and subjected to permanent deferral. The results of returning to the team had statistical differences in reentry items, educational level, age, and marriage（P < 0.05）.

CONCLUSION: The current reentry strategy adopted by the blood donation and supply institution can effectively retain part of blood donors, reduce the negative emotions of blood donors and increase blood resources.

PMID:40326130 | DOI:10.19746/j.cnki.issn.1009-2137.2025.02.033

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025 Apr;33(2):520-525. doi: 10.19746/j.cnki.issn.1009-2137.2025.02.031.

ABSTRACT

OBJECTIVE: To analyze the origin and influencing factors the titer of ABO blood group antibody in neonates.

METHODS: A total of 303 newborn blood samples collected in our hospital from August 2023 to March 2024 were selected for the detection of ABO blood group settings and the determination of the total titers of IgG and IgM blood group antibodies in plasma. IgM antibodies were treated with dithithreitol (DTT) to determine the titers of IgG antibodies. The total titer of the blood group antibody was compared with that of the IgG antibody. The clinical data of mothers and newborns were collected, and the correlation between the antibody titer and these clinical data was analyzed.

RESULTS: Among the 303 newborn specimens, 14 cases (4.62%) were identified to possess blood group antibodies. The influence of the maternal ABO blood group on the generation of high-potency blood group antibodies in newborns was observed to follow the order of O>B>A>AB, with a significant statistical difference ( P < 0.01). Of the 123 (40.59%) newborns born to mothers of type O, 121 (98.37%) had blood group antibody titers > 2. Of the 20 (6.60%) newborns born to mothers of type AB, all 20 (100.00%) had blood group antibody titers < 2. Among 89 (29.37%) mothers of type A and 71 (23.43%) mothers of type B, the titer of 100% newborn blood group antibody was less than 2, when the newborn blood group was incompatible with the mother’s blood group; the titer of the newborn blood type antibody was higher or lower, when the newborn blood type was compatible with the mother’s blood type. The titer of the newborn blood group antibodies is related to the number of pregnancies of the mothers and has no association with other clinical data (such as the mother’s number of obortions), the number of production, fetal gestation age.

CONCLUSION: The majority of ABO blood group antibodies in neonates are IgG antibodies from the mothers, and few are produced by the neonates themselves. In some neonates, IgG anti-A and/or anti-B can agglutinate with anti-stereotyped cells at room temperature. The maternal ABO blood type is the primary factor influencing the titer of the newborn blood type. The number of maternal pregnancies is a factor affecting the high titer ABO blood group antibodies in newborns.

PMID:40326128 | DOI:10.19746/j.cnki.issn.1009-2137.2025.02.031

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025 Apr;33(2):442-446. doi: 10.19746/j.cnki.issn.1009-2137.2025.02.019.

ABSTRACT

OBJECTIVE: To investigate the significance of HALP score as a prognostic indicator for newly diagnosed multiple myeloma (MM).

METHODS: Clinical data of 62 newly diagnosed MM patients in our hospital from January 2020 to December 2022 were collected and retrospectively analyzed. The difference in age, sex, DS stage, R-ISS stage, M protein type, serum creatinine (Scr), β₂-microglobulin (β₂-MG), blood calcium, lactate dehydrogenase (LDH), hemoglobin (Hb), albumin (ALB), platelet count (PLT), and absolute lymphocyte count (ALC) between patients with low and high HALP scores were analyzed. The prognostic value of the above indexes in newly diagnosed MM patients was analyzed by univariate and multivariate analysis.

RESULTS: The optimal cut-off value of HALP score was 41 determined by X-tile software. Based on this, 62 patients were divided into a high HALP group (HALP>41, n=25) and a low HALP group (HALP≤41, n=37). The proportion of patients with Hb≥100 g/L in the high HALP group was significantly higher than that in the low HALP group (P <0.05). The median overall survival (OS) time of patients in the high HALP group and low HALP group were 29 (9-39) months and 20 (4-29) months, respectively, with statistically significant difference between the two groups (P <0.01). Univariate analysis showed that R-ISS stage, ALB, Hb, ALC and HALP were closely related to the prognosis of patients (P <0.05). COX regression multivariate analysis showed that R-ISS stage Ⅲ (HR=4.443, 95%CI : 1.480-13.343，P =0.008) and HALP≤41(HR=8.823, 95%CI : 1.858-41.910，P =0.006) were independent risk factors for shortened OS in newly diagnosed MM patients. The median OS of patients with high HALP at R-ISS stage Ⅲ was significantly higher than that of patients with low HALP at the same stage, and the difference was statistically significant (P <0.05).

