Tag: pubmed

Eur J Med Res. 2025 Aug 13;30(1):747. doi: 10.1186/s40001-025-03039-8.

ABSTRACT

OBJECTIVE: To conduct a comparative assessment of the safety and efficacy of the port repositioning technique and the port re-implantation technique in treating periport skin infections associated with totally implantable venous access ports (TIVAPs).

METHODS: A retrospective analysis was performed on 35 patients who presented with periport skin infections at Jiangyin People’s Hospital between June 2016 and August 2022. Among them, 15 patients in Group A underwent port repositioning surgery, while 20 patients in Group B received port re-implantation surgery. Clinical data of all patients were meticulously collected, including postoperative wound healing status and the functionality of the repositioned or re-implanted TIVAPs.

RESULTS: In Group A, the median age was 58 years (IQR 46-63 years); in Group B, the median age was 60.5 years (IQR 54.3-70 years). The median BMI of Group A patients was 22.2 kg/m² (IQR 20.4-23.5 kg/m²); the median BMI of Group B patients was 21.5 kg/m² (IQR 20.5-23.1 kg/m²). Technical success was achieved in all patients (100%), and all ports were functional postoperatively. In Group A, the median indwelling time of the repositioned TIVAPs was 7 months (IQR 4-11 months); in Group B, the median indwelling time of the newly re-implanted TIVAPs was 5 months (IQR 3-8 months); there was no statistically significant difference between the two groups (P > 0.05).

CONCLUSION: Compared with the port re-implantation technique, the port repositioning technique for periport skin infections is a minimally invasive and cost-effective approach. Nevertheless, further investigations with a larger number of cases are required to comprehensively validate its safety and reliability.

PMID:40796884 | DOI:10.1186/s40001-025-03039-8

Eur J Med Res. 2025 Aug 13;30(1):745. doi: 10.1186/s40001-025-03035-y.

ABSTRACT

BACKGROUND: Elevated albumin-corrected anion gap (ACAG) levels have been shown to be associated with increased mortality in various critical illnesses; however, data specifically addressing heart failure (HF) complicated by acute kidney injury (AKI) are lacking.

METHOD: Data from ICU patients with HF complicated by AKI between 2008 and 2022 were extracted and analyzed from the MIMIC-IV database. The association between baseline ACAG levels and all-cause mortality was assessed using multiple statistical methods, including variance inflation factor analysis, restricted cubic spline (RCS) modeling, Kaplan-Meier analysis, univariate and multivariate Cox regression, subgroup analysis, mediation analysis, and receiver operating characteristic (ROC) curve analysis.

RESULTS: A total of 5425 patients were included in this study. RCS analysis showed a linear relationship between ACAG and mortality (p = 0.075 for nonlinearity). The Kaplan-Meier curve and multivariate Cox regression analysis revealed a positive relationship between ACAG and mortality at both 30 and 365 days post ICU admission. These results were confirmed by subgroup analysis. Mediation analysis showed SAPS II, bicarbonate, BUN, creatinine, hemoglobin, Charlson and ASP III mediated the association between ACAG and all-cause mortality, accounting for 32.34%, – 30.59%, 32.28%, 19.83%, 7.57%, 7.58%, and 25.64% of the mediating effect, respectively (all p values < 0.001). The AUC value for predicting 30-day mortality was 0.643 for ACAG, greater than 0.616 for albumin and 0.604 for AG. For predicting 365-day mortality, the AUC value was 0.641 for ACAG, greater than 0.626 for albumin and 0.597 for AG.

CONCLUSION: Elevated ACAG is associated with increased mortality in HF patients with AKI, emphasizing the importance of monitoring metabolic parameters in this population. ACAG may be a valuable prognostic marker for HF and AKI. Further research is warranted to determine whether targeted interventions to correct metabolic acidosis could improve outcomes in this vulnerable patient group.

PMID:40796876 | DOI:10.1186/s40001-025-03035-y

Global Health. 2025 Aug 12;21(1):47. doi: 10.1186/s12992-025-01142-3.

NO ABSTRACT

PMID:40796857 | DOI:10.1186/s12992-025-01142-3

Virol J. 2025 Aug 12;22(1):277. doi: 10.1186/s12985-025-02905-5.

