Tag: pubmed

BMJ Open. 2023 Oct 9;13(10):e071100. doi: 10.1136/bmjopen-2022-071100.

ABSTRACT

BACKGROUND: Prevalent physical inactivity and poor nutrition contribute to high non-communicable disease (NCD) morbidity and mortality in Kosovo. To improve health services for patients with NCD the Accessible Quality Healthcare project developed behaviour change interventions following the principles of the WHO Package of Essential NCD (PEN) protocol. They were implemented into the public primary healthcare (PHC) system of five early-stage implementation municipalities (ESIM, 2018) and seven late-stage implementation municipalities (2020).

OBJECTIVE: To assess the effect of the behaviour change interventions; motivational stages of behaviour change for physical activity and nutrition; and body mass index (BMI).

DESIGN: Prospective cohort study.

DATA COLLECTION AND ANALYSIS: We included 891 public PHC users aged 40 years and above, who were enrolled in the KOSCO (Kosovo Non-Communicable Disease Cohort) cohort in 2019 and followed-up biannually until February 2021. The PHC users who consulted for themselves any health service were approached and recruited for cohort participation. Each participant contributed up to four self-reports of nutrition and physical activity, and up to three reports of motivation to change for a better lifestyle. These outcomes were modelled prospectively with robust mixed-effects Poisson regressions. The association between behaviour change interventions and BMI was quantified using linear regression.

RESULTS: There was a high rate of smokers 20.5% and obesity 53.1%, and high rates of self-reported diagnoses of diabetes: 57.1%; hypertension 62.6%. We found no effect of residing in an ESIM, but adherence to both guidelines was higher in ESIM at the latest follow-up time point. ESIM residence was also associated with a twofold increase in the probability of reporting a high motivation for a better lifestyle and with a statistically non-significant decrease in BMI of -0.14 kg/m² (95% CI: -0.46 to 0.19) at the latest follow-up.

CONCLUSION: The longitudinal results extend evidence on the effect of WHO PEN protocol in promoting physical activity and nutritional behaviour in the Kosovo context.

PMID:37813529 | DOI:10.1136/bmjopen-2022-071100

Reg Anesth Pain Med. 2023 Oct 9:rapm-2023-104840. doi: 10.1136/rapm-2023-104840. Online ahead of print.

ABSTRACT

INTRODUCTION: Low back pain is a significant burden to society and the lack of reliable outcome measures, combined with a prevailing inability to quantify the biopsychosocial elements implicated in the disease, impedes clinical decision-making and distorts treatment efficacy. This paper aims to validate the utility of a biopsychosocial spine platform to provide standardized wearable sensor-derived functional motion assessments to assess spine function and differentiate between healthy controls and patients. Secondarily, we explored the correlation between these motion features and subjective biopsychosocial measures.

METHODS: An observational study was conducted on healthy controls (n=50) and patients with low back pain (n=50) to validate platform utility. The platform was used to conduct functional assessments along with patient-reported outcome assessments to holistically document cohort differences. Our primary outcomes were motion features; and our secondary outcomes were biopsychosocial measures (pain, function, etc).

RESULTS: Our results demonstrated statistically significant differences in motion features between healthy and patient cohorts across anatomical planes. Importantly, we found velocity and acceleration in the axial plane showed the largest difference, with healthy controls having 49.7% and 55.7% higher values, respectively, than patients. In addition, we found significant correlations between motion features and biopsychosocial measures for pain, physical function and social role only.

CONCLUSIONS: Our study validated the use of wearable sensor-derived functional motion metrics in differentiating healthy controls and patients. Collectively, this technology has the potential to facilitate holistic biopsychosocial evaluations to enhance spine care and improve patient outcomes.

TRIAL REGISTRATION NUMBER: NCT05776771.

PMID:37813527 | DOI:10.1136/rapm-2023-104840

Kidney Res Clin Pract. 2023 Sep;42(5):606-616. doi: 10.23876/j.krcp.22.148. Epub 2023 Sep 27.

ABSTRACT

BACKGROUND: Prevention and diagnosis of postcontrast acute kidney injury (AKI) after contrast-enhanced computed tomography is burdensome in outpatient department. We investigated whether an electronic alert system could improve prevention and diagnosis of postcontrast AKI.

METHODS: In March 2018, we launched an electronic alert system that automatically identifies patients with a baseline estimated glomerular filtration rate of <45 mL/min/1.73 m2, provides a prescription of fluid regimen, and recommends a follow-up for serum creatinine measurement. Participants prescribed contrast-enhanced computed tomography at outpatient department before and after the launch of the system were categorized as historical and alert group, respectively. Propensity for the surveillance of postcontrast AKI was compared using logistic regression. Risks of AKI, admission, mortality, and renal replacement therapy were analyzed.

