Tag: pubmed

Asia Pac Psychiatry. 2025 Dec;17(4):e70009. doi: 10.1111/appy.70009.

ABSTRACT

OBJECTIVE: To determine the effect of hope on functional recovery in individuals diagnosed with schizophrenia.

MATERIALS AND METHODS: This correlational, cross-sectional study was conducted at the Psychiatry Outpatient Clinic of a hospital in eastern Türkiye between June 2022 and January 2023. Data were collected using a personal information form, the Herth Hope Index (HHI), and the Functional Remission of General Schizophrenia (FROGS) scale. The study included 136 patients diagnosed with schizophrenia according to the DSM-5 diagnostic criteria. Data were analyzed using percentage distributions and mean values, as well as Pearson correlation and regression analyses.

RESULTS: The mean total FROGS score of the patients was found to be 47.25 ± 15.2, while the mean total HHS score was 45.22 ± 22.63. A statistically significant positive correlation was identified between the mean scores of all subscales of the FROGS and HHS, as well as between their total scores (p < 0.05). Regression analysis revealed that the level of hope in patients with schizophrenia had a 60% effect on functional recovery (F = 203.61; R² = 0.603; p ≤ 0.001).

CONCLUSION: The findings of this study indicated that patients diagnosed with schizophrenia had moderate levels of hope but low functional recovery scores. Additionally, a significant and positive relationship was observed between hope and functional recovery, demonstrating that hope is an influential factor in enhancing functional recovery. Therefore, it is recommended that interventions aimed at increasing levels of hope be planned and implemented within treatment and rehabilitation programs.

PMID:41214428 | DOI:10.1111/appy.70009

Environ Sci Pollut Res Int. 2025 Nov 10. doi: 10.1007/s11356-025-37136-2. Online ahead of print.

ABSTRACT

The study aims to assess the air pollution tolerance index (APTI) of plants in the vicinity of industrial and residential regions of western Tamil Nadu. Measurements were taken for the years 2020 and 2023. The APTI of eight major tree species was evaluated in the polluted areas. We used and analyzed the chemical analysis and multivariate statistical methods such as T-test, one-way analysis of variance, and correlation matrix in this study. Seventy-five percent of the species showed high relative water content (RWC) values, indicating their tolerance to pollutants. High RWC helps plants maintain adequate chlorophyll levels. Broad-leaved trees with dense canopies required higher chlorophyll concentrations than compound-leaved trees with cone-shaped canopies. The amount of ascorbic acid in the leaves was also used to calculate pollution tolerance. Approximately 38% of the plants tested showed moderate to high tolerance to pollution. The remaining species were classified as moderately tolerant or susceptible to pollution, which is concerning given the rising levels of environmental pollution. The APTI ranges suggest that drought- and heat-resistant plants, along with moderately tolerant species, are used to establish green belts. These green belts have the potential to significantly reduce local air pollution. The study highlights the tolerance thresholds of various plant species to air pollution near Erode process industries. The findings highlight the necessity of selecting appropriate species for green belt development to mitigate air pollution. The number of local plant species that tolerate high pollution levels, along with the presence of species with moderate or low tolerance, highlights the necessity for continuous monitoring and proactive environmental management to maintain and enhance air quality.

PMID:41214403 | DOI:10.1007/s11356-025-37136-2

Neuropsychol Rev. 2025 Nov 10. doi: 10.1007/s11065-025-09685-3. Online ahead of print.

ABSTRACT

Evidence exists that cocaine impacts cognition and behaviour. Yet, uncertainty remains as to what extent cognitive inhibition efficiency decreases in cocaine users. We carried out a systematic review and meta-analysis following the PRISMA 2020 checklist. Our search yielded 1725 articles from Scopus, PubMed and WOS, from which twenty-four studies were finally identified as meeting the inclusion criteria for the systematic review and twenty (providing twenty-three effect sizes) for the meta-analysis. A multi-level random-effects meta-analysis was conducted, and moderation analysis was implemented to examine the potential moderating effects of sex, age, years of regular cocaine use, days of cocaine abstinence, and sample type (clinical vs. community) in the estimated effects. Results showed worse inhibition in cocaine users compared to controls (g = 0.65; 95% CI [0.28, 1.03], p < .001), but none of the moderators significantly impacted this effect. Findings highlight the link between impaired cognitive inhibition and cocaine use disorder and suggest that inhibitory control training approaches would be promising. Future clinical studies are needed to elucidate on the efficacy of neuropsychological approaches for improving inhibitory control and augment the effectiveness of first-line interventions for cocaine use disorder.

