Tag: pubmed

Physiol Res. 2021 Sep 10. Online ahead of print.

ABSTRACT

Diabetic foot ulcer (DFU) is a serious complication of diabetes and hyperbaric oxygen therapy (HBOT) is also considered in comprehensive treatment. The evidence supporting the use of HBOT in DFU treatment is controversial. The aim of this work was to introduce a DFU model in ZDF rat by creating a wound on the back of an animal and to investigate the effect of HBOT on the defect by macroscopic evaluation, quantitative histological evaluation of collagen (types I and III), evaluation of angiogenesis and determination of interleukin 6 (IL6) levels in the plasma. The study included 10 rats in the control group (CONT) and 10 in the HBOT group, who underwent HBOT in standard clinical regimen. Histological evaluation was performed on the 18th day after induction of defect. The results show that HBOT did not affect the macroscopic size of the defect nor IL6 plasma levels. A volume fraction of type I collagen was slightly increased by HBOT without reaching statistical significance (1.350.49 and 1.94+/-0.67 %, CONT and HBOT, respectively). In contrast, the collagen type III volume fraction was ~120 % higher in HBOT wounds (1.41+/-0.81 %) than in CONT ones (0.63+/-0.37 %; p=0.046). In addition, the ratio of the volume fraction of both collagens in the wound ((I+III)w) to the volume fraction of both collagens in the adjacent healthy skin ((I+III)h) was ~65 % higher in rats subjected to HBOT (8.9+/-3.07 vs. 5.38+/-1.86 %, HBOT and CONT, respectively; p=0.028). Vessels density (number per 1 mm2) was found to be higher in CONT vs. HBOT (206.5+/-41.8 and 124+/-28.2, respectively, p<0.001). Our study suggests that HBOT promotes collagen III formation and decreases the number of newly formed vessels at the early phases of healing.

PMID:34505531

Ophthalmic Epidemiol. 2021 Sep 10:1-7. doi: 10.1080/09286586.2021.1976805. Online ahead of print.

ABSTRACT

PURPOSE: This study was undertaken to evaluate the complication rates and visual outcomes of outreach cataract surgeries done in makeshift operating rooms.

METHOD: In this retrospective study, surgical outcomes of consecutive Manual Small Incision Cataract Surgeries (MSICS) done in 11 rural camps in Nepal were compared with the results of consecutive hospital surgeries (MSICS and phacoemulsification) done by the same surgeon. Surgeries were done from September 2018 to March 2020.

RESULTS: Out of 1034 study population in each group, a significantly higher number (p < .001) of camp patients (27%, n = 279) were either blind or had severe visual impairment when compared to hospital patients (18.6%, n = 192). Around 88.9% (n = 919) of cases operated in camps and 85.7% (n = 886) in the hospital achieved uncorrected visual acuity (VA) of 6/18 or better on the first postoperative day. Poor outcome (VA<6/60) was seen in 3.7% (n = 38) of cases in camps and 3.9% (n = 40) in the hospital. The difference in visual outcomes was not significant (p = .162) when the results were controlled for other associated variables. There was no significant difference (p = .126) between complication rates in camps (1.9%, n = 20) and hospital surgeries (3.5%, n = 36) when preoperative conditions were statistically controlled. No cases of endophthalmitis were reported.

CONCLUSIONS: Makeshift operating rooms can be used for cataract surgeries in rural areas where no standard operating rooms are available. If appropriate patient selection criteria and standard surgical protocols are followed, good surgical outcomes can be achieved in camps by an experienced surgical team.

PMID:34505552 | DOI:10.1080/09286586.2021.1976805

Oral Health Prev Dent. 2021 Jan 7;19(1):441-448. doi: 10.3290/j.ohpd.b1993965.

ABSTRACT

PURPOSE: During the past 20 years, a plethora of research reports has been published showing a statistical association between poor oral health and cardiovascular diseases. The aim of this narrative review was to focus on associations between oral infections and non-atherosclerosis-related systemic diseases.

MATERIALS AND METHODS: An open literature search and evaluation of articles were conducted on Medline and Cochrane databases with the key words ‘oral infection’, ‘periodontitis’, ‘pneumonia’, ‘osteoarthritis’, ‘rheumatic diseases’, ‘inflammatory bowel disease’, ‘kidney disease’, ‘liver diseases’, ‘metabolic syndrome’, ‘diabetes’, ‘cancer’, ‘Alzheimer’s disease’. Cardiovascular diseases were excluded from the analysis.

