Tag: statistics

Pediatr Dent. 2022 Nov 15;44(6):416-422.

ABSTRACT

Purpose: The purpose of this study was to evaluate the clinical performance of composite strip crowns (SCs) and zirconia crowns (ZCs) on primary maxillary incisors affected by early childhood caries over 18 months. Methods: A total of 111 primary maxillary anterior teeth were included in 25 three-to five-year-old children. In each patient, the teeth were randomized to the SC and ZC groups (n equals 43 teeth/group) and sound teeth as the control group (n equals 25) in a split-mouth design. Patients’ oral hygiene and clinical variables, including gingival health, plaque accumulation, pulpal health, secondary caries, retention, color match, and material loss, were assessed at baseline and at one, six, 12, and 18 months. Data were statistically analyzed using Fisher’s exact test, the Friedman test, and the Kruskal-Wallis test. Results: Zirconia crowns had significantly lower plaque index values than strip crowns and controls during all recalls (P<0.05). The gingival index scores of both crowns improved after six months, while mild inflammation persisted in both groups due to increased exfoliation mobility. ZCs had better color match and retention (P<0.05) than SCs, with the latter being 100 percent for ZCs and 77.8 percent for SCs. Both crowns had similar and high pulp survival at 18 months (ZC equals 93.1 percent; SC equals 95.4 percent). Conclusions: Zirconia crowns had better clinical performance than composite strip crowns in terms of retention, restoration failure, and color change but similar gingival and pulpal health after 18 months. ZCs showed the lowest plaque accumulation when compared with sound teeth and SCs.

PMID:36947757

Pediatr Dent. 2022 Nov 15;44(6):411-417.

ABSTRACT

Purpose: The purpose of this study was to evaluate the clinical and radiographic outcomes of direct pulp capping (DPC) using calcium hydroxide (CH), mineral trioxide aggregate (MTA), and premedicated DPC with formocresol (FC) in primary teeth. Methods: Sixty primary mandibular second molars with pulp exposures in children aged four to eight years old were treated using DPC. The molars were randomly divided into three groups (n equals 20 per group). Pulp exposures in the CH and MTA groups were capped directly using CH and MTA pastes, respectively, while those in the FC group were premedicated with FC and then capped with zinc oxide eugenol (ZOE) cement. All teeth were finally restored with stainless steel crowns, and clinical and radiographic evaluations were carried out at baseline and three, six, and 12 months after restoration. Fisher’s exact test was performed to define the significance between the groups and follow-up periods. Results: The clinical and radiographic findings showed no significant difference between the three groups. The overall success in the CH, MTA, and FC groups were 88.2 percent, 100 percent, and 73.3 percent, respectively. However, these differences were not statistically significant (P>0.05). Conclusion: All three materials examined in this study exhibited clinical and radiographical efficacy when used as direct pulp capping materials.

PMID:36947754

Medwave. 2023 Mar 22;23(2). doi: 10.5867/medwave.2023.02.2675.

ABSTRACT

INTRODUCTION: Globally, the COVID-19 pandemic has affected people’s mental health care. This study aims to describe mental health care in the first semester of the COVID-19 pandemic of the year 2020 compared to the first semester of the year 2019 in the public health establishments of the commune of Chillán, Chile.

METHODS: A descriptive ecological study. The treated cases were analyzed in aggregate, considering the pandemic, amount of admissions, the reason for consultation, sex, and age for the years 2019 and 2020. Prevalence, percentages, and statistical analysis were evaluated using non-parametric tests.

RESULTS: The prevalence of cases due to admissions to the mental health program in primary health care remained similar between the first semester of 2019 and the first semester of 2020. Most mental health cases concentrate on mood (affective) and anxiety disorders. Statistically significant differences were observed between 2019 and 2020 in the number of mental health admissions for mental and behavioral disorders due to psychotropic substances, harmful use disorders, drug dependence, and personality disorders.

CONCLUSIONS: It is a priority for Chile to increase coverage in primary mental health care. The data provided in this study show at an exploratory level that the initial situation of the pandemic could have affected access to timely care for the most vulnerable people with mental disorders.

PMID:36947748 | DOI:10.5867/medwave.2023.02.2675

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2023 Mar 22:1-12. doi: 10.1080/19440049.2023.2186711. Online ahead of print.

