Tag: statistics

Sci Rep. 2025 Jan 2;15(1):13. doi: 10.1038/s41598-024-84481-2.

ABSTRACT

Universal immunization of children against common vaccine-preventable diseases is crucial in reducing infant and child morbidity and mortality. Assessing the vaccination coverage is a key step to improve utilization and coverage of vaccines for under-five children. Accordingly, vaccination coverage according to the national schedule assesses the vaccination coverage of children aged 12-35 months. However, there is a scarcity of information on the full vaccination coverage according to the national schedule and its determinants in Ghana. Therefore, this study aimed to assess the prevalence and predictors of vaccination coverage according to the national schedule among children aged 12-35 months in Ghana. A cross-sectional study design using the most recent demographic and health survey data from the Ghana Demographic and Health Survey was used. We included a total weighted sample of 1,823 children aged 12-35 months in the five years preceding the survey. We used a multilevel logistic regression model to identify associated factors for vaccination coverage according to the national schedule in Ghana. The adjusted odds ratio at 95% Cl was computed to assess the strength and significance of the association between explanatory and outcome variables. Factors with a p-value of < 0.05 are declared statistically significant. In this study, the full coverage of vaccination according to the national schedule among children aged 12-35 months in Ghana was 56.45% (95% CI 51.77-56.17). Women having an ANC visit were 40% more likely (AOR = 1.40, 95% CI 1.07-1.83), women involved in healthcare decision-making were 35% more likely (AOR = 1.35, 95% CI 1.05-1.75), Women who deliver in a health facility were 1.91 times more likely (AOR = 1.91, 95% CI 1.36-2.66), and communities with high media exposure were 47% more likely (AOR = 1.47, 95% CI 1.06-2.05) to achieve full vaccination coverage as compared to their counterparts. On the other hand, being in the Western (AOR = 0.4, 95% CI 0.18-0.88) and Northern (AOR = 0.33, 95% CI 0.15-0.74) regions decreased the odds of attaining full vaccination coverage according to the national schedule in Ghana. The full vaccination coverage according to the national schedule in Ghana was lower as compared to 90% coverage recommendation by World Health organization, and there is also in-equality among regions. Maternal optimal ANC contact, health facility delivery, women involved in health care decision-making, community media exposure, and region were significantly associated with full vaccination coverage according to the national schedule in Ghana. To improve child immunization coverage, relevant authorities and stakeholders should work together to improve ANC visits, media exposure, facility delivery, and women’s empowerment, and attention should be given to deviant regions.

PMID:39747564 | DOI:10.1038/s41598-024-84481-2

Sci Rep. 2025 Jan 2;15(1):413. doi: 10.1038/s41598-024-84425-w.

ABSTRACT

The latest World Health Organization Classification of Tumors, Fifth Edition, recognizes the invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) as a distinct malignant entity rather than a subtype of papillary thyroid carcinoma (PTC). This reclassification highlights the need to explore potential prognostic differences between IEFVPTC and classic PTC. This study utilized the Surveillance, Epidemiology, and End Results (SEER) database to compare prognoses of patients diagnosed with IEFVPTC and classic PTC between 2004 and 2019. Propensity score matching (PSM) was employed to adjust for confounding variables and reduce selection bias. Kaplan-Meier survival curves and Cox regression models were used to evaluate overall survival (OS) between the two groups. A total of 1,530 IEFVPTC and 81,508 classic PTC patients were analyzed. Before PSM, significant differences were noted in race, T-stage, N-stage, M-stage, laterality, radiotherapy, surgical modality, tumor size, and income. Post-PSM, these differences were not statistically significant (p > 0.05). Kaplan-Meier curves and Cox regression models showed no significant differences in OS between IEFVPTC and classic PTC both before and after PSM. This PSM analysis revealed no significant differences in overall survival between patients with IEFVPTC and classic PTC, suggesting that the reclassification of IEFVPTC does not translate into distinct prognostic outcomes.

PMID:39747560 | DOI:10.1038/s41598-024-84425-w

Sci Rep. 2025 Jan 2;15(1):419. doi: 10.1038/s41598-024-84526-6.

ABSTRACT

With the rapid advancement of technologies like the Internet, big data, and AI, various apps have impacted the daily lives of the elderly, widening the generational “digital divide.” Adapting apps for elderly users is crucial to addressing this issue. To address this challenge, we first focused on the middle-aged and elderly population, verifying the reliability and validity of the survey results. Then, descriptive statistics were used to analyze user behavior and preferences for the APP aging mode. Finally, ACSI path analysis and the fuzzy-IPA model were applied to assess user satisfaction. The key findings are as follows: (1) The APP aging mode is quite popular; (2) middle-aged and elderly users hesitate to use the aging mode due to “loss of original functions” and “secondary interface layout and font adjustments”; (3) better user experience in the aging mode leads to higher satisfaction, whereas higher initial expectations lead to lower satisfaction; (4) four aspects-“simple operation,” “ease of learning,” “understanding of function descriptions,” and “effective help system”-have high importance but low satisfaction levels. Overall, middle-aged and elderly users find the aging mode satisfactory but with room for improvement.

