Tag: statistics

Neuroimage Clin. 2023 Jan 5;37:103311. doi: 10.1016/j.nicl.2022.103311. Online ahead of print.

ABSTRACT

BACKGROUND: Lesions in the periventricular, (juxta)cortical, and infratentorial region, as visible on brain MRI, are part of the diagnostic criteria for Multiple sclerosis (MS) whereas lesions in the subcortical region are currently only a marker of disease activity. It is unknown whether MS lesions follow individual spatial patterns or whether they occur in a random manner across diagnostic regions.

AIM: First, to describe cross-sectionally the spatial lesion patterns in patients with MS. Second, to investigate the spatial association of new lesions and lesions at baseline across diagnostic regions.

METHODS: Experienced neuroradiologists analyzed brain MRI (3D, 3T) in a cohort of 330 early MS patients. Lesions at baseline and new solitary lesions after two years were segmented (manually and by consensus) and classified as periventricular, (juxta)cortical, or infratentorial (diagnostic regions) or subcortical-with or without Gadolinium-enhancement. Gadolinium enhancement of lesions in the different regions was compared by Chi square test. New lesions in the four regions served as dependent variable in four zero-inflated Poisson models each with the six independent variables of lesions in the four regions at baseline, age and gender.

RESULTS: At baseline, lesions were most often observed in the subcortical region (mean 13.0 lesions/patient), while lesion volume was highest in the periventricular region (mean 2287 µl/patient). Subcortical lesions were less likely to show gadolinium enhancement (3.1 %) than juxtacortical (4.3 %), periventricular (5.3 %) or infratentorial lesions (7.2 %). Age was inversely correlated with new periventricular, juxtacortical and subcortical lesions. New lesions in the periventricular, juxtacortical and infratentorial region showed a significant autocorrelative behavior being positively related to the number of lesions in the respective regions at baseline. New lesions in the subcortical region showed a different behavior with a positive association with baseline periventricular lesions and a negative association with baseline infratentorial lesions.

CONCLUSION: Across regions, new lesions do not occur randomly; instead, new lesions in the periventricular, juxtacortical and infratentorial diagnostic region are associated with that at baseline. Lesions in the subcortical regions are more closely related to periventricular lesions. Moreover, subcortical lesions substantially contribute to lesion burden in MS but are less likely to show gadolinium enhancement (than lesions in the diagnostic regions).

PMID:36623350 | DOI:10.1016/j.nicl.2022.103311

Poult Sci. 2022 Dec 26;102(3):102449. doi: 10.1016/j.psj.2022.102449. Online ahead of print.

ABSTRACT

Chicken chaphamaparvovirus (CkChpV) is a novel parvovirus species that belongs to the Chaphamaparvovirus genus and is frequently detected in different vertebrates exhibiting diarrhea symptoms. In this study, screening tests were performed on samples from 478 chickens, including 357 with diarrhea and 121 healthy, collected from 25 farms in China to investigate CkChpV infection in China. CkChpV, avian nephritis virus, rotavirus, chicken parvovirus, Newcastle disease virus, infectious bronchitis virus, chicken proventricular necrosis virus, and chicken circovirus were all detected in the samples at a positivity rate of 32%, 9%, 6%, 2%, 2%, 1%, 0%, and 0%, respectively. Statistical analyses suggested a correlation between the infection by the virus and diarrhea (P < 0.05). The genome of 9 strains from the CkChpV-positive samples, whose length was 4,432 nucleotides, have been completely sequenced. The strains shared 97.2 to 98.7% genomic similarity, 98.1 to 99.1%, and 98.2 to 99.2% amino acid similarity, respectively, for NS1 and VP1 compared with CkChpV strain RS/BR/15/2S in GenBank. The genetic relationship between these strains and CkChpV was established through phylogenetic analysis. These findings indicated the infection existence of CkChpV in China, which enriches our understanding of the diversity of the chaphamaparvoviruses and its host spectrum.

PMID:36623336 | DOI:10.1016/j.psj.2022.102449

J Forensic Odontostomatol. 2022 Dec 30;3(40):2-21.

ABSTRACT

Objective of work: The aim of this study was to determine the most frequent injuries and their relationship with gender, age and aetiology. Materials and Methods: An Epidemiologic Systematic Review was carried out, in the databases PUBMED and Scopus, between 2010-2020. We used Joanna Briggs Institute Checklist to access the Risk of Bias and Grading of recommendations, assessment, development, and the evaluations (GRADE) method was applied to assess the quality of the evidence of the 78 included articles. Results and Conclusions: Out of the 78 articles included, 14 were classified as moderate-risk bias and 58 as low risk. Only 20.5% had a prospective design and the male/female ratio ranged from 0.299 to 11.83. The majority of the studies described fractures (67) and only 26 reported dental injuries. The studies were distributed into five regions of countries: Asia, Africa, Latin America, Europe and Muslin regions. The results showed that road traffic accidents (55.37%) were the most frequent type of trauma, followed by assault (17.56%) and falls (10.21%). Fractures were the most prevalent injuries (84.3%). It was possible to establish an association between road traffic accidents and Asian countries. Assaults were more frequent in Africa, predominantly males, whilst falls increased with age, amongst women, in European countries. Fractures were usually observed in Muslin regions.

