Tag: pubmed

J Foot Ankle Surg. 2021 Oct 22:S1067-2516(21)00387-2. doi: 10.1053/j.jfas.2021.09.028. Online ahead of print.

ABSTRACT

Diabetes increases the risk of developing postoperative complications such as superficial and deep infection, wound dehiscence, and revisional surgery. Prolonged non-weightbearing and/or augmented fixation may reduce postoperative complications in complicated diabetic ankle fractures. This study’s purpose was to compare the development of postoperative infection, wound dehiscence, and revisional surgery in complicated diabetic ankle fractures with respect to weightbearing status. We hypothesized that fewer complications would occur in patients with prolonged non-weightbearing. Medical records of 90 surgically treated complicated diabetic ankle fractures were retrospectively reviewed for postoperative radiographs, weightbearing status, and complications. Complicated diabetes was defined as HbA1c ≥ 8% within 1 year of surgery. Twenty-four out of 90 patients had prolonged non-weightbearing status, which was defined as ≥ 8 weeks of non-weightbearing postoperatively. Twelve out of 90 patients had augmented fixation, which was defined as standard open reduction and internal fixation plus ≥ 2 tetra-cortical or > 2 tri-cortical syndesmotic screws with medial plate, external fixation, or other combination. Thirty-three out of 90 patients (36.7%) patients developed complications postoperatively. Patients with prolonged non-weightbearing had less complications (29.2% vs 39.4%, p = .37) and larger HbA1c values compared with early weightbearing patients (10.0 vs 9.3, p = .04). A one-unit increase in creatinine value (mg/dL) revealed a 3.15-fold increase in development of complications (95% confidence interval 1.29-7.65, p = .01). Although not statistically significant, complicated diabetic ankle fractures treated with prolonged non-weightbearing had less complications postoperatively except for ankle Charcot. Creatinine can be utilized as an independent risk factor for postoperative complications in this population.

PMID:34794875 | DOI:10.1053/j.jfas.2021.09.028

Int J Oral Maxillofac Surg. 2021 Nov 16:S0901-5027(21)00388-X. doi: 10.1016/j.ijom.2021.10.009. Online ahead of print.

ABSTRACT

The aim of this study was to evaluate the accuracy of validated preoperative patient co-morbidity assessments, including the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), with the use of the composite scapula free flap (CSFF) in maxillofacial reconstruction in patients with significant medical co-morbidities. A retrospective cohort review was performed at an academic institution, covering the period from July 2010 through January 2019. All patients who underwent reconstruction with a CSFF with significant medical co-morbidities were included. Co-morbidity assessments and risk factors were analyzed by comparing predicted versus observed early and late medical and surgical complications. Forty-five patients met the inclusion criteria. The surgical complication rate was 47%; the medical complication rate was 38%. Over 90% of patients returned to successful function at 3 months post-surgery. The ACS-NSQIP prediction of complications ranged from 58% to 75% for accuracy, 76% to 100% for sensitivity, and 50% to 69% for specificity. The prediction of a serious complication was statistically significant in patients with a Charlson Co-morbidity Index ≥7. Age ≥80 years did not significantly increase the risk of a serious complication (P = 0.23). The ACS-NSQIP failed to predict the successful use of the CSFF for patients with significant co-morbidities undergoing maxillofacial reconstruction. The selection of patients who will tolerate complex reconstruction cannot be based solely on co-morbidity charts and standardized preoperative indices.

PMID:34794850 | DOI:10.1016/j.ijom.2021.10.009

Chin J Traumatol. 2021 Oct 29:S1008-1275(21)00180-2. doi: 10.1016/j.cjtee.2021.10.005. Online ahead of print.

ABSTRACT

PURPOSE: The COVID-19 pandemic has caused 1.4 million deaths globally and is associated with a 3 to 4 times increase in 30-day mortality after a fragility hip fracture with concurrent COVID-19 infection. Typically, death from COVID-19 infection occurs between 15 and 22 days after the onset of symptoms, but this period can extend up to 8 weeks. This study aimed to assess the impact of concurrent COVID-19 infection on 120-day mortality after a fragility hip fracture.

METHODS: A multi-centre prospective study across 10 hospitals treating 8% of the annual burden of hip fractures in England between 1st March and 30th April, 2020 was performed. Patients whose surgical treatment was payable through the National Health Service Best Practice Tariff mechanism for “fragility hip fractures” were included in the study. Patients’ 120-day mortality was assessed relative to their peri-operative COVID-19 status. Statistical analysis was performed using SPSS version 27.

