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Nevin Manimala Statistics

Effect of leukocyte and platelet rich fibrin (L-PRF) on stability of dental implants. A systematic review and meta-analysis

Br J Oral Maxillofac Surg. 2021 Jan 19:S0266-4356(21)00015-2. doi: 10.1016/j.bjoms.2021.01.001. Online ahead of print.

ABSTRACT

The aim of this study was to assess the impact, if any, of L-PRF application in an implant bed prior to implant placement, focusing on stability by means of implant stability quotient (ISQ) values. The literature was searched in a systematic way by means of the main databases and hand searching of the most relevant journals. The inclusion and exclusion criteria were used to determine the eligible studies included in this review. Only randomised controlled trials (RCT) and controlled clinical trials (CCT) were included. A total of four RCTs were included for data extraction. The risk of bias was deemed moderate to unclear. Meta-analysis was performed to assess the effect of L-PRF, on implant stability, immediately post-insertion in three studies, after one week from the implant placement in three studies and after four weeks for all the included studies. The fixed effects model has shown Hedges g statistic for the one week varying from 0.380 to 1.401 with a pooled figure of 0.764 (95% CI 0.443 to 1.085) and for four weeks varying between 0.74 and 1.1 with a combined effect of 0.888 (95% CI 0.598 to 1.177). The results for both intervals were in favour of the use of L-PRF while the statistical difference immediately post-insertion was not statistically significant. The present systematic review, though acknowledging its limitations, suggests that L-PRF has a positive effect on secondary implant stability and that needs to be correlated to the clinical practice to measure the actual clinical effect by means of reducing treatment times.

PMID:34702597 | DOI:10.1016/j.bjoms.2021.01.001

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Nevin Manimala Statistics

Effect of the COVID-19 pandemic on anxiety in patients with masticatory muscle pain

J Prosthet Dent. 2021 Sep 21:S0022-3913(21)00490-X. doi: 10.1016/j.prosdent.2021.09.002. Online ahead of print.

ABSTRACT

STATEMENT OF PROBLEM: Although psychological disorders have been established as one of the etiological factors for temporomandibular disorders, anxiety levels in individuals with masticatory muscle pain before and during the coronavirus 2019 (COVID-19) pandemic have not previously been compared.

PURPOSE: The purpose of this clinical study was to evaluate anxiety levels in patients with masticatory muscle pain at times before and during the COVID-19 pandemic.

MATERIAL AND METHODS: Eighty patients (18 to 68 years) with masticatory muscle pain were included in the study. All participants had completed the Generalized Anxiety Disorder 7 questionnaire (GAD-7) before the first COVID-19 infection had been reported in Turkey. After the onset of the COVID-19 pandemic, all participants were contacted by telephone to repeat the GAD-7 to evaluate changes in their psychology during the first lockdown. However, 18 of the 80 patients were unreachable. A statistical analysis was performed by using the Mann-Whitney U test. Proportion comparisons between sociodemographic characteristics and GAD-7 levels were performed by using the Fisher exact test (α=.05).

RESULTS: Forty-eight (60%) of the study population were women, and 32 (40%) were men, with a mean age ±standard deviation of 36.63 ±13.85 years. Both before and during the pandemic, GAD-7 scores were statistically similar as was each demographic parameter, including sex, educational status, and occupational status (P>.05). Also, no significant correlation was recorded between age and GAD-7 global scores obtained before and during the pandemic (r=-0.098 and r=-0.052, respectively, P>.05). However, during-pandemic GAD-7 scores were statistically higher than before-pandemic GAD-7 scores (P<.001).

CONCLUSIONS: Demographic parameters had no connection with anxiety levels in patients with masticatory muscle pain before and during the COVID-19 pandemic. However, the COVID-19 pandemic anxiety levels in the participants were higher than the levels before the pandemic.

PMID:34702584 | DOI:10.1016/j.prosdent.2021.09.002

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Nevin Manimala Statistics

Quantifying injury severity for traumatic brain injury with routinely collected health data

Injury. 2021 Oct 17:S0020-1383(21)00881-0. doi: 10.1016/j.injury.2021.10.013. Online ahead of print.

