Tag: pubmed

J Cosmet Laser Ther. 2026 Apr 3:1-8. doi: 10.1080/14764172.2026.2652488. Online ahead of print.

ABSTRACT

This study aimed to evaluate pain levels, patient satisfaction, and preferences for different anesthetic techniques during the cosmetic application of botulinum toxin A in the upper third of the face. A randomized, double-blind, split-face clinical trial was conducted with 100 women undergoing esthetic procedures for facial wrinkle reduction. Patients were assigned to three groups: vibratory anesthesia versus placebo (Group I), topical anesthesia versus placebo (Group II), and vibratory anesthesia versus topical anesthesia (Group III). Pain levels were assessed using the visual analog scale (VAS). Patients identified the side with better pain control, expressed satisfaction, and provided recommendations for each technique. Group I (vibration 5.02 ± 2.56 vs. placebo 6.00 ± 2.75, p = .034), Group II (topical anesthetic 4.69 ± 2.45 vs. placebo 5.50 ± 2.38, p = .039), and Group III (topical anesthetic 4.89 ± 2.29 vs. vibration 6.06 ± 2.22, p = .048). While satisfaction levels showed no statistically significant differences between techniques, topical anesthesia in Group III received the highest recommendations (p = .010). This study suggests that topical anesthesia and vibratory stimulation both offer small-to-medium analgesic benefits over placebo during BoNT-A injections. Despite comparable satisfaction scores, patients preferred topical anesthesia for future use.

PMID:41930421 | DOI:10.1080/14764172.2026.2652488

Monaldi Arch Chest Dis. 2026 Apr 2. doi: 10.4081/monaldi.2026.3644. Online ahead of print.

ABSTRACT

Interstitial lung diseases (ILDs) comprise a heterogeneous group of disorders characterized by varying degrees of inflammation and fibrosis, necessitating precise epidemiological characterization. This ambispective observational study evaluated the clinical spectrum and diagnostic distribution of 1201 patients at a tertiary center in North India, utilizing a multidisciplinary discussion (MDD) framework for final diagnostic consensus. The mean age of the cohort was 52.7 (±13.04) years, with a female predominance of 55.6%. Idiopathic interstitial pneumonia (IIP) was the most prevalent diagnosis (48.8%), followed by connective tissue disease-associated ILD (CTD-ILD; 19.8%) and hypersensitivity pneumonitis (14.6%). Within the IIP subgroup, idiopathic pulmonary fibrosis predominated (49.7%), followed by nonspecific interstitial pneumonia (39.2%). Statistical analysis identified tobacco use as a significant driver for IIP phenotypes (odds ratio: 3.36; 95% confidence interval: 2.37-4.75; p<0.01). Physiological assessment revealed a restrictive ventilatory defect in 83.9% of the cohort. Patients with sarcoidosis (13.4%) exhibited significantly higher functional reserve (mean forced vital capacity %: 74.1±17.9%) compared to more fibrotic subtypes (p<0.01), and demonstrated superior exercise capacity (mean 6-minute walk distance: 392.4±85.6 m vs. 347.7±90.1 m in CTD-ILD; p<0.01). These findings establish that fibrotic IIPs constitute the primary disease burden in North India, highlighting the clinical necessity of standardized, MDD-based pathways to ensure accurate phenotype differentiation and timely initiation of targeted therapies in a region characterized by complex environmental triggers.

PMID:41930418 | DOI:10.4081/monaldi.2026.3644

Worldviews Evid Based Nurs. 2026 Apr;23(2):e70137. doi: 10.1111/wvn.70137.

ABSTRACT

BACKGROUND: Chronic diseases require sustained medication adherence, yet nonadherence remains common, leading to poor outcomes and increased healthcare costs. Digital self-management technologies such as mobile health (mHealth) apps, SMS reminders, and web-based platforms offer scalable ways to support adherence, but evidence on their overall effectiveness across diverse contexts is fragmented.

