Tag: pubmed

Am J Dent. 2022 Feb;35(1):25-29.

ABSTRACT

PURPOSE: To evaluate the effect of cigarette smoking on the color stability and surface roughness of heat-polymerized poly(methylmethacrylate) (PMMA) and computer-aided design and computer-aided manufacturing (CAD-CAM) PMMA denture base materials.

METHODS: A total of 40 disc-shaped specimens (diameter 15 mm x thickness 2 mm) were divided into two groups according to their processing technique: Group CC, CAD-CAM PMMA; and Group HP, heat-polymerized PMMA. The specimens were exposed to cigarette smoke with 20 cigarettes daily for 5 days. Before the procedure, the color of the denture base was measured using a spectrophotometer in accordance with the Commission Internationale de I’Eclairage (CIE) color system. The surface roughness (Ra) of each sample was measured five times before and after exposure to smoke using a profilometer, and the mean roughness (Ra) values were calculated. The color change and surface roughness were statistically analyzed (P< 0.05).

RESULTS: Greater discoloration was observed in the HP group, whereas the CC group showed clinically acceptable color change. Smoking increased the surface roughness of both denture base materials. However, the HP group had higher mean values than the CC group.

CLINICAL SIGNIFICANCE: Denture base materials are susceptible to changes in color and surface roughness due to oral habits such as cigarette smoking. This in vitro study suggested that smoking can exacerbate the color changes and surface roughness of denture base materials, especially in heat-cured acrylic resins.

PMID:35316589

Am J Dent. 2022 Feb;35(1):12-14.

ABSTRACT

PURPOSE: To evaluate the influence of cannabidiol (CBD) oil on the color stability of resin composites.

METHODS: Three different resin composites were chosen to prepare 90 disk-shaped specimens. The specimens were randomly selected to compose two test groups (classic CBD or chocolate CBD) and one control group (distilled water) for a 14-day test. Two-way ANOVA was used to evaluate the influence of the CBD oil on the color stability of the three resin composites. Tukey post-hoc test (HSD) was used to determine the statistical difference among the groups.

RESULTS: ANOVA indicated statistically significant differences among the storage solutions, resin composite, and their correlations (P< 0.001). HSD indicated significant differences among resin composites after staining. No difference was noticed between the color change of the specimens immersed in classic CBD or chocolate CBD. Color differences of the resin composites were related to the hydrophilic/hydrophobic nature of the resin matrix.

CLINICAL SIGNIFICANCE: CBD oil affected the color stability of all the examined resin composite specimens. Considering the obtained results, appropriate guidance should be provided to patients to prevent potential color alteration owing to the usage of CBD oil.

PMID:35316586

Clin Implant Dent Relat Res. 2022 Mar 22. doi: 10.1111/cid.13078. Online ahead of print.

ABSTRACT

PURPOSE: The aim of the present systematic review was to evaluate the effect of different lateral bone augmentation (LBA) procedures on the complete correction of a peri-implant bone dehiscence (BD) or fenestration (BF) from implant placement to implant surgical uncovering.

METHODS: Electronic (Medline, Scopus, and Cochrane databases) and hand literature searches were performed for studies including at least one treatment arm where any LBA had been applied to correct a BD/BF at implant placement (T0). Studies where BD/BF was left untreated were also retrieved as negative control. Data from 24 selected articles were used to perform a network meta-analysis. Based on the proportion of nonresolved BD/BF at implant surgical uncovering (T1), a hierarchy of LBA procedures, and was determined. Spontaneous healing (i.e., exposed implant surface covered by a full-thickness flap; SELF) was also included in the hierarchy. Resorbable membrane + bone graft (RM + BG) was used as reference group. An analysis on the effect of nonhuman (NHBS) vs human (HBS) derived bone substitutes was also performed. NHBS was used as the reference group.

RESULTS: No statistically significant differences were found among treatments for the proportion of nonresolved BD/BF. SELF performed substantially worse compared to RM + BG (OR: 5.78 × 10, CI: 4.83 × 10 – 1.3 × 10⁸⁶ ). Treatment based on a combination of a graft material and membrane/periosteum appeared to perform slightly better than treatments using graft material or membrane alone. NHBS appeared to perform better than HBS. SELF had the worst effect among all treatments for both BD/BF height reduction (BDH) and BD/BF width reduction (BDW). Nonresorbable membrane (NRM) and patient’s own periosteum (PERI) + BG showed greater increases in buccal bone thickness than RM + BG.