PMID:41214400 | DOI:10.1007/s11065-025-09685-3

J Racial Ethn Health Disparities. 2025 Nov 10. doi: 10.1007/s40615-025-02725-x. Online ahead of print.

ABSTRACT

INTRODUCTION: In 2023, Aotearoa New Zealand’s National Cervical Screening Programme introduced human papillomavirus (HPV) primary screening with the universal option to self-test. This change was informed by a primary care implementation study involving 3308 people due or overdue for cervical screening.

METHODS: A cross-sectional survey conducted in 2023 sought implementation study participants’ perspectives on their experience of HPV primary screening, with separate analysis of responses from indigenous Māori participants – a group historically underserved by the screening programme. Data collection included: information provision, choice of test, receipt of results, screening experience, understanding of HPV testing, future preferences and suggested improvements. Survey data were analysed using descriptive statistics and inductive thematic analysis.

RESULTS: In total, 176 of 921 survey respondents self-identified as Māori ethnicity (aged 24-70 years) so were included in analyses. Most chose to self-test (94%) for comfort, privacy and convenience and because it supports mana motuhake (self-determination). Good communication and support from the health professional had a positive impact on screening experience. Many felt well informed, but key facts about HPV primary screening were later incorrectly recalled. A minority of participants experienced issues related to implementation, including inadequate education, information or instructions. Future screening intent was high (91.8%), with nearly half (48.2%) wanting to self-test at home.

CONCLUSION: HPV self-testing was an acceptable screening method for Māori survey participants. Findings highlight the need for clear, repeated communication and education to improve awareness and understanding of HPV screening. Reducing current inequities in screening and related outcomes will require providers to effectively engage, educate and support Māori into screening.

PMID:41214399 | DOI:10.1007/s40615-025-02725-x

J Racial Ethn Health Disparities. 2025 Nov 10. doi: 10.1007/s40615-025-02720-2. Online ahead of print.

ABSTRACT

Black pregnant women face heightened psychological risks shaped by systemic racism, yet few screening tools capture the racialized stressors they routinely navigate. This study presents the initial psychometric evaluation of the Prepartum Form for Evaluating Race-Related Psychological Stressors (PP-FERRPS©), a novel, culturally responsive instrument grounded in Black feminist thought. In a sample of pregnant Black women (n = 145), exploratory factor analysis supported a five-factor, 30-item structure with strong internal consistency reliability. Evidence of convergent and concurrent validity emerged through significant correlations with gendered racial microaggressions, discrimination in healthcare, and anxiety symptoms. While associations with a standard depression measure were not statistically significant, findings suggest the PP-FERRPS© captures distinct forms of race-related stress that may predict perinatal anxiety. This tool addresses critical gaps in perinatal mental health assessment and offers a theory-driven resource to support accurate, culturally responsive care for Black birthing populations.

PMID:41214398 | DOI:10.1007/s40615-025-02720-2

J Racial Ethn Health Disparities. 2025 Nov 10. doi: 10.1007/s40615-025-02724-y. Online ahead of print.

ABSTRACT

PURPOSE: Breast cancers are the leading cancers in American women. This study aims to reveal racial and ethnic trends observed in breast cancer deaths in the United States (US).

METHODS: We analyzed 1999 to 2021 mortality data from the CDC WONDER database by race/ethnicity. Crude and age-adjusted mortality rates (AAMRs) (per 100,000 population) were calculated for each race/ethnicity, stratified by age and US census region, and then standardized to the 2000 US population. Joinpoint regression software was used to study temporal changes in mortality rates.