AIM: To systematically review and meta-analyze the effectiveness of self-management technologies in improving medication adherence among adults with chronic diseases and to examine potential moderators of intervention impact.

METHODS: Following PRISMA guidelines, we searched PubMed, Scopus, Web of Science, CINAHL, and JMIR for peer-reviewed studies (January 2010-June 2025) evaluating digital self-management interventions with adherence outcomes and comparator groups. Eligible designs included RCTs, quasi-experimental, and controlled before-after studies in adults with chronic disease. Random-effects meta-analysis estimated pooled effect sizes (Cohen’s d). Heterogeneity (I²), subgroup analyses, and publication bias (Egger’s, Begg’s, trim-and-fill) were assessed.

RESULTS: Fifty-two studies were included, spanning 2015-2025. Early interventions (2015-2019) focused on feasibility, using SMS and basic web tools; later years (2021-2025) showed technological maturity, dominated by mHealth apps integrating monitoring, reminders, and education. The pooled random-effects effect size was d = 0.268 (95% CI 0.123-0.414, p = 0.0003), indicating a small-to-moderate benefit. Heterogeneity was high (I² = 89%). Medium-duration (10.8-24 weeks) interventions had the largest effect (d = 0.50), and effects varied markedly by country (e.g., Iran d = 2.29; Taiwan d = -0.94). Begg’s test suggested possible publication bias; trim-and-fill adjustment increased the pooled effect to d = 0.366.

LINKING EVIDENCE TO ACTION: Digital self-management technologies yield a statistically significant, small-to-moderate improvement in medication adherence across chronic diseases, with potential underestimation due to selective reporting. Effectiveness is moderated by temporal trends, geography, intervention duration, and study design, underscoring the need for context-specific adaptation and methodological rigor. Future research should prioritize large, well-controlled trials, pre-registration, and exploration of cultural and systemic determinants to optimize intervention impact.

PMID:41930416 | DOI:10.1111/wvn.70137

Health Soc Care Deliv Res. 2026 Apr 1:1-26. doi: 10.3310/TNFT6414. Online ahead of print.

ABSTRACT

BACKGROUND: Domestic abuse and suicidal ideation are highly prevalent in the United Kingdom, often co-occurring. Numerous practical and psychosocial barriers inhibit help-seeking. This study explored whether community pharmacy could offer an accessible setting for a domestic abuse and suicidal ideation response service.

METHODS: The design was a randomised cluster feasibility trial. Twelve pharmacies were recruited from one pharmacy organisation, randomised into eight intervention pharmacies and four controls. Thirty-seven pharmacy staff were trained to deliver the Lifeguard Pharmacy intervention, which involved providing a consultation and structured referral or signposting to customers identified as experiencing domestic abuse and/or suicidal ideation. Staff learning from the training was evaluated using the validated Continuing Professional Development reaction questionnaire, analysed using a paired t-test. The intervention ran from January to July 2023 and was accompanied by a nested process evaluation consisting of staff focus groups and a multistakeholder final evaluation workshop with a mix of lay, pharmacy staff and representatives from referral organisations. Data were collected on number and category of client contacts from intervention and control pharmacies; descriptive analyses were performed.

RESULTS: After intervention training, pharmacy staff showed statistically significant improvements in their levels of perceived ability, ease and confidence in responding to and referring people in need of help for domestic abuse and suicidal ideation with increased confidence in the ability of other pharmacy staff to support domestic abuse and suicidal ideation. During the intervention period, staff responded to 24 cases in intervention pharmacies: 8 for suicidal ideation, 9 for domestic abuse and 7 for both domestic abuse and suicidal ideation. Of these, 22 were staff-initiated and 2 were client-initiated. Two cases (one suicidal ideation and one domestic abuse) were identified in control pharmacies. Staff participants had a positive perception of the service and its impact on them and their clients. The multistakeholder workshop findings confirmed the feasibility of a staff-initiated response service for both domestic abuse and suicidal ideation in a community pharmacy setting. However, there were challenges marketing and delivering a client-initiated service, and the study was not able to collect all of the information required to inform a future trial.