CONCLUSION: Reconstructive treatment (including use of graft alone, membrane alone, or combinations of grafts and either membrane or patient’s own periosteum) of a BD/BF at implant placement favorably and significantly impacts on the probability to obtain complete correction of the BD/BF at implant uncovering when compared to full-thickness flap repositioning on the BD/BF. When using a bone substitute, a nonhuman derived one may be suggested.

PMID:35316573 | DOI:10.1111/cid.13078

Vet Med Sci. 2022 Mar 22. doi: 10.1002/vms3.787. Online ahead of print.

ABSTRACT

BACKGROUND: Despite their importance to society, dogs are susceptible to various helminths. This study aimed to understand perceptions, attitudes and practices (PAP) regarding canine zoonotic helminthiases (CZH) among dog owners in Rwanda.

METHODS: A cross-sectional study was carried out in Nyagatare district of Rwanda, where 203 dog owners were randomly selected and interviewed. To analyse this study’s data, we used frequency distributions, chi-square test of association and binary logistic regression model.

RESULTS: Overall, 75.9% and 30% of the respondents were aware of canine and human helminthiases, respectively. Around 74.4% knew that dogs source helminthiases from eating raw infected meat. Also, 74.4% knew vomiting, diarrhoea and swelling of the belly as clinical signs of the helminthiases. Around 58.6% washed hands with soap and water after handling a dog. Only 17.2% and 15.5% dewormed the dogs and treated them against ectoparasites using conventional anthelmintics and acaricides manufactured for dogs, respectively. Of all respondents, 33% held genuine perceptions, while 78.3% and 25.1% adopted positive attitudes and appropriate practices about CZH, respectively. The respondents’ educational level and length of dog ownership correlated with their perceptions and practices about CZH, respectively, while sources of information on CZH influenced their PAP of such infections. The adjusted odds ratio (OR) of having genuine perceptions and positive attitudes were more than 82% lower among those who sourced the information from neighbours & colleagues compared to those who gathered it through reading. Again, the length of dog ownership (OR = 0.37, 95% CI: 0.15-0.90) correlated with the respondent’s practices about CZH.

CONCLUSIONS: Only 33% and 25.1% of the respondents held genuine perceptions and adopted positive attitudes regarding CZH, respectively. The findings indicate increased zoonotic helminths in dogs, possible spillover in humans and anthelmintic resistance. Therefore, awareness campaigns are needed to upgrade dog owners’ knowledge of the zoonotic helminthiases in dogs in Nyagatare district.

PMID:35316578 | DOI:10.1002/vms3.787

J Neurosci Res. 2022 Mar 22. doi: 10.1002/jnr.25035. Online ahead of print.

ABSTRACT

Herein, we combined neurite orientation dispersion and density imaging (NODDI) and synthetic magnetic resonance imaging (SyMRI) to evaluate the spatial distribution and extent of gray matter (GM) microstructural alterations in patients with relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica spectrum disorder (NMOSD). The NODDI (neurite density index [NDI], orientation dispersion index [ODI], and isotropic volume fraction [ISOVF]) and SyMRI (myelin volume fraction [MVF]) measures were compared between age- and sex-matched groups of 30 patients with RRMS (6 males and 24 females; mean age, 51.43 ± 8.02 years), 18 patients with anti-aquaporin-4 antibody-positive NMOSD (2 males and 16 females; mean age, 52.67 ± 16.07 years), and 19 healthy controls (6 males and 13 females; mean age, 51.47 ± 9.25 years) using GM-based spatial statistical analysis. Patients with RRMS showed reduced NDI and MVF and increased ODI and ISOVF, predominantly in the limbic and paralimbic regions, when compared with healthy controls, while only increases in ODI and ISOVF were observed when compared with NMOSD. Compared to NDI and MVF, the changes in ODI and ISOVF were observed more widely, including in the cerebellar cortex. These abnormalities were associated with disease progression and disability. In contrast, patients with NMOSD only showed reduced NDI mainly in the cerebellar, limbic, and paralimbic cortices when compared with healthy controls and patients with RRMS. Taken together, our study supports the notion that GM pathologies in RRMS are distinct from those of NMOSD. However, owing to the limitations of the study, the results should be cautiously interpreted.

PMID:35316545 | DOI:10.1002/jnr.25035

Laryngoscope. 2021 Mar;131(3):509-512. doi: 10.1002/lary.28861. Epub 2020 Jul 6.

