Tag: statistics

Int Tinnitus J. 2022 Dec 1;26(2):143-146. doi: 10.5935/0946-5448.20220023.

ABSTRACT

The present study compared the Auditory Brainstem Response (ABR) of children with thalassemia major and typically developing children. A total of 16 children participated in this study. Group I included 8 children with thalassemia major regularly undergoing blood transfusions and chelating therapy. Group II included 8 age and gender-matched typically developing children. All children in both groups had hearing sensitivity within normal limits. The Auditory Brainstem Response (ABR) was recorded monaurally for click stimuli from both ears. Results showed that the mean latencies of peaks of ABR were similar in both groups. The mean peak amplitude of peaks I and V of the ABR were different between groups, but it was not statistically significant. The present study showed no abnormality in the latency and amplitude of peaks of the ABR in children with thalassemia major with hearing sensitivity within normal limits.

PMID:36724364 | DOI:10.5935/0946-5448.20220023

Int Tinnitus J. 2022 Dec 1;26(2):133-138. doi: 10.5935/0946-5448.20220021.

ABSTRACT

PURPOSE: The purpose of the present study is to find the functions of vestibular reflexes in individuals’ with normal hearing and tinnitus, to identify vestibular dysfunctions earlier, and helps with the management of the same.

METHOD: The present study aimed to administer cVEMP and oVEMP to all the participants having a normal hearing with tinnitus (experimental group) and without tinnitus (Control group) and compared p13, n23 latencies and peak-to-peak amplitude of cVEMP; n10, p15 latencies of oVEMP and peak-to-peak amplitude between two groups and within tinnitus group.

RESULTS: The present study stated that there is no statistically significant difference seen in cVEMP except n23 latency of bilateral tinnitus than control group. However, there is statistically significant difference in left ear p15 latency, left ear peak-to-peak amplitude, bilateral peak-to-peak amplitude between the two groups and Right Vs Left ear peak-to-peak amplitude in within the tinnitus group was seen in oVEMP. T-test was used to compare the latencies of p13, n23, and peak-to-peak amplitude of cVEMP and n10, p15 latencies and peak-to-peak amplitude of oVEMP between the experimental and control group and within the tinnitus group.

CONCLUSION: There is no significant difference seen in cVEMP except n23 latency of bilateral tinnitus than control group and However, there is statistically significant difference in left ear p15 latency, left ear peak-to-peak amplitude, bilateral peak-to-peak amplitude between the two groups and Right Vs Left ear peak-to-peak amplitude in within the tinnitus group was seen in oVEMP and the current study concluded that the significant results with several parameters and no significant results with other parameters in cVEMP and oVEMP recording might be Presymptomatic tinnitus is regarded to occur in ears with normal hearing and abnormal VEMP, while asymptomatic tinnitus may occur in ears with normal VEMP. Tinnitus may be the first signs of secondary or delayed endolymphatic hydrops. If this is demonstrated to be accurate, we should anticipate that such patients will gradually develop other endolymphatic hydrops symptoms like SNHL and clinical vestibular dysfunction.

PMID:36724362 | DOI:10.5935/0946-5448.20220021

Int Tinnitus J. 2022 Dec 1;26(2):122-126. doi: 10.5935/0946-5448.20220019.

ABSTRACT

BACKGROUND: There is many civilians and soldiers who exposed to explosions in Iraq each month and they need an otolaryngological and audiological assessment.

OBJECTIVE: To recognize the possible auditory insults and the recovery period of the acquired damages that may resulted from explosion and help for planning of optimal management strategies of otological manifestations and prevent undesirable consequences.

PATIENTS AND METHODS: A prospective, descriptive study included forty-seven patients who were exposed to blast injuries within two weeks came to otolaryngology unit in Basrah Teaching Hospital complaining from otological symptoms from July 2017 tell January 2019. Three periodic assessments were done for each patient. An initial evaluation was done in the 1st visit included a detailed history and examination to evaluate the symptoms and assess the associated non-otological injury. An otological examination were done for all patients in the three visits, included microscopic ear examination, photos for the perforated tympanic membrane were taken to grade the perforations depending on their surface area, Pure tone audiometry and tympanometry. Thirty-eight patients were available to follow up in the 2nd and 3rd visits.