LIMITATIONS: There were challenges to collecting data and obtaining informed consent from Lifeguard Pharmacy clients, especially when distressed or time-pressured. Consequently, full data sets were only collected from 4 of the 24 people who used the service. All 12 participating pharmacies were located in 1 region of England, hence a future study would need to test implementation across a broader range of settings.

CONCLUSIONS: It is feasible to implement a staff-initiated response service for domestic abuse and/or suicidal ideation in selected pharmacies. The combination of staff training, consultation guide, referral tool and client support resources and organisational support empowered staff to proactively identify people experiencing domestic abuse and/or suicidal ideation.

FUTURE WORK: Further development work would be needed before a client-initiated service could be delivered, and a future implementation study is contingent on finding ways to safely consent and collect data from clients. Some preliminary health economic work was conducted but a full health economic analysis would be needed as part of a future study.

FUNDING: This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme as award number NIHR133132.

PMID:41930409 | DOI:10.3310/TNFT6414

Inquiry. 2026 Jan-Dec;63:469580261427422. doi: 10.1177/00469580261427422. Epub 2026 Apr 3.

ABSTRACT

Improving medication adherence can reduce the burden of cardiovascular disease (CVD) in Saudi Arabia and its related healthcare expenses. This study aimed to assess physicians’ awareness and knowledge of barriers to medication adherence in cardiovascular patients in Saudi Arabia and to evaluate the strategies they employ in clinical practice to enhance adherence. A sample of Saudi Arabian licensed physicians specializing in CVD participated in an observational cross-sectional investigation. Participants were recruited using convenience sampling method through in-person visits conducted at various healthcare facilities. Using a standardized, peer-reviewed questionnaire spanning areas of knowledge, awareness, and practice, data were gathered. SPSS version 27 was used for statistical analysis; multivariate linear regression was utilized to identify independent factors. A total of 265 physicians participated. Among physicians, 44.9% always asked about medication habits, 26.8% about missed doses, 28.3% discussed illness severity, and 19.2% explained consequences of nonadherence. None consistently addressed side effects, though 46.4% did so frequently. Over half (58.1%) reported that 36% to 65% of patients failed to start therapy after the first prescription. Univariate analysis identified age as associated factors for knowledge, and sex, age, and training for practice. Regression analysis identified age and private work significant independent predictor for knowledge (β = -.05, -.68; P = .01, and .03; respectively), and only training remained a significant independent predictor for practice (β = 8.03, P < .001). Physicians showed modest knowledge with major gaps in practice especially educating patients about side effects and consequences of nonadherence. Knowledge was lower among older physicians and those in private practice, while training was the strongest predictor of better clinical practice, highlighting the need for targeted education and training to improve adherence-related practices.

PMID:41930408 | DOI:10.1177/00469580261427422

Int J Dent Hyg. 2026 Apr 3. doi: 10.1111/idh.70055. Online ahead of print.

ABSTRACT

BACKGROUND: This study assessed the impact of toothbrushing and exposure to cherry juice on the discoloration of various restorative materials commonly used in paediatric dentistry.

METHODS: Forty specimens of each of the three types of restorative material (compomer, resin-modified glass ionomer cement and composite) were prepared. The specimens were immersed in cherry juice and distilled water for 10 days, forming two subgroups (brushed and unbrushed) within each material group (n = 10). The brushed samples were treated every 8 h for 1 min daily over 10 days. The colour change was measured at baseline and after 10 days, and the data were analysed using three-way ANOVA and Tamhane’s T2 post hoc test.

RESULTS: After 10 days, the brushed, cherry juice-soaked resin-modified glass ionomer cement exhibited the highest ΔE00 value (13.91 ± 2.9), while the lowest value was observed in the unbrushed, distilled water-soaked microhybrid composite (0.90 ± 0.46). Statistically significant differences were found between materials (p < 0.001), brushed and unbrushed (p = 0.005), and cherry juice- and distilled water-soaked (p < 0.001).

