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Nevin Manimala Statistics

Aseptic revisions and pulmonary embolism after surgical treatment of femoral neck fractures with cemented and cementless hemiarthroplasty in Germany : An analysis from the Germany Arthroplasty Registry (EPRD)

Orthopadie (Heidelb). 2023 Jul 8. doi: 10.1007/s00132-023-04412-3. Online ahead of print.

ABSTRACT

BACKGROUND: Femoral neck fractures (FNF) are among the most common fractures in Germany and are often treated by hemiarthroplasty (HA). The aim of this study was to compare the occurrence of aseptic revisions after cemented and uncemented HA for the treatment of FNF. Secondly, the rate of pulmonary embolism was investigated.

METHODS: Data collection for this study was performed using the German Arthroplasty Registry (EPRD). HAs after FNF were divided into subgroups stratified by stem fixation (cemented vs uncemented) and paired according to age, sex, BMI, and the Elixhauser score using Mahalanobis distance matching.

RESULTS: Examination of 18,180 matched cases showed a significantly increased rate of aseptic revisions in uncemented HA (p < 0.0001). After 1 month 2.5% of HAs with uncemented stems required an aseptic revision, whereas 1.5% were reported in cemented HA. After 1 and 3 years’ follow-up 3.9% and 4.5% of uncemented HA and 2.2% and 2.5% of cemented HA needed aseptic revision surgery. In particular, the proportion of periprosthetic fractures was increased in cementless implanted HA (p < 0.0001). During in-patient stays, pulmonary emboli occurred more frequently after cemented HA (0.81% vs 0.53% in cementless HA [OR: 1.53; p = 0.057]).

CONCLUSION: For uncemented hemiarthroplasties a statistically significantly increased rate of aseptic revisions and periprosthetic fractures was evident within a time period of 5 years after implantation. During the in-hospital stay, patients with cemented HA experienced an increased rate of pulmonary embolism compared with patients with cementless HA, but this difference was not statistically significant. Based on the present results, with knowledge of prevention measures and the correct cementation technique, the use of cemented HA should be preferred in the treatment of femoral neck fractures.

PMID:37422578 | DOI:10.1007/s00132-023-04412-3

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Nevin Manimala Statistics

Exploring the nonlinear relationship among financial development, human capital and CO2 emissions: a comparative study of South and East Asian emerging economies

Environ Sci Pollut Res Int. 2023 Jul 8. doi: 10.1007/s11356-023-28512-x. Online ahead of print.

ABSTRACT

Despite worldwide commitments to reduce fossil fuel consumption in favour of alternative energies, several countries still rely on carbon-intensive sources to meet their energy demands. The previous studies show inconsistent results on the association between financial development and CO2 emissions. As a result, the impact of financial development, human capital, economic growth and energy efficiency on CO2 emission is evaluated here. Empirical research on a panel of 13 South and East Asian (SEA) nations between 1995 and 2021 using the CS-ARDL. Estimates from the empirical analysis considering energy efficiency, human capital, economic growth and overall energy use yield different findings. Financial development has a negative effect on CO2 emission, while economic growth positively impacts CO2 emission. The data also show that improving human capital and energy efficiency has a positive, though statistically insignificant, impact on CO2 emission. According to the causes and effects analysis, CO2 emission will be influenced by policies that aim to improve financial development, human capital, and energy efficiency, but not vice versa. Policy considerations that can be implemented in light of these findings and sustainable development goals can be accomplished by promoting financial resources and human capital.

PMID:37422559 | DOI:10.1007/s11356-023-28512-x

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Nevin Manimala Statistics

Diagnostic trajectories of mental disorders in children and adolescents: a cohort study

Eur Child Adolesc Psychiatry. 2023 Jul 8. doi: 10.1007/s00787-023-02254-0. Online ahead of print.

ABSTRACT

Mental disorders in children and adolescents may follow different trajectories, such as remission, change of diagnosis, or addition of two or more comorbid diagnoses, showing a heterotypic pattern. This study aims to describe the main diagnostic trajectories across a broad range of mental disorder diagnostic categories, from childhood to adolescence and from adolescence to young adulthood in a clinical population. A prospective study was conducted among a clinical sample of children and adolescents who were aged 3-17 years at the face-to-face baseline interview. Electronic health records of these participants were reviewed 10 years later. The diagnostic stability over time was examined using the kappa coefficient, and factors associated with stability were explored using simple logistic regression. The study included a sample of 691 participants. The kappa coefficient for diagnostic stability across all diagnoses was 0.574 for the transition from childhood to adulthood, 0.614 from childhood to adolescence, and 0.733 from adolescence to adulthood. Neurodevelopmental diagnoses had the highest stability. Factors associated with higher diagnostic stability included family history of mental disorders, receiving psychopharmacological treatment, and symptom severity at baseline. We found a variable diagnostic stability across different diagnoses and age categories. The different life transitions represent complex periods that should not be overlooked from a clinical standpoint. An appropriate transition from child and adolescent mental health services to adult mental health services may have a positive impact on children and adolescents with mental disorders.

