Tag: pubmed

Mov Disord. 2025 Oct 10. doi: 10.1002/mds.70084. Online ahead of print.

ABSTRACT

BACKGROUND: Friedreich’s ataxia is a rare, neurodegenerative, multisystem disorder. While ataxia is a hallmark, non-ataxia signs, including muscle weakness, spasticity, and dysphagia are equally disabling. The Inventory of Non-Ataxia Signs (INAS) is a symptom list transformable to a 16-item count.

OBJECTIVE: To evaluate the responsiveness of a modified INAS in this population.

METHODS: Participants were drawn from the European Friedreich’s Ataxia Consortium for Translational Studies (EFACTS). The modified INAS count (presence/absence, 0-16 scale) and modified INAS sum (severity-weighted, 0-84 scale) were evaluated using linear mixed-models and standardized response means (SRMs). Items rare (<5%) and uncharacteristic in Friedreich’s ataxia were excluded (chorea, myoclonus, fasciculations, resting tremor, rigidity) RESULTS: A total of 1129 participants (mean age, 32.3 years) were assessed for up to 12 years. The mean modified INAS count was 4.6 (±2.2) and modified INAS sum 15.1 (± 9.9). Both correlated strongly with existing outcome measures. Longitudinally, the modified INAS count increased by 0.13 points/year (95% CI 0.12, 0.14; P < 0.001) and modified INAS sum by 0.68 points/year (95% CI 0.64, 0.72; P < 0.001). The modified INAS sum demonstrated greater responsiveness, with SRMs of 0.26, 0.38, 0.53, and 0.80 at 1, 2, 3, and 5 years, respectively, compared with 0.16, 0.27, 0.31, and 0.46 for the modified INAS count. In non-ambulatory patients and children, responsiveness of the modified INAS sum was higher (SRM 0.82 and 1.7 at 5 years, respectively).

CONCLUSIONS: The modified INAS sum showed good responsiveness over 5 years but not over 1-3 years. It may supplement existing outcome measures, contributing to holistic assessment of this multisystem disease, especially in non-ambulatory patients, in whom ataxia-focused measures may show ceiling effects, and children, who typically progress faster. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

PMID:41070559 | DOI:10.1002/mds.70084

J Oral Facial Pain Headache. 2025 Jun;39(2):202-209. doi: 10.22514/jofph.2025.039. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: This study investigated how cumulative lifetime stress, as measured by the Stress and Adversity Inventory (STRAIN) scale, relates to salivary cortisol levels in temporomandibular disorders (TMD) patients compared to controls. Furthermore, to determine which specific lifetime stress domains are the strongest predictors of TMD.

METHODS: The study was conducted with 110 participants (55 TMDs patients, 55 controls). Lifetime stress was assessed using the STRAIN questionnaire, and salivary cortisol levels were measured at two time points (7 AM and 10 AM) using Enzyme-Linked Immunosorbent Assay (ELISA). Statistical analyses included t-tests, Analysis of variance (ANOVA) and multiple regression to identify significant stress predictors for TMD.

RESULTS: The TMDs patients had significantly higher stress scores (11.10 ± 3.26) compared to the controls (1.43 ± 0.99) (p = 0.001). Myalgia showed highest stress levels (11.69 ± 3.72), while patients with myofascial pain had the lowest (8.80 ± 1.14) (p = 0.043). Cortisol levels were highest in the of disc displacement without reduction with limited mouth opening (DDWoR with LO) group (82.49 ± 124.34) and lowest in myalgia patients (4.69 ± 3.90) (p = 0.001). Significant stress predictors for TMDs included relationship stress (p = 0.04), humiliation (p = 0.02), marital/partner stress (p < 0.001) and death-related stress (p = 0.01).

CONCLUSIONS: TMDs patients experience significantly higher lifetime stress and cortisol levels than controls. Myalgia patients showed a complex psychological and physiological stress link, whereas the DDWoR with LO subgroup exhibited a distinct physiological stress response. Specific life stressors, particularly relationship- and partner-related stress, are key predictors of TMDs. These findings reinforce the importance of a biopsychosocial approach in understanding and managing TMDs. Future research should focus on longitudinal and interventional studies to further elucidate causal mechanisms and effective therapeutic strategies.

