Tag: statistics

Leg Med (Tokyo). 2021 Dec 27;55:102006. doi: 10.1016/j.legalmed.2021.102006. Online ahead of print.

ABSTRACT

BACKGROUND: Coronary artery disease (CAD), including coronary atherosclerosis (CAS), is one of the most common causes of death. The FURIN SNP rs17514846 is assumed to be a risk factor for CAD. We evaluated this relationship using autopsy specimens and autopsy data, such as the histopathological degree of CAS.

MATERIALS AND METHODS: A total of 106 samples were genotyped from obtained blood samples. Myocardial and coronary arterial FURIN levels were quantified by ELISA. The degree of CAS was classified histopathologically according to the Stary classification, and the localization of FURIN was examined by immunostaining. The obtained data were analyzed statistically.

RESULTS: FURIN expression was widely observed in the myocardium, vascular smooth muscle cells, endothelial cells, adipocytes, and macrophages. FURIN level in the myocardium of cases with the AA genotype at the FURIN SNP rs17514846 was higher than that in CC cases. Additionally, FURIN levels in both coronary arteries and myocardium were higher at the early stage of CAS than at the late stage microscopically.

CONCLUSION: Our study suggested that the A allele of rs17514846 is associated with higher FURIN level in the heart and that FURIN exhibits a higher level in the early stage of CAS. These findings deepen our understanding of the mechanism of CAS.

PMID:35008003 | DOI:10.1016/j.legalmed.2021.102006

Food Chem. 2022 Jan 5;377:132047. doi: 10.1016/j.foodchem.2022.132047. Online ahead of print.

ABSTRACT

As the most important marine edible shellfish, the nutritional quality of abalone has been paid attention. In this study, the chemical and nutritional compositions of abalones were obtained, and three cooking methods, steaming, boiling and frying, were evaluated by in vitro gastric digestion simulation to understand their nutritional changes by ¹H NMR spectroscopy combined with multivariate statistical analyses. The nutritional losses were also monitored under different cold storage conditions. The results indicated that boiling can keep more amino acids and fatty acids than steaming and frying, thus being recommended as the best cooking method of abalone. The abalone could maintain fresh within one day under 4 °C, and the deterioration process occurred subsequently. These results help to understand the digestion of cooked abalone and the changes of nutrients through storage and cooking process, leading to a scientific recommendation of cooking method and storage condition for healthy eating.

PMID:35008016 | DOI:10.1016/j.foodchem.2022.132047

ESMO Open. 2021 Dec 17;7(1):100374. doi: 10.1016/j.esmoop.2021.100374. Online ahead of print.

ABSTRACT

BACKGROUND: COVID-19 has had a significant impact on the well-being and job performance of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate and monitor well-being since COVID-19 in relation to work, lifestyle and support factors in oncology professionals 1 year on since the start of the pandemic.

METHODS: An online, anonymous survey was conducted in February/March 2021 (Survey III). Key outcome variables included risk of poor well-being or distress (expanded Well-Being Index), feeling burnout (single item from expanded Well-Being Index), and job performance since COVID-19. Longitudinal analysis of responses to the series of three surveys since COVID-19 was carried out, and responses to job demands and resources questions were interrogated. SPSS V.26.0/V.27.0 and GraphPad Prism V9.0 were used for statistical analyses.

RESULTS: Responses from 1269 participants from 104 countries were analysed in Survey III: 55% (n = 699/1269) female, 54% (n = 686/1269) >40 years, and 69% (n = 852/1230) of white ethnicity. There continues to be an increased risk of poor well-being or distress (n = 464/1169, 40%) and feeling burnout (n = 660/1169, 57%) compared with Survey I (25% and 38% respectively, P < 0.0001), despite improved job performance. Compared with the initial period of the pandemic, more participants report feeling overwhelmed with workload (45% versus 29%, P < 0.0001). There remain concerns about the negative impact of the pandemic on career development/training (43%), job security (37%). and international fellowship opportunities (76%). Alarmingly, 25% (n = 266/1086) are considering changing their future career with 38% (n = 100/266) contemplating leaving the profession.