RESULTS: The historical and alert groups included 289 and 309 participants, respectively. The alert group was more likely to be men and take diuretics. The most frequent volume of prophylactic fluid in historical and alert group was 1,000 and 750 mL, respectively. Follow-up for AKI was more common in the alert group (adjusted odds ratio, 6.00; p < 0.001). Among them, incidence of postcontrast AKI was not statistically different. The two groups did not differ in risks of admission, mortality, or renal replacement therapy.

CONCLUSION: The electronic alert system could assist in the detection of high-risk patients, prevention with reduced fluid volume, and proper diagnosis of postcontrast AKI, while limiting the prescribing clinicians’ burden. Whether the system can improve long-term outcomes remains unclear.

PMID:37813523 | DOI:10.23876/j.krcp.22.148

Arch Psychiatr Nurs. 2023 Oct;46:8-13. doi: 10.1016/j.apnu.2023.06.007. Epub 2023 Jun 22.

ABSTRACT

AIM: This study aimed to determine the effect of personal values on self-esteem and meaning in life in adolescents.

METHODS: This cross-sectional study was conducted with 404 adolescents in Turkey. The data were collected with the “Portrait Values Questionnaire” (PVQ), the “Rosenberg Self-Esteem Scale” (RSE), and the “Meaning in Life Questionnaire” (MLQ) between September and December 2021. Descriptive statistics were used in the analysis of the data, and multivariate correlation and regression analyses were performed. The STROBE checklist was used for reporting.

RESULTS: The mean PVQ score was 4.84 ± 0.59, indicating good individual values. The mean RSES score was 1.86 ± 0.62, showing moderate self-esteem. The mean MLQ score was 4.24 ± 1.17, indicating a moderate meaning in life. There was a positive relationship between the PVQ scores of the adolescents and their RSE and MLQ. PVQ was a positive predictor of RSE and MLQ in these adolescents.

CONCLUSIONS: This study revealed that adolescents have good individual values, and moderate self-esteem and meaning in life. Individual values have a positive effect on adolescents’ self-esteem and meaning in life. Future studies are expected to explore how personal values affect self-esteem and meaning in life in adolescents using longitudinal study data. Understanding how adolescents’ personal values affect self-esteem and well-being can contribute to the development of further strategies to increase adolescents’ self-esteem and happiness levels.

PMID:37813509 | DOI:10.1016/j.apnu.2023.06.007

Arch Psychiatr Nurs. 2023 Oct;46:71-75. doi: 10.1016/j.apnu.2023.08.001. Epub 2023 Aug 13.

ABSTRACT

OBJECTIVE: To explore the status and influencing factors of job burnout among psychiatric nurses and provide a reference for hospital managers to carry out occupational and psychological interventions.

METHODS: Between September 2021 and September 2022, the psychiatric nurses in Wuhan Wudong Hospital (Wuhan Second Psychiatric Hospital) were selected as research participants using convenience sampling. The Chinese version of the nursing burnout scale was used to investigate the psychiatric nurses in the hospital, and a multiple linear regression analysis was performed on the factors affecting job burnout.

RESULTS: Among the 121 psychiatric nurses, 57.85 % had no or only mild job burnout, 36.36 % had mild to moderate job burnout and 5.79 % had severe job burnout. The one-way analysis of variance indicated that there were statistical differences in the scores in terms of marital status, educational background, working years, income, work departments and shifts (p < 0.05). The multiple linear regression analysis indicated that the main influencing factors of job burnout were working years and work department (p < 0.05).

CONCLUSION: The detection rate of nurses’ job burnout in the featured psychiatric hospital was 42.10 %. The main influencing factors of job burnout were working years and work department, and targeted intervention can be carried out according to these two factors.

PMID:37813507 | DOI:10.1016/j.apnu.2023.08.001

Arch Psychiatr Nurs. 2023 Oct;46:51-57. doi: 10.1016/j.apnu.2023.06.008. Epub 2023 Jul 4.

ABSTRACT

Patients diagnosed with schizophrenia are characterized by early mortality compared to the general population. The main cause of this premature death reflects medical complications linked to metabolic syndrome (MetS). The use of antipsychotics such as clozapine is associated with weight gain and metabolic disturbances in certain predisposed individuals. Non-pharmacological interventions for weight control have become a key element for secondary prevention in the health of patients diagnosed with schizophrenia. Here, we aim to evaluate the physical health effects of a nurse-led non-pharmacological intervention program in patients with a diagnosis of schizophrenia treated with clozapine. Thirty-one outpatients from the outpatient clinical facility of Hospital Clinic in Barcelona, Spain diagnosed with schizophrenia and other psychotic disorders receiving clozapine treatment were enrolled in a prospective interventional study, comprising an 8-week group program of therapeutic education in a healthy lifestyle. MetS factors, physical activity, diet, and lifestyle were evaluated at baseline, post-intervention (8 weeks), and 3 months after the program. Weight, body mass index, high-density lipoprotein cholesterol, and diet patterns displayed significant differences post-intervention and after 3 months, while only waist, hip perimeter, and lifestyle improved post-intervention. Our results suggest the effectiveness of the lifestyle intervention in patients under clozapine treatment despite its long-time differential effect. Strategies to prevent weight gain and metabolic decline will help prevent premature cardiometabolic disease in this vulnerable population.

