Tag: pubmed

Head Neck. 2025 Nov 27. doi: 10.1002/hed.70106. Online ahead of print.

ABSTRACT

BACKGROUND: Postoperative adjuvant therapy strategies are generally determined based on pathological risk stratification in oral cancer. However, the efficacy of postoperative adjuvant therapy in patients with intermediate-risk factors for recurrence of oral cancer such as close surgical margins, pT3-T4 classification, pN2-N3 nodal status, perineural invasion, vascular invasion, lymphatic invasion and pattern of invasion remains unclear, and no standardized treatment guidelines or consensus have been established to date. Therefore, this study retrospectively analyzed the clinical significance of risk factors for pathological recurrence in patients with advanced oral cancer and evaluated the impact of postoperative adjuvant therapy on patient prognosis.

METHODS: This retrospective clinical study included 130 patients who underwent initial radical surgical resection for advanced oral squamous cell carcinoma (OSCC) at our institution between January 2010 and December 2023. The postoperative recurrence risk factors included ENE of the cervical lymph nodes, positive surgical margins, close surgical margins, pathological T classification (pT3 or pT4), pathological N classification (pN2 or pN3), metastasis to level IV or V lymph nodes, perineural invasion, vascular invasion, and lymphatic invasion. We analyzed the relationships among the presence of these risk factors, administration of postoperative adjuvant therapy (RT or CRT), occurrence of recurrence or metastasis, and patient prognosis (DFS).

RESULTS: Patients with lymphatic invasion had a significantly lower survival rate than those without lymphatic invasion (66.7% vs. 82.8%, p < 0.05). Although pT4, pN2-N3, perineural invasion-positive and vascular invasion-positive did not reach statistical significance, a trend toward reduced survival was observed in each case. The perineural invasion-positive group had significantly higher recurrence and metastasis rates than the perineural invasion-negative group (51.9% vs. 23.6%, p < 0.05). Multivariate analysis using logistic regression also confirmed the presence of perineural invasion as an independent prognostic factor (HR = 4.496, p = 0.019).

CONCLUSIONS: This study demonstrated that perineural invasion is a significant risk factor for recurrence and that lymphatic invasion is a poor prognostic factor in oral cancer. Postoperative adjuvant therapy in patients with perineural or lymphatic invasion-positive disease contributed to reduced recurrence rates and prolonged survival. These findings suggest that the pathological evaluation of perineural and lymphatic invasions is an important indicator in determining the appropriateness of postoperative adjuvant therapy.

PMID:41307158 | DOI:10.1002/hed.70106

Hand (N Y). 2025 Nov 27:15589447251392939. doi: 10.1177/15589447251392939. Online ahead of print.

ABSTRACT

BACKGROUND: Hand and wrist injuries place a large burden on US emergency departments, and the injury mechanism is often related to consumer products. The purpose of this study is to identify the consumer products most frequently associated with injuries of the hand and wrist that present to US emergency departments and analyze demographic variables and disposition status.

METHODS: The National Electronic Injury Surveillance System database was queried for hand and wrist injuries in patients of all ages from 2018 to 2022. Consumer product codes, demographics, injury sustained, diagnosis, and disposition were analyzed using descriptive statistics and multivariate logistic regression analysis.

RESULTS: Knives accounted for 11% of all injuries, and doors were the next most common consumer product identified (n = 15 827; 5.8%). The highest proportion of injuries occurred in patients ages 15 through 24 (n = 51 900; 19%). The consumer product varied significantly by age group: doors were most common for ages 1 through 9, sports equipment for ages 10 through 14, knives for ages 15 through 80, and floors or stairs for patients older than 80. Discharge disposition was primarily outpatient (n = 257 895; 94%). Age, male sex, stairs, floors, and windows were associated with significantly higher odds of admission.

CONCLUSIONS: The most common consumer product codes involved in injuries varied significantly between age groups, likely reflecting different common injury mechanisms. Knives were the most common consumer product identified. Patients were more likely to be admitted if older than 65, male, or injured with floor, stairs, or windows.

PMID:41307144 | DOI:10.1177/15589447251392939

Spine (Phila Pa 1976). 2025 Nov 27. doi: 10.1097/BRS.0000000000005581. Online ahead of print.

ABSTRACT

STUDY DESIGN: Systematic review and proportional meta-analysis.

OBJECTIVE: To assess and compare overall and specific complication rates across tubular, uniportal, and biportal minimally invasive techniques for cervical spine surgery.

SUMMARY OF BACKGROUND DATA: The three primary minimally invasive spine surgery (MISS) approaches are tubular retractor-based surgery, uniportal endoscopic spine surgery, and biportal endoscopic spine surgery. Each has distinct benefits: tubular approaches rely on familiar instruments and surgical corridors, uniportal techniques reduce skin incision size and tissue disruption, and biportal methods preserve tissue while providing dual working channels that improve surgical access compared to uniportal approaches. However, the relative complication rates of tubular, uniportal, and biportal techniques remain unclear.

