Tag: statistics

J Affect Disord. 2022 Dec 29:S0165-0327(22)01423-9. doi: 10.1016/j.jad.2022.12.063. Online ahead of print.

ABSTRACT

OBJECTIVES: Despite growing emphasis on the benefits of physical activity for promoting mental health, inclusion of muscle-strengthening (MS) (e.g., body-weight exercises, resistance machines) activities is limited. Notably, few studies collectively assess MS behavioural frequency, duration, and intensity. To address the gap, the current study examined associations between frequency (days), intensity (rating of perceived exertion in relation to repetitions in reserve [RPE/RIR]), and duration (minutes per typical session) of MS activities on anxiety, depression, and mental well-being.

METHOD: A cross-sectional study of 601 participants (Mean age = 30.92 years [SD = 12.70]; 57.7 % female) across Ireland was conducted. Participants completed a self-report questionnaire containing MS instruments previously used, or adapted from valid and reliable measures (i.e., International Physical Activity Questionnaire IPAQ, RPE/RIR), alongside, the Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-8 (PHQ-8) and the Mental Health Continuum- Short Form (MHC-SF). A multivariate regression model was tested in MPLUS, using dummy coding for MS frequency in relation to no activity (i.e., 0-days) non-adherence (i.e., 1-day), adherence (i.e., 2-days) and enhanced adherence (i.e., ≥3 days) to the MS public health guidelines, with the mental health variables representing the dependent variables. Intensity and duration were specified in the model as continuous variables; gender and age were included as statistical controls.

RESULTS: Three or more days engaged in MS activities was associated with fewer anxiety (β = -0.12, p < .05) and depression (β = -0.14, p < .01) symptoms. Increased intensity had a negative association with anxiety (β = -0.10, p < .05) and depression (β = -0.15, p < .001). Unexpectedly, adherence to the MS guidelines (2-days) did not predict any of the mental health outcomes, whereas 1-day of MS activity was associated with fewer depression symptoms (β = -0.11). No effects were observed for mental well-being, and MS duration exerted a null effect across all mental health outcomes.

CONCLUSION: Higher frequency and intensity of MS activities may protect against anxiety and depression symptoms. Doing some MS activities (at least 1-day) is likely more beneficial than none for depression. Evidence-based, MS interventions may help curb mental illness rates, and future longitudinal, intervention-based research could consider inclusion of MS frequency, intensity and duration variables to enhance efforts to identify at-risk groups and trends within physical activity and mental illness surveillance.

PMID:36587908 | DOI:10.1016/j.jad.2022.12.063

J Affect Disord. 2022 Dec 29:S0165-0327(22)01501-4. doi: 10.1016/j.jad.2022.12.140. Online ahead of print.

ABSTRACT

BACKGROUND: Alcohol use disorder (AUD) is exceedingly common among individuals with bipolar disorder and schizophrenia. However, studies on alcohol use in psychiatric illness rely largely on population surveys with limited representation of severe mental illness (SMI); schizophrenia, bipolar disorder.

METHODS: Using data from the Genomic Psychiatry Cohort (GPC) (Pato MT, 2013), associations of bipolar disorder and schizophrenia with alcohol use problems were examined in a diverse US based sample, considering the influence of self-described race (African Ancestry (AA), European Ancestry (EA), or Latinx Ancestry (LA)), sex, and tobacco use. Participants answered alcohol use problem items derived from the CAGE instrument, yielding a summed “probable” alcohol use disorder (pAUD) risk score.

RESULTS: This study included 1952 individuals with bipolar disorder with psychosis (BDwP), 409 with bipolar disorder without psychosis (BD), 9218 with schizophrenia (SCZ), and 10,416 unaffected individuals. We found that SMI (BDwP, BD, SCZ) was associated with elevated AUD risk scores (B = 0.223, p < 0.001), an association which was strongest in females, particularly those of AA and LA, and in tobacco users. Schizophrenia was associated with the greatest increase in pAUD score (B = 0.141, p < 0.001). pAUD risk scores were increased among participants with bipolar disorder, with greater increases in BDwP (B = 0.125, p < 0.001) than in BD without psychosis (B = 0.027, p < 0.001).

LIMITATIONS: Limitations include reliance on self-report data, screening items for AUD, voluntary recruitment bias, and differences in race/sex distribution between groups, which were statistically adjusted for in analytic models.