CONCLUSION: Brushing and the consumption of colouring negatively influence the colour stability of restorative materials. The composites demonstrate greater resistance to discoloration from brushing and exposure to coloured beverages.

PMID:41930404 | DOI:10.1111/idh.70055

J Forensic Sci. 2026 Apr 3. doi: 10.1111/1556-4029.70322. Online ahead of print.

ABSTRACT

Soft tissue removal is a fundamental step in forensic anthropology, allowing for the detailed analysis of bone morphology and trauma. Among the available maceration techniques, hot water maceration is widely used due to its efficiency and ease of application. However, its effects on internal bone structure remain poorly documented. This study assessed the impact of simmering water maceration (85°C, 6 days) on cortical bone density using computed tomography (CT). Twelve paired femora and humeri from six human donors were scanned before and after maceration. Cortical bone density was measured in Hounsfield units (HU) at the proximal and distal diaphyses. Results showed no statistically significant changes in bone density post-maceration (p > 0.05). Femora demonstrated higher density than humeri, and male donors exhibited greater values than females. Intra- and inter-observer reproducibility was excellent, validating the reliability of the imaging protocol. These findings tend to support the idea that hot water maceration preserves bone mineral integrity and supports its continued use in forensic settings. The study also demonstrates the utility of CT-based densitometry as a precise, non-invasive method for postmortem bone analysis, contributing to the standardization of forensic protocols.

PMID:41930402 | DOI:10.1111/1556-4029.70322

Zhongguo Gu Shang. 2026 Mar 25;39(3):270-6. doi: 10.12200/j.issn.1003-0034.20250580.

ABSTRACT

OBJECTIVE: To compare clinical efficacy of direct opening with a pointed cone and opening assisted by a honeycomb guide for proximal femoral nail anti-rotation (PFNA) in treating intertrochanteric fractures in elderly.

METHODS: A retrospective analysis was conducted on 76 elderly patients with intertrochanteric fractures of femur treated with PFNA from January 2019 to December 2023, including 34 males and 42 females, aged from 65 to 93 years old with an average of (73.82±4.98) years old. According to the different opening methods at the top of the large rotor, all patients were divided into direct opening group with pointed cone and opening group assisted by honeycomb guide. There were 35 patients direct opening group with pointed cone in pointed cone direct opening group, including 16 males and 19 females, aged from 65 to 91 years old with an average of (73.44±5.12) years old;a sharp cone was used to directly open apex of the greater trochanter, and fluoroscopy was adjusted to the best position after satisfactory fracture reduction. There were 41 patients in opening group assisted by honeycomb guide, including 18 males and 23 females, aged from 65 to 93 years old with an average of (74.15±4.84) years old;at the apex of the large rotor, the positioning needle was adjusted to the optimal position with the assistance of honeycomb guide before opening. Operation time, fluoroscopy frequency, the occurrence of fracture re-displacement during the main screw insertion process, the quality of immediate fracture reduction after operation, fracture healing time, hip joint function at the final follow-up and the failure of internal fixation were compared between two groups.

RESULTS: Seventy-six were successfully followed up from 12 to 18 months (14.5±2.3) months. No internal fixation failures such as withdrawal or cutting of helical blade and fracture of screw occurred in either group. The quality of fracture reduction in opening group assisted by honeycomb guide showed 28 patients with excellent and 13 with acceptable;in direct opening group with pointed cone, the quality was excellent in 13 patients and acceptable in 22 patients;there was statistically significant difference between two groups(P<0.05). Harris hip score of opening group assisted by honeycomb guide was(85.64±7.91) points, which was better than that of direct opening group with pointed cone(82.06±7.52) points, and the difference was statistically significant (P<0.05). There was 1 patient of re-displacement of opening group assisted by honeycomb guide, and 5 patients of re-displacement in direct opening group with pointed cone, there was a statistically significant difference between two groups(P<0.05).

