Tag: statistics

Medicine (Baltimore). 2022 Dec 30;101(52):e32583. doi: 10.1097/MD.0000000000032583.

ABSTRACT

OBJECTIVE: This study aimed to evaluate the efficacy of modified HuangLian JieDu decoction (MHLJDD) as a supplementary medication for early enteral nutrition in septic patients.

METHODS: This study was designed as a randomized controlled preliminary study. Septic patients were randomly divided into control (treated with the base treatment) and intervention (co-treated with MHLJDD and the base treatment) groups. The primary outcomes of this study were 60-day (d) mortality rate, length of mechanical ventilation (MV), and length of stay in the intensive care unit (ICU).

RESULTS: Of the 86 included patients, 44 and 42 were allocated to the intervention and control groups, respectively. Lengths of MV and ICU stay were significantly shorter in the intervention group than in the control group (10.31 ± 3.92 d vs 8.66 ± 2.84 d, P = .028; and 11.88 ± 5.25 d vs 10.41 ± 3.14 d, P = .029; respectively). However, the difference in 60-d mortality rate between the 2 groups was not statistically significant (20.45% vs 38.10%, P = .071). The enteral-nutrition tolerance score of the control group was higher than that of the intervention group (6.81 ± 4.28 vs 4.68 ± 4.04, P = .020). Incidence of hyperglycemia and gastric retention (gastric residual volume > 250 mL) was higher in the control group than in the intervention group (59.52% vs 29.55%, P = .005; and 28.57% vs 11.36%, P = .020, respectively).

CONCLUSIONS: MHLJDD can shorten the MV and ICU stay of septic patients.

PMID:36596025 | DOI:10.1097/MD.0000000000032583

Medicine (Baltimore). 2022 Dec 30;101(52):e32546. doi: 10.1097/MD.0000000000032546.

ABSTRACT

This study aims to assess the prevalence, clinical, and ultrasonography (US) in thyroid screening in healthy subjects with general symptoms of thyroid abnormality in low iodine intake in Bajulmati primary care center, East Java Indonesia. We retrospectively reviewed US thyroid examination of 74 subjects with symptoms of mass in the neck, shaky, sleep difficulties, over sweating, and chronic fatigue on September 15th, 2021. Following the WHO guidelines, subjects also underwent physical examination in which the result were classified into 3 categories, that is, no palpable nor visible goiter, palpable but no visible goiter, as well as palpable and visible goiter. We evaluate US thyroid characteristics following Korean Society of Thyroid Radiology guidelines. Image analysis was reviewed by 4 general radiologists with 2 to 13 years’ experience. Categorical variables were compared using chi-squared or Fisher exact tests. Correlation between variables was measured with gamma statistics. Statistical analyses were conducted using IBM SPSS Statistics 23.0. A P-value < .05 was considered to indicate statistical significance. Of the 74 subjects, 32 (43.2%) show abnormalities. Statistical analysis showed no significant differences in the result of thyroid US in subjects with complaint fatigue (P = .464), insomnia (P = .777), over sweating (P = .158), and tremor (P = .778), but there were significant differences with the complaint of mass in the neck (P = .008). Furthermore, there was also a strong correlation between goiter palpation and US thyroid result (R = 0.773, P = .00). We conclude there were significant differences in US result of patients with and without complaint of mass in the neck. We also found a strong correlation between goiter palpation and US examination. Clinical findings, laboratory examination, cytology and molecular markers, patients’ age, nodules size, and ultrasound features should be considered for the treatment planning.

PMID:36596021 | DOI:10.1097/MD.0000000000032546

Medicine (Baltimore). 2022 Dec 30;101(52):e32562. doi: 10.1097/MD.0000000000032562.

ABSTRACT

To investigate the effect of preoperative tropisetron treatment on postoperative cognitive function on the basis of patients’ Mini-Cog scale scores. In this retrospective cohort study, data were retrieved from the medical record database. This research did not involve concerns with patient safety and violation of their interests, and therefore, no ethical review was required. Depending on tropisetron exposure status, patients were assigned to the exposure group (86 patients) and the non-exposure group (74 patients). Patients in the exposure and non-exposure groups were administered tropisetron (10 mg; intravenously 15 minutes before operation) and other antiemetics, respectively. Data on the patients’ demographic characteristics, American society of Anesthesiologists (ASA) classification, comorbid underlying diseases, sleep quality, education level, anesthesia method, duration of fasting, intraoperative blood loss and fluid replacement, intraoperative minimum and maximum systolic blood pressures (SBPs), intraoperative minimum and maximum diastolic blood pressures (DBPs), postoperative Mini-Cog scale (a simple intelligence status assessment scale) score, and postoperative visual analogue scale (VAS) pain score were collected in both the groups. The postoperative Mini-Cog score (as an indicator of cognitive function) and the rate of postoperative cognitive impairment were compared between the exposure and non-exposure groups. A multifactorial logistic regression equation was constructed to analyze the factors associated with impaired cognitive function in the postoperative period. The postoperative cognitive impairment rate in the exposure group was significantly lower than that in the non-exposure group (3.5% vs 16.2%; P < .05). Multifactorial logistic regression analysis suggested that tropisetron was a protective factor for postoperative cognitive function, with a statistically significant effect (odds ratio [OR] = 5.04, 95% confidence interval [CI] = 1.31-19.4). Preoperative tropisetron exposure significantly reduces the incidence of postoperative cognitive impairment in patients, and it is a protective factor for postoperative cognitive function.

