Tag: statistics

Sci Rep. 2023 Jan 7;13(1):348. doi: 10.1038/s41598-023-27644-x.

ABSTRACT

Metallic glasses are one of the most interesting mechanical materials studied in the last years, but as amorphous solids, they differ strongly from their crystalline counterparts. This matter can be addressed with the development and application of predictive techniques capable to describe the plastic regime. Here, machine learning models were employed for the prediction of plastic properties in CuZr metallic glasses. To this aim, 100 different samples were subjected to tensile tests by means of molecular dynamics simulations. A total of 17 materials properties were calculated and explored using statistical analysis. Strong correlations were found for stoichiometry, temperature, structural, and elastic properties with plastic properties. Three regression models were employed for the prediction of six plastic properties. Linear and Ridge regressions delivered the better prediction capability, with coefficients of determination above [Formula: see text]80% for three plastic properties, whereas Lasso regression rendered lower performance, with coefficients of determination above [Formula: see text]60% for two plastic properties. Overall, our work shows that molecular dynamics simulations together with machine learning models can provide a framework for the prediction of plastic behavior of complex materials.

PMID:36611063 | DOI:10.1038/s41598-023-27644-x

Sci Rep. 2023 Jan 7;13(1):340. doi: 10.1038/s41598-022-25570-y.

ABSTRACT

Amid its massive increase in energy demand, Southeast Asia has pledged to increase its use of renewable energy by up to 23% by 2025. Geospatial technology approaches that integrate statistical data, spatial models, earth observation satellite data, and climate modeling can be used to conduct strategic analyses for understanding the potential and efficiency of renewable energy development. This study aims to create the first spatial model of its kind in Southeast Asia to develop multi-renewable energy from solar, wind, and hydropower, further broken down into residential and agricultural areas. The novelty of this study is the development of a new priority model for renewable energy development resulting from the integration of area suitability analysis and the estimation of the amount of potential energy. Areas with high potential power estimations for the combination of the three types of energy are mostly located in northern Southeast Asia. Areas close to the equator, have a lower potential than the northern countries, except for southern regions. Solar photovoltaic (PV) plant construction is the most area-intensive type of energy generation among the considered energy sources, requiring 143,901,600 ha (61.71%), followed by wind (39,618,300 ha; 16.98%); a combination of solar PV and wind (37,302,500 ha; 16%); hydro (7,665,200 ha; 3.28%); a combination of hydro and solar PV (3,792,500 ha; 1.62%); and a combination of hydro and wind (582,700 ha; 0.25%). This study is timely and important because it will inform policies and regional strategies for transitioning to renewable energy, with consideration of the different characteristics present in Southeast Asia.

PMID:36611056 | DOI:10.1038/s41598-022-25570-y

Sci Rep. 2023 Jan 7;13(1):372. doi: 10.1038/s41598-022-27108-8.

ABSTRACT

The corpse plant (Amorphophallus titanum) is so named because it produces a pungent, foul odor when flowering. Little is known about how the emitted volatiles change throughout the two-day flowering period. In this study, the comprehensive monitoring of the presence and change in volatile molecules during the female and the male flowering phases of A. titanum was conducted, and the plant temperature was monitored. A total of 422 volatile features were detected over the entire sampling period, of which 118 features were statistically significantly different between the pre-flowering and both flowering phases, and an additional 304 features were found present throughout the flowering period. A total of 45 molecules could be assigned putative names. The volatile profile of A. titanum changes over the two-day flowering period, with the S-containing molecules and aldehydes dominant in the female flowering phase, and the alcohols and hydrocarbons dominant in the male flowering phase. The two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) enabled us to identify 32 new molecules produced by A. titanum. Each of these molecules alone, and in combination, likely contribute to the different odors emitted during the flowering phase of A. titanum.

PMID:36611048 | DOI:10.1038/s41598-022-27108-8

J Trop Pediatr. 2022 Dec 5;69(1):fmac115. doi: 10.1093/tropej/fmac115.

ABSTRACT

BACKGROUND: Pediatric patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) displayed milder symptoms than adults. However, they play an important role in case numbers and virus transmission. Therefore, we aimed to determine the epidemiological features of all pediatric patients infected with SARS-CoV-2 and put forth case numbers longitudinally throughout the delta variant dominant period.

METHODS: A retrospective study was conducted at a university hospital and included patients between 0 and18 years old with a SARS-CoV-2 polymerase chain reaction (PCR) positive result, including inpatients and outpatients. Epidemiological and clinical features were recorded from electronic files, and telephone visits were performed between March 2020 and December 2021.