CONCLUSION: Both direct opening with a pointed cone and opening with the assistance of a honeycomb guide in treating intertrochanteric fractures of femur in elderly patients with PFNA could achieve good therapeutic effects. Opening assited with a honeycomb guide is superior to direct opening with pointed cone in avoiding re-displacement of fracture during the process of opening and expanding bone marrow, improving the quality of immediate fracture reduction after operation, and restoring hip joint function.

PMID:41930387 | DOI:10.12200/j.issn.1003-0034.20250580

Zhongguo Gu Shang. 2026 Mar 25;39(3):263-9. doi: 10.12200/j.issn.1003-0034.20221201.

ABSTRACT

OBJECTIVE: To compare clinical efficacy of endoscopic lumbar interbody fusion (Endo-PLIF) and traditional posterior lumbar interbody fusion (PLIF) in treating single-segment lumbar spinal stenosis.

METHODS: From July 2021 to April 2022, 56 patients with lumbar spinal stenosis who underwent lumbar decompression and fusion were included, and divided into observation group and control group according to treatment methods. There were 29 patients in observation group, including 16 males and 13 females;aged from 41 to 65 years old with an average of(53.64±6.34) years;body mass index (BMI) ranged from 10 to 35 kg·m^-2 with an average of (23.38±2.92) kg·m^-2;2 patients with L_3,4, 15 patients with L_4,5, and 12 patients with L₅S₁;treated with Endo-PLIF. There were 27 patients in control group, including 15 males and 12 females;aged from 42 to 60 years old with an average of (55.41±5.82) years;BMI ranged from 12 to 28 kg·m^-2 with an average of (24.20±2.18) kg·m^-2;1 patient with L_3,4, 17 patients with L_4,5, and 9 patients with L₅S₁;treated with PLIF. Operation time, incision length, intraoperative blood loss, postoperative drainage volume, hospital stay, and occurrence of postoperative complications between two groups were compared. Visual analogue scale (VAS) for lower back and lower limb pain and Oswestry Disability index (ODI) at preoperative, 3 days postoperative, 3 months postoperative, and the latest follow-up postoperative were assessed.

RESULTS: Both groups of patients were followed up, the follow-up period for observation group ranged from 4 to 8 months with an average of (7.3±2.2) months, and for control group ranged from 6 to 10 months with an average of (8.1±1.7) months;there was no statistically significant difference between two groups (P>0.05). Operation time, incision length, intraoperative blood loss, postoperative drainage volume and hospital stay of observation group were (140.24±45.39) min, (3.10±0.70) cm, (125.36±25.59) mL, (50.36±15.59) mL and (11.00±2.36) days respectively, while those of control group were (132.56±48.26) min, (10.10±1.00) cm, (258.51±38.25) mL, (155.28±21.34) mL and (18.00±2.58) days respectively;and the differences were statistically significant compared between two groups (P<0.05). VAS and ODI scores of lumbar and leg regions at 3 days, 3 months, and the final follow-up after operation were all improved compared with those of preoperative, and the differences were statistically significant (P<0.05). Moreover, VAS and ODI scores of lumbar and leg regions at each time point after operation in observation group were better than those in control group (P<0.05). At the latest follow-up, there were no cases of screw fracture, loosening, or fusion device withdrawal were found. No nerve root injuries occurred in either group after surgery. In observation group, 1 patient experienced increased leg pain and 1 patient experienced increased leg numbness;1 patient had cerebrospinal fluid leakage, 2 patients had increased leg pain, 1 patient had leg numbness, and 2 patients had incision necrosis in control group;the number of complications in observation group was better than that in control group, and had siginificant difference(P<0.05).

CONCLUSION: Compared with PLIF, Endo-PLIF has satisfactory therapeutic effects. It has advantages of reducing surgical trauma, shortening hospital stay of patients, and effectively improving symptoms.