ABSTRACT

BACKGROUND: Routinely collected health data (RCHD) offers many opportunities for traumatic brain injury (TBI) research, in which injury severity is an important factor.

OBJECTIVE: The use of clinical injury severity indices in a context of RCHD is explored, as are alternative measures created for this specific purpose. To identify useful scales for full body injury severity and TBI severity this study focuses on their performance in predicting these currently used indices, while accounting for age and comorbidities.

DATA: This study utilized an extensive population-based RCHD dataset consisting of all patients with TBI admitted to any Belgian hospital in 2016.

METHODS: Full body injury severity is scored based on the (New) Injury Severity Score ((N)ISS) and the ICD-based Injury Severity Score (ICISS). For TBI specifically, the Abbreviated Injury Scale (AIS) Head, Loss of Consciousness and the ICD-based Injury Severity Score for TBI injuries (ICISS) were used in the analysis. These scales were used to predict three outcome variables strongly related to injury severity: in-hospital death, admission to intensive care and length of hospital stay. For the prediction logistic regressions of the different injury severity scales and TBI severity indices were used, and error rates and the area under the receiver operating curve were evaluated visually.

RESULTS: In general, the ICISS had the best predictive performance (error rate between 0.06 and 0.23; AUC between 0.82 [0.81;0.83] and 0.86 [0.85;0.86]). A clearly increasing error rate can be noticed with advancing age and accumulating comorbidity.

CONCLUSION: Both for full body injury severity and TBI severity, the ICISS tends to outperform other scales. It is therefore the preferred scale for use in research on TBI in the context of RCHD. In their current form, the severity scales are not suitable for use in older populations.

PMID:34702594 | DOI:10.1016/j.injury.2021.10.013

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Nevin Manimala Statistics

Effect of alumina particle morphology used for air abrasion on loss of enamel and luting composite resin

Dent Mater. 2021 Oct 23:S0109-5641(21)00281-5. doi: 10.1016/j.dental.2021.10.003. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate the volume loss after air abrasion with alumina particles with different morphology on bovine enamel and luting composite resin.

METHODS: Air abrasion was performed on 12 unscathed bovine teeth and 72 luting composite resin discs with 85 μm round-shaped and 50 μm sharp-edged alumina particles applied for 20 s, 40 s and 60 s (n = 12). Air abrasion was standardized by uniform areas of 2 mm diameter, a pressure of 0.25 MPa and a distance of 3 mm. The volume loss was determined by using a laboratory scanner.

RESULTS: Air abrasion with round-shaped alumina particles was mostly not measurable with the laboratory scanner, while sharp-edged alumina air abrasion resulted in significant loss of enamel. The median of volume loss by sharp-edged alumina particles ranged from 0.78 mm3 (20 s) to 2.52 mm3 (60 s). In contrast to round-shaped alumina the removal caused by sharp-edged alumina increased significantly with increasing application times (p ≤ 0.05). For air abrasion on luting composite resin the median of the removed volume ranged from 2.25 mm3 (20 s) to 6.18 mm3 (60 s), while round-shaped alumina showed a range from 0.45 mm3 (20 s) to 1.40mm3 (60 s). The round-shaped alumina produced a statistically significant lower volume loss than sharp-edged alumina for all three air abrasion times.

SIGNIFICANCE: The 85 μm round-shaped alumina particles removed less composite resin than 50 μm sharp-edged alumina particles but barely any enamel, making it an option for removing composite resin residues from enamel.

PMID:34702558 | DOI:10.1016/j.dental.2021.10.003

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Nevin Manimala Statistics

The dispersion of viscoelastic properties of fascicle bundles within the tendon results from the presence of interfascicular matrix and flow of body fluids

Mater Sci Eng C Mater Biol Appl. 2021 Nov;130:112435. doi: 10.1016/j.msec.2021.112435. Epub 2021 Sep 16.

