Malar J. 2025 Apr 24;24(1):134. doi: 10.1186/s12936-025-05328-3.
NO ABSTRACT
PMID:40275316 | DOI:10.1186/s12936-025-05328-3
Tag: pubmed
BMC Med Educ. 2025 Apr 24;25(1):604. doi: 10.1186/s12909-025-07168-w.
ABSTRACT
OBJECTIVE: This study aims to investigate nursing staff’s current knowledge-attitude-practice(KAP) regarding nursing document quality control and to explore effective methods to enhance their awareness of nursing documents’ importance through intensive training.
METHODS: We developed the questionnaire based on a systematic literature review and two rounds of Delphi expert consultation. Then, we sent the questionnaire to the nurses before and after the intensive training.Data processing and statistical analysis were conducted using R 4.4.0 software.
RESULTS: Altogether, 722, 701, and 800 nurses participated in the questionnaire survey before the training and after two training rounds, respectively. There was no statistically significant difference between the respondents’ baseline data (gender, age, professional title, position, educational background, and working years) before and after the training. After two rounds of intensive quality control training, the nursing staff’s median scores in the knowledge, attitude, and practice dimensions increased from 45 points before the training to 49, 50, and 50 points, respectively, and the difference was statistically significant (P < 0.05). Regression analysis indicated that the longer the working years, the higher the scores of the nursing staff after the training (3-5 years, P < 0.01, 95% Confidence Interval (CI), 0.2-0.57), (6-10 years, P < 0.01, 95% CI, 0.35-0.73), (> 10 years, P = 0.003, 95% CI, 0.32-0.72).The nursing staff with the titles of Chief Nurse (P < 0.01, 95% CI, 0.2-0.54) and Deputy Chief Nurse (P < 0.01, 95% CI, 0.21-0.74) scored higher after the training.
CONCLUSION: This study shows that, after two rounds of training, nurses’ KAP of the quality control of nursing documents significantly improved. The training had a positive impact on their KAP, which is conducive to enhancing the quality of nursing documents and nursing care. Therefore, hospitals should emphasize the quality control of nursing documents and take effective measures to help nurses continuously improve the quality of nursing documents.
PMID:40275301 | DOI:10.1186/s12909-025-07168-w
World J Emerg Surg. 2025 Apr 24;20(1):36. doi: 10.1186/s13017-025-00614-6.
ABSTRACT
BACKGROUND: Guidance on managing acute mesenteric ischaemia (AMI) is largely based on expert opinion and retrospective studies pooling different subtypes of AMI. In clinical practice, management strategy is often selected based on the patient’s severity of illness, whereas randomized controlled trials or even adjusted analyses comparing different strategies are rarely available. We aimed to perform a systematic review and meta-analysis on the effect of different management options when adjusted for the baseline severity of illness.
METHODS: A literature search was performed in PubMed, the Cochrane Library, Web of Science and Scopus. Studies recruiting patients after the year 2000, assessing at least 10 adult patients with reliably confirmed AMI, and comparing different management approaches were considered for inclusion. Thirteen study questions on different management strategies in different subtypes of AMI were formulated a priori. We included studies reporting results of adjusted analyses or reporting any variables reflecting the severity of illness in both study groups under comparison.
RESULTS: A total of 3324 publications were identified, 321 were selected for full-text review and 31 included in the review and analysis. Most of the studies comparing different management strategies of AMI did not report the severity of illness in the groups under comparison. Any variable that could be considered to reflect the severity of illness was reported in 26 studies. The available data only allowed one meta-regression analysis comparing initial endovascular revascularization versus open surgery in arterial occlusive AMI, including four studies that reported white blood cell count and lactate. The results indicate that the significant advantage of the endovascular approach suggested in the crude analysis may be abolished when adjusting for the severity of the illness. Narrative summaries and raw data are presented for other research questions.
CONCLUSIONS: The severity of illness plays an important role in the selection of management strategy and largely determines the outcome of any treatment, yet is generally not considered in available studies assessing the management of AMI. There is a major gap in the literature precluding appropriate analyses on treatment effects. Future studies should report subtypes of AMI and the severity of illness for each group.
STUDY REGISTRATION: PROSPERO CRD42024568497, date of registration: July 20th, 2024.