RESULTS: The scarcity of controlled studies did not allow conducting a systematic review with meta-analysis on the topics, but dental infections have been shown be associated with several general diseases also beyond the atherosclerosis paradigm. However, there is no causal evidence of the role of dental infections in this regard. Poor oral health has nevertheless often been observed to be associated with worsening of the diseases and may also affect treatments.

CONCLUSIONS: Maintaining good oral health is imperative regarding many diseases, and its importance in the daily life of any patient group cannot be over emphasised.

PMID:34505498 | DOI:10.3290/j.ohpd.b1993965

Oral Health Prev Dent. 2021 Jan 7;19(1):449-456. doi: 10.3290/j.ohpd.b1993989.

ABSTRACT

PURPOSE: Dental symptoms of post-traumatic stress disorder (PTSD) patients include a majority of painful temporomandibular joint and masticatory muscle findings, restricted mouth opening, and pronounced attritions. Traumatic occlusal force resulting in injury of the teeth and/or the periodontal attachment apparatus may exceed the adaptive capacity of the individual person or site. This observational cross-sectional study in soldiers with PTSD and a non-PTSD control group after military deployments aimed to evaluate a possible relationship between bruxism and periodontal diagnosis.

MATERIALS AND METHODS: Ninety-six in-patients and 27 out-patients (21 women, 102 men) with specialist-confirmed PTSD and bruxism after up to 17 foreign assignments, and 36 male non-PTSD controls with up to 15 foreign assignments underwent general dental, functional, and periodontal examinations.

RESULTS: All three groups showed no statistically significant differences in terms of age (34.8 ± 8.6 years), number of teeth (n: 26.3 ± 3.4), status of dentition (DMFT 9.7 ± 6.6), incidence of periodontitis (36%) and recessions (n: 5.8 ± 5.7). From the control group to the out-patient group to the in-patient group, the proportion of smokers and tobacco use increased statistically significantly, as did the extent of attrition. In the in-patient group, with statistically significantly lower educational levels, the number of perceived prophylaxis sessions was statistically significantly reduced in the last two years.

CONCLUSIONS: Taking into account the retrospective recording of the last traumatic event, the average time of five years until therapy does not seem to have any consequences for the frequency and severity of inflammatory periodontal disease, recession, and wedge-shaped defects in soldiers with bruxism in PTSD, regardless of the need for in-patient or out-patient treatment.

PMID:34505499 | DOI:10.3290/j.ohpd.b1993989

Oral Health Prev Dent. 2021 Jan 7;19(1):425-431. doi: 10.3290/j.ohpd.b1993907.

ABSTRACT

PURPOSE: To assess the impact of participation in a group oral health education course on oral hygiene in Romanian military students compared to a non-participant control group.

MATERIALS AND METHODS: A sample of 318 participants was enrolled from 805 recruited students. Baseline and 6-month post-intervention Simplified Oral Hygiene Index (OHI-S) scores were compared between an oral health education intervention (OHE) group (N = 159) and a control group (N = 159) using Student’s t-test. All participants received individualised instruction; only those in the OHE group participated in interactive group oral-health training.

RESULTS: Post-intervention OHI-S scores improved statistically significantly (p< 0.05) in both groups compared to baseline scores. The OHE group’s post-intervention OHI-S scores were statistically significantly better (p< 0.05) than the control group’s intervention scores. Women had better OHI-S scores than men at both time points.

CONCLUSIONS: An interactive educational module produced favorable oral health results. It would be appropriate to provide an oral health course to military students aimed at supporting the maintenance of good oral health.

PMID:34505496 | DOI:10.3290/j.ohpd.b1993907

Oral Health Prev Dent. 2021 Jan 7;19(1):433-440. doi: 10.3290/j.ohpd.b1993933.

ABSTRACT

PURPOSE: To investigate the possibility of reducing the erosive potential of salad dressings by adding yoghurt.

MATERIALS AND METHODS: Two hundred enamel samples from bovine teeth were allocated to 20 groups (n = 10). Three modified commercially available balsamic dressings (addition of 10%, 20%, 50% yoghurt or 8.8 mM calcium chloride) and two homemade salad dressings with and without modifications were tested. Enamel samples were eroded for 2 min, rinsed for 30 s with tap water and finally abraded (20 brushing strokes with toothpaste slurry). After 40 of these cycles of erosion/abrasion, the dental hard tissue loss was determined by contact profilometry.

