Tag: pubmed

Phytopathology. 2021 Apr 8. doi: 10.1094/PHYTO-11-20-0492-R. Online ahead of print.

ABSTRACT

Hop powdery mildew, caused by the ascomycete fungus Podosphaera macularis is a consistent threat to sustainable hop production. The pathogen utilizes two reproductive strategies for overwintering and perennation: (i) asexual vegetative hyphae on dormant buds that emerge the following season as infected shoots; and (ii) sexual ascocarps (chasmothecia), which are presumed to discharge ascospores during spring rain events. We demonstrate that P. macularis chasmothecia, in the absence of any asexual P. macularis growth forms, are a viable overwintering source capable of causing early season infection two to three orders of magnitude greater than that reported for perennation via asexual growth. Two epidemiological models were defined that describe (i) temperature-driven maturation of P. macularis chasmothecia; and (ii) ascosporic discharge in response to the duration of leaf wetness and prevailing temperatures. Podosphaera macularis ascospores were confirmed to be infectious at temperatures ranging from 5 to 20°C. The organism’s chasmothecia were also found to adhere tightly to the host tissue on which they formed, suggesting that these structures likely overwinter wherever hop tissue senesces within a hop yard. These observations suggest that existing early season disease management practices are especially crucial to controlling hop powdery mildew in the presence of P. macularis chasmothecia. Furthermore, these insights provide a baseline for the validation of weather driven models describing maturation and release of P. macularis ascospores that can eventually be incorporated into hop disease management programs.

PMID:33829855 | DOI:10.1094/PHYTO-11-20-0492-R

Psychol Addict Behav. 2021 Apr 8. doi: 10.1037/adb0000721. Online ahead of print.

ABSTRACT

OBJECTIVE: Research indicates that a substance user identity (i.e., drinking, smoking, and marijuana identity) is positively correlated with substance use-related outcomes (e.g., frequency, quantity, consequences, and disorder symptoms). The current study aimed to meta-analytically derive single, weighted effect size estimates of the identity-outcome association as well as to examine moderators (e.g., substance use type, explicit/implicit assessment, demographic characteristics, and research design) of this association.

METHOD: Random effects meta-analysis was conducted on 70 unique samples that assessed substance user identity and at least one substance use-related outcome (frequency, quantity, consequences, and/or disorder symptoms), and provided the necessary information for effect size calculations.

RESULTS: Substance user identity was found to be a statistically significant moderate-to-large correlate of all substance use-related outcomes examined in the current study (r _w = .365, p < .001, r_w² = .133). The strongest associations were observed between identity and disorder symptoms (alcohol) and frequency of substance use (tobacco or marijuana). In terms of moderators of the identity-outcome association, the link between explicit drinking identity and alcohol use-related outcomes appeared to be stronger in magnitude than the relationship between implicit drinking identity and alcohol use-related outcomes; however, this difference appears to be largely due to the finding that implicit measures have lower reliability. The strongest identity-outcome association was observed among younger individuals.

CONCLUSIONS: Substance user identity is clearly an important correlate of substance use-related outcomes and this association is stronger among younger individuals. Additional theoretical, empirical, and intervention research is needed to utilize knowledge gleaned from the current study on the identity-outcome association. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:33829814 | DOI:10.1037/adb0000721

J Exp Psychol Gen. 2021 Apr 8. doi: 10.1037/xge0001059. Online ahead of print.