CONCLUSIONS: SMI is associated with risk for AUD, particularly among females from racial minority groups, smokers, and those with psychotic disorders.

PMID:36587907 | DOI:10.1016/j.jad.2022.12.140

J Affect Disord. 2022 Dec 29:S0165-0327(22)01440-9. doi: 10.1016/j.jad.2022.12.080. Online ahead of print.

ABSTRACT

BACKGROUND: This study aimed to examine the association of bullying victimization with anxiety and depressive symptoms among Chinese adolescents and explored the role of coping styles in the foregoing associations.

METHOD: Data were drawn from the 2019 School-based Chinses Adolescents Health Survey (n = 19,809). Information about bullying victimization, coping styles, anxiety symptoms, and depressive symptoms were measured. Linear mixed-effects models were performed.

RESULTS: After adjusting for covariates, verbal victimization (β = 1.94 for anxiety symptoms; β = 4.62 for depressive symptoms), relational victimization (β = 3.40 for anxiety symptoms; β = 8.37 for depressive symptoms), physical victimization (β = 2.63 for anxiety symptoms; β = 6.07 for depressive symptoms) and cyber victimization (β = 4.68 for anxiety symptoms; β = 10.72 for depressive symptoms) were associated with anxiety and depressive symptoms. Moreover, the severity of anxiety and depressive symptoms tended to increase with the number of victimization types. The interaction effects between bullying victimization and coping style on anxiety and depressive symptoms were significant. Further stratified analyses by coping styles indicated that the association of relational and cyber victimization on anxiety and depressive symptoms were significantly stronger in adolescents with negative coping style than in those with positive coping style.

LIMITATIONS: Causal inference is limited due to the cross-sectional design.

CONCLUSION: Bullying victimization is associated with anxiety and depressive symptoms, and coping styles may play a moderate role in these associations. Interventions to promote mental health could focus on developing positive coping styles, particularly among adolescents with bullying victimization.

PMID:36587905 | DOI:10.1016/j.jad.2022.12.080

World Neurosurg. 2022 Dec 29:S1878-8750(22)01826-5. doi: 10.1016/j.wneu.2022.12.120. Online ahead of print.

ABSTRACT

BACKGROUND: Pedicle screw fixation provides one of the most stable spinal constructs. Their designs together with osseous characteristics have been known to influence the screw-bone interplay during surgical maneuvers and thereafter the fusion process. Various technical modifications to enhance screw performance have been suggested. This study evaluated the pull-out strength and axial stiffness of a novel pedicle screw design with variable thread geometry and pitch.

METHODS: The newly designed triple threaded pedicle screw is tapered, and has unique out-turned flanges to hold the cancellous bone and a finer pitch at its distal and proximal end to engage the cortical bone. Five lumbar and 4 lower thoracic cadaveric vertebrae were divided into hemivertebrae. A standard cancellous pedicle screw and the newly designed pedicle screw were inserted into each hemivertebra. Axial stiffness and peak pull-out force between the screw types were compared; a finite element analysis was also performed to additionally compare the pull out under toggle forces.

RESULTS: In cadaveric study, the axial stiffness of the new screw was significantly better than that of the standard screw. However, the peak load between the screws was not statistically different. Finite element analyses suggested lesser stress at bone-implant interface for the new screw along with better axial stiffness under both co-axial and toggle forces.

CONCLUSIONS: Our novel pedicle screw design with variable thread geometry demonstrates greater axial stiffness compared with the standard screws, and therefore is likely to withstand a greater surgical manipulation.

PMID:36587893 | DOI:10.1016/j.wneu.2022.12.120

Neurosurg Focus. 2023 Jan;54(1):E9. doi: 10.3171/2022.10.FOCUS22608.

ABSTRACT

OBJECTIVE: Sacroiliac joint (SIJ) fusion utilizing intraoperative navigation requires a standard reference frame, which is often placed using a percutaneous pin. Proper placement ensures the correct positioning of SIJ fusion implants. There is currently no grading scheme for evaluation of pin placement into the pelvis. The purpose of this study was to evaluate the occurrence of ideal percutaneous pin placement into the posterior ilium during navigated SIJ fusion.

METHODS: After IRB approval was obtained, electronic medical records and intraoperative computed tomography images of patients who underwent navigated SIJ fusion by the senior author between October 2013 and January 2020 were reviewed. A pin placement grading scheme and the definition of “ideal” placement were developed by the authors and deemed acceptable by fellow attending surgeons. Six attending surgeons completed two rounds of pin placement grading, and statistical analysis was conducted.

