Tag: pubmed

J Adv Nurs. 2022 Feb 7. doi: 10.1111/jan.15171. Online ahead of print.

ABSTRACT

AIM: To describe Australian registered nurses’ awareness, and implementation of reasonable adjustments within their practice when caring for people with intellectual disability and/or autism. Additionally, the association between key demographic, workforce, and respondent variables and familiarity of the term and regularity of use was explored.

DESIGN: Cross-sectional survey.

METHODS: Survey data were collected between August and October 2020 using an online survey tool. Data were analysed using descriptive and inferential statistics.

RESULTS: Familiarity of the concept of reasonable adjustments was relatively low, compared to respondents who report applying adjustments when caring for people with intellectual disability and/or autism. Higher levels of confidence, comfort, and knowledge when caring for this cohort were associated with greater awareness and application of reasonable adjustments.

CONCLUSION: A higher volume, and diversity in type of, nursing education related to care for people with intellectual disability and/or autism is indicated.

PMID:35128714 | DOI:10.1111/jan.15171

Health Soc Care Community. 2022 Feb 6. doi: 10.1111/hsc.13737. Online ahead of print.

ABSTRACT

Most people living with dementia want to continue living in their own home for as long as possible and many rely on support from homecare services to do so. There are concerns that homecare often fails to meet the needs of clients with dementia, but there is limited evidence regarding effective interventions to improve its delivery for this client group. We aimed to assess whether a co-designed, 6-session dementia training intervention for homecare workers (NIDUS-professional) was acceptable and feasible. Facilitated training sessions were delivered over 3 months, followed by 3, monthly implementation meetings to embed changes in practice. Two trained and supervised facilitators without clinical qualifications delivered the intervention via group video-calls during Oct 2020-March 2021 to a group of seven homecare workers from one agency in England. Participants provided qualitative feedback 3- and 6-months post intervention. Qualitative interview data and facilitator notes were integrated in a thematic analysis. Adherence to the intervention and fidelity of delivery were high, indicating that it was acceptable and feasible to deliver in practice. Thirty of a possible 42 (71.4%) group sessions were attended. In our thematic analysis we report one over-arching theme: ‘Having time and space to reflect is a rare opportunity’. Within this we identified four subthemes (Having time to reflect is a rare opportunity; Reflecting with peers enhances learning; Reflection and perspective taking can improve care; Recognising skills and building confidence) through which we explored how participants valued the intervention to discuss their work and learn new skills. Attendance was lower for the implementation sessions, perhaps reflecting participants’ lack of clarity about their purpose. We used our findings to consider how we can maintain positive impacts of the manualised sessions, so that these are translated into tangible, scalable benefits for people living with dementia and the homecare workforce. A randomised feasibility trial is underway.

PMID:35128740 | DOI:10.1111/hsc.13737

J Med Virol. 2022 Feb 6. doi: 10.1002/jmv.27640. Online ahead of print.

ABSTRACT

AIM: The aim of this study was to investigate the change in Nuclear Factor Erythroid 2-related factor (Nrf2), which plays a critical role in cytoprotection against oxidative stress, in paediatric patients with COVID-19 infection positivity, and to evaluate the relationship between Nrf2 and oxidative balance.

METHODS: The study included 40 children with confirmed COVID-19 infection and 35 healthy children. The groups were compared in respect of Nrf2, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), in addition to clinical findings of fever, cough shortness of breath, and contact history, and demographic data of age and gender.

RESULTS: The mean Nrf2 values and TAS levels were determined to be statistically significantly low (p<0.001) and the TOS level and OSI were statistically significantly high in the children with COVID-19 compared to the control group. A significant positive correlation was determined between Nrf2 and TAS (p<0.01); as the Nrf2 value increased, so the TAS value increased. A significant negative correlation was determined between Nrf2 and TOS and OSI (p<0.01); as the Nrf2 value increased, there was determined to be a significant decrease in the TOS and OSI values.