PMID:40275298 | DOI:10.1186/s13017-025-00614-6
BMC Med Educ. 2025 Apr 24;25(1):602. doi: 10.1186/s12909-025-07192-w.
ABSTRACT
BACKGROUND: The advancement of science and technology has significantly impacted nursing, emphasizing the importance of professional attitudes and caring behaviors. While previous studies have examined this relationship, limited research has considered the specific educational and sociocultural context of Iranian nursing students. This study addresses this gap by investigating how these factors shape professional attitudes and caring behaviors in an Iranian nursing education setting.
METHODS: Conducted at Tehran University of Medical Sciences in June 2024, the study involved 291 nursing students from their second to fourth years, selected through proportional random sampling. Data were gathered using the Professional Attitude for Student Nurses (IPASN) and Caring Behavior Inventory (CBI) instruments. Descriptive statistics, Pearson correlation, and multiple linear regression analyses were performed using Stata version 14.
RESULTS: A weak but statistically significant positive correlation was found between overall IPASN and CBI scores (r = 0.29, p < 0.01). Multiple regression analysis identified professional attitude (β = 0.257, p < 0.001) and satisfaction with nursing (β = 0.136, p = 0.017) as significant predictors of caring behaviors.
CONCLUSIONS: Enhancing professional attitudes and satisfaction in nursing can improve caring behaviors, highlighting the need for targeted educational interventions and organizational changes.
CLINICAL TRIAL NUMBER: Not applicable.
PMID:40275295 | DOI:10.1186/s12909-025-07192-w
Clinics (Sao Paulo). 2025 Apr 23;80:100642. doi: 10.1016/j.clinsp.2025.100642. Online ahead of print.
ABSTRACT
SARS-CoV-2 presents a hyperinflammatory scenario due to systemic inflammatory response syndrome with intense cytokine release, with consequent extrapulmonary involvement in 20 % of patients. The authors studied whether COVID-19 intestinal damage is a direct action of the virus on intestinal epithelial cells, with damage mainly at the tight junction. This is a retrospective observational study in a tertiary hospital emergency department. The authors studied 87 patients (46 patients over 61 years and 41 patients under 60 years old) with severe SARS-CoV-2 infection. The authors measured two plasma markers, LPS-Binding Protein (LBP) and ileal Fatty Acid-Binding Protein (iFABP). Furthermore, the authors evaluated the interaction between the two markers. TNF-α and IL-1 β were higher in bacterial co-infected patients and TNF-α was also higher in the older patients. Plasma iFABP levels were not statistically different in patients with bacterial co-infection; however, higher levels were found in the older population. Plasma LBP levels were higher in patients with bacterial co-infection when compared to patients without infection; however, when comparing plasma LBP levels in the older population with younger patients, no differences could be found. LBP, FABP, and cytokines can discriminate between bacterially infected patients and also discriminate elderly patients. The present study suggests that intestinal barrier dysfunction in SARS-CoV-2 infections is mainly due to damage to the intestinal tight junction complex with a disproportionately lower damage to enterocyte. In the older population, the authors also observed an increase in intestinal epithelial damage.
PMID:40273498 | DOI:10.1016/j.clinsp.2025.100642
Clinics (Sao Paulo). 2025 Apr 23;80:100605. doi: 10.1016/j.clinsp.2025.100605. Online ahead of print.
ABSTRACT
OBJECTIVE: The COVID-19 pandemic has a significant impact on the physical and mental health of people around the world. Parkinson’s patients need to visit hospitals regularly to evaluate and adjust the dosage of drugs. Studies have shown that anxiety, exacerbated by existing conditions ‒ including the challenges posed by the COVID-19 pandemic ‒ can aggravate the symptoms of Parkinson’s disease. This study aims to assess the impact of the quarantine period on the severity of movement symptoms, quality of life, non-motor symptoms, and the relationship with sex, education level, and age in patients with Parkinson’s disease.
METHODS: This descriptive cross-sectional study includes 200 patients with Parkinson’s disease who were treated in Bu Ali Hospital from April 2019 to the end of 2021. Primary data was collected using the patients’ files, which included information on age, gender, education level, medications and dosage, duration of Parkinson’s disease, the severity of the disease was evaluated based on the Hohen and Yehr (H&Y) criteria, and Quality of Life (QOL) and the impact of the quarantine period on their illness and quality of life has been collected through the Parkinson’s Disease Questionnaire (PDQ-39) questionnaire. The collected data were analyzed using SPSS software, descriptive statistics, t-test, and analysis of variance.