ABSTRACT

In this work, we investigate differences in the mechanical and structural properties of tendon fascicle bundles dissected from different areas of bovine tendons. The properties of tendon fascicle bundles were investigated by means of uniaxial tests with relaxation periods and hysteresis, dynamic mechanical analysis (DMA), as well as magnetic resonance imaging (MRI). Uniaxial tests with relaxation periods revealed greater elastic modulus, hysteresis, as well as stress drop during the relaxation of samples dissected from the posterior side of the tendon. However, the normalized stress relaxation curves did not show a statistically significant difference in the stress drop between specimens cut from different zones or between different strain levels. Using dynamic mechanical analysis, we found that fascicle bundles dissected from the anterior side of the tendon had lower storage and loss moduli, which could result from altered fluid flow within the interfascicular matrix (IFM). The lower water content, diffusivity, and higher fractional anisotropy of the posterior part of the tendon, as observed using MRI, indicates a different structure of the IFM, which controls the flow of fluids within the tendon. Our results show that the viscoelastic response to dynamic loading is correlated with fluid flow within the IFM, which was confirmed during analysis of the MRI results. In contrast to this, the long-term relaxation of tendon fascicle bundles is controlled by viscoplasticity of the IFM and depends on the spatial distribution of the matrix within the tendon. Comparison of results from tensile tests, DMA, and MRI gives new insight into tendon mechanics and the role of the IFM. These findings may be useful in improving the diagnosis of tendon injury and effectiveness of medical treatments for tendinopathies.

PMID:34702520 | DOI:10.1016/j.msec.2021.112435

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Nevin Manimala Statistics

Physical Activity Engagement outside of College Physical Education: Application of the Transtheoretical Model

Am J Health Behav. 2021 Sep 30;45(5):924-932. doi: 10.5993/AJHB.45.5.12.

ABSTRACT

Objective: In this study, we examined physical activity (PA) engagement outside of college physical education (PE) classes using the Transtheoretical Model (TTM). Methods: Overall, 414 university students enrolled in PE classes voluntarily participated in this study. Participants were asked to complete a survey packet to measure 4 core constructs of TTM and their PA level performed outside of PE classes. Among the participants, 150 randomly selected students were asked to wear a triaxial accelerometer for 7 consecutive days to identify their PA level. Descriptive statistics and multivariate analyses of variance were used to determine the association between stages of motivational readiness and other strategic core constructions. Results: We categorized 77% of respondents into either the “action” stage or the “maintenance” stage for engaging in additional PA outside of the classes. Behavioral processes of change showed a graded and significant association with the stages. Both self-efficacy and decisional balance were significantly higher in students at higher stages. Conclusion: Our findings showed that most students enrolled in college PE classes had additional PA outside of the class participation. In addition, behavioral processes may be effective strategies for this specific target group to promote PA.

PMID:34702439 | DOI:10.5993/AJHB.45.5.12

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Nevin Manimala Statistics

Prevalence and Correlates of HIV Testing among Sexual Minorities

Am J Health Behav. 2021 Sep 30;45(5):879-894. doi: 10.5993/AJHB.45.5.8.

ABSTRACT

Objectives: We established baseline prevalence rates of HIV testing among adult, sexual minorities and identified the correlates of never being HIV tested. Methods: We used a 20-state sample of the 2017-2019 Behavioral Risk Factor Surveillance System to identify sexual minorities who responded to the HIV testing question (N=433,042). Using weighted multivariate logistic regression analysis, we identified the characteristics associated with never being HIV tested and the impact of state health departments’ HIV testing messages on testing status. Results: Overall, 41.6% of sexual minorities reported never being HIV tested with statistically significant state-level variation. Being younger (18-24 years) or older (65+ years), not black, married, and in good health significantly increased the odds of never being HIV tested as did lacking regular healthcare access and reporting no high-risk HIV behaviors. States’ HIV testing messages had no statistically significant effect on HIV testing status. Conclusions: Although sexual minorities were less likely than straight respondents to report never being HIV tested, a sizable population remained untested. Specific characteristics associated with sexual minorities’ HIV testing status can be used to tailor public health messages and optimize testing rates.