ABSTRACT

INTRODUCTION: Acute transverse myelitis (ATM) is a rare neurological disorder often associated with infections, autoimmunity, and vaccination. During the COVID-19 pandemic, the incidence of ATM appeared to increase; however, the causal relationship remains uncertain due to limited follow-up and variability in case reporting. This study aims to evaluate the incidence of ATM in SARS-CoV-2 patients, identify associated risk factors, and explore potential links to vaccination using real-world data.

METHODS: A retrospective cohort analysis was conducted using electronic health records from the USA collaborative network within the TriNetX database. The study included SARS-CoV-2-infected patients and a matched non-COVID-19 cohort from 2020 to 2023. Propensity score matching (1:1) was applied to minimize baseline differences between the groups. Kaplan-Meier survival curves and Cox proportional hazards models were used to assess the risk of developing ATM within a one-year follow-up period.

RESULTS: Patients with SARS-CoV-2 infection had a significantly higher risk of developing ATM compared to non-infected individuals (HR = 1.46, 95% CI = 1.21-1.74). Stratified analyses confirmed this increased risk across various subgroups, including patients younger and older than 65 years, both males and females, and those infected during the Alpha strain-dominant period. No statistical significance between patients with and without SARS-CoV-2 infection after received different SARS-CoV-2 Vaccines.

CONCLUSION: SARS-CoV-2 infection appears to be more strongly associated with ATM than COVID-19 vaccination. Given the potential for lifelong disability and the need for long-term care in affected individuals, further studies are warranted to explore the underlying mechanisms and preventive strategies.

PMID:40796844 | DOI:10.1186/s12985-025-02905-5

BMC Psychiatry. 2025 Aug 12;25(1):783. doi: 10.1186/s12888-025-07234-z.

NO ABSTRACT

PMID:40796843 | DOI:10.1186/s12888-025-07234-z

BMC Health Serv Res. 2025 Aug 13;25(1):1070. doi: 10.1186/s12913-025-13266-8.

ABSTRACT

BACKGROUND: The Automated Dispensing Cabinets (ADCs) represent one of the most widely deployed forms of technology integrated with today’s medication-use systems. Despite the rise of ADC use and subsequent benefits, research exploring the impacts of ADCs on staff acceptance and satisfaction is still relatively limited and not thoroughly investigated. The present study aims to address this by assessing the impact of ADC implementation on healthcare staff satisfaction.

METHODS: This cross-sectional study was conducted in Almoosa Specialist hospital, Al-Ahsa, KSA, involving 203 healthcare staff participants selected through a convenience sampling approach considering the busy and tough schedule of staff. The questionnaire, named ADC User Acceptance Survey (ADC-UAS), was developed using a 10-item scale designed to measure Perceived Ease of Use (PEOU), Perceived Usefulness (PU), and Behavioral Intention to Use ADCs. This instrument employed a 7-point Likert scale and was based on the Modified Technology Acceptance Model (TAM). Pearson’s correlation was computed to investigate the correlation between demographic and TAM factors. The Artificial Neural Network (ANN) model was applied to assess the influential factors, and results were declared statistically significant if p < 0.05.

RESULTS: Out of 203 healthcare professionals, the majority were nurses (82.8%) and females (86.7%), with a mean age of 31.94 ± 5.96 years. The findings demonstrated high ADC acceptance and satisfaction, with 87.2% of participants reporting improved efficiency and 92.1% acknowledging enhanced patient safety. The strong positive relationship between current unit experience and acceptance (r = 0.304, p = 0.000) showed that individuals with more experience in their current unit are more likely to accept the system. Acceptance of ADC was significantly correlated with its usefulness (r = 0.820, p = 0.000). Positive correlation was also observed between professional experience and the perceived usefulness of the system (r = 0.144, p = 0.040). The result of the ANN model identified professional experience (100%), current unit experience (99.9%), and automation experience (97.8%) as the strongest predictors of ADC acceptance.

CONCLUSION: The study revealed high acceptance and satisfaction with ADCs among Almoosa healthcare staff, emphasizing that these systems make work more manageable and efficient. Given the high levels of acceptance and satisfaction among healthcare professionals regarding ADCs, it is recommended that healthcare facilities continue to invest in and expand the use of ADC systems.