RESULTS: All of the 47 patients were young and middle age male, hearing loss and tinnitus were the most presenting symptoms, which improved with time. Hearing impairment mostly in the high frequencies however there was improvement in the subsequent visits. The majority of patients (93.6%) presented with tympanic membrane perforation mostly grade I which usually healed spontaneously. There was a statistically significant associations between the degree of tympanic membrane perforation and associated nonotological injuries and with the explosions if occurred in closed space.

CONCLUSION: Blast related otological injury constitute the main cause of morbidity as the ear is the most sensitive organ to explosive blast injury. Hearing loss was the dominant symptoms at presentation mainly in high frequencies, but fortunately most of patients improved with time. Tympanic membrane perforation constituted the mostly seen sign, however spontaneous healing can be expected in the majority of cases.

PMID:36724360 | DOI:10.5935/0946-5448.20220019

Int Tinnitus J. 2022 Dec 1;26(2):101-106. doi: 10.5935/0946-5448.20220015.

ABSTRACT

INTRODUCTION: Cochlear Implantation (CI) surgery has long been used as an effective treatment for children with bilateral profound sensorineural hearing loss who failed to benefit from the use of hearing aids. Among other factors, the age at which implantation is done is thought to have an effect on the speech progression outcome of patients postoperatively.

OBJECTIVES: The Jordanian CI Program has limited resources, and Jordan has an underdeveloped early screening and intervention program for deafness. In this study, we aimed to explore the effect of age at time of implantation on receptive and expressive language outcomes in Jordan, to guide funding and focus efforts on patient groups who would benefit most, thus reducing unnecessary longterm morbidity and disability, and improving cost efficiency.

METHODS: Data was gathered from all major sectors in Jordan on patients who underwent CI from 2006 to 2018 (a total of 1815 patients). We compared the language outcome 2 to 4 years after implantation for patients aged below 3 years, 3 to under 6, 6 to under 9 years, and 9 and older at the time of implantation.

RESULTS AND CONCLUSION: We found a statistically significant difference in language outcomes between patients aged below 6 years vs those 6 and older, with better receptive and expressive language outcomes in the younger age groups.

PMID:36724356 | DOI:10.5935/0946-5448.20220015

Int Tinnitus J. 2022 Dec 1;26(2):79-88. doi: 10.5935/0946-5448.20220012.

ABSTRACT

OBJECTIVES: To examine the differences in auditory evoked cortical responses that may underlie the tendency of some people to perceive tinnitus. The study hypothesis is that the mean ALR and P300 amplitudes in normal hearing adults who perceive temporary tinnitus after exposure to sustained silence will be larger than the mean ALR and P300 amplitudes in normal hearing adults who do not perceive temporary tinnitus after exposure to sustained silence.

DESIGN: This was a prospective cross-sectional study. The approval for the study was obtained from the IRB and COVID ramp up committee of University of North Carolina Greensboro (UNCG). Participants completed comprehensive hearing screening and preand postsilence ALR and P300 recordings were obtained. After the first ALR/P300 recording participants were exposed to ten minutes of silence. Participants completed a Qualtrics questionnaire to report any tinnitus perception that emerged during silence exposure. Absolute N1, P2 and P300 waveform amplitudes and latencies were identified and were entered into an SPSS spreadsheet for data analysis.

RESULTS: Thirty adult females with normal pure tone hearing thresholds and no history of persistent tinnitus were included in the study. The mean age of the participants was 22.5 ± 3.9 years. When exposed to silence, eight (26.7%) participants perceived temporary tinnitus. N1 and P300 waveforms were smaller in amplitude and faster in latency in the tinnitus perception group; however, the ALR and P300 waveform latencies and amplitudes did not statistically differ significantly between the participants who perceived temporary tinnitus in silence and those who did not (p>0.05). The difference in waveform morphology between the tinnitus perception group and the non-tinnitus perception group revealed a greater difference in P300 amplitude after exposure to silence.