CONCLUSION: COVID-19 infection in paediatric patients causes a decrease in Nrf2 level. By causing a decrease in TAS level and an increase in TOS and OSI levels, the decrease in Nrf2 may explain the tissue damage which can be caused by COVID-19. This article is protected by copyright. All rights reserved.

PMID:35128704 | DOI:10.1002/jmv.27640

Psychophysiology. 2022 Feb 6:e14003. doi: 10.1111/psyp.14003. Online ahead of print.

ABSTRACT

The error-related negativity (ERN) and the error positivity (Pe) are electrophysiological components associated with error processing that are thought to exhibit distinctive developmental trajectories from childhood to adulthood. To investigate the age and age moderation effects on the ERN and the Pe strength during development, we conducted a preregistered three-level meta-analysis synthesizing 120 and 41 effect sizes across 18 group comparison studies and 19 correlational studies, respectively. The meta-analysis included studies with mean age between 3.6 and 28.7 (min-max age range: 3.5 and 49.8) years for age-group comparisons and 6.1 to 18.7 (min-max age range: 4.0-35.7) years for age correlations. Results showed that age was associated with a more negative ERN (SMD = -.433, r = -.230). No statistically significant association between age and the Pe was found (SMD = .059, r = -.091), except for in a group comparison between younger and older adolescents. The age effects were not significantly moderated by whether a Flanker or a Go/No-Go task was used, whereas a probabilistic learning task moderated the age effect on the Pe. Moreover, the Fz and Cz electrode sites yielded stronger negative associations between age and the ERN and the Pe, respectively. The results confirm that the ERN and the Pe show differential development courses and suggest that sample and methodological characteristics influence the age effects, and lay the foundation for investigations of developmental patterns of the ERN and the Pe in relation to psychopathology and early genetic and environmental risk factors.

PMID:35128651 | DOI:10.1111/psyp.14003

J Forensic Sci. 2022 Feb 6. doi: 10.1111/1556-4029.14991. Online ahead of print.

ABSTRACT

Forensic camera device identification addresses the scenario, where an investigator has two pieces of evidence: a digital image from an unknown camera involved in a crime, such as child pornography, and a person of interest’s (POI’s) camera. The investigator wants to determine whether the image was taken by the POI’s camera. Small manufacturing imperfections in the photodiode cause slight variations among pixels in the camera sensor array. These spatial variations, called photo-response non-uniformity (PRNU), provide an identifying characteristic, or fingerprint, of the camera. Most work in camera device identification leverages the PRNU of the questioned image and the POI’s camera to make a yes-or-no decision. As in other areas of forensics, there is a need to introduce statistical and probabilistic methods that quantify the strength of evidence in favor of the decision. Score-based likelihood ratios (SLRs) have been proposed in the forensics community to do just that. Several types of SLRs have been studied individually for camera device identification. We introduce a framework for calculating and comparing the performance of three types of SLRs – source-anchored, trace-anchored, and general match. We employ PRNU estimates as camera fingerprints and use correlation distance as a similarity score. Three types of SLRs are calculated for 48 camera devices from four image databases: ALASKA; BOSSbase; Dresden; and StegoAppDB. Experiments show that the trace-anchored SLRs perform the best of these three SLR types on the dataset and the general match SLRs perform the worst.

PMID:35128659 | DOI:10.1111/1556-4029.14991

Health Serv Res. 2022 Feb 6. doi: 10.1111/1475-6773.13949. Online ahead of print.

ABSTRACT

OBJECTIVE: To develop and test of a measure of patient-centered care (PCC) culture in hospital-based perinatal care.

DATA SOURCES: US perinatal hospitals; 1 provided survey development data and 14 contributed data for survey testing.