ABSTRACT

OBJECTIVES: Adverse events are common occurrences in hospitals that detract from quality of care. There are few data on errors in otolaryngology (ENT) and even fewer data comparing ENT to other services.

METHODS: We retrospectively reviewed adverse event data collected across a regional hospital network from July 2014 to August 2017. We examined categories of adverse events that occurred most commonly in ENT and compared the number of adverse events reported in ENT to those reported across all other departments. Descriptive analysis and the paired t test were used to analyze the data.

RESULTS: Two hundred ninety-one adverse events were reported in ENT departments during the period studied compared to 58,219 events reported across all other specialties. In ENT, the most commonly reported adverse events occurred in the perioperative setting, followed by issues regarding equipment and medical devices and, lastly, airway management. Across all other departments, the most common categories included medication and fluid errors, falls, and safety and security events. ENT departments had significantly higher proportions of perioperative and airway management errors and significantly lower proportions of events related to diagnosis and treatment (P = .004), falls (P < .001), lab results and specimens (P = .001), medication and fluids (P < .001), and safety and security (P < .001).

CONCLUSION: Perioperative and airway management errors occur with a statistically higher frequency in ENT compared to other in-patient and out-patient departments across hospitals. It is important to analyze adverse event reporting in surgical specialties to ensure the development of appropriate quality initiatives.

LEVEL OF EVIDENCE: 4 Laryngoscope, 131:509-512, 2021.

PMID:35316544 | DOI:10.1002/lary.28861

Australas J Dermatol. 2022 Mar 22. doi: 10.1111/ajd.13828. Online ahead of print.

ABSTRACT

BACKGROUND/OBJECTIVE: The association between antiglaucoma medications and the development of ocular pseudopemphigoid (OPP) has been described; however, the independent risk of each medication has not been quantified.

METHODS: Case/non-case analyses were performed in the FDA Adverse Events Reporting System (FAERS) using data from 2010-2020 to examine the reporting odds ratio (ROR) signal for OPP for all classes of antiglaucoma medications under multiple conditions: (i) comparison to all other drugs in FAERs, (ii) comparison to other antiglaucoma medications, (iii) comparison to vehicle/hydrating eye drops with cases of OPP and (iv) comparison to vehicle/hydrating eyedrops with and without cases of OPP to control for topical irritant and preservative effects.

RESULTS: A statistically significant ROR for OPP was found for aggregate antiglaucoma medications under the first condition but not the third or fourth (i.96.97 (95% CI 52.54-178.98). The largest signal for OPP when compared to other glaucoma drugs and eye drops was seen with unoprostone (ii.68.96 (95% CI 8.35-569.50, iii.39.85 (95% CI 4.14-383.33), iv.581.67 (95% CI 49.38-6851.57) followed by carteolol (ii.32.51(95% CI 9.02-117.67), iii.10.67 (95% CI 1.77-64.13), iv.77.84 (95% CI 12.95-467.78) and betaxolol (ii.23.38 (95% CI 7.28-74.46), iii.6.94 (95% CI 1.27-38.01), iv.50.67 (95% CI 9.26-277.25). A statistically significant ROR was noted only for the beta-blockers class aggregate under conditions ii and iv.

CONCLUSIONS: Our findings support an association between OPP and antiglaucoma medications; under the most stringent control for topical irritant/preservative effect by of comparison to topical eye drops, unoprostone, carteolol, betaxolol and timolol all had a significant ROR for OPP.

PMID:35316535 | DOI:10.1111/ajd.13828

Gen Thorac Cardiovasc Surg. 2022 Mar 22. doi: 10.1007/s11748-022-01795-6. Online ahead of print.

ABSTRACT

BACKGROUND: The peculiarity and the lack of clinical studies of dual primary lung cancer (DPLC) led to limited knowledge about its clinical characteristics and prognosis. This study performed a retrospective analysis to assess the prognostic factors and clinical characteristics of DPLC.

METHODS: A total of 1419 DPLC patients from SEER were analyzed by univariate and multivariable Cox regression analyses. The independent prognostic factors were included to establish a nomogram. The accuracy and reliability of prognostic model were evaluated by C indexes, calibration plots, receiver operating characteristic (ROC) curves, decision curve analyses (DCA) and integrated discrimination improvement (IDI) scores. Chi-square test was used to assess the differences between DPLC and single primary lung cancer (SPLC) or synchronous DPLC (sDPLC) and metachronous DPLC (mDPLC).