PMID:39747540 | DOI:10.1038/s41598-024-84526-6

Sci Rep. 2025 Jan 2;15(1):271. doi: 10.1038/s41598-024-84359-3.

ABSTRACT

With an increasing number of studies delving into the impact of dietary supplements on combat sports performance, researchers are actively seeking a more efficient dietary supplement for use in these sports. Nonetheless, controversies persist. Hence, we undertook a systematic review and Bayesian network meta-analysis to discern the most effective dietary supplements in combat sports by synthesizing the available evidence. We conducted a comprehensive search across PubMed, Web of Science, Cochrane, Embase, and SPORTDiscus, covering the period from their establishment to November 2, 2023. Our aim was to identify randomized controlled trials that evaluated the benefits of various dietary supplements for elite combat sports athletes. The risk of bias in these trials was assessed using the revised Cochrane Risk of Bias Tool for Randomized Trials. Subsequently, we employed Bayesian network meta-analysis through R software and Stata 15.0. During the analysis, we performed subgroup analysis based on the type of combat, distinguishing between striking and grappling disciplines. The analysis is based on 67 randomized controlled trials that meet all the inclusion criteria, involving 1026 elite combat sports athletes randomly assigned to 26 different dietary supplements or placebos. Results from the 50 trials included in the network meta-analysis indicate that compared to a placebo, sodium bicarbonate combined with caffeine (SMD: 2.3, 95% CrI: 1.5, 3.2), caffeine (SMD: 0.72, 95% CrI: 0.53, 0.93), beta-alanine (SMD: 0.58, 95% CrI: 0.079, 1.1), and sodium bicarbonate (SMD: 0.54, 95% CrI: 0.30, 0.81) was associated with a statistically significant increase in blood lactate concentrations. Compared to placebo, caffeine (SMD: 0.27, 95% CrI: 0.12, 0.41) was associated with a statistically significant increase in the final heart rate. Compared to placebo, creatine combined with sodium bicarbonate (SMD: 2.2, 95% CrI: 1.5, 3.1), creatine (SMD: 1.0, 95% CrI: 0.38, 1.6), and sodium bicarbonate (SMD: 0.42, 95% CrI: 0.18, 0.66) was associated with a statistically significant increase in mean power. Compared to placebo, creatine combined with sodium bicarbonate (SMD: 1.6, 95% CrI: 0.85, 2.3), creatine (SMD: 1.1, 95% CrI: 0.45, 1.7), and sodium bicarbonate (SMD: 0.35, 95% CrI: 0.11, 0.57) was associated with a statistically significant increase in peak power. Compared to placebo, caffeine (SMD: 1.4, 95% CrI: 0.19, 2.7) was associated with a statistically significant increase in the number of kicks. Compared to placebo, caffeine (SMD: 0.35, 95% CrI: 0.081, 0.61) was associated with a statistically significant increase in the number of throws. This study suggests that a range of dietary supplements, including caffeine, sodium bicarbonate, sodium bicarbonate combined with caffeine, creatine, creatine combined with sodium bicarbonate, and beta-alanine can improve the athletic performance of elite combat sports athletes.

PMID:39747536 | DOI:10.1038/s41598-024-84359-3

Sci Rep. 2025 Jan 2;15(1):262. doi: 10.1038/s41598-024-84169-7.

ABSTRACT

To investigate the relationship between the novel acromial angle and rotator cuff tears through imaging studies. We retrospectively selected 148 patients who underwent complete imaging examinations including scapular outlet X-rays and shoulder MRIs from January 2023 to September 2024 at our hospital. Based on whether the subjects had rotator cuff tears, they were divided into an injury group and a normal group, and the differences in the novel acromial angle between the two groups were compared. The novel acromial angle in the normal group was (149.1 ± 5.957)°, while in the injury group, it was (142.3 ± 6.558)°, showing a statistically significant difference between the two groups (P < 0.001). The probability of rotator cuff injury was 79.07% for individuals with a novel acromial angle smaller than the average in the injury group. The novel acromial angle in the injury group was generally smaller than that in the normal group. A novel acromial angle smaller than the average was associated with a higher probability of rotator cuff injury, and smaller angles were more likely to lead to more severe rotator cuff tears. Therefore, the novel acromial angle may serve as a simple and objective method to predict the probability of rotator cuff tears.

PMID:39747528 | DOI:10.1038/s41598-024-84169-7

Sci Rep. 2025 Jan 2;15(1):169. doi: 10.1038/s41598-024-84069-w.