RESULTS: Of 90 eligible patients, 73.3% had ideal pin placement, 17.8% medial/lateral breach, and 8.9% complete miss. Male patients were 3.7 times more likely to have ideal placement than females (p < 0.05). There was no relationship between BMI, SIJ fusion laterality, or pin placement laterality and ideal placement. Interobserver reliability was 0.72 and 0.70 in the first and second rounds, respectively, and defined as “substantial agreement.” Intraobserver reliability ranged from 0.74 (substantial agreement) to 0.92 (almost perfect agreement).

CONCLUSIONS: Nonideal pin placement occurred in 26.7% of cases, but a true “miss” into the sacrum was rare. Ideal pin placement was more likely in males and was not associated with BMI, SIJ fusion laterality, or pin placement laterality. The grading scheme developed has high intraobserver and interobserver reliability, indicating that it is reproducible and can be used for future studies. When placing percutaneous pins, surgeons must be aware of factors that can decrease placement accuracy, regardless of location.

PMID:36587403 | DOI:10.3171/2022.10.FOCUS22608

Neurosurg Focus. 2023 Jan;54(1):E8. doi: 10.3171/2022.10.FOCUS22601.

ABSTRACT

OBJECTIVE: A CSF leak is a potential complication in a lumbar laminectomy. An analysis of the author’s surgical experience identified inadvertent durotomies that occurred when resecting the ligamentum flavum at its insertion into the superior aspect of the caudal lamina. Anatomical analyses of the lumbar canal diameter demonstrate that the insertion point of the caudal ligamentum flavum is the most constrained area of the canal. The surgical technique was modified to eliminate the need for direct action in that anatomical region after the author compared the efficacy of piecemeal resection of the ligamentum flavum with en bloc resection with a laminotomy of the caudal lamina beyond the insertion point of the ligamentum flavum in the lumbar laminectomy.

METHODS: An analysis of a single surgeon’s experience managing 147 consecutive patients with lumbar stenosis who underwent single-level lumbar hemilaminectomies over a 4-year period was performed. Patients were managed with either piecemeal resection (cohort 1) or en bloc resection with a laminotomy beyond the caudal insertion (cohort 2) of the ligamentum flavum.

RESULTS: Seventy-seven patients underwent piecemeal resection (cohort 1), and 70 underwent en bloc resection (cohort 2). There were 5 CSF leaks (6.4%) in cohort 1. There were no CSF leaks in cohort 2. There was a statistically significant difference in operative times between the two groups (p = 0.04), but there was no statistically significant difference in patient-reported outcomes at 6 months between the groups.

CONCLUSIONS: En bloc resection of the ligamentum flavum with a laminotomy below the caudal insertion point appears to decrease the risk of a CSF leak by working beyond the most constrained diameter of the lumbar canal to release the caudal insertion of the ligamentum flavum.

PMID:36587402 | DOI:10.3171/2022.10.FOCUS22601

Mol Oncol. 2023 Jan 1. doi: 10.1002/1878-0261.13371. Online ahead of print.

ABSTRACT

The identification of the high-efficiency and non-invasive biomarkers for hepatocellular carcinoma (HCC) detection is urgently needed. This study aims to screen out potential autoantibodies to tumor-associated antigens (TAAbs) and to assess their diagnostic value for HCC. Fifteen potential TAAbs were screened out from the Human Proteome Microarray by 30 HCC sera and 22 normal control sera, of which 8 passed multiple-stage validations by ELISA with a total of 1,625 human serum samples from normal controls (NCs) and patients with HCC, liver cirrhosis, chronic hepatitis B, gastric cancer, esophageal cancer and colorectal cancer. Finally, an immunodiagnostic model including 6 TAAbs (RAD23A, CAST, RUNX1T1, PAIP1, SARS, PRKCZ) was constructed by logistic regression, and yielded the area under curve (AUC) of 0.835 and 0.788 in training and validation sets, respectively. The serial serum samples from HCC model mice were tested to explore the change in TAAbs during HCC formation, and an increasing level of autoantibodies was observed. In conclusion, the panel of 6 TAAbs can provide potential value for HCC detection, and the strategy to identify novel serological biomarkers can also provide new clues in understanding immunodiagnostic biomarkers.

