Tag: statistics

Nurs Forum. 2022 Aug 29. doi: 10.1111/nuf.12795. Online ahead of print.

ABSTRACT

BACKGROUND: Communication and collaboration with colleagues are crucial for new graduate nurses (NGNs) because of the adaptation to both the healthcare system and professional role. Therefore, working units with effective collaboration among nurses may increase new graduates’ work readiness.

AIM: This study aimed to determine the relationship between the perceptions of nurse-nurse collaboration and the work readiness level among NGNs.

METHODOLOGY: This descriptive, cross-sectional study was carried out with 198 NGNs in four private hospitals affiliated with a university. A self-administered questionnaire, including a personal information form, the Nurse-Nurse Collaboration Scale, and Work Readiness Scale, was used to collect data. Data analysis was performed using descriptive tests, and Spearman’s rank correlation coefficients.

RESULTS: NGNs had moderate perceptions of nurse-nurse collaboration, with a median score of 2.46 (2.23-2.88) out of 4. Work readiness among NGNs was moderate, with a median score of 304 (270-332) out of 460. There was a statistically significant correlation between nurse-nurse collaboration and work readiness (r_s = 0.26; p < .001).

CONCLUSION: The results of this study demonstrated that improving nurse-nurse collaboration is an effective way to increase work readiness among NGNs.

PMID:36036181 | DOI:10.1111/nuf.12795

Indian Pediatr. 2022 Aug 26:S097475591600449. Online ahead of print.

ABSTRACT

OBJECTIVES: To determine the prevalence of delirium and its risk factors among children admitted to a Pediatric intensive care unit (PICU).

METHOD: A descriptive study in which consecutive patients admitted to the PICU over a period of 12 months were screened daily for delirium using the Cornell Assessment of Pediatric Delirium (CAPD) score. Treatment-related and demographic variables were collected and analyzed. The statistically significant risk factors for delirium were analyzed by multivariable logistic regression for independent associations.

RESULTS: Among the 476 screened patients, 96 (20.2%) developed delirium. The independent risk factors associated with the development of delirium were respiratory failure (P<0.001), administration of benzodiazepines during PICU stay (P<0.001), and presence of multiple (≥2) risk factors for delirium (P<0.001). The mean length of PICU stay was significantly higher among delirious subjects with P<0.001.

CONCLUSION: Delirium is a frequent complication in critically ill children, and recognition of associated factors may assist in early diagnosis and focussed management.

PMID:36036188

Int J Audiol. 2022 Aug 27:1-11. doi: 10.1080/14992027.2022.2114024. Online ahead of print.

ABSTRACT

OBJECTIVE: Subjective promontory stimulation is used to evaluate cochlear implant (CI) candidacy, but the test reliability is low. Electrically evoked auditory brainstem response (EABR) can verify the function of the auditory system objectively. This study’s procedure uses a trans-tympanic rounded bent-tip electrode to perform pre-operative EABR under local anaesthesia (LA-TT-EABR) using MED-EL Software and Hardware. This study aimed to determine usability and effectiveness for CI candidates.

DESIGN: We hypothesised that LA-TT-EABR waveforms of good quality would be related to successful hearing outcomes. We assumed that the duration of hearing loss/deafness was a confounding factor to study outcomes.

STUDY SAMPLE: 19 borderline CI candidates.

RESULTS: Positive LA-TT-EABR results were confirmed in 14 patients. LA-TT-EABR’s mean latency was 2.05 ± 0.31 ms (eII/eIII) and 4.24 ± 0.39 ms (eIV/eV). Latencies weren’t statistically different from intra-operative EABR elicited by basal CI contacts. All positive LA-TT-EABR patients benefitted from CI and speech performance improved one year after implantation. One patient with negative LA-TT-EABR was cochlear-implanted and had no hearing sensation.