ABSTRACT

Cancers of the mesothelium, such as malignant mesothelioma (MM), historically have been attributed solely to exposure to asbestos. Recent large scale genetic and genomic functional studies now show that approximately 20% of all human mesotheliomas are causally linked to highly penetrant inherited (germline) pathogenic mutations in numerous cancer related genes. The rarity of these mutations in humans makes it difficult to perform statistically conclusive genetic studies to understand their biological effects. This has created a disconnect between functional and epidemiological studies. However, since the molecular pathogenesis of MM in mice accurately recapitulates that of human disease, this disconnect between functional and epidemiological studies can be overcome by using inbred mouse strains that harbor mutation(s) in genes involved in the disease. Most mouse studies have focused on the effect of asbestos exposure, leaving the effects of genetic mutations in the absence of exposure understudied. Here, using existing peer-reviewed studies, we investigate the rate of spontaneous MM among mice with and without germline genetic mutations, in the absence of asbestos exposure. We leveraged these published data to generate a historical control dataset (HCD) to allow us to improve statistical power and account for genetic heterogeneity between studies. Our Bayesian analyses indicate that the odds of spontaneous MM among germline BAP1 mutant mice is substantially larger than that of wildtype mice. These results support the existing biological study findings that mesotheliomas can arise in the presence of pathogenic germline mutations, independently of asbestos exposure.

PMID:39747518 | DOI:10.1038/s41598-024-84069-w

Sci Rep. 2025 Jan 2;15(1):601. doi: 10.1038/s41598-024-84261-y.

ABSTRACT

Transcription factors (TFs), including steroidogenic factor-1 (SF-1), T-box transcription factor (TPIT) and pituitary transcription factor-1 (PIT-1), play a pivotal role in the cytodifferentiation of adenohypophysis. However, the impact of TFs on the growth patterns of nonfunctioning pituitary adenomas (NFPAs) remains unclear. This study aims to investigate the correlation between the expression of TFs and NFPAs growth patterns. Preoperative MRI in 171 patients who underwent surgery for nonfunctioning pituitary macroadenomas were analyzed to determine tumor growth patterns. Immunohistochemical staining for transcription factors PIT-1, TPIT, and SF-1 was done on all samples. Extrasellar growth was divided into three principal directions: infrasellar, suprasellar and lateral cavernous sinus invasion (CSI). Suprasellar extension was defined as tumor extension superior to the tuberculum sellae-dorsum sellae line, inferior extension as invasion through the sellar floor into the sphenoid sinus or clivus and CSI as Knosp grading score of 3 ~ 4. Statistical analysis to compare the groups was conducted using the Fisher’s exact test and t-test. TPIT-expressing tumors were more likely to exhibit combined infrasellar extension (55.17 vs 17.70%, p < 0.0001), as well as isolated infrasellar extension (18.97 vs 0%, p < 0.0001) compared to SF-1-expressing tumors. Conversely, SF-1-expressing tumors were more likely to exhibit combined suprasellar extension (92.92 vs 77.59%, p = 0.0061), as well as isolated suprasellar extension (75.22 vs 41.38%, p < 0.0001). TPIT-expressing tumors had a significantly higher CSI invasion (55.17 vs 35.40%, p = 0.0148). The mean maximal tumor diameter in TPIT and SF-1 macroadenomas was similar (28 vs 26 mm, p = 0.1213). The expression of TFs affects the extrasellar growth pattern of NFPAs. TPIT tumors exhibit a higher propensity for bone invasion and CSI, while SF-1 tumors tend to extend into the suprasellar region. Isolated infrasellar extension is specific to TPIT tumors and can serve as a radiologic sign to distinguish between TPIT tumors and SF-1 tumors.

PMID:39747515 | DOI:10.1038/s41598-024-84261-y

Sci Rep. 2025 Jan 2;15(1):74. doi: 10.1038/s41598-024-84026-7.

ABSTRACT

Acute mesenteric ischaemia (AMI) is a sudden onset of impaired bowel perfusion. Has a high mortality rate and is difficult to diagnose. Therapy involves endovascular, surgical, or a combination of both. Because of baseline differences, the comparison between endovascular and open surgical treatment is subject to selection bias. The aim of this study was to evaluate the results of treatment of AMI by open or endovascular approach in combination with laparotomy, and evaluation of treatment strategy in similar situations. Clinical data from 21 patients treated for AMI between 2018 and 2022 were retrospectively reviewed and compared. The primary endpoint of the study was in-hospital mortality. The secondary endpoint was the statistical evaluation of risk factors for mortality. All patients underwent acute endovascular revascularisation. Aspiration thromboembolectomy was performed in nine patients, stenting in seven, PTA in one and surgery in three. Endovascular therapy was unsuccessful for technical reasons in 3 patients. None of the monitored parameters reached statistical significance. The best results were achieved in the early diagnosis group. The overall mortality of acute mesenteric ischaemia in our cohort was 34.8%. Acute mesenteric ischaemia is a serious condition affecting mainly elderly patients with a high mortality rate, but the diagnosis of mesenteric ischaemia is not an automatic death sentence. To achieve the best therapeutic outcome, mesenteric ischaemia needs to be diagnosed and treated at an early stage. The best therapeutic outcomes are achieved in centres with 24-hour access to endovascular revascularisation and surgical therapy.

