Tag: pubmed

BMC Oral Health. 2023 Nov 8;23(1):841. doi: 10.1186/s12903-023-03613-8.

ABSTRACT

BACKGROUND: The primary objective of the study was to evaluate the effects of SEC III (Splints, Class III Elastics, and Chin cup) protocol on the upper airway dimensions using lateral cephalometric radiographs. The secondary objectives were to evaluate the skeletal and dental effects of the SEC III protocol using lateral cephalometric radiographs.

METHODS: The pre- and post-treatment lateral cephalometric radiographs of 24 patients treated using the SEC III protocol were used to address the aim of the study. Children in the pre-pubertal (CS-1 or CS-2) or circumpubertal (CS-3 or CS-4) skeletal maturation stage and having class III dentoskeletal malocclusion were included in the study. Patients with a history of previous orthodontic treatment, maxillofacial surgery or trauma, tonsillectomy, adenoidectomy, or craniofacial malformations were excluded. The pre-treatment and post-treatment lateral cephalometric radiographs were traced, then airway measurements, skeletal measurements, and dental measurements were performed. The results were analysed using paired samples t-test or Wilcoxon signed rank test according to the data normality.

RESULTS: Data of 6 males and 18 females were analysed (Mean age = 11.21 ± 1.02 years). Duration of active treatment was 5.75 ± 1.03 months. Treatment using SEC III protocol resulted in a significant increase in ANB angle (2.92 ± 1.50 degrees, p < 0.001) and Wits appraisal (3.31 ± 1.99 mm) (p < 0.001). The increase in the mandibular plane angle (0.75 ± 1.42 degrees, p = 0.02) and the maxillary length (2.29 ± 2.69 mm, p < 0.001) was statistically significant. Contrarily, the mandibular length did not change significantly (p = 0.10). The maxillary incisors were significantly proclined (4.38 ± 4.28 degrees; p < 0.001), while the mandibular incisors were significantly retroclined (-5.79 ± 6.21 degrees; p < 0.001) following treatment. The change in the nasopharyngeal airway and the retropalatal airway was not statistically significant. The middle and inferior pharyngeal space (retroglossal airway) significantly decreased by 1.33 ± 1.97 mm (p = 0.003) and 1.96 ± 2.48 mm (p = 0.001), respectively.

CONCLUSIONS: Early class III correction using SEC III protocol reduced the retroglossal airway dimensions but did not affect the nasopharyngeal and retropalatal airway dimensions. Correction of the class III dentoskeletal relationship was obtained through both skeletal and dental changes.

PMID:37940933 | DOI:10.1186/s12903-023-03613-8

BMC Womens Health. 2023 Nov 8;23(1):583. doi: 10.1186/s12905-023-02730-4.

ABSTRACT

OBJECTIVE: This study aimed to reveal the urine metabolic change of endometrial cancer (EC) patients during fertility-sparing treatment and establish non-invasive predictive models to identify patients with complete remission (CR).

METHOD: This study enrolled 20 EC patients prior to treatment (PT) and 22 patients with CR, aged 25-40 years. Eligibility criteria consisted of stage IA high-grade EC, lesions confined to endometrium, normal hepatic and renal function, normal urine test, no contraindication for fertility-sparing treatment and no prior therapy. Urine samples were analyzed using ultraperformance liquid chromatography mass spectrometry (UPLC-MS), a technique chosen for its high sensitivity and resolution, allows for rapid, accurate identification and quantification of metabolites, providing a comprehensive metabolic profile and facilitating the discovery of potential biomarkers. Analytical techniques were employed to determine distinct metabolites and altered metabolic pathways. The statistical analyses were performed using univariate and multivariate analyses, logistic regression and receiver operating characteristic (ROC) curves to discover and validate the potential biomarker models.

RESULTS: A total of 108 different urine metabolomes were identified between CR and PT groups. These metabolites were enriched in ascorbate and aldarate metabolism, one carbon pool by folate, and some amino acid metabolisms pathways. A panel consisting of Baicalin, 5beta-1,3,7 (11)-Eudesmatrien-8-one, Indolylacryloylglycine, Edulitine, and Physapubenolide were selected as biomarkers, which demonstrated the best predictive ability with the AUC values of 0.982/0.851 in training/10-fold-cross-validation group, achieving a sensitivity of 0.975 and specificity of 0.967, respectively.