ABSTRACT

This study aimed to assess the spatiotemporal bioavailability of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in wild adult mussels, Mytilus galloprovincialis, collected along the Portuguese Atlantic coast between 2009 and 2020. The work is part of a national environmental monitoring program. The purpose was to evaluate the dioxins’ temporal trends, the human and ecological risks, and the correlation between mussels’ location and the main pollutant sources in Portugal. The levels and congener patterns of the most toxicity-relevant 17 PCDD/Fs and 12 dl-PCBs were determined, with the dl-PCBs dominant. The sum of Σ₁₇PCDD/Fs and Σ₁₂dl-PCBs values ranged from 2.0 to 4.0 ng WHO-TEQ kg^-1, (wet weight basis), below the limits established by the European Commission for contamination in fish and fishery products (6.5 ng per kg^-1). The study included five years – 2009, 2010, 2016, 2018 and 2020 -, allowing to verify the impact of European Directive 2013/39/UE against the pollution of water in Portugal; it was observed that dioxin levels in mussels diminished over the time. Statistical analysis allowed verification of different spatial trends of dl-PCB profiles along the Portuguese Atlantic coast. The mono-ortho dl-PCB pentachlorinated congener IUPAC #118 prevailed in 2009 and 2018 in all sampling sites, and it was predominant in 2010, 2016 and 2020, followed by the congeners IUPAC #105, #156 and #167. The IUPAC #167, #169 and #123 were the most abundant hexachlorinated congeners, and the IUPAC #77 the most abundant tetrachlorinated congener. This work emphasises the importance of monitoring dioxins and mapping the congeners in Atlantic coastal ecosystems, to contribute to their elimination.

PMID:36947716 | DOI:10.1080/19440049.2023.2186711

Aging (Albany NY). 2023 Mar 22;15. doi: 10.18632/aging.204602. Online ahead of print.

ABSTRACT

Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. The intervention consisted of an 8-week program that included diet, sleep, exercise and relaxation guidance, supplemental probiotics and phytonutrients and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline [a]) was conducted on blood samples at baseline and at the end of the 8-week period. Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants’ mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.

PMID:36947707 | DOI:10.18632/aging.204602

Medwave. 2023 Mar 8;23(2). doi: 10.5867/medwave.2023.02.2613.

ABSTRACT

OBJECTIVE: This study examines the clinical and sociodemographic factors associated with adverse health outcomes (falls, emergency room visits, hospital admissions and death) in a cohort of patients older than 55 years with HIV infection.

METHODS: It is an exploratory prospective study with four years follow-up. People with HIV infection followed in the infectious diseases consultation unit of two hospitals in Madrid were included. Sociodemographic data and clinical variables were collected. The functional, mental, and social situations of the participants were assessed. Patient clinical histories were reviewed to gather data on the number of falls, visits to emergency departments and hospital admissions during the period studied.

RESULTS: One hundred seventeen patients with a mean age of 61,4 (SD 6,6) years and a median follow-up of 47 months(35 to 50) were included. Of these subjects, 25% had depressive symptoms, and 10% had some degree of cognitive impairment at the baseline visit. The recorded frequencies were: falls 7,7%, visits to the emergency room 53%, hospital admission 33,3% and deaths 2,6%. Depressive symptoms were associated with falls and emergency room visits in the univariate analysis. The factors associated with hospital admission were having acquired the infection through intravenous drug use, frailty and being under 65 years of age. Multivariate analysis was conducted for the hospital admissions outcome, with the variables showing p < 0,07 in the univariate analysis, none of which reached statistical significance.

CONCLUSIONS: Depression screening and cognitive evaluation should be done systematically in this population group. More studies with more patients and longer follow-up times are necessary.

PMID:36947704 | DOI:10.5867/medwave.2023.02.2613

Shock. 2023 Mar 23. doi: 10.1097/SHK.0000000000002119. Online ahead of print.

ABSTRACT

OBJECTIVE: To explore the impact of early serum phosphate levels on the prognosis of critically ill patients with sepsis.

METHODS: In this retrospective large cohort study, data of patients with sepsis were obtained from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Patients were retrospectively divided into a control group and three study groups according to their daily serum phosphate levels within two days of ICU admission. A Cox regression model was used to evaluate the association between serum phosphate levels and 28-day morbidity.

RESULTS: This study included 9691 patients diagnosed with sepsis. During the first two days of ICU admission, patients with hyperphosphatemia in either of the two days had higher 28-day mortality, while patients in the hypophosphatemia group had lower 28-day mortality (first day,32.9%vs16.3%; second day, 36.3%vs14.7%). After adjusting for potential confounders, hyperphosphatemia was significantly associated with 28-day mortality; however, only hypophosphatemia on the second day was independently associated with reduced 28-day mortality. After stratification in the hypophosphatemia group, subgroup analysis showed that only the association between the mild hypophosphatemia group and 28-day mortality reached statistical significance (HR = 0.76, 95% CI 0.65 to 0.89, p = 0.001).

