Tag: pubmed

Int J Oral Maxillofac Implants. 2022 Mar-Apr;37(2):320-327. doi: 10.11607/jomi.9406.

ABSTRACT

PURPOSE: To determine the effect of 0.7- and 2.4-mm transmucosal abutment height titanium bases on the crestal bone stability and peri-implant soft tissue condition of bone-level implants with platform switching in patients with vertically thick soft tissues.

MATERIALS AND METHODS: Sixty bone-level platform-switched implants were placed in the molar and premolar regions of both arches in 60 patients. All epicrestally inserted nonsubmerged implants had a 4.1-mm diameter and, after osteointegration, were randomly allocated into two groups: (1) the short group, with a titanium base of 0.7-mm transmucosal abutment height, and (2) the high group with a 2.4-mm height. Monolithic zirconia restorations were fabricated for all implants. Parallel intraoral radiographs were obtained after the delivery of restorations (T1) and after 1 year (T2). Crestal bone levels and peri-implant soft tissue conditions were calculated for each implant. The significance level was set at α = .05.

RESULTS: After 1 year, 55 patients were evaluated, with a mean bone loss of 0.6 ± 0.51 mm (median: 0.71, range: 0 to 2.09 mm) in the short group (23 patients) and 0.45 ± 0.59 mm (median: 0.65, range: 0 to 2.12 mm) in the high group (22 patients), showing no significant difference between groups (P = .168). A significant increase in marginal bone height was noted between the T1 and T2 time points in the short and high (P = .029 and .001, respectively) groups. The peri-implant soft tissue health parameters did not show statistically significant differences.

CONCLUSION: Crestal bone stability after 1 year of follow-up around epicrestally placed platform-switched implants is not influenced by transmucosal abutment height, if the vertical soft tissue thickness is ≥ 3 mm.

PMID:35476860 | DOI:10.11607/jomi.9406

Int J Oral Maxillofac Implants. 2022 Mar-Apr;37(2):250-269. doi: 10.11607/jomi.9286.

ABSTRACT

PURPOSE: The exposure of nonresorbable membranes following alveolar bone augmentation is one of the most frequently occurring complications. This review aimed to investigate the treatments that can be adopted to manage the exposure of polytetrafluoroethylene-based membranes (PTFE-ms) and titanium meshes (TMs) and their outcomes.

MATERIALS AND METHODS: Two independent reviewers electronically and manually searched the EMBASE, PubMed/MEDLINE, Scopus, and Cochrane bibliographic databases to retrieve pertinent articles available between January 2000 and March 2021. Only human studies describing the type of treatment and the soft tissue outcome following exposure of PTFE-ms or TMs were included.

RESULTS: Overall, 11 articles in the PTFE-ms group and 24 in the TM group were included for data analysis. Results indicated that, in both groups, two distinct therapeutic strategies are mostly applied in case of exposure, namely, pharmacologic and mechanical treatments. Other options have been identified seldomly. Statistically significant evidence of an association between the type of barrier membrane and the exposure rate (28.7% vs 38.5% for TMs and PTFE-ms, respectively; P = .019) and between the type of exposed device and the treatment outcome in terms of removal rate following therapy (11.9% and 44.4% for TMs and PTFE-ms, respectively; P < .001) was noted.

CONCLUSION: In both groups, chlorhexidine applications and meticulous plaque control may lead to improved healing conditions after exposure. Surgical removal of the exposed portion can be considered to promote secondary intention healing. The beneficial effects of systemic antibiotics could not be demonstrated in the management of the exposure but should be evaluated in case of graft infection.

PMID:35476854 | DOI:10.11607/jomi.9286

PLoS One. 2022 Apr 27;17(4):e0266060. doi: 10.1371/journal.pone.0266060. eCollection 2022.

ABSTRACT

The reason for the existence of adversarial samples is still barely understood. Here, we explore the transferability of learned features to Out-of-Distribution (OoD) classes. We do this by assessing neural networks’ capability to encode the existing features, revealing an intriguing connection with adversarial attacks and defences. The principal idea is that, “if an algorithm learns rich features, such features should represent Out-of-Distribution classes as a combination of previously learned In-Distribution (ID) classes”. This is because OoD classes usually share several regular features with ID classes, given that the features learned are general enough. We further introduce two metrics to assess the transferred features representing OoD classes. One is based on inter-cluster validation techniques, while the other captures the influence of a class over learned features. Experiments suggest that several adversarial defences decrease the attack accuracy of some attacks and improve the transferability-of-features as measured by our metrics. Experiments also reveal a relationship between the proposed metrics and adversarial attacks (a high Pearson correlation coefficient and low p-value). Further, statistical tests suggest that several adversarial defences, in general, significantly improve transferability. Our tests suggests that models having a higher transferability-of-features have generally higher robustness against adversarial attacks. Thus, the experiments suggest that the objectives of adversarial machine learning might be much closer to domain transfer learning, as previously thought.