PMID:39747507 | DOI:10.1038/s41598-024-84026-7

Ecotoxicol Environ Saf. 2024 Dec 31;290:117637. doi: 10.1016/j.ecoenv.2024.117637. Online ahead of print.

ABSTRACT

INTRODUCTION: Expanding evidence suggests beneficial impacts of greenspace on human health, yet the relationships between greenness and stillbirth remain unknown. This study aimed to quantify the risk and burden of stillbirth associated with maternal greenness exposure during pregnancy.

METHODS: A total of 3,982,304 eligible birth records across 31 provinces in Iran from 2013 to 2018 were included in this study. Greenness exposure during pregnancy was assessed using the satellite-based normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) with multiple buffers. Stillbirth was defined as the birth of babies with no signs of life at ≥22 weeks of gestation. Multivariable-adjusted logistic regression models were employed to investigate greenness-stillbirth associations. To estimate the exposure-response functions, greenness exposures were fitted as smooth terms using restricted cubic splines. Avoidable burden of stillbirth under the predefined scenarios of improved greenness was estimated through a counterfactual analysis.

RESULTS: A total of 29,770 stillbirths occurred during 2013-2018, totaling to an overall annual rate of 748 cases per 100,000 births. Lower stillbirth risks were consistently seen in pregnant mothers being exposed to greater greenness within buffers of 500-3000 m. For instance, per 0.1-unit increase of NDVI and EVI within a 3000-m buffer was associated with the estimated odds of 0.971 (95 % confidence interval: 0.963-0.978) and 0.957 (0.947-0.968) for stillbirth, respectively. Evidently nonlinear relationships were identified between greenness exposure and stillbirth, exhibiting approximately an inverted L-shaped pattern with the steeper slope at high greenness levels. Assuming causality, 34-41 stillbirths per 100,000 births could be avoidable by achieving the 80th percentile of NDVI/EVI during 2013-2018, representing 4.6-5.4 % of nationwide registry-based stillbirths in Iran.

CONCLUSIONS: Our findings provided robust national evidence on beneficial effects of surrounding greenness in alleviating risk and burden of stillbirth in Iran, suggesting a greener environment could potentially serve as a promising intervention strategy for reducing stillbirth risk in less developed countries.

PMID:39746225 | DOI:10.1016/j.ecoenv.2024.117637

Biomed Phys Eng Express. 2025 Jan 2. doi: 10.1088/2057-1976/ada4b6. Online ahead of print.

ABSTRACT

Clinical adoption of innovative EEG technology is contingent on the non-inferiority of the new devices relative to conventional ones. We present the four key results from testing the signal quality of Zeto’s WR19 EEG system against a conventional EEG system conducted on patients in a clinical setting. &#xD;Methods: We performed 30-minute simultaneous recordings using the Zeto WR19 (zEEG) and a conventional clinical EEG system (cEEG) in a cohort of 15 patients. We compared the signal quality between the two EEG systems by computing time domain statistics, waveform correlation, spectral density, signal-to-noise ratio, and signal stability. &#xD;Results: All statistical comparisons resulted in signal quality non-inferior relative to cEEG. (i) Time domain statistics, including the Hjorth parameters, showed equivalence between the two systems, except for a significant reduction of sensitivity to electric noise in zEEG relative to cEEG. (ii) The point-by-point waveform correlation between the two systems was acceptable (r>0.6; P<0.001). (iii) Each of the 15 datasets showed a high spectral correlation (r>0.99; P<0.001) and overlapping spectral density across all electrode positions, indicating no systematic signal distortion. (iv) The mean signal-to-noise ratio (SNR) of the zEEG system exceeded that of the cEEG by 4.82 dB, equivalent to a 16% improvement. (v) The signal stability was maintained through the recordings.&#xD;Conclusion: In terms of signal quality, the zEEG system is non-inferior to conventional clinical EEG systems with respect to all relevant technical parameters that determine EEG readability and interpretability. Zeto’s WR19 wireless dry electrode system has signal quality in the clinical EEG space at least equivalent to traditional cEEG recordings.

PMID:39746217 | DOI:10.1088/2057-1976/ada4b6