STUDY DESIGN: We used qualitative and quantitative methods to develop the Mother-Infant Centered Care (MICC) culture survey. Qualitative methods included observation, focus group, interviews, and expert consultations to adapt items from other settings and create new items capturing dimensions of PCC articulated by The Commonwealth Fund. We quantitatively assessed survey psychometric properties using reliability (Cronbach’s α and Pearson correlation coefficients) and validity (exploratory and confirmatory factor analysis [CFA]) statistics, and refined the survey. After confirming aggregation suitability (ICCs), we calculated “MICC culture scores” at the individual-, unit-, and hospital-level and assessed associations between scores and survey-collected, staff-reported outcomes to evaluate concurrent validity.

DATA COLLECTION: Survey development included 12 site-visit observations, one semi-structured focus group (five participants), two semi-structured interviews, five cognitive interviews, and three expert consultations. Survey testing used online surveys administered to obstetric and neonatal unit staff (N=316).

PRINCIPAL FINDINGS: Using responses from 10 hospitals with ≥4 responses from both units (n=240), the 20-item MICC culture survey demonstrated reliability (Cronbach’s α=0.95) while capturing all PCC dimensions (subscale Cronbach’s α=0.72-0.87). CFA showed validity through goodness-of-fit (overall chi-square=214 [p-value=0.012], SRMR=0.056, RMSEA=0.041, CFI=0.97, and TLI=0.96). Aggregation statistics (ICCs<0.05) justify unit- and hospital-level aggregation. Demonstrating preliminary validity, individual-, unit-, and hospital-level MICC culture scores were associated with all outcomes (satisfaction with care provided, within-unit team effectiveness, and relational coordination [RC] between units) (p-values<0.05), except for neonatal unit scores and RC (p-value=0.11).

CONCLUSIONS: The MICC culture survey is a psychometrically sound measure of PCC culture for hospital-based perinatal care. Survey scores are associated with staff-reported outcomes. Future studies with patient outcomes will aid identification of improvement opportunities in perinatal care.

PMID:35128641 | DOI:10.1111/1475-6773.13949

J Ayub Med Coll Abbottabad. 2021 Oct-Dec;33(4):659-663.

ABSTRACT

BACKGROUND: In January, 2020 COVID-19 infection was declared a public health emergency characterized as pandemic by the World Health Organization (WHO). In March 2020, special guidelines were issued to address mental and psychological aspects of the disease survivors and community at large. This study was conducted with the aim to evaluate the psychological impact of COVID-19 on mothers in the postpartum period.

METHODS: It was cross-sectional study of six months duration on COVID-19 positive deliveries and Covid negative mothers. A total of 84 women (42 Covid Positive and 42 Covid negative) were included through non-probability quota with consecutive sampling technique. Mothers with pre-existing mental health issues, those who had been on medication for any psychological issues or those who suffered from obstetrical and neonatal complications or required transfer to High Dependency Unit (HDU) were excluded from the study. The Edinburgh Postnatal Depression Scale (EPDS) was used to screen the women for postpartum depression. Independent sample t test was used for continuous variables and Fisher exact test was used for qualitative variables.

RESULTS: Mean EPDS score was 9.48±6.33 in COVID-19 positive group. The sub-scale analysis showed mean scores 1.6±1.76 and 4.86±2.94 for Anhedonia and Anxiety with statistically significant difference.

CONCLUSIONS: Women experiencing COVID-19 infection during pregnancy were found to have greater anxiety and nervousness in post-natal period compared to their COVID-19 negative counterparts.

PMID:35124926

J Ayub Med Coll Abbottabad. 2021 Oct-Dec;33(4):664-667.

ABSTRACT

BACKGROUND: The present era has been commanded by ample studies correlating breathing modes & risk of occurrence of malocclusion. The early intervention of altered breathing patterns can head off the long-lasting effects of already established malocclusion. The main intention of this project was to establish the possible correlation between mouth-breathing & malocclusions.