PMID:37813503 | DOI:10.1016/j.apnu.2023.06.008

Arch Psychiatr Nurs. 2023 Oct;46:1-7. doi: 10.1016/j.apnu.2023.06.011. Epub 2023 Jun 21.

ABSTRACT

This study investigated the mediating effect of depression on the relationship between sleep quality and internet addiction in Taiwanese junior college students. We recruited 590 (53 males, 537 females) students, aged from 15 to 22 years from a day school of a junior college in northern Taiwan. We used a cross-sectional study design. The Chen Internet Addiction Scale, Chinese Version of the Pittsburgh Sleep Quality Index, and Adolescent Depression Scale were used as measurement instruments. Using the IBM SPSS Statistics 26 software package, descriptive statistics, reliability analysis, correlation analysis, and inferential statistics were used to evaluate the participants’ demographics and relationships between the study variables. The mediation model was tested using the Z test. The prevalence of internet addiction in junior college students was 21.2 %. The indirect effects were determined using Sobel’s test and bootstrapping confirming that depression completely mediated the relationship between sleep quality and internet addiction. The findings would help to build holistic and comprehensive prevention and intervention programs that should be developed to reduce the addictive behaviors of adolescents.

PMID:37813492 | DOI:10.1016/j.apnu.2023.06.011

BMJ Glob Health. 2023 Oct;8(10):e012015. doi: 10.1136/bmjgh-2023-012015.

ABSTRACT

The African Region reports the heaviest burden of public health emergencies globally. This paper presents an exploratory analysis of public health events data collected the past 22 years in the WHO Africa region, to explore patterns and trends that can inform public health strategies, policy changes and develop appropriate tools to improve disease surveillance, preparedness and response to public health emergencies. A suite of exploratory data analysis methods combining time series analysis, summary statistics, temporal visualisations, geographic information system (GIS) mapping, trend analysis and statistical tests were used to derive patterns and trends from the data. An in-depth analysis of zoonotic disease outbreaks by geography and time was explored. The analysis also focused on whether these outbreaks were viral haemorrhagic related or had other characteristics. Results reveal that between 2001 and 2022, a total of 2234 public health events have been recorded in the WHO African Region of which 1886 events (84.4%) were substantiated. The paper confirms an average of 102 public health events reported yearly during the last 22 years time frame. The large majority (92%) of the substantiated events were infectious diseases (n=1730), 30% (n=566) are zoonoses and 5% (n=95) are humanitarian crises such as disaster events and conflicts. The number of zoonotic disease outbreaks has significantly increased (by 87%) between the past two decades, from 2003 to 2012 period (M=18.6, SD=4.8) and 2013-2022 period (M=34.7, SD=14); t(18) = 3.4, p=0.0032. This analysis shows growing challenges faced in the Africa region every year. One-health approach and its coordination across multiple sectors, disciplines and communities is critical to achieve the objectives.

PMID:37813470 | DOI:10.1136/bmjgh-2023-012015

BMJ. 2023 Oct 9;383:e075294. doi: 10.1136/bmj-2023-075294.

NO ABSTRACT

PMID:37813465 | DOI:10.1136/bmj-2023-075294

J Am Chem Soc. 2023 Oct 9. doi: 10.1021/jacs.3c08248. Online ahead of print.

ABSTRACT

Here, we present the synthesis and characterization of statistical and block copolymers containing α-lipoic acid (LA) using reversible addition-fragmentation chain-transfer (RAFT) polymerization. LA, a readily available nutritional supplement, undergoes efficient radical ring-opening copolymerization with vinyl monomers in a controlled manner with predictable molecular weights and low molar-mass dispersities. Because lipoic acid diads present in the resulting copolymers include disulfide bonds, these materials efficiently and rapidly degrade when exposed to mild reducing agents such as tris(2-carboxyethyl)phosphine (M_n = 56 → 3.6 kg mol^-1). This scalable and versatile polymerization method affords a facile way to synthesize degradable polymers with controlled architectures, molecular weights, and molar-mass dispersities from α-lipoic acid, a commercially available and renewable monomer.

PMID:37813389 | DOI:10.1021/jacs.3c08248