METHODS: This review was registered in PROSPERO (CRD42024594335). Following PRISMA guidelines, we conducted a systematic review and meta-analysis. PubMed, Medline, Embase, and Cochrane Library were searched (Jan 2013-Mar 2024) for cervical MISS studies. Studies with ≥10 adult patients reporting UESS complication rates were included. Conference abstracts, reviews, meta-analyses, and non-English articles were excluded. Study quality was assessed using the Cochrane Risk of Bias tool and Newcastle-Ottawa Scale. A random-effects model was applied.

RESULTS: Twenty-one studies (1299 patients) were included, with average patient ages ranging from 47 to 74.5 years and 64% male. All studies had low bias risk. Follow-up periods ranged from 3 to 33 months. The pooled complication rate for cervical MISS was 5% (95% CI [3%-7%]), with heterogeneity (I²=59%). Subgroup analysis showed complication rates of 4% (95% CI [1%-10%], I²=70%) for tubular, 6% (95% CI [2% -12%], I2=46%) for uniportal, and 5% (95% CI [2%-8%], I2=39%) for biportal. No statistically significant differences were found (P=0.85). Nerve injury rates were higher with the uniportal approach (6%, 95% CI [2%-16%], P=0.02). Dural tears (1%, 95% CI [0%-2%], I²=0%) and postoperative hematomas (0%, 95% CI [0%-3%], I²=0%) had low incidence, with no significant differences between approaches (P=0.61 and P=0.78, respectively).

CONCLUSIONS: Cervical MISS demonstrates a low overall complication rate, with tubular approaches showing a numerically lower risk, though differences were not statistically significant. Larger comparative studies are needed to provide more definitive results for better clinical application.

PMID:41307142 | DOI:10.1097/BRS.0000000000005581

Pediatr Dev Pathol. 2025 Nov 27:10935266251385782. doi: 10.1177/10935266251385782. Online ahead of print.

ABSTRACT

BACKGROUND: Intervillous thrombi (IVT) is one of the most common pathology findings during placental examination. The etiology and clinical significance of IVT are controversial.

MATERIALS AND METHODS: We previously collected placental data with fetal birth data and maternal pregnancy characteristics, and we examined IVT in the context of maternal, fetal, and placental pathology.

RESULTS: A total of 3119 placentas with fetal birth and maternal pregnancy characteristics were examined, and IVT was found in 644 placentas (20.6%). IVT was statistically associated with advanced maternal age (P = .01) and clinical preeclampsia (P = .02). IVT was significantly associated with placental infarcts (P < .01), mural arterial hypertrophy (P = .02) as well as placental abruption (P < .01). In addition, IVT was significantly associated with velamentous cord insertion (P < .01). Regression analysis demonstrated the persistence of association between IVT placental infarct, in addition to 2 vessel cord (SUA) and fetal inflammatory response (FIR, acute funisitis/fetal vasculitis).

CONCLUSION: Our data showed that IVT was independently associated with placental infarct, single umbilical artery, and fetal inflammatory response after regression analysis. The association of IVT with single umbilical artery and fetal inflammatory response points to fetal blood flow as potential pathogenic basis, providing new insight into pathogenic mechanisms and clinical significance.

PMID:41307115 | DOI:10.1177/10935266251385782

Spine (Phila Pa 1976). 2025 Nov 27. doi: 10.1097/BRS.0000000000005580. Online ahead of print.

ABSTRACT

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, controlled pivotal study.

OBJECTIVE: Compare time-to-fusion in patients treated with P-15L (PearlMatrixTM P-15 Peptide Enhanced Bone Graft) versus local autograft over 24 months and evaluate changes in pain and quality of life at 24 months relative to baseline.

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated Breakthrough Device, is a composite bone graft with P-15, a 15-amino acid polypeptide that promotes cellular adhesion, proliferation, and differentiation to support bone formation.

METHODS: Patients (22-80 y) with degenerative disc disease were randomized to the investigational (P-15L) or control (local autograft) group during single-level transforaminal lumbar interbody fusion (TLIF) with a PEEK cage and supplemental pedicle screw fixation. Fusion assessments occurred at 6, 12, and 24 months. Time-to-fusion was tested for superiority as compared to the control using Kaplan-Meier survival analysis. Back and leg pain were measured using the Visual Analog Scale (VAS) and quality of life was assessed using the Short Form Survey (SF-12).