PMID:36596014 | DOI:10.1097/MD.0000000000032562

Medicine (Baltimore). 2022 Dec 30;101(52):e32561. doi: 10.1097/MD.0000000000032561.

ABSTRACT

Novel corona virus disease 2019 is the major threat for human life nowadays worldwide. This study aims to assess the knowledge, attitude and practices regarding COVID-19 among patients with type 2 diabetes attending Abdullah Khalil diabetes center (Omdurman Teaching Hospital). A facility-based observational descriptive cross-sectional study was carried out between January and February 2021, using non-probability quota sampling technique in Abdullah-Khalil diabetes center via the use of a structured close-ended interview questionnaire. It consisted of 19, 10, and 10 questions pertaining to knowledge, attitude and practices towards COVID-19 respectively. A total of 249 patients with type 2 diabetes were included. Of them, 132 (53.0%) were females and the majority (53.0%) aged between 41 and 60 years old. Concerning their education and marital status, 70 (28.1%) were primary school level and 208 (83.5%) were married. 89.6% of participants reported mass media as main source of information regarding COVID-19. Patients with type 2 diabetes attending Abdullah-Khalil diabetes center have good knowledge, positive attitude and good prevention practices towards COVID-19. Most respondents had good knowledge, positive attitude and good practices as 78.7%, 97.6%, and 69.9%, respectively. Educational level and source of information showed statistically significant association with the knowledge, attitude. However, the practice showed only statistical association with the mass media as a source of information (P = .006).

PMID:36596011 | DOI:10.1097/MD.0000000000032561

Medicine (Baltimore). 2022 Dec 30;101(52):e32036. doi: 10.1097/MD.0000000000032036.

ABSTRACT

BACKGROUND: We designed this systematic review and meta-analysis protocol to provide new medical evidence for clinical management by comparing the prognostic outcomes of visual laryngoscopy with those of conventional blinded insertion methods.

METHODS: We will intend to search English databases including Medicine, Embase, Web of Science, Cochrane Central Register of Controlled Trials, Scopus, and Google Scholar. The Chinese databases, such as Wanfang, China Knowledge Network, and China Biomedical Literature Database will also be searched. The outcome measures include intubation success rate, pain score, intubation-related complications, patient satisfaction, operation time, and cost. The Jadad scale will be used to evaluate the methodological quality of each randomized controlled trial in this meta-analysis. We will use the Methodological Index of Non-Randomized Studies criteria to assess the risk of bias in non-randomized study. An I2 value greater than 50% indicates the presence of significant heterogeneity. P < .05 in a 2-tailed test is considered statistically significant.

RESULTS: It is hypothesized that video laryngoscope will provide better outcomes compared with traditional blind gastric tube insertion.

CONCLUSIONS: The results of our review will be reported strictly following the PRISMA criteria and the review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.

PMID:36596002 | DOI:10.1097/MD.0000000000032036

Medicine (Baltimore). 2022 Dec 30;101(52):e32497. doi: 10.1097/MD.0000000000032497.

ABSTRACT

Insufficient lymph node harvest (< 12) may lead to incorrect classification of stage I and II disease. Many studies have indicated a poor prognosis with inadequate lymph node harvest in stages I to III, but few studies have demonstrated the relationship between low lymph node harvest and T4 disease. This study aimed to identify the influence of insufficient number of lymph nodes harvested on survival in T4N0 colorectal cancer. We enrolled patients with T4N0 colorectal cancer who underwent radical resection between 2010 and 2016. A total of 155 patients were divided into 2 groups; 142 patients had ≥ 12 harvested lymph nodes, and the other 13 had < 12 lymph nodes. All patients were followed up for at least 5 years. The primary outcome was the impact of the number of lymph nodes harvested on disease-free survival and overall survival, which were investigated using Kaplan-Meier survival techniques. There were no significant differences in recurrence rate, emergent or elective surgery, laparoscopic or open surgery, or chemotherapy between the 2 groups. Kaplan-Meier analyses showed no statistical differences in 5-year disease-free survival (P = .886) and 5-year overall survival (P = .832) between the groups. There were no significant differences in disease-free survival and overall survival between patients with adequate (≥ 12) and inadequate (< 12) lymph node harvest in T4N0 colorectal cancers.