CONCLUSION: Oncology professionals continue to face increased job demands. There is now significant concern regarding potential attrition in the oncology workforce. National and international stakeholders must act immediately and work closely with oncology professionals to draw up future-proof recovery plans.

PMID:35007996 | DOI:10.1016/j.esmoop.2021.100374

Eur J Radiol. 2022 Jan 4;147:110149. doi: 10.1016/j.ejrad.2021.110149. Online ahead of print.

ABSTRACT

PURPOSE: To compare the diagnostic performance of shear wave elastography (SWE) and pulsed Doppler ultrasound in breast lesions, and to explore whether the quantitative SWE parameters correlated with pulsed Doppler ultrasound parameters.

MATERIALS AND METHODS: Seventy-nine patients with 79 breast lesions who had undergone conventional ultrasound, pulsed Doppler ultrasound and SWE examination were included. All of them underwent core needle biopsy or surgery within one week. Parameters including Emax (the maximum elastic modulus), Emean (mean elastic modulus), Emin (minimum elastic modulus), Esd (elastic modulus standard deviation), and RI (resistive index), PI (pulsatility index), PSV (peak systolic velocity) and EDV (end diastolic velocity) were obtained for statistical analysis.

RESULTS: Almost all SWE parameters were significantly different between benign and malignant breast lesions (P＜0.05). There was no significant difference between Esd and PI (P＞0.05), which had the best AUC among SWE and vascular parameters respectively (0.877 vs. 0.871). Emax showed a moderate correlation with PI (P = 0.000, r = 0.552) and RI (P = 0.000, r = 0.544), and Esd moderately correlated with PI (P = 0.000, r = 0.567) and RI (P = 0.000, r = 0.546). For the benign group, no parameters showed any significant correlation (P＞0.05), while for the malignant group, Emax and Esd also significantly correlated with PI or RI.

CONCLUSIONS: SWE and pulsed Doppler ultrasound had similar diagnostic efficacy for breast lesions. SWE and pulsed Doppler parameters were significantly correlated in breast lesions, especially in malignant ones, indicating the potential association between elastographic and vascular characteristics of breast tumors.

PMID:35007981 | DOI:10.1016/j.ejrad.2021.110149

Eur J Radiol. 2021 Dec 29;147:110136. doi: 10.1016/j.ejrad.2021.110136. Online ahead of print.

ABSTRACT

PURPOSE: Understanding how mechanical properties relate to functional changes in glioblastomas may help explain different treatment response between patients. The aim of this study was to map differences in biomechanical and functional properties between tumor and healthy tissue, to assess any relationship between them and to study their spatial distribution.

METHODS: Ten patients with glioblastoma and 17 healthy subjects were scanned using MR Elastography, perfusion and diffusion MRI. Stiffness and viscosity measurements G’ and G”, cerebral blood flow (CBF), apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in patients’ contrast-enhancing tumor, necrosis, edema, and gray and white matter, and in gray and white matter for healthy subjects. A regression analysis was used to predict CBF as a function of ADC, FA, G’ and G”.

RESULTS: Median G’ and G” in contrast-enhancing tumor were 13% and 37% lower than in normal-appearing white matter (P < 0.01), and 8% and 6% lower in necrosis than in contrast-enhancing tumor, respectively (P < 0.05). Tumors showed both inter-patient and intra-patient heterogeneity. Measurements approached values in normal-appearing tissue when moving outward from the tumor core, but abnormal tissue properties were still present in regions of normal-appearing tissue. Using both a linear and a random-forest model, prediction of CBF was improved by adding MRE measurements to the model (P < 0.01).

CONCLUSIONS: The inclusion of MRE measurements in statistical models helped predict perfusion, with stiffer tissue associated with lower perfusion values.

PMID:35007982 | DOI:10.1016/j.ejrad.2021.110136

Child Abuse Negl. 2022 Jan 7;124:105481. doi: 10.1016/j.chiabu.2021.105481. Online ahead of print.

ABSTRACT

BACKGROUND: To prevent abusive head trauma (AHT), many studies focus on understanding the risk factors. Few studies assess the role of household composition.

OBJECTIVE: To describe the household composition of children diagnosed with AHT and assess the relationships between patient and household characteristics, perpetration, and fatality.