PMID:41070548 | DOI:10.22514/jofph.2025.039

J Oral Facial Pain Headache. 2025 Jun;39(2):175-182. doi: 10.22514/jofph.2025.036. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: Masseter muscle hypertrophy is characterized by either symmetrical or asymmetrical enlargement of the muscle, often associated with bruxism and other parafunctional habits. Traditional methods for assessing muscle hypertrophy, such as palpation and visual inspection, can be subjective and heavily dependent on the clinician’s experience. In contrast, devices like MyotonPRO offer a standardized, objective and reproducible approach, enhancing the precision and reliability of clinical diagnostics. The primary aim of our study was to evaluate the intra- and inter-rater reliability of the MyotonPRO device in assessing the viscoelastic properties of the masseter muscle. Additionally, we sought to investigate the potential correlation between subjective assessments of masseter hypertrophy and objective measurements obtained through myotonometry.

METHODS: A clinical examination using muscle palpation was conducted to identify masseter hypertrophy, categorizing participants into Normal Muscle Volume (NMV) and Muscle Hypertrophy (MH) groups. The viscoelastic properties of their masseter muscles were then measured using MyotonPRO in both relaxed and maximal contraction states. Two experienced operators performed the myotonometry on the same day, with the first operator repeating the procedure 7 days later.

RESULTS: Among the 58 participants, 51.7% were female, with a mean age of 28.6 years. The inter-rater reliability of masseter muscle measurements using MyotonPRO ranged from moderate to excellent, both at rest and during contraction, while intra-rater reliability ranged from moderate to good. The MH group showed higher levels of tension and stiffness, along with reduced relaxation time and creep during contraction, compared to the NMV group. The only statistically significant difference in relaxation between the groups was observed in muscle elasticity.

CONCLUSIONS: The MyotonPRO device effectively detects statistically significant differences (p < 0.05) between the MH and NMV groups for certain viscoelastic parameters. However, these differences were primarily significant during contraction, with elasticity being the only parameter showing a significant difference in the relaxed state.

PMID:41070545 | DOI:10.22514/jofph.2025.036

J Oral Facial Pain Headache. 2025 Jun;39(2):124-136. doi: 10.22514/jofph.2025.031. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: Migraine is a chronic neurological disorder affecting over one billion individuals globally. It is a leading cause of disability, significantly impacting daily functioning, social relationships and work-related productivity. This study aims to explore the impact of migraine-related disability in everyday life in terms of missed days and productivity loss, as well as to identify work-related difficulties associated with migraine and the potential factors that exacerbate these difficulties.

METHODS: This cross-sectional study was conducted from October 2023 to June 2024, involving 604 adult patients with migraine in Greece, selected through a convenience sampling method. Data collected included socio-demographic and clinical information, obtained using two validated self-reported questionnaires: the Migraine Disability Assessment (MIDAS) and the HEADWORK questionnaire. Statistical analysis was performed using IBM SPSS (Version 20.0), and descriptive statistics, chi-square tests, t-tests and Spearman’s correlation were employed to evaluate the relationship between disability and work-related challenges.

RESULTS: The MIDAS score revealed a high level of disability, with 52.2% of participants classified in the Severe Disability grade. HEADWORK scores highlighted moderate-to-severe work-related difficulties, particularly concerning stress management and environmental factors such as noise and brightness. Females, patients experiencing migraine with aura, and individuals with chronic migraine exhibited higher MIDAS and HEADWORK scores.

CONCLUSIONS: This study reveals the substantial impact of migraine on professional productivity and social relationships, emphasizing challenges in work-related performance and daily activities. The findings underscore the need for workplace accommodations and targeted interventions to improve the quality of life of individuals with migraine.

PMID:41070540 | DOI:10.22514/jofph.2025.031

J Oral Facial Pain Headache. 2025 Jun;39(2):101-111. doi: 10.22514/jofph.2025.029. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: Temporomandibular disorder (TMD) is a prevalent condition associated with pain and dysfunction of the temporomandibular joint (TMJ) and surrounding structures. Sleep disturbances are common in TMD patients, yet the bidirectional causal relationship between specific sleep behaviors and TMD remains unclear. This study aimed to investigate this relationship using a two-sample Mendelian randomization (MR) approach.

METHODS: A bidirectional two-sample MR analysis was conducted using genome-wide association study (GWAS) summary statistics for seven sleep behaviors and TMD/TMD related pain (TMD-pain). Single nucleotide polymorphisms (SNPs) were used as instrumental variables. The analysis included data from the UK Biobank and FinnGen Consortium, focusing on individuals of European ancestry. Statistical methods included inverse variance weighting (IVW), MR-Egger regression and sensitivity analyses to ensure robust findings.

RESULTS: The analysis identified that genetically predicted “morning person” status reduced the risk of TMD (β: -0.173, p = 0.014), while longer sleep duration decreased the risk of TMD-pain (β: -0.382, p = 0.015). In reverse MR analysis, TMD-pain increased the risk of insomnia, obstructive sleep apnea (OSA) and sleep disorders (p < 0.05). No significant associations were found between other sleep behaviors and TMD or TMD-pain.