RESULTS: The quarantine period has a significant effect on the severity of Parkinson’s disease and quality of life. The mean severity of the disease increased from 2.85 before quarantine to 3.30 during quarantine (p < 0.05), indicating an increase in motor symptoms. Similarly, quality of life scores in all dimensions decreased from 62.8 before quarantine to 48.2 during quarantine (p < 0.05), indicating a decrease in quality of life. Pearson’s correlation test was used to investigate the relationship between age and the change in patients’ quality of life and the change in disease severity (p < 0.05).
CONCLUSION: The quarantine period due to the COVID-19 epidemic has had a significant impact on the severity of Parkinson’s disease and the quality of life of patients. The findings of this study indicate the need to develop strategies to provide better health care, social support, and physical activity for patients with Parkinson’s disease during quarantine and the pandemic.
PMID:40273495 | DOI:10.1016/j.clinsp.2025.100605
Clinics (Sao Paulo). 2025 Apr 23;80:100630. doi: 10.1016/j.clinsp.2025.100630. Online ahead of print.
ABSTRACT
OBJECTIVES: To systematically evaluate the efficacy and superiority of glucocorticoids in the treatment of severe pneumonia.
METHOD: Randomized Controlled Trials (RCTs) on glucocorticoids in the treatment of severe pneumonia were retrieved from CNKI, CBM, China Science and Technology Journal Database (VIP), Wanfang Database, and PubMed as of January 1, 2017. The literature was independently and objectively screened, extracted, and evaluated by two researchers, and a meta-analysis of the extracted data was performed using Revman 5.3 software.
RESULTS: Ten studies that met the inclusion criteria were included, with a cumulative total of 1120 cases. The meta-analysis results confirmed that the observation group was superior to the control group in terms of efficacy rate, temperature recovery time, cough relief time, rale disappearance time, and serum CRP level. There was no statistically significant difference in terms of the incidence of adverse reactions, mortality rate, and reinfection rate between the two groups.
CONCLUSIONS: Glucocorticoids showed an obvious clinical efficacy in patients with severe pneumonia. However, due to the small number of included studies and the ambiguity of numerous bias risk assessments, high-quality and large-sample RCTs are still needed to provide corroborating evidence.
PMID:40273494 | DOI:10.1016/j.clinsp.2025.100630
Clinics (Sao Paulo). 2025 Apr 23;80:100654. doi: 10.1016/j.clinsp.2025.100654. Online ahead of print.
ABSTRACT
OBJECTIVE: This study aimed to evaluate the effect of Omega-3 Fatty Acids (ω-3 PUFAs) on endometriosis.
DESIGN: The authors conducted a comprehensive search of the PubMed, Embase, Cochrane Library and Web of Science databases, focusing exclusively on Randomised Controlled Trials (RCTs) to study the impact of ω-3 PUFAs on endometriosis. The included studies were assessed for methodological quality using the Cochrane bias risk assessment tool and analyzed using data analysis software.
RESULTS: The search yielded five RCTs conducted between the database’s inception and July 2023, with a total sample size of 424 patients with endometriosis. The meta-analysis results showed no statistically significant effects of ω-3 Polyunsaturated Fatty Acids (PUFAs) on pain (Mean Difference [MD = -0.387], 95 % Confidence Interval [95 % CI -1.742-0.967], I2 = 93.3 %, z = 0.56, p = 0.575), sexual activity (MD = 0.143, 95 % CI -0.210-0.497, I2 = 0 %, z = 0.79, p = 0.427), pain intervention (MD = -0.216, 95 % CI -0.717-0.285, I2 = 0.0 %, z = 0.84, p = 0.399), catastrophic thinking (MD = 0.158, 95 % CI -0.315-0.632, I2 = 0.0 %, z = 0.66, p = 0.512) and the 12-item short form health survey (MD = 0.001, 95 % CI -0.053-0.503, I2 = 0.0 %, z = 0.00, p = 1.000), which were all statistically insignificant. However, ω-3 PUFAs appeared to reduce the inflammatory response in patients with endometriosis (MD = -5.20, 95 % CI -6.21–4.20, I2 = 0 %, z = 10.13, p < 0.001).