PMID:35476838 | DOI:10.1371/journal.pone.0266060

PLoS One. 2022 Apr 27;17(4):e0267495. doi: 10.1371/journal.pone.0267495. eCollection 2022.

ABSTRACT

BACKGROUND: Previous studies proposed possible applications of spectral-domain optical coherence tomography (SD-OCT) measurements in prognosticating pathologies observed in overweight/obesity, including ocular, vascular, and neurologic consequences. Therefore, we conducted a systematic review and meta-analysis to investigate the changes in the in SD-OCT measurements of the patients with higher body mass index (BMI) compared to normal weight individuals.

MATERIALS AND METHODS: We conducted a systematic search on PubMed, Scopus, and Embase. The search results underwent two-phase title/abstract and full-text screenings. We then analyzed SD-OCT measurements differences in patients with high BMI and controls, and performed meta-regression, sub-group analysis, quality assessment, and publication bias assessment. The measurements included macular thickness, cup to disc ratio, ganglion cell-inner plexiform layer (GC-IPL) and its sub-sectors, RNFL and peripapillary RNFL (pRNFL) and their sub-layers, and choroidal thickness and its sub-sectors.

RESULTS: 19 studies were included in this meta-analysis accounting for 1813 individuals, 989 cases and 824 controls. There was an overall trend towards decreased thickness in high BMI patients, but only two measurements reached statistical significance: temporal retinal nerve fiber layer (RNFL) (Standardized mean difference (SMD): -0.33, 95% confidence interval (CI): -0.53 to -0.14, p<0.01) and the choroidal region 1.0 mm nasal to fovea (SMD: -0.38, 95% CI: -0.60 to -0.16, p<0.01).

CONCLUSION: Some ocular layers are thinner in patients with higher BMI than the controls. These SD-OCT measurements might correlate with adverse events related to increased body weight and have prognostic abilities. As SD-OCT is a robust, rapid and non-invasive tool, future guidelines and studies are needed to evaluate the possibility of their integration into care of the patients with obesity.

PMID:35476846 | DOI:10.1371/journal.pone.0267495

PLoS One. 2022 Apr 27;17(4):e0267578. doi: 10.1371/journal.pone.0267578. eCollection 2022.

ABSTRACT

OBJECTIVE: To assess the levels of stress, burnout, and job satisfaction among mental healthcare professionals in Jeddah City, Saudi Arabia.

METHODS: A cross-sectional study was conducted on mental healthcare professionals in Jeddah between January 2017 and October 2018. Sociodemographic characteristics and levels of stress, burnout, and job satisfaction were assessed using the Perceived Stress Scale-14 (PSS-14), Maslach Burnout Inventory (MBI), and Job Satisfaction Scale (JSS). Descriptive statistics were used. Independent sample t-test, one-way ANOVA, Mann-Whitney, and Kruskal-Wallis tests were conducted to assess for effects of demographic variables on the perceived stress score, emotional exhaustion (EE) score, depersonalization (DP) score, professional accomplishment (PA) score, and the job satisfaction score (JSS).

RESULTS: A total of 107 participants were included (50.5% men; 49.5% women) with response rate of 79.2%. Prevalence of stress was 56.1%. High levels of emotional exhaustion and depersonalization were present among 41 (38.3%) and 26 (24.3%) of the respondents, respectively, while high score of low personal accomplishment were present among 61 (57%) respondents. In terms of job satisfaction, 25 (23.4%) were satisfied and 74 (69.2%) were indecisive. Male participants’ emotional exhaustion score (27±12) was significantly higher than females (22 ±10), (t(105) = 1.99, p-value = 0.049). Also, participants with a monthly income above SR 20,000 had significantly higher total job satisfaction (p-value = 0.041).

CONCLUSIONS: Our findings suggest rates of stress and burnout among mental health professionals that warrant attention, with less than one-quarter of the participants being satisfied with their jobs. Further studies are needed to expand the findings and to explore the contributing factors. Additionally, interventions should be established by authorities to address the increasing rates of stress and burnout.

PMID:35476815 | DOI:10.1371/journal.pone.0267578

PLoS One. 2022 Apr 27;17(4):e0267291. doi: 10.1371/journal.pone.0267291. eCollection 2022.