PARTICIPANTS AND SETTING: Children admitted to a large pediatric hospital with AHT between January 1, 2010 and December 31, 2019.

METHODS: The diagnosis of AHT was made at initial hospitalization by a child abuse pediatrician with a multidisciplinary team review. The electronic medical records of identified patients were reviewed to identify demographic information, the number and ages of all of their siblings and the number and relationship to patients of all adults who were reported as being present at the time of AHT and therefore considered to be possible perpetrators. Descriptive statistics were used to characterize the sample. Comparisons were made using Fisher exact tests and Mann-Whitney tests.

RESULTS: Children with AHT who were under 12 months of age and had siblings in the home, particularly siblings under age 5, had greater odds of being injured by a biological parent. Children 12 months or older and children without siblings had greater odds of being injured by a boyfriend or girlfriend of their parent or guardian.

CONCLUSIONS: In cases of AHT, the possible perpetrator differed based on the presence of young siblings living in the home, which has important implications for AHT prevention.

PMID:35007972 | DOI:10.1016/j.chiabu.2021.105481

Child Abuse Negl. 2022 Jan 7;124:105459. doi: 10.1016/j.chiabu.2021.105459. Online ahead of print.

ABSTRACT

BACKGROUND: Adverse Childhood Experiences (ACEs) have been associated with a greater risk of later criminal offending. However, existing research in this area has been primarily conducted in Western developed countries and cross-cultural studies are rare.

OBJECTIVES: This study examined the relationship between ACEs and criminal behaviors in young adults living in 10 countries located across five continents, after accounting for sex, age, and cross-national differences.

PARTICIPANTS AND SETTING: In total, 3797 young adults aged between 18 and 20 years (M = 18.97; DP = 0.81) were assessed locally in community settings within the 10 countries.

METHOD: The ACE Questionnaire was used to assess maltreatment and household dysfunction during childhood and a subset of questions derived from the Deviant Behavior Variety Scale (DBVS) was used to determine past-year criminal variety pertaining to 10 acts considered crime across participating countries.

RESULTS: Physical and sexual abuse, physical neglect, and household substance abuse were related to criminal variety, globally, and independently across sexes and countries ranked differently in the United Nations Human Development Index (HDI). In addition, three out of five experiences of household dysfunction were related to criminal variety, but subsequent analyses indicate that some forms of household dysfunction only hold statistical significance among males or females, or in countries ranking lower in the HDI.

CONCLUSIONS: This research strengthens the finding that there are cross-cultural mechanisms perpetuating the cycle of violence. It also indicates that forms of household dysfunction have an impact on criminal behavior that is shaped by gender and the country’s levels of social well-being.

PMID:35007971 | DOI:10.1016/j.chiabu.2021.105459

Accid Anal Prev. 2022 Jan 7;166:106548. doi: 10.1016/j.aap.2021.106548. Online ahead of print.

ABSTRACT

In recent years, pedestrian safety has emerged to be of major concern to selected States in the US and at the national level. With the transition to the mobility of people, pedestrian safety has become more prevalent for governmental agencies to address and prioritize for strategic implementation. It was crucial to address the pedestrian-vehicular conflict within Florida as it was reported as having the highest four pedestrian incident locations in the country. Many pedestrian sidewalks in Florida are not continuous and there is a concern among planners and engineers in the Florida Department of Transportation (FDOT) that these gaps constitute discontinuity of flow and are potentially posing threats to pedestrian safety. This paper investigates the correlation between pedestrian safety and sidewalk gaps within the Central Florida region. A sidewalk gap is defined as a length of a roadway segment with missing or absent sidewalk between existing sidewalks (before and after) along the same segment. “Missing” sidewalks are locations where the sidewalk is not only absent, but there is a desire to have one constructed or it would be used if it were constructed. The missing sidewalk can be on one side of the road or both sides. A wide array of Geographic Information Systems (GIS) information associated with the sidewalk gaps and the safety data were secured by FDOT. The data included all the Roadway Characteristics Inventory (RCI) within the district. Crash data combined with other geometric design data, traffic data, and census data were used to develop a statistical model. The results showed that presence of sidewalk along roadway segments is one of the main factors that have significant impact on the expected number of pedestrian crashes at a specific location. Other factors included daily traffic volumes, roadway category, specifically along urban two-way divided and undivided arterials with four to six lanes as well as the population within half-mile radius surrounding the crash location. The model results revealed that the Incident Risk Ratio (IRR) of a pedestrian crash along roadways with no sidewalk is 1.67 times greater than the likelihood of a crash with the presence of a sidewalk at 95% Confidence Interval (C.I.). The analysis also concluded that the likelihood of a pedestrian crash per mile along roadways with no sidewalk is three times greater than the likelihood of a crash per mile with the presence of a sidewalk.