ABSTRACT

Recent statistical regularities have been demonstrated to influence visual search across a wide variety of learning mechanisms and search features. To function in the guidance of real-world search, however, such learning must be contingent on the context in which the search occurs and the object that is the target of search. The former has been studied extensively under the rubric of contextual cuing. Here, we examined, for the first time, categorical cuing: The role of object categories in structuring the acquisition of statistical regularities used to guide visual search. After an exposure session in which participants viewed six exemplars with the same general color in each of 40 different real-world categories, they completed a categorical search task, in which they searched for any member of a category based on a label cue. Targets that matched recent within-category regularities were found faster than targets that did not (Experiment 1). Such categorical cuing was also found to span multiple recent colors within a category (Experiment 2). It was observed to influence both the guidance of search to the target object (Experiment 3) and the basic operation of assigning single exemplars to categories (Experiment 4). Finally, the rapid acquisition of category-specific regularities was also quickly modified, with the benefit rapidly decreasing during the search session as participants were exposed equally to the two possible colors in each category. The results demonstrate that object categories organize the acquisition of perceptual regularities and that this learning exerts strong control over the instantiation of the category representation as a template for visual search. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:33829823 | DOI:10.1037/xge0001059

Am J Orthopsychiatry. 2021 Apr 8. doi: 10.1037/ort0000545. Online ahead of print.

ABSTRACT

In the United States, Muslims have increasingly been the targets of discrimination. While prior research suggests that increased perceived discrimination is associated with elevated depression and anxiety symptoms in this population, no existing studies have explored whether this relationship is mediated by acculturative stress, and few have examined potential moderating factors. This study aimed to investigate whether acculturative stress mediates the relationship between perceived discrimination and depression and anxiety symptoms, as well as examine the moderating roles of Muslim identity and religious support. Participants included 205 Muslim college students, who completed an online survey. Findings revealed that the indirect effect of perceived discrimination on depression and anxiety symptoms via acculturative stress was statistically significant. In addition, religious support emerged as a significant moderator, with higher levels of religious support increasing the strength of the indirect effect on depression and anxiety symptoms. The results suggest clinicians and higher education staff working with Muslim college students should assess for perceptions of discrimination and acculturative stress, as well as examine the role that religious support plays in that individual’s life. Future research should examine how discrimination, acculturative stress, and involvement in one’s religious congregation affect mental health outcomes, as well as investigate whether these findings are generalizable to other religions. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:33829813 | DOI:10.1037/ort0000545

Oral Health Prev Dent. 2021 Jan 7;19(1):235-243. doi: 10.3290/j.ohpd.b1176847.

ABSTRACT

PURPOSE: This systematic review addressed flap designs in endodontic surgery which can have an impact on the Oral Health Related Quality of Life (OHRQoL).

MATERIALS AND METHODS: Four electronic databases were searched (PubMed, Cochrane Library, Web of Science, and Scopus) to identify all studies up to November 2019 that investigated the effect of flap designs on gingival recession and quality of life among healthy adults.

RESULTS: The initial search identified 2701 references. Ten studies were included in this systematic review; two were randomised clinical trials and eight were non-randomised clinical trials. Studies showed that sulcular incision increases the risk of gingival recession and decreases OHRQoL. Two studies were included in the meta-analysis in relation to gingival recession. The pooled results demonstrated that submarginal incision showed a decreased weighted mean difference in gingival recession by 0.31 mm (95% CI: 0.12 – 0.51) (p = 0.002) compared to sulcular incision.

CONCLUSION: Sulcular incision flap unfavourably affect the level of gingiva and OHRQoL. All nonrandomised studies had a statistically significant bias and the sample sizes in all studies were relatively small. More gingival recession and lower OHRQoL were associated with sulcular incision. Additional investigations are warranted to provide more evidence.

PMID:33829721 | DOI:10.3290/j.ohpd.b1176847

Minerva Gastroenterol (Torino). 2021 Apr 8. doi: 10.23736/S2724-5985.21.02809-9. Online ahead of print.

ABSTRACT

BACKGROUND: Metabolic-Associated Fatty Liver Disease (MAFLD), affects nearly one quarter of the world’s adult population creating large health loads and economic loads in society with no approved pharmacotherapy found yet. The number of studies showing the effect of nutrition on fibrosis accompanying MAFLD are insufficient. This study was planned with the aim of investigating the effect of nutritional treatment on liver injury.

METHODS: This research is a prospective, non-medication interventional study completed with 39 participants chosen from MAFLD patients with fibrosis. Post treatment lasting three months, patients had liver stiffness measurements (LSM), anthropometric measurements and biochemical tests repeated.