CONCLUSION: The urine metabolic analysis revealed the metabolic changes in EC patients during the fertility-sparing treatment. The predictive biomarkers present great potential diagnostic value in fertility-sparing treatments for EC patients, offering a less invasive means of monitoring treatment efficacy. Further research should explore the mechanistic underpinnings of these metabolic changes and validate the biomarker panel in larger, diverse populations due to the small sample size and single-institution nature of our study.

PMID:37940929 | DOI:10.1186/s12905-023-02730-4

Risk Anal. 2023 Nov 8. doi: 10.1111/risa.14251. Online ahead of print.

ABSTRACT

Nonrenewable energy sources have been shown to be a cause of conflict and terrorism, highlighting the global conflict aspect, but little is known about the causal relationship between the energy system and terrorism in Turkey. This study aims to fill this gap by examining the causal links among renewable energy consumption, fossil fuels, terrorist attacks, education, trade opening, and geopolitical risks in Turkey from 1980 to 2016. Using the autoregressive distributed lag (ARDL) approach and Granger causality tests, the study analyzes the short and long-term relationships between the variables. Additionally, robustness tests are conducted using a powerful multiresolution ARDL approach to ensure the stability of the statistical findings. The results reveal the existence of long-term relationships between all the variables, particularly among terrorism, renewable energy, and education. In the short term, a one-way relationship exists between terrorism and education to renewable energies and from trade openness to terrorism. The study demonstrates that nonrenewable energy increases terrorism in the long term, whereas renewable energy and trade openness reduce terrorism, highlighting the potential impact of global conflicts on Turkey’s sustainable development. Therefore, renewable energy is a powerful tool to fight against terrorism, and Turkey has encouraged its use and deployment of diplomatic efforts to resolve political and military conflicts, particularly in the Middle East. This study provides insights into the complex relationship among sustainable energy consumption, terrorism, education, and trade opening, contributing to the understanding of the geopolitical risks and economics in Turkey. It has implications for policymakers in the region, highlighting the importance of renewable energy and trade openness as tools for conflict resolution and sustainable development in the face of global conflicts.

PMID:37939400 | DOI:10.1111/risa.14251

Appl Physiol Nutr Metab. 2023 Nov 8. doi: 10.1139/apnm-2023-0329. Online ahead of print.

ABSTRACT

The present meta-analysis aimed to assess the effects of low-volume high-intensity interval training (LV-HIIT; i.e., ≤5 min high-intensity exercise within a ≤15-min session) on cardiometabolic health and body composition. A systematic search was performed in accordance with PRISMA guidelines to assess the effect of LV-HIIT on cardiometabolic health and body composition. Twenty-one studies (moderate to high quality) with a total of 849 participants were included in this meta-analysis. LV-HIIT increased cardiorespiratory fitness (CRF, SMD=1.19 [0.87, 1.50]) while lowering systolic blood pressure (SMD=-1.44 [-1.68, -1.20]), diastolic blood pressure (SMD=-1.51 [-1.75, -1.27]), mean arterial pressure (SMD=-1.55 [-1.80, -1.30]), MetS z-score (SMD=-0.76 [-1.02, -0.49]), fat mass (kg) (SMD=-0.22 [-0.44, 0.00]), fat mass (%) (SMD=-0.22 [-0.41, -0.02]), and waist circumference (SMD= -0.53 [-0.75, -0.31]) compared to untrained control (CONTROL). Despite a total time-commitment of LV-HIIT of only 14-47% and 45-94% compared to moderate-intensity continuous training and HV-HIIT, respectively, there were no statistically significant differences observed for any outcomes in comparisons between LV-HIIT and moderate-intensity continuous training (MICT) or high-volume HIIT. Significant inverse dose-responses were observed between the change in CRF with LV-HIIT and sprint repetitions (β=-0.52 [-0.76, -0.28]), high-intensity duration (β=-0.21 [-0.39, -0.02]), and total duration (β=-0.19 [-0.36, -0.02]), while higher intensity significantly improved CRF gains. LV-HIIT can improve cardiometabolic health and body composition and represent a time-efficient alternative to MICT and HV-HIIT. Performing LV-HIIT at a higher intensity drives higher CRF gains. More repetitions, longer time at high-intensity, and total session duration did not augment gains in CRF.

PMID:37939367 | DOI:10.1139/apnm-2023-0329

Am J Public Health. 2023 Dec;113(12):1309-1317. doi: 10.2105/AJPH.2023.307400.