CONCLUSION: HALP score can be used as a prognostic indicator for newly diagnosed MM patients.

PMID:40326116 | DOI:10.19746/j.cnki.issn.1009-2137.2025.02.019

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025 Apr;33(2):365-372. doi: 10.19746/j.cnki.issn.1009-2137.2025.02.009.

ABSTRACT

OBJECTIVE: To investigate the prognostic value of ¹⁸ F-deoxyglucose (FDG) PET/CT metabolic parameters combined with clinicopathological features for newly diagnosed diffuse large B-cell lymphoma (DLBCL) before treatment, and analyze the relationship between tumor metabolic volume (MTV), total lesion glycolysis (TLG) and clinicopathological features.

METHODS: The clinical data of 120 patients with pathologically confirmed DLBCL were retrospectively analyzed and ¹⁸F-FDG PET/CT was performed 1 week before treatment. The metabolic parameters including SUVmax, SUVmean, tumor-to-blood standardized uptake value ratio (TBR), tumor-to-liver standardized uptake value ratio (TLR) were obtained. MTV and TLG of the lesions were obtained with 41% of SUVmax as the threshold, and the correlation of MTV and TLG with clinicopathological features were analyzed. Progression-free survival (PFS) was calculated by follow-up for 6-153 months. Receiver operating characteristic (ROC) curve, chi-square test, Kaplan-Meier test, log-rank test and Cox proportional hazards model were used to analyze the date.

RESULTS: The optimum cut-off values of the SUVmax, MTV, TLG, TBR and TLR for predicting tumor progression were 22.25, 256.05, 5 232.67, 12.97 and 10.60, respectively. The patients were divided into two groups according to the above cut-off values, respectively. Kaplan-Meier survival analysis showed that there were statistically significant differences in PFS between the two group (all P <0.05). The MTV and TLG values were correlated with NCCN-IPI score, Ann Arbor stage, serum lactate dehydrogenase level, and C-MYC, BCL-2, BCL-6 gene rearrangement (all P <0.05). Univariate analysis showed that NCCN-IPI score >3, C-MYC, BCL-2, BCL-6 gene rearrangement positive, SUVmax≥22.25, MTV≥256.05 cm³, TLG≥5 232.67 g and TBR≥12.97 were adverse factors for prognosis (HR: 1.949-5.759, all P <0.05). Multivariate Cox regression analysis showed that C-MYC, BCL-2 gene rearrangement positive and TLG≥5 232.67 g were all independent risk factors affecting PFS (HR: 4.660, 3.350, 4.031, all P <0.05).

CONCLUSION: The ¹⁸F-FDG PET/CT metabolic parameters SUVmax, MTV, TLG, TBR and TLR can be used as important indicators to predict PFS of DLBCL patients, and combining clinicopathological features can better predict the prognosis of patients.

PMID:40326106 | DOI:10.19746/j.cnki.issn.1009-2137.2025.02.009

Spine (Phila Pa 1976). 2025 May 5. doi: 10.1097/BRS.0000000000005384. Online ahead of print.

ABSTRACT

STUDY DESIGN: Biomechanical cadaveric study.

OBJECTIVE: To evaluate whether pre-tapping reduces the risk of pedicle fractures following pedicle screw instrumentation.

SUMMARY OF BACKGROUND DATA: Pedicle screw instrumentation is the standard for rigid fixation of the thoracolumbar spine. While complications such as screw loosening and misplacement are well-documented, pedicle fractures are rare and poorly understood. Pre-tapping, a technique used during screw insertion, has been proposed to enhance fixation strength and potentially reduce the risk of fractures. However, its biomechanical effects on pedicle integrity remain unclear.

METHODS: Twenty lumbar vertebrae (L1-L5) were harvested from four cadavers. Preoperative CT scans were used to plan screw trajectories and assess bone mineral density (BMD). Each vertebra was alternately instrumented with screws using pre-tapping and non-pre-tapping techniques. Biomechanical testing measured maximum bending force to failure under a flexion moment. Pedicle fractures were classified based on CT imaging, and statistical analysis was performed to evaluate factors influencing fracture risk.

RESULTS: The maximum bending force to failure showed no significant difference between pre-tapping (103.9±47.5 Nm) and non-pre-tapping (98.1±43.4 Nm) groups (P=0.321). Pre-tapping significantly reduced maximum insertion torque (1.30±1.05 Nm vs. 2.91±2.65 Nm, P=0.025). Pedicle fill was a significant predictor of bending force (β=222.29 Nm, P=0.035), while BMD and pedicle diameter were not. Fracture patterns did not differ significantly between groups (P=0.384).