RESULTS: In pre- and post-treatment, there were statistically significant correlations found between LSM with serum gamma glutamyl transferase (GGT) values, and between controlled attenuation parameter (CAP) with body mass index (BMI) and fat mass (p<0.05). Post-treatment, statistically significant improvements were determined in the anthropometric measurements and biochemical findings. Moreover, post-treatment LSM and CAP values showed significant positive correlation compared to pre-treatment (p<0.05).

CONCLUSIONS: This study found dietary interventions have an important place within the scope of fibrosis treatment. Preparation and application of medical nutrition treatment suitable for the clinical features of patients and completing correct lifestyle changes has an ameliorating effect on disease prognosis. There is a need for advanced studies with larger sample groups to further enlighten this topic.

PMID:33829726 | DOI:10.23736/S2724-5985.21.02809-9

J Consult Clin Psychol. 2021 Mar;89(3):188-199. doi: 10.1037/ccp0000538.

ABSTRACT

INTRODUCTION: Studies have found that psychological treatments produce positive clinical outcomes for many problems experienced by youth. However, there is limited research on whether therapist adherence and competence in delivering these treatments are related to differential clinical outcomes.

METHOD: We examined the relationship of therapist adherence and competence to clinical outcomes in a sample of 51 youth aged 7-14 years (M age = 10.36, SD = 1.90; 86.3% white; 60.8% male) treated for anxiety disorders with a manualized individual cognitive-behavioral therapy. Adherence and competence were measured via coding of recorded treatment session content and outcomes were measured by caregiver and youth report across multiple timepoints. We used two-level mixed-effects regression models to test the degree to which adherence and competence predicted differential youth clinical outcomes.

RESULTS: Across multiple caregiver- and child-reported symptom and diagnostic outcomes, we found no statistically significant relationship between adherence or competence and clinical outcomes.

DISCUSSION: Although there was variability in both treatment integrity and clinical outcome, neither adherence to nor competence in youth anxiety treatment was related to clinical outcomes for youth with anxiety disorders treated with individual cognitive-behavioral treatment (CBT) in a research clinic-based efficacy trial. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:33829807 | DOI:10.1037/ccp0000538

Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 Mar;52(2):326-333. doi: 10.12182/20210360203.

ABSTRACT

OBJECTIVE: To explore the best treatment plan of intravesical instillation for patients with non-muscular invasive bladder cancer (NMIBC), to explore recurrence-related clinicopathological factors after intravesical instillation, and to evaluate the value of the prognosis and prediction models currently used for NMIBC patients.

METHODS: Starting from 2016, patients who underwent transurethral resection of bladder tumor (TURBT) in our hospital and who received post-surgery diagnosis of having intermediate or high risks for NMIBC were enrolled in the study. They were randomly assigned to different group sat a ratio of 2∶2∶1 for receiving intravesical instillation therapy of Bacillus Calmette-Guérin (BCG) for 19 times, BCG for 15 times, and epirubicin (EPI) for 18 times. The clinicopathological data of the patients were recorded before, during and after instillation therapy, and survival curves were drawn to evaluate the effects of the three regimens, using recurrence-free survival as the endpoint. Clinicopathological data were analyzed to study the associations between various factors and post-instillation recurrence. The consistency index (c-index) was used to evaluate the predictive accuracy of the scoring model of the Spanish Urological Club for Oncological Treatment (CUETO) and the risk tables of European Organization for Research and Treatment of Cancer (EORTC).

RESULTS: A total of 93 NMIBC patients (35 in the 19-time BCG group, 37 in the 15-time BCG group, and 21 in the EPI group) were included, with a median follow-up time of 33.46 months. Twenty-two patients experienced tumor recurrence and eight, tumor progression. The survival curve showed that the BCG group had better recurrence-free survival than the EPI group ( P=0.002), while the difference in recurrence-free survival between 19-time BCG and 15-time BCG groups was not statistically significant. Higher general complication rate was seen in the BCG groups compared with the EPI group (84.7% vs. 61.9%, P=0.022), but there was no grade 3-5 adverse events in any group. The c-index of CUETO scoring model and EORTC risk tables was higher than that of the prediction based solely on T stage, nuclear grade, or EAU risk stratification. In addition, the c-index in the BCG group was higher than that in the whole cohort.