PMID:36623294

Obes Rev. 2023 Jan 9:e13544. doi: 10.1111/obr.13544. Online ahead of print.

ABSTRACT

The objective of this scoping review is to understand the extent and impact of youth involvement in policy processes within public health, education, and social work. Youth involvement in policy processes may enhance the relevance of policies and strengthen democratic practices. This scoping review aims to explore the nature, extent, and impact of youth involvement in policy processes in public health, education, and social work, with a focus on health, well-being, and obesity prevention. Empirical studies published from 1989 and evaluating involvement of youth aged 10 to 19 years old from all socioeconomic backgrounds and countries. Studies will be searched in seven databases. Data will be extracted and synthesized narratively by rights-based perspectives on youth involvement, practical processes of the involvement, and social experiences using descriptive statistics and visuals.

PMID:36623282 | DOI:10.1111/obr.13544

Orthopedics. 2023 Jan 10:1-3. doi: 10.3928/01477447-20230104-01. Online ahead of print.

ABSTRACT

Patellofemoral complications following total knee arthroplasty (TKA) are some of the most commonly cited complications in the literature, accounting for up to 50% of secondary procedures in the literature. Lateral dislocation of the patella, while rare, is one of many causes of extensor mechanism dysfunction. We sought to evaluate a novel patellar centralization procedure by comparing patients’ pre- and postoperative clinical and radiographic data. A retrospective case-series study was performed on 12 patient knees (5 male and 7 female) presenting with ambulatory dysfunction due to laterally dislocating patella. All of the knees had component revision combined with hamstring autograft tendon weave and medial reefing of the retinaculum and vastus medialis. The results revealed reliable stabilization of the patella and improved extensor lag at a mean 2.2±2.2 years’ short-term follow-up, which correlated with improved postoperative radiographic measurements. Range of motion in both flexion and extension was improved postoperatively. Improvements in radiographic measures of patellar tilt and patellar displacement were statistically significant, with reductions in the mean patellar tilt from 41.5°±25.9° to 3.9°±13.7° (P=.004), and in the mean patellar displacement from 2.8±2.1 cm to 0.8±0.9 cm (P=.012). Our study findings support the use of the extensor mechanism centralization procedure with autograft hamstring in management of laterally dislocating patella after TKA. [Orthopedics. 20XX;XX(X):xx-xx.].

PMID:36623271 | DOI:10.3928/01477447-20230104-01

Adv Mater. 2023 Jan 9:e2209094. doi: 10.1002/adma.202209094. Online ahead of print.

ABSTRACT

Room-temperature interaction between light-matter hybrid particles such as exciton-polaritons under extremely low-pump plays a crucial role in future coherent quantum light sources. However, the practical and scalable realization of coherent quantum light sources operating under low-pump remains a challenge because of the insufficient polariton interaction strength. Here, at room temperature, we demonstrate a very large polariton interaction strength, g ≈ 128 ± 21 μeVμm² realized in a 2D nano-layered Metal-Organic Framework (MOF). As a result, a polariton lasing at an extremely-low pump fluence of P₁ ≈ 0.01 ± 0.0015 μJcm^-2 (first threshold) was observed. Interestingly, as pump fluencies increase to P₂ ≈ 0.031 ± 0.003 μJcm^-2 (second threshold), a spontaneous transition to a polariton breakdown region occurred, which was not reported before. Finally, an ordinary photon lasing occurred at P₃ ≈ 0.11 ± 0.077 μJcm^-2 (third threshold), or above. Our experiments and statistical model reveal new insights on the transition mechanisms characterized by three distinct optical regions. This work introduces MOF as a new type of quantum material, with their naturally formed polariton cavities, as a cost-effective and scalable solution to build micro-scale coherent quantum light sources and polaritonic devices. This article is protected by copyright. All rights reserved.

PMID:36623260 | DOI:10.1002/adma.202209094

J Clin Oncol. 2023 Jan 9:JCO2201485. doi: 10.1200/JCO.22.01485. Online ahead of print.

ABSTRACT

PURPOSE: The results in terms of side effects vary among the published accelerated partial-breast irradiation (APBI) studies. Here, we report the 5-year results for cosmetic outcomes and toxicity of the IRMA trial.