RESULTS: The analysis included 290 patients from 33 sites; 141 (48.6%) received P-15L and 149 (51.3%) received local autograft. At randomization, at least 1 risk factor for pseudoarthrosis (obesity, nicotine use, or diabetes) was reported in 58.9% (83/141) of the investigational group and 60.4% (90/149) of the control group. More patients in the investigational than the control group achieved fusion at 6 months (Kaplan-Meier fusion rates 57.6% vs 26.9%, respectively), 12 months (68.8% vs 41.5%, respectively), and 24 months (81.1% vs 54.9%, respectively). P-15L was statistically superior to autograft for time-to-fusion (hazard ratio=1.87, 95% CI: 1.47, 2.38; P<0.0001). There was marked improvement in VAS and SF-12 relative to baseline in both groups at 24 months.

CONCLUSION: P-15L promotes statistically superior earlier time-to-fusion than local autograft in instrumented TLIF. Both treatments resulted in clinically meaningful improvements in pain and quality of life at 24 months.

LEVEL OF EVIDENCE: 1.

PMID:41307110 | DOI:10.1097/BRS.0000000000005580

Adv Biomed Res. 2025 Oct 31;14:116. doi: 10.4103/abr.abr_201_24. eCollection 2025.

ABSTRACT

BACKGROUND: Obesity stands as a significant contributor to physical disability and is associated with a range of health issues, particularly cardiovascular diseases. This study aims to explore the impact of aerobic exercise on the expression levels of lipo-toxicity genes within the cardiac tissue of obese male rats that have been subjected to a diet high in fat and fructose.

MATERIALS AND METHODS: Twenty-four male Wistar rats were randomly divided into three groups (n = 8 rats): 2 months of standard diet, 2 months of high-fat diet containing fructose (60% fat and 25% fructose diet), and aerobic exercise group (consumed 60% fat food containing 25% fructose; in addition, from the eighth week to the end of the research period, they performed continuous aerobic exercise with an average intensity of 15 m/min for 30 min on a treadmill). At the end of the study, the anthropometrical parameters and markers of obesity and also genes expression of peroxisome proliferator-activated receptor alpha (PPARα), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α), pyruvate dehydrogenase kinase 4 (PDK4), and mast cell protease-1 (mCPT1) were measured using the real-time polymerase chain reaction technique. One-way analysis of variance and Tukey’s post hoc test were used for statistical analysis.

RESULTS: The expression level of PPARα, PGC1-α, PDK4, and mCPT1 genes in the cardiac tissue of obese rats was significantly lower than that of the healthy control group. Also, the gene expression level of PGC1-α, PDK4, and mCPT1 significantly decreases, whereas the gene expression level of the PPARα increased in the exercise group compared to the obese groups.

CONCLUSION: It seems that aerobic exercise can modulate the expression of PPARα, PGC1-α, PDK4, and mCPT1 genes and improve fat metabolism in cardiac tissue samples. It is suggested that aerobic exercise can be useful for obese patients with cardiovascular problems.

PMID:41307085 | PMC:PMC12646347 | DOI:10.4103/abr.abr_201_24

Adv Biomed Res. 2025 Oct 31;14:125. doi: 10.4103/abr.abr_655_24. eCollection 2025.

ABSTRACT

BACKGROUND: To compare the outcomes of 12-hour versus 24-hour latent phase durations in low-risk women with premature rupture of membranes (PROM).

MATERIALS AND METHODS: This prospective study included 213 women with PROM at ≥37 weeks of gestation, randomized into two groups: 12-hour (n = 142) and 24-hour (n = 71) latent phase management. Participants underwent cervical ripening followed by oxytocin induction. Primary outcomes included cesarean section rates and maternal and neonatal complications.

RESULTS: The 24-hour latent phase group showed a clinically relevant but non-significant 32% reduction in cesarean section rates compared to the 12-hour group (OR: 1.32, 95% CI: 0.73-2.38, P = 0.360). No statistically significant differences were observed in maternal complications (emergency cesarean section, atony, chorioamnionitis) or neonatal outcomes (NICU admission, Apgar scores <7) between groups (all P values > 0.05). Nulliparous women had numerically higher but statistically nonsignificant complication rates than multiparous women (all P values > 0.05).

CONCLUSION: Extending the latent phase to 24 hours in carefully selected PROM cases may offer a clinically meaningful reduction in cesarean sections, though this finding was not statistically significant. The approach did not increase maternal or neonatal risks. Parity-specific trends warrant further investigation.

PMID:41307084 | PMC:PMC12646336 | DOI:10.4103/abr.abr_655_24

R Soc Open Sci. 2025 Nov 26;12(11):251377. doi: 10.1098/rsos.251377. eCollection 2025 Nov.