CONCLUSIONS: LA-TT-EABR is a tool in the frame of pre-operative objective testing the auditory pathway. It seems useful for clinical testing CI candidacy. Based on this study’s outcomes, LA-TT-EABR should be recommended for uncertain CI candidates.

PMID:36036176 | DOI:10.1080/14992027.2022.2114024

J Int Med Res. 2022 Aug;50(8):3000605221119366. doi: 10.1177/03000605221119366.

ABSTRACT

OBJECTIVE: This study aimed to assess the time to severe coronavirus disease 2019 (COVID-19) and risk factors among confirmed COVID-19 cases in Southern Ethiopia.

METHOD: This two-center retrospective cohort study involved patients with confirmed COVID-19 from 1 October 2020 to 30 September 2021. Kaplan-Meier graphs and log-rank tests were used to determine the pattern of COVID-19 severity among categories of variables. Bivariable and multivariable Cox proportional regression models were used to identify the risk factors of severe COVID-19.

RESULTS: Four hundred thirteen patients with COVID-19 with a mean age of 41.9 ± 15.3 years were involved in the study. There were 194 severe cases (46.9.1%), including 77 (39.6%) deaths. The median time from symptom onset to severe COVID-19 was 8 days (interquartile range: 7-12 days). The risk factors for severe COVID-19 were age >65 (adjusted hazard ratio [AHR] = 2.65, 95% confidence interval [95%CI]: 1.02, 3.72), cough (AHR = 1.59, 95%CI: 1.39, 2.84), chest pain (AHR = 1.47, 95%CI: 1.34, 2.66), headache (AHR = 2.04, 95%CI: 1.43, 2.88), comorbidity (AHR = 1.3, 95%CI: 1.01, 2.04), asthma (AHR = 1.6. 95%CI: 1.04, 2.24), and symptom onset to admission more than 5 days (AHR = 0.48, 95%CI: 0.34, 0.68).

CONCLUSION: Patients with symptoms and comorbidities should be closely monitored.

PMID:36036178 | DOI:10.1177/03000605221119366

Drug Deliv. 2022 Dec;29(1):2773-2783. doi: 10.1080/10717544.2022.2115165.

ABSTRACT

Based on the administration convenience, transmucosal buccal drug delivery allows special strength points over peroral routes for systemic delivery. It could achieve local or systemic effect and boost drugs’ bioavailability for agents with first pass metabolism. The current study aimed to manufacture and optimize a lavender oil-based nanoemulsion loaded with zaleplon and incorporate it into fast-disintegrating tablets to promote its dissolution and oral bioavailability via oral mucosa. Zaleplon-loaded nanoemulsions were devised with various levels of lavender oil (10% to 25%), the surfactant Sorbeth-20 (35% to 65%), and the co-surfactant HCO-60 (20% to 40%); the extreme vertices mixture statistical design was adopted. The droplet size and drug-loading efficiency were the evaluated. The optimal formulation was transformed into self-nanoemulsified lyophilized tablets (ZP-LV-SNELTs), which were tested for their uniformity of content, friability, and disintegration time with in-vitro release. Finally, the pharmacokinetic parameters of the ZP-LV-SNELTs were determined and compared with those of marketed formulations. The optimal nanoemulsion had a droplet size of 87 nm and drug-loading capacity of 185 mg/mL. ZP-LV-SNELTs exhibited acceptable friability and weight uniformity and a short disintegration time. The in-vitro release of ZP-LV-SNELTs was 17 times faster than that of the marketed tablet. Moreover, the optimal ZP-LV-SNELTs increased the bioavailability of zaleplon in rabbits by 1.6-fold compared with the commercial tablets. Hence, this investigation revealed that ZP-LV-SNELTs delivered zaleplon with enhanced solubility, a fast release, and boosted bioavailability thru oral mucosa which provided a favorable route for drug administration which is suggested to be clinically investigated in future studies.

PMID:36036168 | DOI:10.1080/10717544.2022.2115165

Cogn Sci. 2022 Sep;46(9):e13189. doi: 10.1111/cogs.13189.