RESULTS: A total of 746 patients were included in this study, of which 87 (11.7%) were COVID-19 positive. Mortality rates at 30 and 120-day were significantly higher for COVID-19 positive patients relative to COVID-19 negative patients (p < 0.001). However, mortality rates between 31 and 120-day were not significantly different (p = 0.107), 16.1% and 9.4% respectively for COVID-19 positive and negative patients, odds ratio 1.855 (95% confidence interval 0.865-3.978).

CONCLUSION: Hip fracture patients with concurrent COVID-19 infection, provided that they are alive at day-31 after injury, have no significant difference in 120-day mortality. Despite the growing awareness and concern of “long-COVID” and its widespread prevalence, this does not appear to increase medium-term mortality rates after a hip fracture.

PMID:34794857 | DOI:10.1016/j.cjtee.2021.10.005

Clin Ther. 2021 Nov 15:S0149-2918(21)00434-3. doi: 10.1016/j.clinthera.2021.10.012. Online ahead of print.

ABSTRACT

PURPOSE: This study was conducted to examine and verify the use of saliva as an alternative matrix for monitoring phenytoin drug levels in patients with epilepsy. Drug concentrations are measured to evaluate whether a suitable drug level has been achieved to minimize the risk for toxicity, inadequate efficacy, or therapy resistance and compliance issues.

METHODS: Quantitative analysis was performed by using reverse-phase HPLC after sample pretreatment with acetonitrile. Seventy-eight patients who met the inclusion/exclusion criteria were examined in this study. Trough concentrations of both saliva and serum were taken at steady state.

FINDINGS: Of the 78 patients enrolled, only 11 (14.1%) had normal levels. Twenty-eight patients (35.9%) had subtherapeutic levels, and 39 (50%) had toxic levels. Simultaneously, salivary phenytoin levels were analyzed; only 13 patients (17.3%) had therapeutic levels, 25 patients (33.3%) had subtherapeutic levels, and 37 (49.3%) had toxic levels. Among the study population, most of the patients were aged 31 to 40 years (25.6%) followed by the age group 21 to 30 years (19.2%). The lowest percentage of patients were in the age groups 71 to 80 years and >80 years (1.3%) each. This study found a statistically significant relationship between free serum and salivary phenytoin levels (P < 0.001). A very weak and insignificant correlation was observed between serum/salivary phenytoin levels and sex/age of the study population. The results of the present study support the use of saliva as an alternative to serum/plasma for monitoring phenytoin therapy.

IMPLICATIONS: The free concentration of a drug represents the freely diffusible drug fraction, which is the therapeutically active form. Accordingly, the free drug concentration correlates to clinical efficacy and drug toxicity better than total concentration.

PMID:34794834 | DOI:10.1016/j.clinthera.2021.10.012

J Pediatr Nurs. 2021 Nov 15:S0882-5963(21)00314-6. doi: 10.1016/j.pedn.2021.10.017. Online ahead of print.

ABSTRACT

PURPOSE: In this study, we examined the influence of interprofessional American Heart Association (AHA) resuscitation courses on pediatric health care professionals’ (N = 218) self- reported collaborative practice behaviors (CPBs) and examined differences in CPBs between nursing, medicine, and respiratory therapy.

DESIGN AND METHODS: A mixed methods explanatory design was utilized with a sample of pediatric nurses, nurse practitioners, physicians, and respiratory therapists. Data were collected using the Interprofessional Collaborative Competency Attainment Survey (ICCAS) and two open-ended questions. Data analysis included: exploratory factor analysis, paired t-tests, mixed effects modeling and directed content analysis. Inferences were made across quantitative and qualitative data.

RESULTS: Statistically significant improvement in mean CPB scores was demonstrated by all professions (t (208) = -12.76; ρ < 0.001) immediately after the AHA courses. Qualitative responses indicated physicians identified roles and responsibilities (94%, n = 17) as the most important CPB. Communication was identified by nurses (78%, n = 76), nurse practitioners (100%, n = 11) and respiratory therapists (71%, n = 5) as most important.

CONCLUSIONS: Participation in an interprofessional AHA course significantly increased mean self-reported CPB scores. Changes in mean CPB scores were sustained over 6 weeks upon return to clinical practice.

PRACTICE IMPLICATIONS: Future research focused on CPBs of front-line health care professionals can provide an accurate portrayal of an interprofessional team and can inform how collaborative practice is established in everyday clinical practice.