PMID:41930386 | DOI:10.12200/j.issn.1003-0034.20221201

Zhongguo Gu Shang. 2026 Mar 25;39(3):254-62. doi: 10.12200/j.issn.1003-0034.20240929.

ABSTRACT

OBJECTIVE: To explore clinical efficacy of fixed-platform unicompartmental knee arthroplasty (UKA) with biologic femoral condyle prosthesis in treating medial compartment osteoarthritis of knee joint.

METHODS: A total of 89 patients with medial compartment osteoarthritis of knee joint who were admitted from January 2021 to December 2023 were selected, and divided into biological group and bone cement group according to different treatment methods. There were 45 patients in biological group, including 18 males and 27 females;aged from 54 to 68 years old with an average of (61.42±6.28) years old;the course of disease ranged from 1 to 5 months with an average of (3.74±0.52) months;28 patients with gradeⅡand 17 patients with grade Ⅲ according to Kellgren-Lawrence (K-L) classification;biological femoral head prosthesis was used. There were 44 patients in bone cement group, including 20 males and 24 females;aged from 52 to 69 years old with an average of (61.59±6.18) years old;the course of disease ranged from 0 to 6 months with an average of (3.80±0.49) months;28 patients with grade Ⅱand 16 patients with grade Ⅲ according to K-L classification;bone cement type femoral head prosthesis was used. Operative time, intraoperative blood loss, intraoperative tourniquet usage time, postoperative drainage volume, hospital stay, and complications between two groups were compared. The changes of Oxford University knee score (OKS), Western Ontario and McMaster Universities osteoarthritis index(WOMAC), and knee joint range of motion(ROM) between two groups before operation and after operation at 1, 3, and 6 months, visual analogue scale(VAS) before operation and after operation at 1, 3, 6 and 12 months were used to evaluate pain relief, changes of typeⅠcollagen carboxy-terminal peptideβ-specific sequence (β-CTX), total N-terminal propeptide of typeⅠprocollagen (tPⅠNP), and intact parathyroid hormone (iPTH) between two groups before operation and 6 months after operation were compared between two groups.

RESULTS: The usage time of hemostatic band during operation and hospital stay in biological group were (54.23±5.69) min and (13.13±1.36) days respectively, while those in bone cement group were (62.11±6.34) min and (10.02±1.27) days respectively;there were statistically significant differences between two groups (P<0.05). There were no statistically significant differences in operation time, intraoperative blood loss, and postoperative drainage volume between two groups (P>0.05). Postoperative OKS and WOMAC scores of biological group at 3 and 6 months were (21.13±2.45), (19.44±1.98), (25.14±2.65), (20.23±2.16) points respectively, which were all lower than those of cement group (24.83±2.57), (23.15±2.46), (29.33±2.98), (24.55±2.67) points;ROM was (119.42±12.57)° and (128.56±13.15)°, which were greater than those of cement group (112.34±12.58)° and (120.44±12.73)°;there were statistically significant differences between two groups (P<0.05). Postoperative VAS of biological group at 1 and 3 months were (2.23±0.24) and (1.92±0.23) respectively, which were higher than those of cement group (1.87±0.21) and (1.67±0.18), and the differences were statistically significant (P<0.05);however, there were no statistically significant differences in postoperative VAS between two groups at 6 and 12 months (P>0.05). At six months after operation, there were no significant differences inβ-CTX, tPⅠNP, and iPTH between two groups (P>0.05). There were no occurrences of implant-related complications such as sterile loosening or radiolucent lines of the prosthesis in both groups.

CONCLUSION: For the treatment of medial compartment osteoarthritis of knee joint with fixed-platform unicompartmental knee arthroplasty (UKA) with biologic femoral condyle prosthesis, bone cement type femoral condyle prosthesis results in less pain in the short term, while biological type femoral condyle prosthesis has a more advantageous long-term effect, which could improve knee joint function. Clinically, the type of prosthesis could be selected based on individual circumstances.

PMID:41930385 | DOI:10.12200/j.issn.1003-0034.20240929