CONCLUSION: Differences in ALR and P300 latencies and amplitudes were observed between the tinnitus perception group and non-tinnitus perception group, with smaller P300 amplitudes appearing in the group perceiving tinnitus. While the results did not statistically significant, this pattern may reflect a mismatch between the neuronal response in the auditory cortex (N1 and P2 amplitudes and latencies) and the neuronal activity in the modulatory network regions (P300).

PMID:36724353 | DOI:10.5935/0946-5448.20220012

Acad Med. 2023 Feb 1. doi: 10.1097/ACM.0000000000005157. Online ahead of print.

ABSTRACT

PURPOSE: Accurate assessment of clinical performance is essential to ensure graduating residents are competent for unsupervised practice. The Accreditation Council for Graduate Medical Education milestones framework is the most widely used competency-based framework in the United States. However, the relationship between residents’ milestones competency ratings and their subsequent early career clinical outcomes has not been established. It is important to examine the association between milestones competency ratings of U.S. general surgical residents and those surgeons’ patient outcomes in early career practice.

METHOD: A retrospective, cross-sectional study was conducted using a sample of national Medicare claims for 23 common, high-risk inpatient general surgical procedures performed between July 1, 2015, and November 30, 2018 (n = 12,400 cases) by nonfellowship-trained U.S. general surgeons. Milestone ratings collected during those surgeons’ last year of residency (n = 701 residents) were compared with their risk-adjusted rates of mortality, any complication, or severe complication within 30 days of index operation during their first 2 years of practice.

RESULTS: There were no associations between mean milestone competency ratings of graduating general surgery residents and their subsequent early career patient outcomes, including any complication (23% proficient vs 22% not yet proficient; relative risk [RR], 0.97, [95% CI, 0.88-1.08]); severe complication (9% vs 9% respectively; RR, 1.01, [95% CI, 0.86-1.19]); and mortality (5% vs 5%; RR, 1.07, [95% CI, 0.88-1.30]). Secondary analyses yielded no associations between patient outcomes and milestone ratings specific to technical performance, or between patient outcomes and composites of operative performance, professionalism, or leadership milestones ratings (P ranged 0.32 to 0.97).

CONCLUSIONS: Milestone ratings of graduating general surgery residents were not associated with the patient outcomes of those surgeons when they performed common, higher risk procedures in a Medicare population. Efforts to improve how milestones ratings are generated might strengthen their association with early career outcomes.

PMID:36724304 | DOI:10.1097/ACM.0000000000005157

J Appl Microbiol. 2022 Dec 16:lxac062. doi: 10.1093/jambio/lxac062. Online ahead of print.

ABSTRACT

AIMS: This study looked at the survival, mobilization, and transport of Escherichia coli from sheep faeces over an extended period, which was then repeated for all four seasons.

METHODS AND RESULTS: Rain simulation was used to measure E. coli mobilization directly from faecal pats and subsequent transport across a soil surface. The rain simulation experiments were conducted over the same 90-day period and for the four seasons as per the survival experiments conducted to determine E. coli survival in faecal pats. The survival experiments demonstrated up to three orders of magnitude increase of E. coli in sheep faeces. Peak E. coli concentrations in the faeces were observed on Day 2 through to Day 30, with no significant effect of seasons or weather patterns. The E. coli concentrations in the runoff followed the survival pattern of E. coli concentrations in the faeces.

CONCLUSIONS: There was a statistically significant relationship between the E. coli concentrations in the faeces and the runoff.

SIGNIFICANCE AND IMPACT OF STUDY: The data generated on the relationship between Escherichia coli concentrations in the faeces and in the runoff can support the development of runoff risk models for sheep grazing pastureland to support catchment modelling, land use decisions, and public health.