CONCLUSION: Pre-tapping does not significantly influence the biomechanical stability of pedicle screws or the risk of pedicle fractures under flexion moments. However, pedicle fill is a critical factor in screw fixation strength. These findings suggest that optimizing pedicle fill is more relevant than pre-tapping in enhancing construct stability.

PMID:40325503 | DOI:10.1097/BRS.0000000000005384

Spec Care Dentist. 2025 Apr;45(3):e70038. doi: 10.1111/scd.70038.

ABSTRACT

INTRODUCTION: Children with special health care needs (CSHCN) rely heavily on their caregivers. Therefore, caregivers must possess adequate oral health knowledge, attitudes, and practices (KAP) to maintain the oral health of CSHCN.

OBJECTIVES: To assess caregivers’ oral health KAP toward CSHCN.

METHODS: A cross-sectional study using convenience sampling was conducted. Data from 295 caregivers attending support group meetings in Harare Province were analyzed using STATA, with p < 0.05 considered statistically significant.

RESULTS: Most caregivers were aged 31-40, with cerebral palsy being the most common disability. Caregivers’ oral health knowledge and practices were satisfactory, while their attitudes were good. Significant associations were found between caregivers’ oral health knowledge and educational level (p = 0.001), and between oral health attitude and both educational level and employment status (p = 0.001, p = 0.003, respectively).

CONCLUSIONS: Caregivers generally had a positive attitude. However, their knowledge about oral health and their practical application of this knowledge was fair. This could be due to a lack of sufficient information or skills to effectively implement good oral health practices.

PMID:40325495 | DOI:10.1111/scd.70038

Trop Med Health. 2025 May 6;53(1):65. doi: 10.1186/s41182-025-00743-3.

ABSTRACT

BACKGROUND: Hypertension (HPT) and diabetes mellitus (DM) are major contributors to morbidity and mortality in Ghana. A key challenge in managing these conditions is non-adherence to follow-up visits, commonly referred to as “lost- to- follow-up” (LTFU). Data from the National Health Insurance Authority (NHIA) between 2017 and 2019 revealed that 37% (232,442/634,981) of patients were LTFU at NHIA-accredited health facilities. This study aimed to investigate the factors driving this high LTFU rate in Ghana.

METHODS: A total of 480 hypertensive and diabetic patients, randomly selected from the NHIA electronic claims database from facilities in the Greater Accra and Ashanti regions between 2019 and 2020, were interviewed. Participants were divided into two groups: LTFU, which consisted of only one visit (351, 73%), and follow-up (FU), which consisted of more than one visit (129, 27%). The sample included patients diagnosed with hypertension only (308, 64%), diabetes only (45, 9%), and both hypertension and diabetes (127, 26%).

RESULTS: No statistically significant socioeconomic differences were observed between the LTFU and FU groups, except in their adherence to follow-up visits. The likelihood of LTFU was higher among patients without follow-up awareness (OR = 2.5, 95% CI: 1.05-4.83), those who felt stigmatized (OR = 15.51, 95% CI: 1.01-238.90), those who attended facilities where physicians were available only some of the time (OR = 7.37, 95% CI: 1.07-50.61), those attending facilities without the necessary diagnostic equipment, those who described the NHIS coverage for DM diagnostic tests as inadequate, and those receiving traditional or herbal treatments (OR = 16.90, 95% CI: 3.12-91.45). Conversely, patients from the Ashanti Region (OR = 0.58, 95% CI: 0.35-0.96), those educated on diagnostic procedures (OR = 0.28, 95% CI: 0.08-0.98), and those whose treatment was not under control (OR = 0.04, 95% CI: 0.00-0.69) were less likely to be LTFU. Additionally, patients diagnosed more than ten years ago (OR = 0.44, 95% CI: 0.24-0.79) and those who were neutral about establishing support groups were less likely to be LTFU.

CONCLUSIONS: The study found that lack of follow-up awareness, stigmatization, and preference for traditional or herbal treatments are key drivers of lost-to-follow-up behavior among hypertension and diabetes patients. Thus, remedial policies should include increasing patient education on the importance of follow-up visits, ensuring the availability of essential medications, diagnostic equipment, and physicians, expanding the NHIA financial coverage, and integrating traditional medicine into standard healthcare to improve treatment adherence and reduce LTFU rates.

PMID:40325488 | DOI:10.1186/s41182-025-00743-3