CONCLUSION: Based on the available evidence, ω-3 PUFAs may reduce the inflammatory response in patients with endometriosis, specifically by decreasing levels of pro-inflammatory cytokines, such as TNF-alpha, IL-6 and IL-1, indicating potential anti-inflammatory properties that warrant further investigation.
TRIAL REGISTRATION: PROSPERO: CRD42023441699.
PMID:40273491 | DOI:10.1016/j.clinsp.2025.100654
Clinics (Sao Paulo). 2025 Apr 23;80:100644. doi: 10.1016/j.clinsp.2025.100644. Online ahead of print.
ABSTRACT
OBJECTIVE: This research aimed to determine the feasibility and accuracy of CLR and clinical features to formulate a prediction model for Peptic Ulcer (PU)-induced Upper Gastrointestinal Bleeding (UGIB).
METHODS: The clinical data of 146 PU patients were prospectively collected, and patients were divided into the UGIB group (n = 48) and the non-UGIB group (n = 98). The factors affecting UGIB were analyzed using multifactorial logistic regression and collinearity analysis. The prediction model of UGIB was constructed, the predictive value of which was analyzed using the Receiver Operating Characteristic Curve (ROC) and Area Under the Curve (AUC), while the accuracy was analyzed using the calibration curve and Hosmer Lemeshow goodness-of-fit tests, and the application value was assessed using decision curve analysis (DCA).
RESULTS: Statistical significance was observed between the two groups regarding HP infection, ulcer diameter, ulcer stage, use of nonsteroidal anti-inflammatory drugs, Neutrophil, LYM, NEUT/LYM Ratio (NLR), CRP, and CLR. HP infection, ulcer stage, use of NSAIDs, NLR, and CLR were independent risk factors for UGIB, and PCT was a non-independent risk factor. The AUC for this model was 0.921. The calibration curve of the model matched the actual curve. The model achieved a better fitting effect in predicting UGIB (χ2 = 8.5069, df = 8, p = 0.3856) and had a better clinical application value.
CONCLUSION: A predictive model for PU-induced UGIB, based on CLR and clinical features, can assist in developing clinical treatment plans to prevent UGIB.
PMID:40273489 | DOI:10.1016/j.clinsp.2025.100644
Reprod Biomed Online. 2024 Dec 24;50(6):104781. doi: 10.1016/j.rbmo.2024.104781. Online ahead of print.
ABSTRACT
RESEARCH QUESTION: Does an association exist between maternal, reproductive and perinatal factors, and the risks of major non-chromosomal birth defects?
DESIGN: This population-based cohort study included 1,126,058 naturally conceived singleton live births (21,644 with and 1,104,414 without a major non-chromosomal defect) who were born between 2004 and 2018 in New York, Texas, Massachusetts and North Carolina. All study children were linked to their respective state birth defect registries to identify major birth defects diagnosed within the first year of life, and to state death records. Children with chromosomal defects were excluded. Genitourinary defects were only evaluated in boys. Placental and bleeding issues included placenta previa, placental abruption, uterine bleeding and other excessive bleeding, and, at delivery, blood transfusion or unplanned hysterectomy. Adjusted odds ratios and 95% confidence intervals were modelled using logistic regression.
RESULTS: Among major non-chromosomal defects, the highest significant risks were with pre-gestational diabetes (adjusted OR 2.48, 95% CI 2.25 to 2.74), followed by placental or bleeding issues (adjusted OR 1.82, 95% CI 1.66 to 1.99); this pattern was also evident for congenital heart defects, blastogenesis defects, orofacial defects, gastrointestinal defects and musculoskeletal defects. Hypertension (pre-gestational and gestational), prior caesarean delivery, older maternal age and higher body mass index were also significant risk factors.
CONCLUSIONS: The risk factors most strongly associated with major non-chromosomal birth defects were pre-gestational diabetes and placental or bleeding issues; other significantly increased risks were hypertension (pre-gestational and gestational), prior caesarean delivery, older maternal age and pre-pregnancy body mass index 30 kg/m2 or above.
PMID:40273488 | DOI:10.1016/j.rbmo.2024.104781