RESULTS: During the study period, 3175 coronavirus disease 2019 (COVID-19) pediatric patients were admitted to our hospital with a mean age of 10.61 ± 4.6 years. Of the 1815 patients who could be interviewed, 85.7% reported at least one symptom. Before the delta variant period, 0-4 years aged children were more commonly infected, while school-aged children and adolescents were more common, and the rate of pediatric cases to all COVID-19 cases increased to 35.8% after the delta variant became dominant. Symptomatic cases were significantly higher before the delta variant (87.8% vs. 84.06%, p = 0.016). The hospitalization rate was higher before the delta variant (p < 0.001), whereas PICU admission showed no statistical difference.

CONCLUSIONS: The frequency of school-aged children and adolescents raised with the impact of both school openings and the delta variant, and the rate of pediatric cases increased in total COVID-19 patient numbers.

PMID:36611014 | DOI:10.1093/tropej/fmac115

J Clin Oncol. 2023 Jan 6:JCO2200509. doi: 10.1200/JCO.22.00509. Online ahead of print.

ABSTRACT

PURPOSE: To present primary and final analyses from the randomized, double-blind, placebo-controlled, phase III iNTEGRATE study, which evaluated the safety and efficacy of ibrutinib with prednisone in previously untreated patients with chronic graft-versus-host disease (cGVHD).

METHODS: Patients (age ≥ 12 years) with newly diagnosed moderate or severe cGVHD, requiring systemic corticosteroid therapy, and with no prior systemic treatment for cGVHD were randomly assigned 1:1 to receive ibrutinib 420 mg once daily plus prednisone, starting at 1 mg/kg once daily or placebo plus prednisone. The primary end point was response rate at 48 weeks according to 2014 National Institutes of Health Consensus Development Project Criteria. Other end points included event-free survival, duration of response, time to withdrawal of immunosuppressants, improvement in Lee cGVHD Symptom Scale score, overall survival (OS), and safety.

RESULTS: Ninety-five and 98 patients enrolled in the ibrutinib-prednisone and placebo-prednisone arms, respectively. At 48 weeks, response rates were 41% (ibrutinib-prednisone) and 37% (placebo-prednisone; P = .54). At 33 months of follow-up, median duration of response was 19 months (ibrutinib-prednisone) and 10 months (placebo-prednisone; P = .10). Median event-free survival was 15 months (ibrutinib-prednisone) and 8 months (placebo-prednisone; hazard ratio, 0.76; 95% CI, 0.54 to 1.1; P = .11). Improvement in overall Lee cGVHD Symptom Scale was 43% (ibrutinib-prednisone) and 31% (placebo-ibrutinib; P = .07). Median OS was not reached in either arm. The 24-month Kaplan-Meier OS estimates were 80% for both arms (hazard ratio, 1.06; 95% CI, 0.59 to 1.90). Grade ≥ 3 serious adverse events occurred in 49% (ibrutinib-prednisone) and 47% (placebo-prednisone) of patients.

CONCLUSION: There was no statistical difference observed in the primary and secondary end points with ibrutinib-prednisone treatment. No new safety signals were observed with ibrutinib treatment in previously untreated patients with cGVHD. The primary end point of iNTEGRATE was not met.

PMID:36608310 | DOI:10.1200/JCO.22.00509

Expert Opin Drug Saf. 2023 Jan 6. doi: 10.1080/14740338.2023.2166485. Online ahead of print.

ABSTRACT

BACKGROUND: This study aimed to evaluate efficacy and safety of dapagliflozin as a monotherapy glucose lowering drug treatment for older adults with diabetes.

RESEARCH DESIGN & METHODS: Randomised controlled trials (RCTs) reports were retrieved from PubMed, Embase Cochrane Library and Web of Science from database inception to May 8, 2021. Publication bias and heterogeneity were assessed using the Cochrane risk-of-bias tool and the Cochrane Q statistic, respectively.

RESULTS: Compared with placebo, dapagliflozin as a monotherapy glucose lowering drug did improve the control of HbA1c and fasting plasma glucose levels in older adults. Our analysis also confirmed that the body weight of older adults was well controlled under treatment of dapagliflozin as a monotherapy glucose lowering drug. Patients in older adults with diabetes took a higher risk of genital infection and renal impairment or failure after treatment of dapagliflozin. In addition, treatment with dapagliflozin reduced risk of hypoglycemia, and did not reveal increased risk of urinary tract infection and developing fractures compared to placebo in older adults.

CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.

PMID:36608279 | DOI:10.1080/14740338.2023.2166485

Phys Rev Lett. 2022 Dec 16;129(25):251103. doi: 10.1103/PhysRevLett.129.251103.

ABSTRACT

We present the measurement of the energy dependence of the boron flux in cosmic rays and its ratio to the carbon flux in an energy interval from 8.4 GeV/n to 3.8 TeV/n based on the data collected by the Calorimetric Electron Telescope (CALET) during ∼6.4 yr of operation on the International Space Station. An update of the energy spectrum of carbon is also presented with an increase in statistics over our previous measurement. The observed boron flux shows a spectral hardening at the same transition energy E_{0}∼200 GeV/n of the C spectrum, though B and C fluxes have different energy dependences. The spectral index of the B spectrum is found to be γ=-3.047±0.024 in the interval 25<E<200 GeV/n. The B spectrum hardens by Δγ_{B}=0.25±0.12, while the best fit value for the spectral variation of C is Δγ_{C}=0.19±0.03. The B/C flux ratio is compatible with a hardening of 0.09±0.05, though a single power-law energy dependence cannot be ruled out given the current statistical uncertainties. A break in the B/C ratio energy dependence would support the recent AMS-02 observations that secondary cosmic rays exhibit a stronger hardening than primary ones. We also perform a fit to the B/C ratio with a leaky-box model of the cosmic-ray propagation in the Galaxy in order to probe a possible residual value λ_{0} of the mean escape path length λ at high energy. We find that our B/C data are compatible with a nonzero value of λ_{0}, which can be interpreted as the column density of matter that cosmic rays cross within the acceleration region.

PMID:36608255 | DOI:10.1103/PhysRevLett.129.251103

Phys Rev Lett. 2022 Dec 16;129(25):258001. doi: 10.1103/PhysRevLett.129.258001.

ABSTRACT

Active nematics can be modeled using phenomenological continuum theories that account for the dynamics of the nematic director and fluid velocity through partial differential equations (PDEs). While these models provide a statistical description of the experiments, the relevant terms in the PDEs and their parameters are usually identified indirectly. We adapt a recently developed method to automatically identify optimal continuum models for active nematics directly from spatiotemporal data, via sparse regression of the coarse-grained fields onto generic low order PDEs. After extensive benchmarking, we apply the method to experiments with microtubule-based active nematics, finding a surprisingly minimal description of the system. Our approach can be generalized to gain insights into active gels, microswimmers, and diverse other experimental active matter systems.

PMID:36608242 | DOI:10.1103/PhysRevLett.129.258001

Phys Rev Lett. 2022 Dec 16;129(25):253602. doi: 10.1103/PhysRevLett.129.253602.

ABSTRACT

We explore the emergence and active control of optical bistability in a two-level atom near a graphene sheet. Our theory incorporates self-interaction of the optically driven atom and its coupling to electromagnetic vacuum modes, both of which are sensitive to the electrically tunable interband transition threshold in graphene. We show that electro-optical bistability and hysteresis can manifest in the intensity, spectrum, and quantum statistics of the light emitted by the atom, which undergoes critical slow-down to steady state. The optically driven atom-graphene interaction constitutes a platform for active control of driven atomic systems in coherent quantum control and atomic physics.

PMID:36608233 | DOI:10.1103/PhysRevLett.129.253602

Phys Rev Lett. 2022 Dec 16;129(25):250501. doi: 10.1103/PhysRevLett.129.250501.

ABSTRACT

Triply degenerate points (TDPs), which correspond to new types of topological semimetals, can support novel quasiparticles possessing effective integer spins while preserving Fermi statistics. Here by mapping the momentum space to the parameter space of a three-level system in a trapped ion, we experimentally explore the transitions between different types of TDPs driven by spin-tensor-momentum couplings. We observe the phase transitions between TDPs with different topological charges by measuring the Berry flux on a loop surrounding the gap-closing lines, and the jump of the Berry flux gives the jump of the topological charge (up to a 2π factor) across the transitions. For the Berry flux measurement, we employ a new method by examining the geometric rotations of both spin vectors and tensors, which lead to a generalized solid angle equal to the Berry flux. The controllability of a multilevel ion offers a versatile platform to study high-spin physics, and our Letter paves the way to explore novel topological phenomena therein.

PMID:36608231 | DOI:10.1103/PhysRevLett.129.250501