PMID:37422547 | DOI:10.1007/s00787-023-02254-0

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Nevin Manimala Statistics

Human-caused wolf mortality persists for years after discontinuation of hunting

Sci Rep. 2023 Jul 8;13(1):11084. doi: 10.1038/s41598-023-38148-z.

ABSTRACT

By the mid-twentieth century, wolves were nearly extinct in the lower 48 states, with a small number surviving in northern Minnesota. After wolves were placed on the endangered species list in 1973, the northern Minnesota wolf population increased and stabilized by the early 2000s. A wolf trophy hunt was introduced in 2012-2014 and then halted by a court order in December 2014. The Minnesota Department of Natural Resources collected wolf radiotelemetry data for the years 2004-2019. Statistical analysis showed that wolf mortality remained close to constant from 2004 until the initiation of the hunt, and that mortality doubled with the initiation of the first hunting and trapping season in 2012, remaining at a nearly constant elevated level through 2019. Notably, average annual wolf mortality increased from 21.7% before wolf hunting seasons (10.0% by human causes and 11.7% natural causes) to 43.4% (35.8% by human causes and 7.6% natural causes). The fine-grained statistical trend implies that human-caused mortality increased sharply during the hunting seasons, while natural mortality initially dropped. After the hunt’s discontinuation, human-caused mortality remained higher than prior to the hunting seasons throughout the five years of the available after-hunt radiotelemetry data.

PMID:37422540 | DOI:10.1038/s41598-023-38148-z

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Nevin Manimala Statistics

Extension and update of multiscale monthly household carbon footprint in Japan from 2011 to 2022

Sci Data. 2023 Jul 8;10(1):439. doi: 10.1038/s41597-023-02329-2.

ABSTRACT

Household consumption significantly contributes to greenhouse gas emissions as it is the largest component of final demand in the national accounting system. Nevertheless, there is an apparent lack of comprehensive and consistent datasets detailing emissions from household consumption. Here, we expand and update Japan’s multiscale monthly household carbon footprint from January 2011 to September 2022, combining data from government statistics and surveys. We constructed a dataset comprising 37,692 direct and 4,852,845 indirect emission records, covering households at the national, regional, and prefectural city levels. The dataset provides critical spatiotemporal information that allows for revealing carbon emission patterns, pinpointing primary sources of emissions, and discerning regional variances. Moreover, the inclusion of micro-scale carbon footprint data enables the identification of specific consumption habits, thereby regulating individual consumption behavior to achieve a low-carbon society.

PMID:37422522 | DOI:10.1038/s41597-023-02329-2

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Nevin Manimala Statistics

Prediction of injuries, traumas and musculoskeletal pain in elite Olympic and Paralympic volleyball players

Sci Rep. 2023 Jul 8;13(1):11064. doi: 10.1038/s41598-023-38112-x.

ABSTRACT

The study aimed to identify the prevalence and location of injuries, traumas, and musculoskeletal complaints in Paralympic and Olympic volleyball players with different impairments and initial playing positions (sitting/standing); and to identify the predictors of the abovementioned variables using a multivariate CRT model. Seventy-five elite volleyball players from seven countries took part in the study. They were divided into three study groups: (SG1)-lateral amputee Paralympic volleyball players, (SG2)-able-bodied Paralympic volleyball players, (SG3)-able-bodied Olympic volleyball players. The prevalence and location of the analyzed variables were assessed with surveys quessionaires, while game-related statistics was interpreted based on the CRT analysis. Regardless of the impairment or initial playing position, both the humeral and knee joints were found to be the most frequent locations of musculoskeletal pain and/or injuries in all studied groups, followed by LBP. Players from SG1 and SG3 were characterized by an almost identical prevalence of reported musculoskeletal pain and injuries, what was not noted in SG2. Extrinsic compensatory mechanism (playing position) may be a crucial variable for prediction of musculoskeletal pain and injuries in volleyball players. Lower limb amputation seems to impact the prevalence of musculoskeletal complaints. Training volume may predict the prevalence of LBP.

PMID:37422521 | DOI:10.1038/s41598-023-38112-x

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Nevin Manimala Statistics

Quantification of cartilage and subchondral bone cysts on knee specimens based on a spectral photon-counting computed tomography

Sci Rep. 2023 Jul 8;13(1):11080. doi: 10.1038/s41598-023-38238-y.