RESULTS: Cox regression analysis showed that age, sex, histological type, stage, lymph node (LN) metastasis, surgery, chemotherapy were independent prognostic factors, we included these factors to establish a nomogram. In the training cohort, the C index was 0.690, and the area under curves (AUC) of 3 and 5-year survival time were 0.720 and 0.723. The calibration plots in training cohort and validation cohort were in excellent agreement. DCA and IDI showed that the predictive effect of the novel prognostic model was better than the model based on 8th AJCC TNM system. Chi-square test indicated that DPLC and SPLC had statistical differences on pathological and clinical features.

CONCLUSIONS: The clinical and pathological characteristics of DPLC were different from the SPLC. The nomogram could provide accurate and individualized survival predictions for DPLC.

PMID:35316521 | DOI:10.1007/s11748-022-01795-6

Adv Ther. 2022 Mar 22. doi: 10.1007/s12325-022-02106-4. Online ahead of print.

ABSTRACT

INTRODUCTION: The prevalence of type 2 diabetes (T2D) represents a rising burden in the US and worldwide, with the condition shown to be associated with relatively large human and economic costs. Part of the reason for such high costs associated with T2D is that the condition is often accompanied by additional health-related complications. The goal of this research is to examine the association between glycemic control and diabetes-related complications for individuals with T2D.

METHODS: The Optum Clinformatics® Data Mart (CDM) database from 2007 to 2020 was used to identify adults with T2D. Individuals were classified as having sustained glycemic control (all hemoglobin A1c [HbA1c] < 7%) or poor glycemic control (all HbA1c ≥ 7%) over the 5-year post-period, and diabetes-related complications were identified based upon the Diabetes Complications Severity Index. Multivariable analyses examined the association between sustained glycemic control and diagnosis of a diabetes-related complication in the post-period.

RESULTS: Maintaining HbA1c < 7% over the 5-year post-period, compared to maintaining HbA1c ≥ 7%, was associated with reduced odds of the diabetes-related complications of cardiovascular disease (odds ratio [OR] = 0.76, 95% confidence interval [CI] 0.61-0.94), metabolic disease (OR = 0.37, 95% CI 0.22-0.600), neuropathy (OR = 0.62, 95% CI 0.45-0.84), nephropathy (OR = 0.81, 95% CI 0.69-0.94), and peripheral vascular disease (OR = 0.52, 95% CI 0.33-0.83). There was no statistically significant association between sustained glycemic control and cerebrovascular disease.

CONCLUSIONS: Sustained glycemic control was found to be associated with significant reductions in the odds of being diagnosed with diabetes-related complications over a 5-year post-period.

PMID:35316502 | DOI:10.1007/s12325-022-02106-4

Ann Surg Oncol. 2022 Mar 22. doi: 10.1245/s10434-022-11480-w. Online ahead of print.

ABSTRACT

BACKGROUND: Knowledge on the optimal extent of lymphadenectomy among elderly patients with advanced gastric cancer is limited. This study was designed to compare standard D2 and limited lymphadenectomy for evaluating the appropriate extent of lymphadenectomy.

PATIENTS AND METHODS: We retrospectively reviewed patient’s data based on a prospectively collected gastric cancer registry. The inclusion criteria were age above 75 years and histologically confirmed stage II or more advanced gastric cancer. In this study, 103 patients who underwent limited lymph node dissection and 134 patients who underwent standard D2 lymph node dissection were included to evaluate surgical and oncological outcomes using propensity score matching (PSM) analysis.

RESULTS: The mean age after PSM was approximately 78 years in both groups. The Charlson Comorbidity Index was 5.81 ± 0.87 and 5.75 ± 0.76, respectively, and 12.5% of the patients in both groups had American Society of Anesthesiologists scores of more than 3. The limited lymphadenectomy group showed a shorter operation time and fewer retrieved lymph. However, other surgical outcomes and pathological data were not significantly different between the groups. No postoperative mortality within 30 days was observed. There were no significant differences in overall complications between the groups. The 3-year overall survival rates of the limited and standard lymphadenectomy groups were 58.3% and 73.6%, respectively. The 3-year recurrence-free survival rate of the limited lymphadenectomy group was lower than that of the standard lymphadenectomy group; however, the difference was not statistically significant.

CONCLUSIONS: Standard D2 lymphadenectomy has better oncological outcomes in elderly patients with advanced gastric cancer.

PMID:35316435 | DOI:10.1245/s10434-022-11480-w