CONCLUSION: Among the subjects of this study, the recurrence rate of bladder cancer in the intravesical BCG instillation groups was lower than that of the epirubicin group. EORTC risk tables and CUETO scoring model exhibited higher predictive accuracies in BCG-treated patients than its performance for the whole NMIBC cohort.

PMID:33829710 | DOI:10.12182/20210360203

Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 Mar;52(2):340-344. doi: 10.12182/20210360603.

ABSTRACT

OBJECTIVE: To explore the relationship between abdominal obesity and diabetes among middle-aged and older adults with normal body mass index (BMI) and to provide reference information for formulating targeted diabetes prevention and control measures for this population.

METHODS: Data were extracted from the China Health and Retirement Longitudinal Study (CHARLS) done in 2015. Middle-aged and older adults who were aged 45 and older and had normal BMI were included in the study. According to their status of diabetes, the subjects were divided into two groups, non-diabetes and diabetes groups. χ ² test was used to investigate the difference between two groups. Logistic regression was used to do the multivariate analysis of factors influencing diabetes.

RESULTS: A total of 5 197 middle-aged and older adults with normal BMI ranging between 18.5 and 24 kg/m ² were included. The prevalence of diabetes was 11.26% (585/5 197) and the prevalence of abdominal obesity was 41.56% (2 160/5 197). Univariate analysis showed that the difference in age, residence, the status of hypertension, dyslipidemia and abdominal obesity between non-diabetic group and the diabetic group were statistically significant ( P<0.01). The prevalence of diabetes among adults with abdominal obesity was 14.2% (307/2 160) and that among people with no abdominal obesity was 9.2% (278/3 037). Compared with people with no abdominal obesity, the prevalence of diabetes among people with abdominal obesity was higher and the difference were statistically significant ( P<0.01). Multivariate logistic regression analysis showed that, among middle-aged and older adults with normal BMI, those with abdominal obesity, aged 60 years and older, living in urban areas, having hypertension and having dyslipidemia had higher probability of developing diabetes.

CONCLUSION: Abdominal obesity and diabetes are becoming a serious problem among middle-aged and older adults with normal BMI and abdominal obesity may be related to higher risks of diabetes. It is recommended that more attention is given to abdominal obesity in this population to reduce the possibilities of diabetes.

PMID:33829712 | DOI:10.12182/20210360603

Oral Health Prev Dent. 2021 Jan 7;19(1):229-233. doi: 10.3290/j.ohpd.b1179501.

ABSTRACT

PURPOSE: To assess the effectiveness of a 40% miswak compared to a 0.12% chlorhexidine mouthwash.

MATERIALS AND METHODS: A total of 60 patients aged 20-55 years who attended the Periodontics Clinics at the College of Dentistry, Al-Iraqia University, Baghdad, Iraq, were allocated into 2 groups to use either 40% miswak mouthwash or 0.12% chlorhexidine gluconate Kin Gingival (Laboratorios KIN) twice daily for 2 months. Gingival, bleeding, and plaque indices were assessed.

RESULTS: There were statistically significant differences between the effectiveness of miswak and chlorhexidine mouthwashes in terms of gingivitis. The means of gingival, bleeding, and plaque indices using miswak mouthwash were 1.2, 0.4, and 0.53, respectively, i.e. indicating lower effectiveness, than when 0.12% chlorhexidine mouthwash was used (0.87, 0.43, 0.23, respectively).

CONCLUSION: Miswak mouthwash is a good oral hygiene agent especially for long-term use even if its efficacy is lower than chlorhexidine mouthwash.

PMID:33829720 | DOI:10.3290/j.ohpd.b1179501