METHODS: Sixty-two (62) patients undergoing orthodontic treatment were evaluated via data form (including history & clinical evaluation). SPSS software version 25.0 was used for data analysis. Patient’s age, gender, type of Angle’s malocclusion & breathing pattern was taken in account while analysing data. Descriptive statistics & Chi- Square test was applied on the data. It was anticipated that mouth breathing is associated with malocclusion. p-value of less than 0.05 was considered to be statistically significant.

RESULTS: A total of 29 males & 33 females participated in the study. The mean age was 13 years (range 6-20 years). A significant correlation was found between mouth-breathing, tongue thrust (p=0.03) & bleeding gums (p=0.006). Other parameters had no significant correlation with mouth-breathing.

CONCLUSIONS: The current study revealed that mouth breathing has significant association with opened mouth at rest & gingival abnormalities (bleeding/ swollen gums) implying that timely diagnosis of such abnormal breathing pattern can hinder with development of altered occlusion & dentofacial conformation.

PMID:35124927

J Ayub Med Coll Abbottabad. 2021 Oct-Dec;33(4):598-601.

ABSTRACT

BACKGROUND: The study was to look for effectiveness of vitamin D-3 in cutaneous warts in comparison with cryotherapy at dermatology department of Pak Emirates Military Hospital Rawalpindi. It was a randomized control trial conducted at the Department of dermatology Pak Emirates Military Hospital Rawalpindi. Ten months, June 2019 to May 2020.

METHODS: A total of 50 patients of cutaneous warts diagnosed by consultant dermatologist were included in the study. Patients were randomized into groups by lottery method. Group A received the Intralesional vitamin D 3 while Group B received cryotherapy. Comparison was made in both the groups regarding the response as complete or partial or no resolution of the wart.

RESULTS: Out of 50 patients with cutaneous warts on any location of the body, 23 (46%) received intralesional vitamin D3 while 27 (54%) received cryotherapy as allocated treatment. Twenty-four (48%) patients were female while 26 (52%) were male. Planter warts 41 (82%) were the commonest type according to the site of warts followed by palmar 6 (12%). Application of chi-square test revealed that Vitamin D3 was statistically significantly related to complete resolution of warts as compared to cryotherapy (p-value<0.05).

CONCLUSION: Cutaneous warts were most commonly seen on the feet of the affected patients. They had a good response to both of the therapies but intralesional vitamin D3 emerged as more effective option of the two in terms of management of these cutaneous warts.

PMID:35124915

J Ayub Med Coll Abbottabad. 2021 Oct-Dec;33(4):607-611.

ABSTRACT

BACKGROUND: Tamoxifen is a selective oestrogen receptor modulator; in the breast, it decreases the growth and proliferation of breast epithelial cells. We assessed the weight change after Tamoxifen use in breast cancer patients.

METHODS: This was a single-centred, prospective, observational cohort study. All patients diagnosed with breast cancer with ER and/or PR positivity were enrolled in the study. Out of these, 90 patients who have been prescribed Tamoxifen treatment either in adjuvant or palliative setting gave their consent to participate. Demographic data, treatment plan, menstrual status, weight, BMI, serum fasting lipid profile, change in diet, and change in physical activity were recorded at the time of diagnosis and then quarterly until 1 year of treatment.

RESULTS: A mean age of 42.12±8.5 years was reported, and the mean weight was 62.22±10.6 kg. The majority of the patients, i.e., 68 (75.55%) had advanced tumour stages (III and IV). The study reported that the mean weight of the patients changed significantly at different time intervals during the treatment course (p<0.0005). Moreover, there was an upward trend in weight from the time of starting Tamoxifen to 3-months (62.22±1.51 kg vs 62.88±1.45 kg, respectively). There was a statistically significant increase in weight at 6-month, 9-month, and 12-month of Tamoxifen treatment (63.72±1.46 kg, 64.35±1.42 kg, 65.12±1.44 kg, respectively). Also, most of the patients gained weight as time passed by.

CONCLUSIONS: This study indicated that Tamoxifen has a significant correlation with the increase in weight in hormone receptor-positive breast cancer patients in our population.

PMID:35124917