PMID:36724280 | DOI:10.1093/jambio/lxac062

Stat Appl Genet Mol Biol. 2023 Feb 1;22(1). doi: 10.1515/sagmb-2021-0068. eCollection 2023 Jan 1.

ABSTRACT

Many human disease conditions need to be measured by ordinal phenotypes, so analysis of ordinal phenotypes is valuable in genome-wide association studies (GWAS). However, existing association methods for dichotomous or quantitative phenotypes are not appropriate to ordinal phenotypes. Therefore, based on an aggregated Cauchy association test, we propose a fast and efficient association method to test the association between genetic variants and an ordinal phenotype. To enrich association signals of rare variants, we first use the burden method to aggregate rare variants. Then we respectively test the significance of the aggregated rare variants and other common variants. Finally, the combination of transformed variant-level P values is taken as test statistic, that approximately follows Cauchy distribution under the null hypothesis. Extensive simulation studies and analysis of GAW19 show that our proposed method is powerful and computationally fast as a gene-based method. Especially, in the presence of an extremely low proportion of causal variants in a gene, our method has better performance.

PMID:36724206 | DOI:10.1515/sagmb-2021-0068

PLoS One. 2023 Feb 1;18(2):e0281137. doi: 10.1371/journal.pone.0281137. eCollection 2023.

ABSTRACT

We examined whether and how L1-L2 crosslinguistic formal lexical similarity influences L2 word choice. Our sample included two learner subcorpora, containing 8,500 and 6,390 English texts, written in an educational setting, by speakers of diverse L1s in the A1-B2 CEFR range of L2 proficiency. We quantified similarity based on phonological overlap between L1 words and their L2 (English) translations. This similarity relates to psycholinguistic cognancy, which occurs when words and their translations share a high level of formal similarity, often due to historical cognancy from shared etymology or language contact. We then used mixed-effects statistical models to examine how this similarity influences the rate of use of the L2 words; essentially, we checked whether L2 words that are more similar to their L1 translations are used more often. We also controlled for potential confounds, including the baseline L1 frequency of the English words. The type of crosslinguistic similarity that we examined did not influence learners’ choice of L2 words in their writing in the present sample, which represents a type of educational setting that many learners encounter. This suggests that the influence of such similarity is constrained, and that communicative needs can override transfer from learners’ L1 to their L2, which raises questions regarding when and how else situational factors can influence transfer.

PMID:36724191 | DOI:10.1371/journal.pone.0281137

PLoS One. 2023 Feb 1;18(2):e0277499. doi: 10.1371/journal.pone.0277499. eCollection 2023.

ABSTRACT

Spatial variation and genotype by environment (GxE) interaction are common in varietal selection field trials and pose a significant challenge for plant breeders when comparing the genetic potential of different varieties. Efficient statistical methods must be employed for the evaluation of finger millet breeding trials to accurately select superior varieties that contribute to agricultural productivity. The objective of this study was to improve selection strategies in finger millet breeding in Ethiopia through modeling of spatial field trends and the GxE interaction. A dataset of seven multi-environment trials (MET) conducted in randomized complete block design (RCBD) with two replications laid out in rectangle (row x column) arrays of plots was used in this study. The results revealed that, under the linear mixed model, the spatial and factor analytic (FA) models were efficient methods of data analysis for this study, and this was demonstrated with evidence of heritability measure. We found two clusters of correlated environments that helped to select superior and stable varieties through ranking average Best Linear Unbiased Predictors (BLUPs) within clusters. The first cluster was chosen because it contained a greater number of environments with high heritability. Based on this cluster, Bako-09, 203439, 203325, and 203347 were the top four varieties with relatively high yield performance and stability across correlated environments. Hence, scaling up the use of this efficient analysis method will improve the selection of superior finger millet varieties.

PMID:36724188 | DOI:10.1371/journal.pone.0277499