METHODS: We ran this randomized phase III trial in 35 centers. Women with stage I-IIA breast cancer treated with breast-conserving surgery, age ≥ 49 years, were randomly assigned 1:1 to receive either whole-breast irradiation (WBI) or external beam radiation therapy APBI (38.5 Gy/10 fraction twice daily). Patients and investigators were not masked to treatment allocation. The primary end point was ipsilateral breast tumor recurrence. We hereby present the analysis of the secondary outcomes, cosmesis, and normal tissue toxicity. All side effects were graded with the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer Radiation Morbidity Scoring Schema. Analysis was performed with both intention-to-treat and as-treated approaches.

RESULTS: Between March 2007 and March 2019, 3,309 patients were randomly assigned to 1,657 WBI and 1,652 APBI; 3,225 patients comprised the intention-to-treat population (1,623 WBI and 1,602 APBI). At a median follow-up of 5.6 (interquartile range, 4.0-8.4) years, adverse cosmesis in the APBI patients was higher than that in the WBI patients at 3 years (12.7% v 9.2%; P = .009) and at 5 years (14% v 9.8%; P = .012). Late soft tissue toxicity (grade ≥ 3: 2.8% APBI v 1% WBI, P < .0001) and late bone toxicity (grade ≥ 3: 1.1% APBI v 0% WBI, P < .0001) were significantly higher in the APBI arm. There were no significant differences in late skin and lung toxicities.

CONCLUSION: External beam radiation therapy-APBI with a twice-daily IRMA schedule was associated with increased rates of late moderate soft tissue and bone toxicities, with a slight decrease in patient-reported cosmetic outcomes at 5 years when compared with WBI, although overall toxicity was in an acceptable range.

PMID:36623246 | DOI:10.1200/JCO.22.01485

J Clin Oncol. 2023 Jan 9:JCO2201359. doi: 10.1200/JCO.22.01359. Online ahead of print.

ABSTRACT

PURPOSE: Although level 1 evidence supports 45-Gy twice-daily radiotherapy as standard for limited-stage small-cell lung cancer, most patients receive higher-dose once-daily regimens in clinical practice. Whether increasing radiotherapy dose improves outcomes remains to be prospectively demonstrated.

METHODS: This phase III trial, CALGB 30610/RTOG 0538 (ClinicalTrials.gov identifier: NCT00632853), was conducted in two stages. In the first stage, patients with limited-stage disease were randomly assigned to receive 45-Gy twice-daily, 70-Gy once-daily, or 61.2-Gy concomitant-boost radiotherapy, starting with either the first or second (of four total) chemotherapy cycles. In the second stage, allocation to the 61.2-Gy arm was discontinued following planned interim toxicity analysis, and the study continued with two remaining arms. The primary end point was overall survival (OS) in the intention-to-treat population.

RESULTS: Trial accrual opened on March 15, 2008, and closed on December 1, 2019. All patients randomly assigned to 45-Gy twice-daily (n = 313) or 70-Gy once-daily radiotherapy (n = 325) are included in this analysis. After a median follow-up of 4.7 years, OS was not improved on the once-daily arm (hazard ratio for death, 0.94; 95% CI, 0.76 to 1.17; P = .594). Median survival is 28.5 months for twice-daily treatment, and 30.1 months for once-daily treatment, with 5-year OS of 29% and 32%, respectively. Treatment was tolerable, and the frequency of severe adverse events, including esophageal and pulmonary toxicity, was similar on both arms.

CONCLUSION: Although 45-Gy twice-daily radiotherapy remains the standard of care, this study provides the most robust information available to help guide the choice of thoracic radiotherapy regimen for patients with limited-stage small-cell lung cancer.

PMID:36623230 | DOI:10.1200/JCO.22.01359

Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2218957120. doi: 10.1073/pnas.2218957120. Epub 2023 Jan 9.

NO ABSTRACT

PMID:36623183 | DOI:10.1073/pnas.2218957120

Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2207595120. doi: 10.1073/pnas.2207595120. Epub 2023 Jan 9.

ABSTRACT

Over the past two decades, multiple countries with high vaccine coverage have experienced resurgent outbreaks of mumps. Worryingly, in these countries, a high proportion of cases have been among those who have completed the recommended vaccination schedule, raising alarm about the effectiveness of existing vaccines. Two putative mechanisms of vaccine failure have been proposed as driving observed trends: 1) gradual waning of vaccine-derived immunity (necessitating additional booster doses) and 2) the introduction of novel viral genotypes capable of evading vaccinal immunity. Focusing on the United States, we conduct statistical likelihood-based hypothesis testing using a mechanistic transmission model on age-structured epidemiological, demographic, and vaccine uptake time series data. We find that the data are most consistent with the waning hypothesis and estimate that 32.8% (32%, 33.5%) of individuals lose vaccine-derived immunity by age 18 y. Furthermore, we show using our transmission model how waning vaccine immunity reproduces qualitative and quantitatively consistent features of epidemiological data, namely 1) the shift in mumps incidence toward older individuals, 2) the recent recurrence of mumps outbreaks, and 3) the high proportion of mumps cases among previously vaccinated individuals.

PMID:36623178 | DOI:10.1073/pnas.2207595120