CONCLUSIONS: This study demonstrates a bidirectional relationship between sleep behaviors and TMD. Being a morning person and having longer sleep duration protect against TMD and TMD-pain, respectively, while TMD-pain increases the risk of certain sleep disorders. These findings highlight the importance of addressing sleep issues in TMD management.

PMID:41070538 | DOI:10.22514/jofph.2025.029

J Oral Facial Pain Headache. 2025 Jun;39(2):48-65. doi: 10.22514/jofph.2025.025. Epub 2025 Jun 12.

ABSTRACT

BACKGROUND: Understanding the global prevalence and characteristics of a given health problem is essential for sizing its global and regional burden, estimating treatment needs, prioritizing healthcare services, and formulating targeted policies. This systematic review and meta-analysis aimed to estimate the global prevalence of temporomandibular disorders (TMDs) by gender, age, and continent, and the prevalence of specific categories such as myalgia, arthralgia, clicking/joint sounds, and limited mouth opening.

METHODS: A comprehensive search was conducted across three databases-PubMed, Scopus and Web of Science and supplemented by manual search up to June 2024. TMD diagnoses were based on the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) or Diagnostic Criteria for Temporomandibular Disorders (DC/TMD).

RESULTS: The database search yielded 15,628 records, from which 27 studies involving 20,971 subjects, including 6075 diagnosed with TMDs, were selected for final analysis. All meta-analyses utilized a random effects model. It is estimated that nearly a third of the global population (29.5%) suffers from TMDs. TMDs affected females at a significantly higher rate compared to males (36.7% versus 26.7%), representing a 1.75-fold greater likelihood among females. Prevalence among individuals under 18 years of age is 38.5%, compared to 34.1% in those 18 and older. TMDs are most prevalent in Europe (33.8%), followed by Asia (27.9%) and South America (27.3%); the lowest prevalence was in North America (19.4%). The most frequently reported signs and symptoms of TMDs are myalgia (37.2%), clicking/joint sounds (29.8%), and arthralgia (16.8%), with limited mouth opening/locking being the least prevalent (8.1%).

CONCLUSIONS: TMDs represent a significant and largely unrecognized health burden. Although conducting further primary studies is urgent for confirmation, this current research underscores that TMDs might constitute a silent epidemic that has not garnered the urgent attention it deserves from healthcare providers, the local community, and researchers.

THE PROSPERO REGISTRATION: PROSPERO number is CRD42024583777.

PMID:41070533 | DOI:10.22514/jofph.2025.025

Turk Psikiyatri Derg. 2025;36:57. doi: 10.5080/u27671.

ABSTRACT

OBJECTIVE: The aim of this study was to compare cognitive flexibility and executive functions in adolescents diagnosed with social anxiety disorder (SAD) who have autistic traits with those who do not, and to investigate whether there is a significant difference compared to healthy controls.

METHOD: The study included 36 adolescents diagnosed with SAD and 36 healthy controls. All participants completed the Cognitive Flexibility Scale (CFS), and the Liebowitz Social Anxiety Scale was administered to the SAD group. Neuropsychological tests including the Stroop Test TBAG Form, the Wisconsin Card Sorting Test (WCST), Raven&rsquo;s Standard Progressive Matrices Test, and Visual-Auditory Digit Span Test-B were applied. Autistic traits were assessed using the Autism Spectrum Quotient-Adolescent&rsquo;s Version (AQ-Adolescent) and the Childhood Autism Rating Scale.

RESULTS: There was no statistically significant difference in CFS scores between the social anxiety disorder and control groups. The SAD group showed poorer performance in the subdomains of the WCST. Additionally, in all subtestes of the Stroop test, the SAD group took significantly longer to complete the test. The AQ-Adolescent scores were significantly higher in the SAD group compared to the controls. In 25% (n=9) of the cases, autistic traits were above the cutoff. There were no significant difference in neuropsychological test results between the groups who have and do not have autistic traits within the case group. A weak negative correlation was found between the Liebowitz total and avoidance subscale scores and the AQ-imagination and attention to detail scores, while no correlation was found between the Liebowitz dimensions and CFS scores.

CONCLUSION: This is the among the first studies to examine autistic traits and executive functions among adolescents with SAD. While no difference was found in cognitive flexibility scale scores between the SAD and control groups, the SAD group showed poorer performance in tests measuring other executive functions. However, this difference was not significantly influenced by the presence of autistic traits.

PMID:41070518 | DOI:10.5080/u27671

BMC Public Health. 2025 Oct 9;25(1):3426. doi: 10.1186/s12889-025-24643-7.