PMID:34794847 | DOI:10.1016/j.pedn.2021.10.017

Clin Ther. 2021 Nov 15:S0149-2918(21)00410-0. doi: 10.1016/j.clinthera.2021.10.007. Online ahead of print.

ABSTRACT

PURPOSE: Currently available references provide evidence on the efficacy of probiotics strains but exclude product-specific information, making it challenging for health care professionals (HCPs) to provide consumers with suitable recommendations on probiotics. An online probiotics e-reference database was developed to assist HCPs in delivering evidence-based recommendations on probiotics to consumers. The usability and applicability of the database in health care practice were evaluated.

METHODS: Information on the efficacy of probiotics and probiotic products was collated using a PubMed literature search, and from local pharmacies and online supplement stores. A web database was compiled using various programming scripts and uploaded onto a web server. The database was beta-tested using an online self-administered questionnaire for community-based pharmacists, and responses were analyzed using descriptive statistics.

FINDINGS: The database comprised 584 clinical study excerpts, 449 probiotic products, and 1879 unique product-study links. Users can search for suitable probiotics based on their indication profile or for a specific probiotic product. Information provided includes the probiotic constituents, dosage regimen, and indications of the product, with supporting clinical evidence. Overall, all participants of the beta-test indicated that they were satisfied with the database and were willing to use it again (both, 13 participants [100%]). In addition, all participants indicated that they found the database intuitive to use and smooth functioning, without inconsistencies (both, 13 [100%]). The majority also indicated that they found the information provided to be clear, comprehensive, and useful in health care practice (12 [92.3%] each).

IMPLICATIONS: The probiotics e-reference database is an integrated resource that is user-friendly, and provides HCPs with ready access to clear and comprehensive information on probiotic products and clinical studies, so that HCPs can provide consumers with relevant and evidence-based recommendations on probiotics.

PMID:34794833 | DOI:10.1016/j.clinthera.2021.10.007

J Psychiatr Res. 2021 Nov 9:S0022-3956(21)00668-3. doi: 10.1016/j.jpsychires.2021.11.019. Online ahead of print.

ABSTRACT

Gilles de la Tourette Syndrome (GTS) is a multifactorial neurodevelopmental disorder characterized by tics and multiple comorbidities. The pathophysiology is not yet fully understood, but both environmental and genetic risk factors seem to be involved. Twin studies provide important knowledge on genetic factors. We assessed the concordance of GTS and chronic tic disorders (CTD) in monozygotic (MZ) twins, and examined tic severity, symptoms of obsessive-compulsive disorder (OCD), attention deficit/hyperactivity disorder and autism spectrum disorder. Twin pairs, where at least one twin was diagnosed with any tic disorder, were identified through Danish Twin Registry, Psychiatric Central Registry, Danish National Patient Registry and National Tourette Clinic, Copenhagen University Hospital, Herlev. Zygosity was tested with single-nucleotide polymorphism (SNP) genotyping and clinical assessment was done with validated tools. 14 MZ twin pairs were included: five were discordant. Seven twin pairs were concordant for GTS, and for two pairs one twin had GTS and the other CTD. Among the twins with CTD or GTS, 50% had at least one comorbidity, which is higher than in background populations. The GTS + OCD-phenotype was significantly more frequent among GTS-concordant than among discordant twins. No statistically significant differences were found between the GTS-concordant and discordant twin pairs regarding tic severity or comorbidities. Thorough clinical assessment and SNP-based genotyping are important when conducting clinical twin studies. We found high concordance of GTS and CTD, which supports the notion that both disorders have common genetic risk factors. Further studies with larger cohorts including dizygotic twins are warranted for more conclusive results.

PMID:34794811 | DOI:10.1016/j.jpsychires.2021.11.019

Dent Mater. 2021 Nov 15:S0109-5641(21)00285-2. doi: 10.1016/j.dental.2021.10.007. Online ahead of print.

ABSTRACT

OBJECTIVES: To evaluate the influence of filler geometry and viscosity of luting composites on marginal adhesive gap width (MGW) and occlusal surface height (OSH) of all-ceramic partial crowns.

METHODS: Forty-eight all-ceramic partial crowns (Celtra Duo, Dentsply) were created and divided into six groups (n = 8). Restorations were bonded using universal adhesive (Prime & Bond Active, Dentsply) in combination with low-viscosity composites (LV) containing amorphous fillers (Calibra Ceram, Dentsply) (LV-AF), heterogeneous fillers (Tetric EvoFlow, Ivoclar Vivadent) (LV-HF) vs. high-viscosity composites (HV) containing spherical fillers (Ceram.x, Dentsply) (HV-SF) or heterogeneous fillers (Tetric EvoCeram, Ivoclar Vivadent) (HV-HF). HV materials were used either with or without sonication. MGW [µm] was measured by SEM. Displacements of the restorations after luting, such as changes (Δ) in OSH [µm], tilting and rotation [°], were measured using a dial gauge and 3D-analytical software (OraCeck, Cyfex). Statistical analysis was by Mann-Whitney U-test and t-test with α = 0.05.