ABSTRACT

Synesthetes can be distinguished from nonsynesthetes on a variety of experimental tasks because their concurrent synesthetic experiences can affect task performance if these experiences match or conflict with some aspect of the stimulus. Here, we tested grapheme-color synesthetes and nonsynesthetic control participants using a novel perceptual similarity task to assess whether synesthetes’ concurrent color experiences influence perceived grapheme similarity. Participants iteratively arranged graphemes and, separately, their associated synesthetic colors in a display, such that similar items were placed close together and dissimilar items further apart. The resulting relative inter-item distances were used to calculate the pair-wise (dis)similarity between items in the set, and thence to create separate perceptual representational dissimilarity matrices (RDMs) for graphemes and colors, on an individual basis. On the assumption that synesthetes’ similarity judgments for graphemes would be influenced by their concurrent color experiences, we predicted that grapheme and color RDMs would be more strongly correlated for synesthetes than nonsynesthetes. We found that the mean grapheme-color RDM correlation was indeed significantly higher in synesthetes than nonsynesthetes; in addition, synesthetes’ grapheme-color RDM correlations were more likely to be individually statistically significant, even after correction for multiple tests, than those of nonsynesthetes. Importantly, synesthetes’ grapheme-color RDM correlations were scaled with the consistency of their grapheme-color associations as measured by their Synesthesia Battery (SB) scores. By contrast, the relationship between SB scores and grapheme-color RDM correlations for nonsynesthetes was not significant. Thus, dissimilarity analysis quantitatively distinguished synesthetes from nonsynesthetes, in a way that meaningfully reflects a key aspect of synesthetic experience.

PMID:36036150 | DOI:10.1111/cogs.13189

Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(8. Vyp. 2):72-76. doi: 10.17116/jnevro202212208272.

ABSTRACT

OBJECTIVE: To estimate the informativity, sensitivity and specificity of the method of assessing gait function in patients with ataxia and post-stroke hemiparesis using the LA-1 «Laser Analyzer of Kinematic Gait Parameters».

MATERIALS AND METHODS: Main tempo-rhythm and spatial gait parameters were assessed in groups of healthy people of young (n=30) and middle (n=30) age. At the second stage, the gait parameters of healthy people were compared with those of patients with ataxia due to vertebrobasilar stroke (n=30) and with post-stroke hemiparesis (n=30). The following parameters were evaluated: the average length and duration of step, the standard deviation of step length, the standard deviation of step duration, coefficient of variability for step length & duration.

RESULTS: The high sensitivity and specificity of the method were established. Standard values were determined for all indicators in groups of healthy people and statistically significant features of the main gait parameters for these syndromes were identified. There were an increase in the step length and duration, standard deviation of step length and duration, step variability coefficients, and a decrease in walking speed. Conclusion. The results are in line with those of earlier studies on the gait change in patients with post-stroke disorders. The LA-1 method can be recommended for clinical use.

PMID:36036147 | DOI:10.17116/jnevro202212208272

Zhongguo Dang Dai Er Ke Za Zhi. 2022 Aug 15;24(8):874-880. doi: 10.7499/j.issn.1008-8830.2204163.

ABSTRACT

OBJECTIVES: To investigate the carriage status of Streptococcus pneumoniae (S.pneumoniae) and Moraxella catarrhalis (M. catarrhalis) in preschool children and the influencing factors for the carriage status.

METHODS: The stratified cluster sampling method was used to select 2 031 healthy children from seven kindergartens in Shunde District of Foshan in Guangdong, China. Nasal swabs were collected from all children for the isolation and identification of S. pneumoniae and M. catarrhalis. The carriage status of S. pneumoniae and M. catarrhalis was analyzed in terms of its association with demographic features and hospital- and community-related factors.