ABSTRACT

BACKGROUND: MicroRNAs (miRNAs) are frequently deregulated in various types of cancer. While antisense oligonucleotides are used to block oncomiRs, delivery of tumour-suppressive miRNAs holds great potential as a potent anti-cancer strategy. Here, we aim to determine, and functionally analyse, miRNAs that are lowly expressed in various types of tumour but abundantly expressed in multiple normal tissues.

METHODS: The miRNA sequencing data of 14 cancer types were downloaded from the TCGA dataset. Significant differences in miRNA expression between tumor and normal samples were calculated using limma package (R programming). An adjusted p value < 0.05 was used to compare normal versus tumor miRNA expression profiles. The predicted gene targets were obtained using TargetScan, miRanda, and miRDB and then subjected to gene ontology analysis using Enrichr. Only GO terms with an adjusted p < 0.05 were considered statistically significant. All data from wet-lab experiments (cell viability assays and flow cytometry) were expressed as means ± SEM, and their differences were analyzed using GraphPad Prism software (Student’s t test, p < 0.05).

RESULTS: By compiling all publicly available miRNA profiling data from The Cancer Genome Atlas (TCGA) Pan-Cancer Project, we reveal a small set of tumour-suppressing miRNAs (which we designate as ‘normomiRs’) that are highly expressed in 14 types of normal tissues but poorly expressed in corresponding tumour tissues. Interestingly, muscle-enriched miRNAs (e.g. miR-133a/b and miR-206) and miRNAs from DLK1-DIO3 locus (e.g. miR-381 and miR-411) constitute a large fraction of the normomiRs. Moreover, we define that the CCCGU motif is absent in the oncomiRs’ seed sequences but present in a fraction of tumour-suppressive miRNAs. Finally, the gain of function of candidate normomiRs across several cancer cell types indicates that miR-206 and miR-381 exert the most potent inhibition on multiple cancer types in vitro.

CONCLUSION: Our results reveal a pan-cancer set of tumour-suppressing miRNAs and highlight the potential of miRNA-replacement therapies for targeting multiple types of tumour.

PMID:35476804 | DOI:10.1371/journal.pone.0267291

Int Endod J. 2022 Apr 27. doi: 10.1111/iej.13756. Online ahead of print.

ABSTRACT

BACKGROUND: The interaction between heredity and different environmental factors in the modification of apical periodontitis (AP) susceptibility and prediction of its progression remain poorly elucidated.

OBJECTIVES: This umbrella review aimed to (i) analyse the available relevant systematic reviews in an attempt to determine the association between genotype and allelic distribution of different single nucleotide polymorphisms (SNPs) and the development of AP, (ii) report deficiencies and gaps in knowledge in this area, and (iii) present recommendations to conduct future clinical studies and systematic reviews.

METHODS: A literature search was conducted using Clarivate Analytics’ Web of Science, Scopus, PubMed, and Cochrane Database of Systematic Reviews, from inception to October 2021, with no language restrictions, including a grey literature search. Systematic reviews with/without meta-analysis evaluating genotype and allelic distribution of different SNPs between adult patients with/ without AP were included. All other type of studies were excluded. The methodological quality was assessed using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) – 2 tool. Two independent reviewers were involved in study selection, data extraction, and appraising the included reviews; disagreements were resolved by a third reviewer.

RESULTS: The current study includes five systematic reviews. Three reviews performed meta-analysis. Three reviews were graded by AMSTAR 2 as ‘critically low’ quality, whereas other two were graded as ‘low’ and ‘moderate’ quality. Two reviews indicated that carriers of specific genotypes and alleles of tumour necrosis factor – alpha (TNF-α) -308 G>A and interleukin 1-beta (IL-1β) +3954 C/T gene polymorphisms are more susceptible to an acute and persistent form of AP. However, high heterogeneity was observed.

DISCUSSION: The statistical heterogeneity within included systematic reviews was a consequence of clinical and methodological diversity amongst primary studies. Although some of included reviews suggested that carriers of specific genotype and/or allele of TNF-α -308 G>A and IL-1β +3954 C/T SNPs are more susceptible to AP, their conclusions should be interpreted with caution.

CONCLUSIONS: No candidate genes could be identified as a definitive genetic risk or protective factor for the development and progression of AP, and further high-quality genome-wide association studies are warranted.

PMID:35476797 | DOI:10.1111/iej.13756

J Perinat Neonatal Nurs. 2022 Apr-Jun 01;36(2):161-172. doi: 10.1097/JPN.0000000000000622. Epub 2022 Feb 9.