ABSTRACT

Objectives. To assess the association between the New York Secure Ammunition and Firearms Enforcement Act (NY SAFE Act) and firearm suicide and homicide rates. Methods. We employed a synthetic controls approach to investigate the impact of the NY SAFE Act on firearm suicide and firearm homicide rates. We collected state-level data on firearm mortality from the Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (WONDER) database for the period 1999-2019. We derived statistical inference by using a permutation-based in-place placebo test. Results. The implementation of the NY SAFE Act was associated with a significant reduction in firearm homicide rates, demonstrating a decrease of 63%. This decrease corresponds to an estimated prevention of 1697 deaths between 2013 and 2019. However, there was no association between the NY SAFE Act and firearm suicide rates. Conclusions. As the responsibility for enacting firearm policies increasingly falls on states instead of the federal government, this study provides valuable information that can assist states in making evidence-based decisions regarding the development and implementation of firearm policies that prioritize public safety and aim to prevent firearm-related fatalities. (Am J Public Health. 2023;113(12):1309-1317. https://doi.org/10.2105/AJPH.2023.307400).

PMID:37939334 | DOI:10.2105/AJPH.2023.307400

Am J Public Health. 2023 Dec;113(12):1290-1295. doi: 10.2105/AJPH.2023.307490.

NO ABSTRACT

PMID:37939326 | DOI:10.2105/AJPH.2023.307490

Int J Periodontics Restorative Dent. 2023 Nov 8;0(0):1-21. doi: 10.11607/prd.6598. Online ahead of print.

ABSTRACT

PURPOSE: This in vivo study in a canine model assessed the effect of recombinant human platelet-derived growth factor (rhPDGF) on healing of periapical tissues following apical surgery.

MATERIALS AND METHODS: Sixty-four premolar teeth of six 2-year-old beagle dogs were randomly assigned to 4 experimental groups; 16 teeth each. In each tooth, coronal access was done, and the pulp extirpated. The teeth were then left open to the oral cavity for one week and then sealed with IRM for 8 weeks. Nonsurgical endodontic treatment (NSRCT) was then performed. A split-mouth design was used, and intra-animal side randomization was applied to the 4 groups as follows: Group 1) Apical curettage +1.5 mm root-end resection; Group 2) Apicoectomy + mineral trioxide aggregate (MTA) root-end filling; Group 3) Apicoectomy + MTA root-end filling + rhPDGF; and Group 4) Apical curettage + rhPDGF. The animals were sacrificed 24 months following apical surgery and histological and μCT analyses were performed for bone volume loss (BVL).

RESULTS: Group 1 showed partial resolution of the periapical lesions but without signs of tissue regeneration. The BVL was 49.09 ± 10.97 mm3. Group 2 showed reformation of cementum in 9 out of 16 teeth. No direct attachment between the newly formed cementum and the MTA were observed. Bone regeneration was minimal and the BVL was 35.34 ± 10.97 mm3. Group 3 showed regeneration of all damaged apical tissues but without direct contact between the cementum and MTA. The BLV was 4.51± 1.55 mm3. Group 4 showed regeneration of PDL, bone, cementum, and attachment of functional cementum fibers was observed. The BVL for this group was 2.82 ± 2.3 mm3. The difference in BVL was statistically significant only for Group 1 and Group 2 (P<0.05). There was no significance difference in the BVL between Group 3 and Group 4.

CONCLUSIONS: Recombinant human platelet-derived growth factor may play a role in regeneration of apical tissue structures following apical surgery.

CLINICAL RELEVANCE: Oral healthcare providers should be aware that addition of recombinant human platelet-derived growth factor may positively impact the regeneration of periapical tissues following apical surgery.

PMID:37939277 | DOI:10.11607/prd.6598

J Pharm Pract. 2023 Nov 8:8971900231213701. doi: 10.1177/08971900231213701. Online ahead of print.