PMID:36595998 | DOI:10.1097/MD.0000000000032497

Medicine (Baltimore). 2022 Dec 30;101(52):e32053. doi: 10.1097/MD.0000000000032053.

ABSTRACT

BACKGROUND: Extracorporeal shock wave therapy (ESWT) is a relatively new type of treatment for many musculoskeletal disorders. However, ESWT for low back pain remains controversial as the pain relieve benefit is questionable. We performed this systematic review and meta-analysis to explore the effectiveness and safety of ESWT interventions on pain and disability in patients with low back pain (LBP).

METHODS: In this meta-analysis, we searched electronic databases in the Pubmed, Embase, Cochrane’s library, China National Knowledge Infrastructure, and Wanfang Database to determine the equivalence of ESWT and placebo for the treatment of LBP up to April 4, 2022. A number of other outcomes were measured, including functional status, quality of life, and psychological outcomes measured by the Oswestry Disability Index. Weighted mean differences were calculated for continuous outcomes, while risk ratios were calculated for binary outcomes. Stata 12.0 software was used for statistical analysis.

RESULTS: Thirteen randomized controlled trials included for further analysis. Compared with control, the ESWT group showed lower pain intensity at month 1 (P < .05), as well as lower disability score at month 1 (P < .05) and at month 3 (P < .05). There was no statistically significant difference between ESWT and control groups in terms of the pain intensity at month 3 (P > .05). No serious adverse events related to treatment were reported. Sensitivity analysis demonstrates that the conclusions from this analysis were robust.

CONCLUSIONS: ESWT is effective in alleviating pain and improving the functional outcomes for patients with LBP. However, there remains a lack of high-level evidence to verify their effectiveness and safety and support their clinical application.

PMID:36595991 | DOI:10.1097/MD.0000000000032053

STAR Protoc. 2022 Dec 16;3(4):101880. doi: 10.1016/j.xpro.2022.101880. Epub 2022 Dec 12.

ABSTRACT

Understanding dysregulation of the eukaryotic initiation factor 4F (eIF4F) complex across tumor types is critical to cancer treatment development. We present a protocol and accompanying R package “eIF4F.analysis”. We describe analysis of copy number status, gene abundance and stoichiometry, survival probability, expression covariation, correlating genes, mRNA/protein correlation, and protein co-expression. Using publicly available large multi-omics data, eIF4F.analysis permits computationally derived and statistically powerful inferences regarding initiation factor regulation in human cancers and clinical relevance of protein interactions within the eIF4F complex. For complete details on the use and execution of this protocol, please refer to Wu and Wagner (2021).¹.

PMID:36595939 | DOI:10.1016/j.xpro.2022.101880

STAR Protoc. 2022 Dec 16;3(4):101893. doi: 10.1016/j.xpro.2022.101893. Epub 2022 Dec 5.

ABSTRACT

In this protocol, we detail steps for constructing a high-throughput automated platform for thin layer chromatography (TLC) analysis. We describe robotics and computer vision techniques that can handle 32 compounds under three different elution solvents in about 50 min. The established automated platform can obtain statistically standardized retardation factor (R_f) values and enhance reproducibility while reducing labor and time costs. For complete details on the use and execution of this protocol, please refer to Xu et al. (2022).¹.

PMID:36595915 | DOI:10.1016/j.xpro.2022.101893

Medicine (Baltimore). 2022 Dec 23;101(51):e32466. doi: 10.1097/MD.0000000000032466.

ABSTRACT

BACKGROUND: The relationship between hormone replacement therapy (HRT) and osteoarthritis is controversial in epidemiological studies. With the aim of better understanding the effect of HRT use, this first meta-analysis was implemented to explore the association of HRT and knee OA.

METHODS: A series of data is retrieved from Web of Science, PubMed, and Embase databases to observe the association of HRT and knee osteoarthritis up to December 2021. Two separated reviewers chose the research, extracted the data, and evaluated the study quality. Pooled estimates of 95% CI and HRs were acquired through a random-effects model.

RESULTS: Finally, there existed 13 pieces of research, containing one case-control research, four cross-sectional pieces of research, as well as eight cohort pieces of research, involving 2573,164 participants. The overall results showed that the use of HRT was related to a raised risk of knee OA (HR = 1.24, 95% CI 1.07-1.45). And the pooled analysis showed a statistically significant raised risk of knee joint replacement (HR = 1.30, 95% CI 1.09-1.54) when using HRT. In addition, the outcome exhibits the raised knee OA risk for the present users of HRT (HR = 1.40, 95% CI 1.16-1.68) according to HRT status. In the past users of HRT, the augment of knee OA risk was not statistically evident (HR = 1.16, 95% CI 0.94-1.42).

CONCLUSION: We observed that HRT use was related to a raised knee OA risk. Furthermore, future studies might focus on relevant mechanistic to verify our observed associations.

PMID:36595852 | DOI:10.1097/MD.0000000000032466