PMID:35007964 | DOI:10.1016/j.aap.2021.106548

Waste Manag. 2022 Jan 7;139:330-340. doi: 10.1016/j.wasman.2021.11.036. Online ahead of print.

ABSTRACT

The environmental risk assessment and the factors influencing heavy metals (HM) in the soil at the municipal solid waste landfill sites (MSWLs) were studied by literature review, field survey, and statistical methods. The results indicated that the dominant HM contamination in the soil at the MSWLs was caused by chromium (Cr) with the Nemero index values (PI) from 22.7 to 44.3 and zinc (Zn) with the PI from 0.7 to 9.8. There were significant differences in the Cr, mercury (Hg), lead (Pb), Zn, and arsenic (As) concentrations between soil samples from sanitary and non-sanitary landfills (NSLs) where HM contamination (PI = 10.9) was more obvious. As (CRA_As = 2.35 × 10^-4) and cadmium (Cd) (CRA_Cd = 1.45 × 10^-4) posed potential carcinogenic health effects. The soil Cd concentration had a significant negative correlation (r = -0.476^**) with the landfill age. The soil As concentration had a significant positive correlation (r = 0.472^**) with rainfall in NSLs. There were significant differences in the As (P = 0.042) and copper (Cu) (P = 0.042) concentrations between soil samples from the surrounding areas of MSWLs and the base where soil had higher HM concentrations. For the efficient prevention of HM ecological risk, a scientific site selection, undamaged coverage and anti-seepage systems, standardized management, and ongoing monitoring are required.

PMID:35007953 | DOI:10.1016/j.wasman.2021.11.036

J Stroke Cerebrovasc Dis. 2022 Jan 7;31(3):106284. doi: 10.1016/j.jstrokecerebrovasdis.2021.106284. Online ahead of print.

ABSTRACT

OBJECTIVE: Flow diversion is becoming an increasingly established practice for the treatment of acutely ruptured intracranial aneurysms. In this study the authors present a literature review and meta-analysis, adding a retrospective review of institutional registry on emergency treatment of aRIA with flow diverter stent.

MATERIALS AND METHODS: A systematic search of PubMed, SCOPUS, Ovid MEDLINE, and Ovid EMBASE was performed on April 20^th, 2021, extrapolating 35 articles. R language ‘meta’ and ‘metafor’ packages were used for data pooling. The DerSimonian-Laird model was used to calculate the pooled effect. The I² value and Q statistic evaluated study heterogeneity. Additionally, the authors retrospectively reviewed their institutional database for the treatment and outcomes of all patients with acutely ruptured intracranial aneurysms treated with flow diverter stent placement from May 2010 to November 2020 was performed.

RESULTS: From the systematic literature review and meta-analysis, the pooled proportion of complete aneurysm occlusion was 78%, with a pooled rate of 79%, 71%, 80%, and 50% for dissecting, saccular, fusiform, and mycotic aneurysms, respectively. The pooled proportion of aneurysm rebleeding and intrastent stenosis was 12% and 15% respectively, for a total of 27% rate. The analysis of authors retrospective register showed an overall mortality rate of 16.7% (3/18), with a low but not negligible postprocedural rebleeding and intrastent thrombosis rates (5.6% and 11.1% respectively).

CONCLUSION: Although increasingly utilized in the management of selected patients with acutely ruptured intracranial aneurysms, flow diversion for acutely ruptured intracranial aneurysms treatment presents rebleeding and intrastent stenosis rates not negligible.

PMID:35007933 | DOI:10.1016/j.jstrokecerebrovasdis.2021.106284