ABSTRACT

BACKGROUND: Childhood malnutrition remains a public health concern in Rwanda, with stunting rates at 33%, underweight at 8%, and wasting at 1%. These rates are particularly high in rural areas. As primary caregivers, women play a central role in child nutrition, their financial inclusion may significantly influence child health outcomes. This study investigated the relationship between women’s financial inclusion and the nutritional status of children aged under five in Rulindo District, Rwanda.

METHODS: A cross-sectional study was conducted in February 2024 among 315 women with children aged under 5 years. Financial inclusion data were collected using structured questionnaire. Children’s nutritional status was assessed using anthropometric tools. WHO Anthro software, and SPSS version 25.0 were used to analyze the collected data. Bivariate and binary logistic regression analyses were conducted to identify associations between financial inclusion variables and child nutrition outcomes.

RESULTS: Among children, 29.5% were stunted, 7.6% underweight, and 4.1% wasted. Bivariate analysis showed significant associations between financial practices (saving for future use and microfinance membership) and child nutritional status. Women who saved for the future were significantly less likely to have stunted children (p = 0.008) or wasted (p = 0.028). Additionally, microfinance membership was associated with a lower prevalence of stunting (p = 0.07), but a higher risk of underweight (p = 0.035). Logistic regression confirmed the association: women with stable income had children with lower odds of stunting (Adjusted Odds Ratio [AOR] = 4.039, p = 0.022), and those in microfinance groups were less likely to have stunted children (AOR = 2.587, p = 0.009), but more likely to report underweight (Crude Odd Ratio [COR] = 4.711, p = 0.029). Saving behavior was protective in the crude model, though it was not statistically significant in the adjusted model.

CONCLUSION: Women’s financial inclusion is positively associated with improved child nutritional outcomes, particularly regarding stunting and wasting. However, financial literacy and targeted support are needed to ensure that economic tools translate into measurable health benefits. Integrated strategies addressing both financial capacity and nutrition education are essential for long-term child health improvement.

PMID:41068771 | DOI:10.1186/s12889-025-24643-7

BMC Public Health. 2025 Oct 9;25(1):3422. doi: 10.1186/s12889-025-24292-w.

NO ABSTRACT

PMID:41068756 | DOI:10.1186/s12889-025-24292-w

Infect Agent Cancer. 2025 Oct 9;20(1):69. doi: 10.1186/s13027-025-00699-3.

ABSTRACT

BACKGROUND: Methylation of host genes is promising for the triage of women with high-risk human papillomavirus (HR-HPV) infections. This study aimed to validate the potential value of Glycophorin C (GYPC) methylation (GYPC^m) in the early detection of cervical cancer.

METHODS: We recruited HR-HPV-positive women at the hospital outpatient clinic between August and December 2023, using cytology triage. The remaining exfoliated cervical cells were subjected to GYPC^m testing. A total of 549 cases were finally included for analysis: 156 cervicitis, 303 cervical intraepithelial neoplasia (CIN)1, 49 CIN2, 37 CIN3, and 4 CC.

RESULTS: The difference of GYPC^m ΔCp values between CIN1 and CIN2 was statistically significant in the pathology results of 549 participants (P < 0.001). The optimal threshold value of GYPC^m for detecting CIN2 + was 6.35. The GYPC^m adjusted ORs for CIN2 + and CIN3 + were 31.23 (95%CI: 16.53-58.99) and 34.68 (95%CI: 11.90-101.11), respectively. In all individuals, the sensitivity of GYPC^m for CIN2 + and CIN3 + was consistent with that of cytology (CIN2 + 83.3%; CIN3 + 90.2%), with higher specificity than that of cytology (CIN2 + 85.8 vs. 29.4%; CIN3 + 79.7 vs. 28.7%, all P < 0.001). The sensitivity and negative predictive value (NPV) of HPV16/18 combined GYPC^m for CIN3 + were not statistically different from those of HPV combined with cytology (sensitivity 95.1 vs. 97.6%, P = 0.317; NPV 99.4 vs. 99.0%, P = 0.613). The net reclassification improvement for HPV16/18 combined GYPC^m and its combined cytology to classify CIN2 + vs. < CIN2 was 48.8% (95%CI: 39.7-57.9%, P < 0.001), with a relative colposcopy referral rate of 50.1% (95%CI: 45.5-54.7%).

CONCLUSION: GYPC^m has a higher CIN2 + OR and higher specificity and positive predictive value than cytology in HR-HPV-positive women and is a potential molecular biomarker for triaging HR-HPV (+) to detect cervical (pre)cancer.

PMID:41068755 | DOI:10.1186/s13027-025-00699-3