ABSTRACT

Background: Azithromycin is a commonly prescribed antibiotic included in many first-line regimens for pneumonia. Azithromycin also carries an FDA warning for increased risk for abnormal cardiac electrical activity, including QTc prolongation. Objective: To examine the effect of intravenous azithromycin on the QT interval in a cohort of patients receiving antibiotic therapy for community acquired pneumonia. Methods: A single-center, retrospective chart review of patients admitted to the Intensive Care Unit (ICU). The primary endpoint was change in QTc 48-72 hours after antibiotic initiation. The primary outcome was analyzed using ANOVA matched comparison. Results: Between 6/1/2019 and 3/31/2020, 241 total ICU patients received doses of either antibiotic. After application of exclusion criteria, the total number of patients included in analysis was 93, including 75 azithromycin patient and 18 doxycycline patients. The baseline QTc in the azithromycin group was 449 (95% CI 438-461) and the 72-hour QTc was 442 (95% CI 427-453) with an average change in QTc of -4 ms (P = .14). No statistically significant difference was found in QTc interval change between azithromycin and doxycycline. Conclusion: In this study, azithromycin use was not associated with a statistically significant increase in QTc interval. Based on these results, for the majority of patients receiving azithromycin, QTc prolongation is not likely a major concern. However, caution may still be warranted in patients considered high risk.

PMID:37939272 | DOI:10.1177/08971900231213701

Ann Med. 2023;55(2):2279235. doi: 10.1080/07853890.2023.2279235. Epub 2023 Nov 8.

ABSTRACT

Tumour classifications play a pivotal role in prostate cancer (PCa) management. It can predict the clinical outcomes of PCa as early as the disease is diagnosed and then guide therapeutic schemes, such as active monitoring, standalone surgical intervention, or surgery supplemented with postoperative adjunctive therapy, thereby circumventing disease exacerbation and excessive treatment. Classifications based on clinicopathological features, such as prostate cancer-specific antigen, Gleason score, and TNM stage, are still the main risk stratification strategies and have played an essential role in standardized clinical decision-making. However, mounting evidence indicates that clinicopathological parameters in isolation fail to adequately capture the heterogeneity exhibited among distinct PCa patients, such as those sharing identical Gleason scores yet experiencing divergent prognoses. As a remedy, molecular classifications have been introduced. Currently, molecular studies have revealed the characteristic genomic alterations, epigenetic modulations, and tumour microenvironment associated with different types of PCa, which provide a chance for urologists to refine the PCa classification. In this context, numerous invaluable molecular classifications have been devised, employing disparate statistical methodologies and algorithmic approaches, encompassing self-organizing map clustering, unsupervised cluster analysis, and multifarious algorithms. Interestingly, the classifier PAM50 was used in a phase-2 multicentre open-label trial, NRG-GU-006, for further validation, which hints at the promise of molecular classification for clinical use. Consequently, this review examines the extant molecular classifications, delineates the prevailing panorama of clinically pertinent molecular signatures, and delves into eight emblematic molecular classifications, dissecting their methodological underpinnings and clinical utility.

PMID:37939258 | DOI:10.1080/07853890.2023.2279235

Int J Oral Maxillofac Implants. 2023 Nov 8;0(0):1-25. doi: 10.11607/jomi.10560. Online ahead of print.

ABSTRACT

AIM: This report stems from a homogeneous patient cohort from two similarly designed prospective controlled studies in the same center on surgical reconstructive treatment of peri-implantitis. The aim of this re-analysis study was exploring prognostic factors associated with surgical outcomes.

MATERIALS AND METHODS: Individual patient data of both studies were gathered. The initial study employed a submerged healing approach via primary wound closure with implant supra-structure removal and complete coverage of grafted sites. The second study employed a non-submerged healing protocol in which healing abutments were kept in place and the implant was not fully submerged. Both studies measured all outcomes at similar timepoints throughout 1 year, to include clinical and radiographic defect fill (DF and RDF), reduction of pocket depth (PDR) and bleeding on probing (BOP). Multi-level regression was used for statistical assessment of outcomes, relative to the impact of site-/local-, surgical- and patient-related variables.

RESULTS: Overall, 59 implants (30 in submerged and 29 in the non-submerged group) were treated. A statistically significant higher DF (on average 0.9 mm higher), RDF (1.7 mm) and PDR (1.3 mm) were observed when a submerged reconstructive approach was performed, whereas BOP reduction was similar. After controlling for treatment (submerged/non-submerged), there were no other significant associations with patient- (age, gender, smoking, prior periodontitis etc.), or implant-related (previous prosthesis type, arch, KTW, etc.) factors.

CONCLUSION: Within its limitations, we conclude that a submerged reconstructive approach for surgical management of peri-implantitis leads to significantly enhanced clinical and radiographic outcomes when compared to a non-submerged approach.

PMID:37939242 | DOI:10.11607/jomi.10560