PMID:40796839 | DOI:10.1186/s12913-025-13266-8

BMC Psychiatry. 2025 Aug 12;25(1):785. doi: 10.1186/s12888-025-07213-4.

ABSTRACT

BACKGROUND: Major depressive disorder (MDD) is a prevalent mental health condition, wherein the JAK/STAT signaling pathway serves as a potent cellular mechanism implicated in its pathophysiology. Increased expression of JAK2, STAT3, and subsequently IDO1 genes appears to be linked to depressive symptoms. With their antioxidant capabilities and improved absorption due to the nano formula, selenium nanoparticles could potentially modulate this molecular pathway. This study aimed to assess the impact of nano-selenium supplementation on the expression of JAK2, STAT3, and IDO1 genes in patients with MDD.

METHODS: A triple-blind, randomized, placebo-controlled trial was conducted at the Psychosomatic Clinic of Imam Khomeini Hospital Complex. A total of 50 participants, newly diagnosed with MDD were randomized to either a nano-selenium (55 µg/day) or placebo group for 12 weeks. All participants were receiving their standard treatment (sertraline 50 mg/day). Blood samples were collected at baseline and post-intervention to measure the gene expression using RT-qPCR.

RESULTS: At the end of the study, both groups showed reductions in JAK2 and STAT3 relative gene expression after 12 weeks (P < 0.05). Although the reduction was more in the nano-selenium group, the between-group differences were not statistically significant.

CONCLUSIONS: This study is the first to examine nano-selenium as a novel potential adjunct treatment for MDD. Though the degree of reduction in JAK2 and STAT3 levels was greater within the nano-selenium group, it appears that additional investigations are needed to elucidate its effects.

TRIAL REGISTRATION: The research received approval from the Research Ethics Committees of Iran University of Medical Sciences (Approval ID: IR IUMS.REC.1402.206, dated 2023-06-13) and was duly registered with the Iranian Registry of Clinical Trials (IRCT; registration number: IRCT20091114002709N62, dated 2023-07-29).

PMID:40796838 | DOI:10.1186/s12888-025-07213-4

BMC Psychiatry. 2025 Aug 12;25(1):786. doi: 10.1186/s12888-025-07245-w.

ABSTRACT

BACKGROUND: Depression and asthma share several pathophysiologic risk factors, and their precise connection remains unclear. Our research seeks to assess the relationship between depression and asthma.

METHODS: The association between depression and asthma was assessed through a multivariable logistic regression analysis, with data sourced from The National Health and Nutrition Examination Survey (NHANES) 2007-2018 and the English Longitudinal Study of Ageing (ELSA) 2004-2019. Subsequently, a linkage disequilibrium score regression (LDSC) analysis was conducted to evaluate the genetic correlation between depression and asthma. Moreover, a two-sample Mendelian randomization (MR) analysis was conducted by employing genome-wide association study (GWAS) summary statistics by means of both univariable MR (UVMR) and multivariable MR (MVMR).

RESULTS: This study included 31,434 participants from NHANES and 17,021 participants from ELSA for observational research. In the unadjusted model, participants with depression had a significantly increased risk of asthma in comparison to participants without depression, both in NHANES (OR = 2.002, 95%CI: 1.827-2.193, P < 0.001) and in ELSA (OR = 1.753, 95%CI: 1.581-1.943, P < 0.001). After adjusting potential confounders, the results remain significant. The LDSC result revealed a significant positive genetic correlation between depression and asthma (rg = 0.352, P < 0.001).The UVMR results further substantiated a genetically predicted causality of depression on asthma (OR = 1.291, 95%CI: 1.157-1.442, P < 0.001), while the reverse causality does not stand. Similar findings from MVMR were obtained for the causality investigation after adjusting smoking (OR = 1.326, 95%CI: 1.156-1.520, P < 0.001), drinking (OR = 1.375, 95%CI: 1.186-1.593, P < 0.001), and education (OR = 1.425, 95%CI: 1.253-1.621, P < 0.001).