CONCLUSION: Mild hypophosphatemia might improve the short-term prognosis of patients with sepsis, and hyperphosphatemia is an independent risk factor for the outcomes of septic patients. After ICU admission, the serum phosphate levels on the second day had a better independent correlation with 28-day mortality, which prompted us to reconsider the optimal timing of phosphate evaluation.

PMID:36947698 | DOI:10.1097/SHK.0000000000002119

J Am Assoc Nurse Pract. 2023 Mar 22. doi: 10.1097/JXX.0000000000000843. Online ahead of print.

ABSTRACT

BACKGROUND: Type II diabetes mellitus is a chronic medical condition affecting societies worldwide. The duration of hyperglycemia is a strong predictor of adverse outcomes and imposes immense clinical and public health concerns. The best way to prevent complications and reduce the economic burden is by capturing asymptomatic individuals early in the disease process.

LOCAL PROBLEM: Patients at a large urban academic medical center were not consistently identified as having a high risk of hyperglycemia.

METHODS: The project used a pretest-posttest design. Retrospective data on new-onset hyperglycemia incidence were compared for all individuals seeking primary care services 6 weeks before and after the intervention.

INTERVENTION: Patients without a known hyperglycemia history were provided the screening tool to determine risk status. Additional screening measures were implemented for patients identified as high risk on the initial screening.

RESULTS: A total of 52 (61.6%) of the 84 individuals who met inclusion criteria during the intervention period were diagnosed with new-onset chronic hyperglycemia. In contrast, 20 (22.5%) of the 89 individuals identified during the retrospective period resulted in a statistically significant difference (p < .001) in the frequency and accuracy of patients diagnosed with hyperglycemia between groups.

CONCLUSION: A diabetes risk assessment tool is quick and reliable in capturing high-risk individuals who would benefit from additional screening measures.

PMID:36947689 | DOI:10.1097/JXX.0000000000000843

J Hypertens. 2023 Mar 1;41(3):380-387. doi: 10.1097/HJH.0000000000003336. Epub 2022 Dec 16.

ABSTRACT

BACKGROUND: Preexisting hypertension increases risk for preeclampsia. We examined whether a generic blood pressure polygenic risk score (BP-PRS), compared with a preeclampsia-specific polygenic risk score (PE-PRS), could better predict hypertensive disorders of pregnancy.

METHODS: Our study sample included 141 298 genotyped FinnGen study participants with at least one childbirth and followed from 1969 to 2021. We calculated PRSs for SBP and preeclampsia using summary statistics for greater than 1.1 million single nucleotide polymorphisms.

RESULTS: We observed 8488 cases of gestational hypertension (GHT) and 6643 cases of preeclampsia. BP-PRS was associated with GHT [multivariable-adjusted hazard ratio for 1SD increase in PRS (hazard ratio 1.38; 95% CI 1.35-1.41)] and preeclampsia (1.26, 1.23-1.29), respectively. The PE-PRS was also associated with GHT (1.16; 1.14-1.19) and preeclampsia (1.21, 1.18-1.24), but with statistically more modest magnitudes of effect (P = 0.01). The model c-statistic for preeclampsia improved when PE-PRS was added to clinical risk factors (P = 4.6 × 10-15). Additional increment in the c-statistic was observed when BP-PRS was added to a model already including both clinical risk factors and PE-PRS (P = 1.1 × 10-14).

CONCLUSION: BP-PRS is strongly associated with hypertensive disorders of pregnancy. Our current observations suggest that the BP-PRS could capture the genetic architecture of preeclampsia better than the current PE-PRSs. These findings also emphasize the common pathways in the development of all BP disorders. The clinical utility of a BP-PRS for preeclampsia prediction warrants further investigation.

PMID:36947680 | DOI:10.1097/HJH.0000000000003336

Nurs Open. 2023 Mar 22. doi: 10.1002/nop2.1731. Online ahead of print.

ABSTRACT

AIM: This study aimed to investigate psychiatric disorders in Iranian female patients with fibromyalgia (FM).

DESIGN: Female patients, newly diagnosed with FM, were interviewed by a psychiatrist for psychiatric assessments during a 2-year period.

METHODS: The diagnosis of the psychiatric disorders was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI).

RESULTS: In total, 159 patients with the mean age of 42.15 ± 9.89 were recruited in this study. Over 92% of the cases were also diagnosed with at least one type of psychiatric disorder. Sleep disorders (SDs, 90.57%), mood disorders (MDs, 52.83%), personality disorders (PDs, 40.25%) and anxiety disorders (ADs, 16.98%) were the most prevalent diagnoses among these patients. The logistic regression results correspondingly showed that suffering from Cluster-B PDs was associated with a higher prevalence rate of somatic symptom disorders (SSDs), with a p-value of 0.019 and an odds ratio (OR) of 2.7.

PMID:36947671 | DOI:10.1002/nop2.1731