RESULTS: MGW (p = 0.002) and tilting (p = 0.001) were significantly smaller with LV (228.0 ± 112.35 µm; 0.89 ± 1.25°) than with HV (338.1 ± 97.26 µm; 1.95 ± 1.26°). Sonication had no effect on MGW in HV-HF (332.32 ± 91.39 µm) and HV-SF (343.85 ± 105.48 µm; p = 0.74). Sonication decreased ΔOSH by ~50% with HV-SF (64.21 ± 27.90 µm) but remained unchanged with HV-HF (39.06 ± 14.08 µm; p = 0.004). There was no difference in rotation between HV (0.82 ± 0.81°) and LV (0.61 ± 0.74°; p = 0.29). The LV-AF and LV-HF groups showed no statistical differences in MGW, ΔOSH, tilting or rotation (p > 0.05).

SIGNIFICANCE: Irrespective of filler geometry and insertion technique, the use of high-viscosity composites for the adhesive cementation of modern all-ceramic partial crowns increases displacement, marginal misfit and occlusal surface height.

PMID:34794829 | DOI:10.1016/j.dental.2021.10.007

Air Med J. 2021 Nov-Dec;40(6):415-418. doi: 10.1016/j.amj.2021.08.003. Epub 2021 Sep 3.

ABSTRACT

OBJECTIVE: Hospital mergers have made interhospital transfers necessary in the consolidation of medical services. Physicians must make decisions on the level of interfacility transport modalities (ITMs). We sought to assess physician knowledge of and comfort with ITMs.

METHODS: A survey was e-mailed to 2,510 physicians in a health care system. Participation was voluntary and anonymous. The mean and median Likert values were calculated overall. Similar calculations were performed for emergency medicine physicians (EMPs) and critical care physicians (CCPs). These calculations were compared with those for noncritical care physicians (NCCPs) using the t-test and Mann-Whitney test.

RESULTS: Of the 181 physicians who responded, 169 physicians identified a specialty. Sixty-nine were EMPs/CCPs, whereas 100 were NCCPs. The mean and median Likert values were statistically significantly higher for EMPs/CCPs compared with NCCPs (P < .0001) in the areas of knowledge of ITMs, comfort in choosing ITMs, and knowledge in choosing ground versus air critical care transport (CCT). The most important factor for using ground or air CCT was patient stability. Sixty percent believed air CCT to be faster than ground.

CONCLUSION: EMPs/CCPs seem to be more comfortable with ITMs than NCCPs. Further research should evaluate whether educational interventions lead to a more appropriate use of ITMs.

PMID:34794781 | DOI:10.1016/j.amj.2021.08.003

Air Med J. 2021 Nov-Dec;40(6):427-430. doi: 10.1016/j.amj.2021.07.008. Epub 2021 Aug 30.

ABSTRACT

OBJECTIVE: Since the introduction of video laryngoscopy (VL) as a technique for orotracheal intubation, its use has become widespread among prehospital providers. However, little information is available about the efficacy and success of VL compared with direct laryngoscopy (DL) in the helicopter emergency medical services (HEMS) setting. The objective of this study was to investigate whether VL or DL increased successful first-pass orotracheal intubations and overall intubation success by HEMS providers.

DESIGN: A retrospective chart review was performed on adults intubated by a HEMS program from January 2015 to July 2017. All orotracheal intubations with at least 1 attempt were included. Excluded were emergent cricothyrotomies, nonintubated patients, and those intubated before HEMS care.

RESULTS: DL accounted for 21 intubations, whereas VL was used for 150 intubations. Nineteen of 21 (90.5%) DL intubations were successful on first pass, whereas 127 of 150 (84.7%) VL intubations were successful on first pass. The overall success rate was 90.5% for DL and 92.7% for VL. For both first-pass and overall success rates, the differences between modalities were not statistically significant. DL and VL had nearly identical complication rates, with hypoxia being the primary complication in both groups.

CONCLUSION: No statistically significant difference was found in the first-pass rate, the overall success rate, or complications between DL and VL.

PMID:34794783 | DOI:10.1016/j.amj.2021.07.008