ABSTRACT

Spectral photon-counting computed tomography (SPCCT) is a new technique with the capability to provide mono-energetic (monoE) images with high signal to noise ratio. We demonstrate the feasibility of SPCCT to characterize at the same time cartilage and subchondral bone cysts (SBCs) without contrast agent in osteoarthritis (OA). To achieve this goal, 10 human knee specimens (6 normal and 4 with OA) were imaged with a clinical prototype SPCCT. The monoE images at 60 keV with isotropic voxels of 250 × 250 × 250 µm3 were compared with monoE synchrotron radiation CT (SR micro-CT) images at 55 keV with isotropic voxels of 45 × 45 × 45 µm3 used as benchmark for cartilage segmentation. In the two OA knees with SBCs, the volume and density of SBCs were evaluated in SPCCT images. In 25 compartments (lateral tibial (LT), medial tibial, (MT), lateral femoral (LF), medial femoral and patella), the mean bias between SPCCT and SR micro-CT analyses were 101 ± 272 mm3 for cartilage volume and 0.33 mm ± 0.18 for mean cartilage thickness. Between normal and OA knees, mean cartilage thicknesses were found statistically different (0.005 < p < 0.04) for LT, MT and LF compartments. The 2 OA knees displayed different SBCs profiles in terms of volume, density, and distribution according to size and location. SPCCT with fast acquisitions is able to characterize cartilage morphology and SBCs. SPCCT can be used potentially as a new tool in clinical studies in OA.

PMID:37422514 | DOI:10.1038/s41598-023-38238-y

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Nevin Manimala Statistics

The European Tertiary Education Register, the reference dataset on European Higher Education Institutions

Sci Data. 2023 Jul 8;10(1):438. doi: 10.1038/s41597-023-02353-2.

ABSTRACT

The European Tertiary Education Register (ETER) is the reference dataset on European Higher Education Institutions (HEIs). ETER provides data on nearly 3,500 HEIs in about 40 European countries, including descriptive information, geographical information, students and graduates (with various breakdowns), revenues and expenditures, personnel, and research activities; as of March 2023, data cover the years from 2011-2020. ETER complies with OECD-UNESCO-EUROSTAT standards for educational statistics; most data are collected from National Statistical Authorities (NSAs) or ministries of participating countries and are subject to extensive checks and harmonization. The development of ETER has been funded by the European Commission and is part of the current efforts to establish a European Higher Education Sector Observatory; it is closely connected to the establishment of a broader data infrastructure in the field of science and innovation studies (RISIS). The ETER dataset is widely used in the scholarly literature on higher education and science policy, as well as for policy reports and analyses.

PMID:37422512 | DOI:10.1038/s41597-023-02353-2

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Nevin Manimala Statistics

Estimating vaccine coverage in conflict settings using geospatial methods: a case study in Borno state, Nigeria

Sci Rep. 2023 Jul 8;13(1):11085. doi: 10.1038/s41598-023-37947-8.

ABSTRACT

Reliable estimates of subnational vaccination coverage are critical to track progress towards global immunisation targets and ensure equitable health outcomes for all children. However, conflict can limit the reliability of coverage estimates from traditional household-based surveys due to an inability to sample in unsafe and insecure areas and increased uncertainty in underlying population estimates. In these situations, model-based geostatistical (MBG) approaches offer alternative coverage estimates for administrative units affected by conflict. We estimated first- and third-dose diphtheria-tetanus-pertussis vaccine coverage in Borno state, Nigeria, using a spatiotemporal MBG modelling approach, then compared these to estimates from recent conflict-affected, household-based surveys. We compared sampling cluster locations from recent household-based surveys to geolocated data on conflict locations and modelled spatial coverage estimates, while also investigating the importance of reliable population estimates when assessing coverage in conflict settings. These results demonstrate that geospatially-modelled coverage estimates can be a valuable additional tool to understand coverage in locations where conflict prevents representative sampling.

PMID:37422502 | DOI:10.1038/s41598-023-37947-8

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Nevin Manimala Statistics

The relationship between functional constipation and overweight/obesity in children: a systematic review and meta-analysis

Pediatr Res. 2023 Jul 8. doi: 10.1038/s41390-023-02711-1. Online ahead of print.

ABSTRACT

BACKGROUND: Studies have reported the relationship between functional constipation and obesity in pediatric population. However, the results are contradictory. The purpose of this study is to evaluate the possible association between these two disorders in pediatric population.

METHODS: Four databases including PubMed, Embase, CENTRAL, and Web of Science were searched until 30 September 2022. The review was done in accordance with PRISMA guidelines and registered in PROSPERO (CRD42022328992) RESULTS: Nine studies met the eligibility criteria, including 7444 participants. Studies showed the risk of obesity was significantly increased in boys with functional constipation (CI: 1.12, 3.07; P = 0.016). Such an association was also observed in girls (CI: 1.42-4.47; P = 0.00). A statistically significant association was observed between overweight/obesity and increased risk of functional constipation in children and adolescents (CI: 1.14-3.97; P = 0.02). Especially in developed countries (CI: 1.49-3.46; P = 0.00); however, no significant association was observed in developing countries (CI: 0.81-5.3; P = 0.13).

CONCLUSIONS: There is a risk of obesity in either boys or girls with functional constipation. An association exists between the risk of functional constipation and children/adolescents with obesity, especially in developed countries, but not in developing countries.

IMPACT: Our study encourages further research in this field because early detection and intervention are crucial for both functional constipation and overweight/obesity in children, to better identify its complex biology and possibly optimize the treatment approaches.

PMID:37422494 | DOI:10.1038/s41390-023-02711-1