PMID:34702435 | DOI:10.5993/AJHB.45.5.8

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Nevin Manimala Statistics

Smartphone Addiction and Anxiety in Adolescents – A Cross-sectional Study

Am J Health Behav. 2021 Sep 30;45(5):895-901. doi: 10.5993/AJHB.45.5.9.

ABSTRACT

Objectives: The overuse of smartphones affects physical, social, and psychological well-being. However, research on smartphone addiction and anxiety disorders is scarce. Therefore, the objective of this study was to investigate the association between anxiety and smartphone addiction risk in Korean adolescents. Methods: This study used a cross-sectional survey method. We used the Revised Children’s Manifest Anxiety Scale to assess anxiety symptoms and we used the Korean Smartphone Addiction Proneness Scale index to evaluate the degree of high-risk or at-risk for smartphone addiction. Results: Analyses were performed for 1733 adolescents, including 771 boys and 962 girls. The high-risk or at-risk group for smartphone addiction accounted for 20.1% (p < .0001). Total anxiety scale score, as well as physiological anxiety, oversensitivity, and social concern categories were statistically different among levels of smartphone addiction risk (all ps < .0001). Multivariate analysis showed that poor self-reported health level, higher risk of smartphone addiction, having fewer close friends, caffeine drink consumption, female sex, and alcohol use were associated with greater anxiety. Conclusions: Management of smartphone addiction seems to be essential for proper psychological health. There is an urgent need to develop a way to prevent smartphone addiction on a social level.

PMID:34702436 | DOI:10.5993/AJHB.45.5.9

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Validity and Reliability of the Muscularity Oriented Eating Test (MOET) in Turkish

Am J Health Behav. 2021 Sep 30;45(5):856-866. doi: 10.5993/AJHB.45.5.6.

ABSTRACT

Objectives: In this study, we determine the validity and reliability of the Muscularity Oriented Eating Test (MOET) among Turkish university students, thereby creating the MOET-TR. Methods: First, the MOET was translated by using the translation-back translation method for cultural equivalence. Then, the validity and reliability analyses were performed on 460 university students. To analyze the stability of the scale over time, the MOET-TR was applied to approximately 20% of the sample number for a second time after 2-4 weeks. Results: The one-factor structure of the MOET-TR demonstrated a good agreement with the fix index values. Cronbach’s for the MOET-TR was 0.88, and the ICC value was 0.84. In addition, we found a positive statistically significant relationship between the total scores obtained from the DMS, EAT-40, REZZY, and IPAQ-Short forms used to evaluate the convergent divergent validity of the MOET-TR (p < .05). Conclusions: The MOET-TR is suitable for the Turkish culture and can be used to identify individuals who have muscularity oriented eating disorders, who are uncomfortable with their body shape, and who turn their body shapes into a social phobia.

PMID:34702433 | DOI:10.5993/AJHB.45.5.6

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Nevin Manimala Statistics

Meta-Analysis of Joint Test of SNP and SNP-Environment Interaction with Heterogeneity

Hum Hered. 2021 Oct 26:1-9. doi: 10.1159/000519098. Online ahead of print.

ABSTRACT

Many complex diseases are caused by single nucleotide polymorphisms (SNPs), environmental factors, and the interaction between SNPs and environment. Joint tests of the SNP and SNP-environment interaction effects (JMA) and meta-regression (MR) are commonly used to evaluate these SNP-environment interactions. However, these two methods do not consider genetic heterogeneity. We previously presented a random-effect MR, which provided higher power than the MR in datasets with high heterogeneity. However, this method requires group-level data, which sometimes are not available. Given this, we designed this study to evaluate the introduction of the random effects of SNP and SNP-environment interaction into the JMA, and then extended this to the random effect model. Likelihood ratio statistic is applied to test the JMA and the new method we proposed in this paper. We evaluated the null distributions of these tests, and the powers for this method. This method was verified by simulation and was shown to provide similar powers to the random effect meta-regression method (RMR). However, this method only requires study-level data which relaxed the condition of the RMR. Our study suggests that this method is more suitable for finding the association between SNP and diseases in the absence of group-level data.

PMID:34700323 | DOI:10.1159/000519098