ABSTRACT

Pregnant women experienced disruptions in their prenatal care during the coronavirus disease-2019 (COVID-19) pandemic. While there is emerging research about the impact of COVID-19 on experiences of pregnancy, the majority of studies that have reported on prenatal care and birth during COVID-19 have not incorporated the first-person accounts of Black women. The purpose of this mixed-methods study was to explore the perspectives of Black women on prenatal care, labor, and birth during the pandemic. A total of 33 participants completed questionnaires. Fourteen of these 33 women and an additional 2 participated in qualitative interviews. Descriptive statistics and a mixed-methods analysis were employed. Participants expressed disappointment about disruptions in their experiences of pregnancy including the way their prenatal care was experienced, cancellation of planned “rites of passage,” and visitor policy restrictions during and after the birth. Forty-five percent of participants reported being worried about getting COVID-19 and (61%) about their infant getting COVID-19. Many participants experienced a sense of loss that may permeate through other aspects of their lives. Providing extra support and points of contact can help lessen feelings of isolation during the pandemic and can also offer more explanation for rapidly changing policies and procedures.

PMID:35476770 | DOI:10.1097/JPN.0000000000000622

PLoS One. 2022 Apr 27;17(4):e0265446. doi: 10.1371/journal.pone.0265446. eCollection 2022.

ABSTRACT

In this study, we statistically identified and characterized the relationship between the long-run social benefits of creativity and the in-life individual costs (in terms of happiness and health) of creativity. To do so, we referred to a theoretical framework that depicts a creator’s life. We generated a balanced dataset of 200 creators (i.e., composers, painters, mathematicians and physicists, and biologists and chemists born between 1770 and 1879), and calculated standardized evaluations of the long-run social benefits in different domains (performances, exhibitions, citations). We performed regression analysis and identified the statistical determinants of the relationship between a creator’s social benefits and the costs to their happiness and health. We found that creativity represented an individual cost for all four creator groups, with a larger impact on happiness than on health; the cost was greater if creativity was based more on divergent than on convergent thinking or if authors faced greater language issues. The impacts of long-run social benefits on individual happiness and health were similar in the arts and sciences if institutional differences were taken into account.

PMID:35476792 | DOI:10.1371/journal.pone.0265446

J Am Heart Assoc. 2022 Apr 27:e023578. doi: 10.1161/JAHA.121.023578. Online ahead of print.

ABSTRACT

Background Lp(a) (lipoprotein[a]) plays an important role in predicting cardiovascular events in patients with coronary artery disease through its proatherogenic and prothrombotic effects. We hypothesized that prolonged dual antiplatelet therapy (DAPT) might be beneficial for patients undergoing percutaneous coronary intervention who had elevated Lp(a) levels. This study aimed to evaluate the effect of Lp(a) on the efficacy and safety of prolonged DAPT versus shortened DAPT in stable patients with coronary artery disease who were treated with a drug-eluting stent. Methods and Results We selected 3201 stable patients with CAD from the prospective Fuwai Percutaneous Coronary Intervention Registry, of which 2124 patients had Lp(a) ≤30 mg/dL, and 1077 patients had Lp(a) >30 mg/dL. Patients were divided into 4 groups according to Lp(a) levels and the duration of DAPT therapy (≤1 year versus >1 year). The primary end point was major adverse cardiovascular and cerebrovascular event, defined as a composite of all-cause death, myocardial infarction, or stroke. The median follow-up time was 2.5 years. Among patients with elevated Lp(a) levels, DAPT >1 year presented lower risk of major adverse cardiovascular and cerebrovascular event and definite/probable stent thrombosis compared with DAPT ≤1 year. In contrast, in patients with normal Lp(a) levels, the risks of major adverse cardiovascular and cerebrovascular event and definite/probable stent thrombosis were not significantly different between the DAPT >1 year and DAPT ≤1 year groups. Prolonged DAPT had 2.4-times higher risk of clinically relevant bleeding than shortened DAPT in patients with normal Lp(a) levels, although without statistical difference. Conclusions In stable patients with coronary artery disease, who underwent percutaneous coronary intervention with a drug-eluting stent, prolonged DAPT was associated with reduced risk of cardiovascular events among those with elevated Lp(a) levels, whereas it did not show statistically significant evidence of benefit for reducing ischemic events and tended to increase clinically relevant bleeding among those with normal Lp(a) levels.

PMID:35475627 | DOI:10.1161/JAHA.121.023578