RESULTS: For commercially available salad dressings, modification yielded a statistically significant decrease in enamel wear. The exception was Anna’s Best Dressing Balsamico modified with 8.8 mM calcium chloride, for which no reduction was found compared with the unmodified dressing. For all homemade dressings, a significant reduction was observed when modified with 20% yoghurt. However, when only 10% yoghurt was added to the homemade dressings, an increase of the erosive potential was observed compared to the unmodified dressing.

CONCLUSIONS: The study shows that increasing the calcium concentration only with calcium chloride in commercially available salad dressings did not show predictable outcomes to reduce erosion. However, mixing 20% plain yoghurt into the dressings reduced the erosive potential statistically significantly.

PMID:34505497 | DOI:10.3290/j.ohpd.b1993933

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2021 Aug 20;33(4):373-379. doi: 10.16250/j.32.1374.2021117.

ABSTRACT

OBJECTIVE: To analyze the epidemiological characteristics and diagnosis of imported malaria before and after malaria elimination in Nanjing City of Jiangsu Province, so as to provide the scientific evidence for formulating the malaria control strategy after malaria elimination.

METHODS: Data pertaining to the epidemic situation and individual investigation of malaria in Nanjing City before (from 2012 to 2016) and after malaria elimination (from 2017 to 2020) were captured from the National Notifiable Communicable Disease Reporting System and the Information System for Parasitic Diseases Control and Prevention and were analyzed statistically.

RESULTS: A total of 178 malaria cases were reported in Nanjing City from 2012 to 2020, and all were imported cases. There were 99 malaria cases reported before malaria elimination in Nanjing City, including 78 cases with Plasmodium falciparum malaria (78.79%), 5 cases with P. vivax malaria (5.05%), 10 cases with P. ovale malaria (10.10%), 3 cases with P. malariae malaria (3.03%) and 3 cases with mixed infections (3.03%), and 79 malaria cases reported after elimination, including 63 cases with P. falciparum malaria (79.75%), 5 cases with P. vivax malaria (6.33%), 9 cases with P. ovale malaria (11.39%), 2 cases with P. malariae malaria (2.53%). There was no significant difference in the proportion of each type of malaria cases in Nanjing City before and after malaria elimination (χ² =2.400, P > 0.05). Malaria cases mainly acquired Plasmodium infections in African regions, and no significant difference was seen in the proportion of malaria cases returning to Nanjing City from African countries before and after malaria elimination (χ² = 0.093, P > 0.05). The number of malaria cases peaked in Nanjing City in January and during the period from May to July before elimination, and there was no apparent seasonal variation in the distribution of malaria cases after elimination. The proportion of malaria cases living in Nanjing City was significantly greater after malaria elimination than before elimination (72.15% vs. 55.56%; χ² = 5.187, P = 0.023). The proportions of businessmen and international students were both 5.05% before malaria elimination, and increased to 15.19% and 13.92% after elimination, respectively (χ² = 5.229 and 4.229, both P values < 0.05). The percentage of definitive diagnosis of malaria at initial diagnosis was 18.75% in county-level hospitals before malaria elimination and increased to 61.11% after elimination (χ² = 6.275, P = 0.012), while the proportion of malaria cases with definitive diagnoses in county-level hospitals was 4.04% before malaria elimination and increased to 13.92% after elimination (χ² = 5.562, P = 0.018). During the period from 2012 to 2020, the proportion of malaria cases with definitive diagnoses within 1 to 3 days post-admission increased from 27.27% in Nanjing City before malaria elimination to 45.57% after elimination (χ² = 6.433, P = 0.011).

CONCLUSIONS: The epidemic situation of imported malaria remains serious in Nanjing City during the post-elimination stage, and malaria parasite infections predominantly occur in African regions. In addition, there are changes in regional and occupational distributions of malaria cases and the diagnostic capability of malaria increases in county-level hospitals in Nanjing City after malaria elimination. Further improvements in the malaria surveillance system and the diagnostic and treatment capability of malaria in medical institutions at each level are required to consolidate malaria elimination achievements in Nanjing City.

PMID:34505444 | DOI:10.16250/j.32.1374.2021117

Tidsskr Nor Laegeforen. 2021 Aug 25;141(2021-12). doi: 10.4045/tidsskr.21.0037. Print 2021 Sep 7.