RESULTS: From 1999 to 2021, there were 951,536 reported deaths attributed to breast cancer in women. When aggregated, the AAMRs for breast cancer in women decreased over the study period (Annual Average Percent Change (AAPC) decrease of 1.52 (p < 0.001)). Similarly, all racial/ethnic groups, age groups, and US census regions had statistically significant declines in the AAPC over the study period (p < 0.05). However, upon stratification, we found that across all the age groups and US census regions, non-Hispanic Black women had the highest mortality rates, whereas non-Hispanic Asian American/Pacific Islander (AAPI) women had the lowest mortality rates. Across all race/ethnicity groups, women aged ≥ 65 had the highest mortality rates. We also found that most race/ethnicity groups had decreases in AAPCs over the study period for all age groups and US census regions, but non-Hispanic AAPI women had a significant overall AAPC increase of 0.65 (p = 0.002) in the ≥ 65 age group and an AAPC increase of 0.99 (p = 0.007) in the south.

CONCLUSION: Despite overall declines in breast cancer mortality, persistent racial and ethnic disparities remain by age and US census region. Future research should integrate demographic trends with molecular and genetic markers to refine prevention and treatment strategies, ultimately reducing breast cancer disparities and improving outcomes.

PMID:41214396 | DOI:10.1007/s40615-025-02724-y

Behav Res Methods. 2025 Nov 10;57(12):338. doi: 10.3758/s13428-025-02801-4.

ABSTRACT

Selecting an appropriate statistical method is a challenge frequently encountered by applied researchers, especially if assumptions for classical, parametric approaches are violated. To provide some guidelines and support, we compared classical hypothesis tests with their typical distributional assumptions of normality and homoskedasticity with common and easily accessible alternative inference methods (HC3, HC4, and six bootstrap methods) in the framework of ordinary least squares (OLS) regression. The method’s performance was assessed for four different regression models with varying levels of non-normality and heteroskedasticity of errors, and for five different sample sizes ranging from 25 to 500 cases. For each scenario, 10,000 samples of observations were generated. Type I error and coverage rates, power, and standard error bias were examined to assess the methods’ performance. No method considered here performed satisfactorily on all accounts. Using HC3 or HC4 standard errors, or a wild bootstrap procedure with percentile confidence intervals, could yield reliable results in many, but not all, scenarios. We suppose that, in the case of assumption violations, researchers might refer to a method that performed best in a scenario most similar to their data situation. To aid the selection of an appropriate method, we provide tables comparing relative performances in all considered scenarios.

PMID:41214373 | DOI:10.3758/s13428-025-02801-4

Ann Hematol. 2025 Nov 11. doi: 10.1007/s00277-025-06725-z. Online ahead of print.

ABSTRACT

We aimed to evaluate the clinical value of splenectomy as a treatment for Chronic active Epstein-Barr virus disease (CAEBVD). We retrospectively reviewed the clinical data from clinical records of patients received splenectomy in our institution from October 1, 2014, to October 1, 2024. The splenectomy cohort (n = 16) was matched to non-splenectomy controls (n = 32) at a 1:2 ratio using propensity scores derived from gender, age, baseline EBV-DNA copies, whether with HLH, and whether received Allo-HSCT. A total of 48 CAEBVD patients were enrolled in this study. Splenectomy cannot minimize the EBV-DNA copies in peripheral blood. The median OS of patients who received splenectomy was 86 months, while that of patients without splenectomy was 23 months. There was no statistically significant difference between the two groups (P = 0.189). When patients experienced recurrence-related death, no significant difference in survival time was observed between the two groups (P = 0.607). In the CAEBVD with HLH subgroup, there was no significant difference in survival times between patients with and without splenectomy (P = 0.423). A total of 18 patients received Allo-HSCT. The time to WBC and PLT engraftment between the non-splenectomy group and splenectomy group showed no significant difference (P = 0.788, P = 0.407). Splenectomy demonstrated no significant benefit in reducing EBV copies and symptom relief, and suggests splenectomy fails to prolong patient survival supporting its limited role in CAEBVD management.