RESULTS: The carriage rates of S. pneumoniae and M. catarrhalis were 21.81% and 52.44%, respectively among the children. The co-carriage rate of S. pneumoniae and M. catarrhalis was 14.87%. The correspondence analysis showed that the factors such as lower grade, non-local registered residence, living in rural areas, small living area, history of respiratory tract infection but no history of antibiotic use, allergic skin diseases, and no hospital-related exposure history were significantly associated with the co-carriage of S. pneumoniae and M. catarrhalis among the children (P<0.05).

CONCLUSIONS: Co-carriage of S. pneumoniae and M. catarrhalis can be observed in preschool children. Young age, poor living environment, a history of respiratory tract infection but no history of antibiotic use, allergic skin diseases, and no hospital-related exposure history are important risk factors for the co-carriage of S. pneumoniae and M. catarrhalis in preschool children.

PMID:36036125 | DOI:10.7499/j.issn.1008-8830.2204163

Chronobiol Int. 2022 Aug 29:1-11. doi: 10.1080/07420528.2022.2117051. Online ahead of print.

ABSTRACT

The COVID-19 pandemic caused strong restrictions in organized sports. Specifically, adolescent athletes, whose daily routine is usually determined by school and practice schedules, experienced a sudden lifestyle change. The aim of this study was to examine sleep and training patterns of German elite adolescent basketball players (N = 115, 15.70 ± 1.22 years, female = 32.17%) during different phases of the 2021 lockdown. Sleep and training behavior were documented by a subjective monitoring over 10 days at three different lockdown phases in February, April, and June/July. A linear mixed model approach was conducted for the statistical analyses. Sleep duration and time in bed decreased between phase 1 (prohibition of organized sports) and phase 3 (normal training conditions), while sleep efficiency and quality increased. There was no change in training duration over time, but in training intensity, which peaked in the third phase. This study contains meaningful evidence to analyze the lockdown-related return to practice process. Athletes were able to maintain training duration with alternative protocols during pandemic conditions. Interestingly, athletes slept less under non-lockdown conditions, but reported a better sleep quality. It is recommended to consider athletes’ individual preferences when planning training and recovery schedules.

PMID:36036080 | DOI:10.1080/07420528.2022.2117051

Int J Artif Organs. 2022 Aug 29:3913988221120026. doi: 10.1177/03913988221120026. Online ahead of print.

ABSTRACT

OBJECTIVE: To compare the clinical efficacy between personalised 3-dimensional (3D) printed osteotomy and traditional osteotomy in periacetabular osteotomy (PAO).

METHODS: Twenty-two patients with acetabular dysplasia were randomly divided into a personalised 3D-printed osteotomy group and a traditional osteotomy group without 3D printing assistance. The operation time, intraoperative blood loss, X-ray frequency, quantity of postoperative drainage, postoperative transfusion rate, hip angle and Harris hip score of 6 months postoperative were studied and compared to evaluate the surgical efficacy between personalised 3D-printed osteotomy and traditional osteotomy in periacetabular osteotomy.

RESULTS: The operation time, intraoperative blood loss, X-ray frequency, postoperative 24 h drainage volume in the personalised 3D-printed osteotomy group (114.70 ± 2.21 min, 639.70 ± 5.00 mL, 11.82 ± 0.42 times, 231.20 ± 3.86 mL) was superior to the traditional group (150.40 ± 2.45 min, 850.50 ± 5.34 mL, 17.09 ± 0.39 times, 324.30 ± 4.06 mL). There was a statistically significant difference between the 3D-printed osteotomy group and the traditional osteotomy group in terms of the operation time, intraoperative blood loss, X-ray frequency and postoperative 24 h drainage volume (p < 0.05). And there were no substantial differences in the hip angle and the 6-month postoperative Harris hip score between the two groups (p > 0.05).

CONCLUSION: The 3D-printed osteotomy template for PAO is a valid method and its short-term clinical effect is superior to that of traditional osteotomy.

PMID:36036079 | DOI:10.1177/03913988221120026