PMID:36587394 | DOI:10.1002/1878-0261.13371

Int Ophthalmol. 2023 Jan 1. doi: 10.1007/s10792-022-02625-7. Online ahead of print.

ABSTRACT

PURPOSE: To evaluate the effectiveness of incobotulinumtoxinA (Xeomin^®) in treating upper eyelid retraction in patients with Graves orbitopathy (GO) initially scheduled for surgery via two different application sites.

METHODS: This is a comparative, prospective study, conducted at the Department of Ophthalmology, Medical School, University Hospital Centre Zagreb, EUGOGO site (EUropean Group On Graves’ Orbitopathy) in Croatia from January 2020 till January of 2021 in accordance with national health headquarter recommendations. All patients were classified as inactive with marked eyelid retraction and randomly divided into groups according to application sites. Group A underwent transconjunctival application (18 eyes) and group B transcutaneous application (20 eyes) of incobotulinumtoxinA. The primary end point of this study was lowering the eyelid, to alleviate anterior eye segment symptoms and achieve acceptable aesthetic appearance until surgery becomes available.

RESULTS: There were no nonresponders and we found no statistically significant difference in the degree of lowering the eyelid between the two application sites. Following rules for avoiding spread of SARS-CoV-19, none of the patients included in this study were infected. Moreover, participants reported diminishing of anterior eye segment irritation and improved aesthetics.

CONCLUSION: Treatment of inactive GO patients with incobotulinumtoxinA for upper eyelid retraction is efficient and safe and can be used as an adjuvant treatment while patients wait for surgery, by alleviating symptoms and improving the level of aesthetic satisfaction without causing a threat to anterior eye segment and visual function. The study showed that effect of treatment was the same, whether we applied the toxin transconjunctivaly or transcutaneously.

PMID:36587368 | DOI:10.1007/s10792-022-02625-7

Chaos. 2022 Dec;32(12):123103. doi: 10.1063/5.0106922.

ABSTRACT

Quantitatively assessing the level of confidence on a test score can be a challenging problem, especially when the available information is based on multiple criteria. A concrete example beyond the usual grading of tests occurs with recommendation letters, where a recommender assigns a score to a candidate, but the reliability of the recommender must be assessed as well. Here, we present a statistical procedure, based on Bayesian inference and Jaynes’ maximum entropy principle, that can be used to estimate the most probable and expected score given the available information in the form of a credible interval. Our results may provide insights on how to properly state and analyze problems related to the uncertain evaluation of performance in learning applied to several contexts, beyond the case study of the recommendation letters presented here.

PMID:36587360 | DOI:10.1063/5.0106922

Chaos. 2022 Dec;32(12):123118. doi: 10.1063/5.0118717.

ABSTRACT

The aim of this study is to formulate a new methodology based upon informational tools to detect patients with cardiac arrhythmias. As it is known, sudden death is the consequence of a final arrhythmia, and here lies the relevance of the efforts aimed at the early detection of arrhythmias. The information content in the time series from an electrocardiogram (ECG) signal is conveyed in the form of a probability distribution function, to compute the permutation entropy proposed by Bandt and Pompe. This selection was made seeking its remarkable conceptual simplicity, computational speed, and robustness to noise. In this work, two well-known databases were used, one containing normal sinus rhythms and another one containing arrhythmias, both from the MIT medical databank. For different values of embedding time delay τ, normalized permutation entropy and statistical complexity measure are computed to finally represent them on the horizontal and vertical axes, respectively, which define the causal plane H×C. To improve the results obtained in previous works, a feature set composed by these two magnitudes is built to train the following supervised machine learning algorithms: random forest (RF), support vector machine (SVM), and k nearest neighbors (kNN). To evaluate the performance of each classification technique, a 10-fold cross-validation scheme repeated 10 times was implemented. Finally, to select the best model, three quality parameters were computed, namely, accuracy, the area under the receiver operative characteristic (ROC) curve (AUC), and the F1-score. The results obtained show that the best classification model to detect the ECG coming from arrhythmic patients is RF. The values of the quality parameters were at the same levels reported in the available literature using a larger data set, thus supporting this proposal that uses a very small-sized feature space to train the model later used to classify. Summarizing, the attained results show the possibility to discriminate both groups of patients, with normal sinus rhythm or arrhythmic ECG, showing a promising efficiency in the definition of new markers for the detection of cardiovascular pathologies.

PMID:36587353 | DOI:10.1063/5.0118717