ABSTRACT

The spread of misinformation on social media continues to pose challenges. While prior research has shown some success in reducing susceptibility to misinformation at scale, how individual-level interventions impact the quality of content shared on social networks remains understudied. Across two pre-registered longitudinal studies, we ran two Twitter/X ad campaigns, targeting a total of 967 640 Twitter/X users with either a previously validated ‘inoculation’ video about emotional manipulation or a control video. We hypothesized that Twitter/X users who saw the inoculation video would engage less with negative-emotional content and share less content from unreliable sources. We do not find evidence for our hypotheses, observing no meaningful changes in posting or retweeting post-intervention. Our findings are most likely compromised by Twitter/X’s ‘fuzzy matching’ policy, which introduced substantial noise in our data (approx. 7.5% of targeted individuals were actually exposed to the intervention). Our findings are thus probably the result of treatment non-compliance rather than ‘true’ null effects. Importantly, we also demonstrate that different statistical analyses and time windows (looking at the intervention’s effects over 1 h versus 6 h or 24 h, etc.) can yield different and even opposite significant effects, highlighting the risk of interpreting noise from field studies as signal.

PMID:41307058 | PMC:PMC12646748 | DOI:10.1098/rsos.251377

R Soc Open Sci. 2025 Nov 26;12(11):251200. doi: 10.1098/rsos.251200. eCollection 2025 Nov.

ABSTRACT

Pineapple (Ananas comosus) peel, an abundant agro-industrial by-product, offers significant potential as a sustainable natural dye for textile applications. This study optimized colourant extraction using an alkaline-water system and evaluated dyeing performance on cotton fabrics. Statistical optimization through four-factor linear regression identified optimal conditions: mass-to-liquid ratio of 1 : 10, 12% NaOH, 80°C and 2 h extraction time, yielding 35-40% colourant, significantly outperforming organic solvents (<1%). High-performance liquid chromatography analysis revealed distinctive polyphenolic profiles between alkaline and water extraction methods, demonstrating altered compound distribution and enhanced extraction efficiency under alkaline conditions. Thermogravimetric analysis revealed dye stability up to 160°C, while particle size analysis showed a mean size of 266 nm, enabling effective fibre penetration. Quantitative dyeing evaluation demonstrated 43.05% exhaustion, 27.76% total fixation efficiency and 0.64 fixation ratio. Colorimetric analysis revealed significant mordant-dependent variations, with tannic acid achieving superior colour strength (K/S = 21.4) compared to metallic mordants: zinc sulfate, alum and ammonium ferrous sulfate. CIELab coordinates confirmed successful dye uptake (L* = -6.92 to -12.83). Post-mordanting with zinc sulfate achieved excellent fastness properties: wash (4-5), light (4) and rubbing (4) fastness. Cationization minimized electrostatic repulsion between cotton and anionic dye molecules, enhancing dye absorption. The findings demonstrate pineapple peel waste viability as a cost-effective natural dye with quantified performance metrics supporting commercial feasibility and circular economy principles in sustainable textile manufacturing.

PMID:41307052 | PMC:PMC12646757 | DOI:10.1098/rsos.251200

J Multidiscip Healthc. 2025 Nov 20;18:7567-7577. doi: 10.2147/JMDH.S560186. eCollection 2025.

ABSTRACT

BACKGROUND: High-flow nasal cannula (HFNC) has emerged as a promising non-invasive oxygen therapy for patients with chronic obstructive pulmonary disease (COPD), particularly those with mild to moderate hypercapnia. Despite its growing use, no studies in Saudi Arabia have explored healthcare providers’ clinical practices or perceived barriers related to HFNC application in this patient population. This study aimed to assess the current clinical use and implementation challenges of HFNC among physicians and respiratory therapists (RTs) in Saudi Arabia.

METHODS: A cross-sectional survey was conducted among physicians and RTs across Saudi Arabia from October 27, 2024, to May 20, 2025. The survey, distributed via several channels, collected data on HFNC practices, initial settings, weaning approaches, and perceived barriers. Descriptive statistics presented as frequencies and percentages. Chi-square tests were used to assess differences between physicians and RTs, with a significance level set at p < 0.05.

RESULTS: A total of 1724 healthcare providers completed the survey, including 636 (36.9%) physicians and 1,088 (63.1%) RTs. Significant variations were found between the two groups regarding who initiates HFNC, preferred flow rates, and temperature settings (p < 0.05). The most common flow rate selected was 30-40 L/min (47.2%), and initial FiO₂ levels typically ranged between 41% and 60%. Regarding weaning, 43% of respondents reduced flow by 5-10 L/min every 2-4 hours, and 48% disconnected HFNC when the flow rate dropped below 20 L/min. The primary barriers reported by both groups included lack of standardized protocols, insufficient training, and limited HFNC knowledge.

CONCLUSION: There is an inconsistent clinical practice regarding HFNC use in mild to moderate COPD among healthcare providers in Saudi Arabia. Addressing knowledge gaps and standardizing protocols may enhance the effective implementation of HFNC therapy and improve patient outcomes.

PMID:41307048 | PMC:PMC12644235 | DOI:10.2147/JMDH.S560186