ABSTRACT

BACKGROUND: The study aimed to evaluate a new algorithm based on analyses of high-sensitivity troponin I for rapid diagnostic clarification in cases of suspected cardiac chest pain.

MATERIAL AND METHOD: Two time periods – before (01.10.2016-31.12.2016) and after (01.03.2017-28.02.2018) the introduction of a diagnostic algorithm – were studied by reviewing the medical records of patients who arrived at the emergency department with chest pain. The diagnostic algorithm included a high-sensitivity troponin I test on admission (0 hours) and one hour later (the 0 h/1 h algorithm). The primary endpoint was the proportion of patients that were discharged directly from the emergency department. Secondary endpoints were acute cardiac arrest and death within 30 days and within one year.

RESULTS: A larger proportion of patients with chest pain were discharged directly from the emergency department when the 0 h/1 h algorithm was used (10/91 (11 %) before versus 118/306 (39 %) after, p <0.001). Deaths and the incidence of acute myocardial infarction one year after the introduction of the 0 h/1 h algorithm were low (≤ 3 %) and not statistically different from the period before the introduction (p≥ 0.20).

INTERPRETATION: The implementation of a diagnostic algorithm based on measurements of high-sensitivity troponin I resulted in fewer patients being hospitalised, and we did not register more deaths or deaths from myocardial infarction. The algorithm was suitable for identifying patients with chest pain who could safely be discharged without the need for hospitalisation, which we believe may optimise patient flow in hospitals.

PMID:34505494 | DOI:10.4045/tidsskr.21.0037

Endocrinol Diabetes Metab. 2021 Jul 3:e00285. doi: 10.1002/edm2.285. Online ahead of print.

ABSTRACT

INTRODUCTION: The prevalence of gestational diabetes mellitus (GDM) is increasing in developing countries including the South Asian Nations. The current study aimed to examine the association of GDM with adverse pregnancy outcomes from foetal and maternal perspectives in South Asia.

METHODS: A systematic review was conducted including primary studies published since January 2020 from South Asian countries. Following electronic databases were searched to locate the articles: MEDLINE, EMBASE and EMCARE. Data were extracted using a customized extraction tool and methodological quality of the included studies was assessed using modified Effective Public Health Practice Project (EPHPP) quality assessment tool. Narrative synthesis was performed as statistical pooling was not possible due to the heterogeneous nature of the studies.

RESULTS: Eight studies were included in the review. Overall, the review found a positive correlation between GDM and adverse foetal outcomes such as macrosomia, neonatal hyperglycaemia, intrauterine growth retardation (IUGR), stillbirths and low birthweight (LBW), but the findings were not conclusive. GDM was also positively associated with preeclampsia but the association between GDM and C-section delivery was not conclusive.

CONCLUSION: Policymakers, public health practitioners and researchers in South Asia should take in to account the link between GDM and adverse pregnancy outcomes while designing interventions to promote maternal health in South Asia. Researchers should focus on conducting longitudinal studies in future to clearly understand the epidemiology and pathobiology of this issue.

PMID:34505412 | DOI:10.1002/edm2.285

Endocrinol Diabetes Metab. 2021 Jun 23:e00282. doi: 10.1002/edm2.282. Online ahead of print.

ABSTRACT

INTRODUCTION: Bariatric surgery is safe and efficient surgical method for weight loss, but it is not free from complications. We aim to evaluate the prevalence of depression after Sleeve Gastrectomy (SG) in a narrow period of time on Iranian ethnicity.

METHODS: 307 cases that underwent SG in Erfan Niayesh hospital were included. The questionnaire was based on International Classification of Diseases, Ninth Revision (ICD-9) codes to define diagnoses. Screening follow-up period was 20 to 24 months. The level of statistical significance was set at p < .05.

RESULTS: Of 307 subjects, preoperative depression was 30.2% and post-operative depression was 37.7% (p = .025). Besides, BMI, dyslipidaemia, good feelings about body size and weight loss were statistically significant at p < .05.There was an increased risk of depression following the procedure mainly in divorced cases.

CONCLUSION: The prevalence of clinical depression after sleeve gastrectomy was statistically significant and dependent on other variables. We provided guidance for people considering SG and their clinicians in terms of evaluating potential risks and benefits of surgery.

PMID:34505417 | DOI:10.1002/edm2.282