CONCLUSION: Our findings indicate that depression may play a contributory role in the development of asthma, underscoring the potential benefit of implementing prevention strategies aimed at managing depression to mitigate asthma risk.

PMID:40796827 | DOI:10.1186/s12888-025-07245-w

BMC Public Health. 2025 Aug 12;25(1):2741. doi: 10.1186/s12889-025-24129-6.

ABSTRACT

INTRODUCTION: After losing a spouse, a woman experiences diverse changes in her life, and varying cultural settings add to them. Research has shown the impact of widowhood on one’s quality of life. This study evaluated the quality of life and its predictors of widows of Jodhpur enrolled in Ekal Nari Samman Pension Yojna, a state-sponsored pension scheme for widowed, divorced, or abandoned women from an economically weaker section of Rajasthan.

METHODOLOGY: A cross-sectional study was conducted among 260 widows aged 18-45 from Jodhpur City. A semi-structured questionnaire was used to collect data after obtaining informed written consent. The CDC HRQOL-14 questionnaire was used to collect data on quality of life. Data was analysed using descriptive statistics and logistic regression analysis.

RESULTS: The study findings revealed that the number of children, chronic illness, depression, and anxiety were consistently significant predictors of quality of life among widows in Jodhpur.

CONCLUSION: The findings highlight the association of physical and psychological health with the quality of life of widows. There is a critical need to integrate mental health services and chronic illness management into widows’ welfare programs to ensure comprehensive support.

PMID:40796822 | DOI:10.1186/s12889-025-24129-6

BMC Public Health. 2025 Aug 12;25(1):2732. doi: 10.1186/s12889-025-23968-7.

ABSTRACT

BACKGROUND: Effective early childhood education (ECE) programs, including elementary schools, kindergartens, and daycare facilities, are instrumental in fostering cognitive, social, emotional, and motor development. Access to water, sanitation, and hygiene (WASH) facilities, as mandated by Sustainable Development Goals (SDGs) 6, is integral in bolstering health and enhancing educational engagement globally. This study examines the impact of WASH facilities and sociodemographic factors on ECE enrollment in Bangladesh.

METHODS: Data were extracted from the 2022 Bangladesh Demographic and Health Survey (BDHS), on which 2494 children’s information and socioeconomic characteristics were analyzed. The outcome variable was ECE enrollment, and the exposure variable was WASH facilities-defined as having an improved water source, an improved nonshared toilet, and a basic handwashing facility-at the household level. Crude and adjusted logistic regression models were applied to determine significant associations between ECE enrollment and WASH facilities, including other covariates.

RESULTS: Children from households with basic handwashing facilities presented greater odds of ECE enrollment (AOR = 1.33, 95% CI 1.00-1.76, p value = 0.043), whereas improved toilet facilities were correlated with a greater chance of participation (AOR = 1.24, 95% CI 0.97-1.59, p value = 0.085). Treating drinking water significantly increased the probability of enrollment (AOR = 1.55, 95% CI 1.15-2.90, p value = 0.004). Regional disparities were mentionable; children in Rangpur (AOR = 1.94, 95% CI 1.33-2.81, p value = 0.001), Rajshahi (AOR = 1.47, 95% CI 1.01-2.13, p value = 0.043), Mymensingh (AOR = 1.39, 95% CI 0.97-1.99, p value = 0.096), and Khulna (AOR = 1.34, 95% CI 0.93-1.94, p value = 0.116) had higher odds of enrollment than Barishal did. Mothers’ education is also a key determinant; children of mothers with secondary education were 40% more likely to enroll (AOR = 1.40, 95% CI 1.00-1.96, p value = 0.049), and those with higher-educated mothers exhibited a similar trend (AOR = 1.43, 95% CI 0.95-2.16, p value = 0.088) compared with children of mothers with no education.

CONCLUSIONS: Our findings highlight the significance of household access to water, sanitation, and hygiene (WASH) facilities in early childhood education enrollment in Bangladesh. To advance progress toward SDGs 4 (quality education) and 6 (clean water and sanitation), policymakers should prioritize well-established WASH facilities, maternal education programs, and region-specific strategies.

PMID:40796821 | DOI:10.1186/s12889-025-23968-7