PMID:41214341 | DOI:10.1007/s00277-025-06725-z

Aesthetic Plast Surg. 2025 Nov 10. doi: 10.1007/s00266-025-05411-9. Online ahead of print.

ABSTRACT

BACKGROUND: Depression is a major global health issue. Recent studies suggest that botulinum toxin (BoNT/A), commonly used in aesthetic procedures, might have potential as an adjunct to traditional treatments for depressive symptoms. It is hypothesized that BoNT/A could influence neurochemical pathways to help alleviate depressive symptoms.

METHODS: A systematic literature review was conducted focusing on Botulinum Neurotoxin Type A (BoNT/A) for depressive disorders. Primary studies published in English were included. Data were extracted on injection sites, dosage, adverse events, and outcomes. Statistical analysis included chi-squared tests and logistic regression to identify treatment predictors.

RESULTS: Twelve studies were included, primarily targeting the glabellar region with BoNT/A injections. Approximately 71% of patients demonstrated reductions in depression symptoms. The chi-square test revealed a significant association between injection sites and depression improvement (p = 0.009). Higher doses of BoNT/A showed a marginally negative relationship with depression reduction (p = 0.098). Most adverse effects were mild, such as local site reactions and mild headaches, with no severe adverse events like suicidal ideation reported.

CONCLUSIONS: This review describes the possible use of BoNT/A as an adjunct therapy for depressive symptoms, particularly when targeting facial muscles. Further research is needed to optimize dosage and explore the neurobiological mechanisms involved to improve therapeutic outcomes.

LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

PMID:41214321 | DOI:10.1007/s00266-025-05411-9

Biochem Genet. 2025 Nov 11. doi: 10.1007/s10528-025-11270-5. Online ahead of print.

ABSTRACT

Elevated TSH with normal T3 and T4 levels is a sign of subclinical hypothyroidism (SCH), is often linked to autoimmune thyroiditis. Thyroid peroxidase antibodies (anti-TPO) are early markers, but their diagnostic value and genetic associations in Middle Eastern populations are not well understood. This study assessed serum TPO levels and TPO gene polymorphisms in relation to SCH in Duhok, Iraq (September-December 2024). In a case-control design, 78 patients with SCH and 75 age- and gender-matched euthyroid controls were recruited. Serum levels of TSH, T3, T4, Vitamin D, and anti-TPO were measured. Genotyping of the TPO T1936C variant was performed by ARMS-PCR. Two-sided statistical tests were applied. Correlations were assessed using Spearman’s ρ, and genotype frequencies were tested for Hardy-Weinberg equilibrium. Diagnostic performance of anti-TPO was evaluated by receiver operating characteristic (ROC) analysis, including area under the curve (AUC), 95% CI, and Youden index. Patients with SCH showed significantly elevated anti-TPO levels compared to controls (107.5 ± 149.6 vs. 39.5 ± 81.6 IU/mL; p = 0.014). ROC analysis identified ≥ 60.4 IU/mL as the optimal anti-TPO cut-off for SCH prediction (AUC = 0.62, 95% CI: 0.52-0.71, sensitivity = 47.44%, specificity = 89.33%). TPO levels correlated positively with TSH (Spearman ρ = 0.174, p = 0.031), but not with T3, T4, or Vitamin D. TPO (T1936C) gene polymorphism analysis revealed no significant association with SCH (AA genotype: 80.77% in cases vs. 77.33% in controls), (GA genotype: 19.23% in cases vs. 22.67% in controls) p = 0.85. The GG genotype was absent in both groups. Anti-TPO antibodies demonstrated high specificity but modest sensitivity as diagnostic markers for SCH. The TPO T1936C variant was not associated with SCH, though this null finding may reflect the study’s limited statistical power. These results highlight the role of autoimmune markers in SCH diagnosis within the Kurdish population of Duhok, Iraq.

PMID:41214316 | DOI:10.1007/s10528-025-11270-5