Tag: statistics

Psychiatr Pol. 2021 Oct 31;55(5):1139-1155. doi: 10.12740/PP/OnlineFirst/119778. Epub 2021 Oct 31.

ABSTRACT

OBJECTIVES: Assessment of criterion validity and temporal stability of personality disorder diagnosis in adolescents and relationships between attachment styles and personality disorder diagnosis.

METHODS: 50 adolescents (46 girls and 4 boys, aged 15-17) hospitalized at the department of child and adolescent psychiatry were assessed with the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) and the Inventory of Parent and Peer Attachment (IPPA). After one year, adolescents meeting the criteria for apersonality disorder (PD) diagnosis were reassessed with the SCID-II.

RESULTS: In the first stage of assessment, diagnostic criteriafor different types of personality disorders were met by 41 adolescents (82%) (mean number of criteria = 5.9). Criteria were met most often for borderline personality disorder (BPD) (n = 26; mean number of criteria = 7.9). In the second stage of assessment, the interview was re-administered to 21 (51%) adolescents; the mean number of criteria was = 6.6. A statistically significant relationship between the number of PD diagnostic criteria in assessment one and the number of criteria in assessment two was obtained (r = 0.58; p < 0.01). 82% of the participants with PD were insecurely attached to their mothers. In the borderline group, 83% of the participants reported anxious-avoidant attachment style.

CONCLUSIONS: PD traits in adolescence, specifically BPD, are stable across one year.

PMID:34997748 | DOI:10.12740/PP/OnlineFirst/119778

Psychiatr Pol. 2021 Oct 31;55(5):1101-1119. doi: 10.12740/PP/OnlineFirst/115170. Epub 2021 Oct 31.

ABSTRACT

OBJECTIVES: The objective of the study wasto determine the impact of synthetic cathinonesusage on depressive symptoms and oral behaviors among recreational users.

METHODS: Users of online drugs-related forums were asked to fill in a questionnaire via Google Forms Platform. The questionnaire contained questions about patterns of drugs use, the Beck Depression Inventory II, the Oral Behaviors Checklist (OBC), and questions about basic demographic data (age, gender).

RESULTS: 150 participants (75 in the study group, 75 in the control group) took part in the study. In the study group (aged 15-28), all participants used cathinones and other psychoactive substances. 42 participants used cathinones during last month. Statistical analysis showed a correlation between amount of drugs types used and level of depressive symptoms for both groups (study group and control group), as well as a statistically significantly higher mean value of the OBC scores in a group of cathinones users than in controls. Correlation between the BDI-II and OBC results was statistically significant for both the study and control groups.

CONCLUSIONS: Considering easy access to synthetic cathinones, widely spread intoxications and young age of participants of this survey the subject needs to be widely researched. Psychoactive substances can predispose to development of depression and various forms of parafunctional oral behaviors.

PMID:34997746 | DOI:10.12740/PP/OnlineFirst/115170

J Integr Neurosci. 2021 Dec 30;20(4):993-999. doi: 10.31083/j.jin2004100.

ABSTRACT

Previous studies have revealed significant changes in electroencephalogram (EEG) microstates in neuropsychiatric diseases, including schizophrenia, depression, and dementia. To explore the resting-state EEG microstate with amputation, we collected the EEG datasets from 15 patients with lower limb amputation and 20 healthy controls. Then, we analyzed the parameters of four classical EEG microstates (A-D) between the two groups. Specifically, the parameters were statistically analyzed, including duration, occurrence rate, time coverage, and transition rate. According to the results, the duration of microstate C (t = 2.95, p = 0.005) in the lower limb amputation group was significantly smaller compared with the control group, while the occurrence rate of microstate B (t = -2.22, p = 0.03) and D (t = -3.35, p = 0.002) were significantly larger in the lower limb amputation group. In addition, the transition rate of microstate differed significantly in AC, CA, DB between the two groups. Our results implied: (1) amputation has changed the resting-state EEG microstate; (2) EEG microstate analysis can be an approach to explore the alteration of cortical function.

PMID:34997722 | DOI:10.31083/j.jin2004100

J Integr Neurosci. 2021 Dec 30;20(4):1011-1017. doi: 10.31083/j.jin2004102.

ABSTRACT

This paper investigates whether diffusion tensor imaging performed within 2 weeks of intracerebral hemorrhage onset could predict the motor outcome by categorizing previous diffusion tensor imaging studies based on the time-point of performing diffusion tensor imaging (<2 weeks and ≥2 weeks after intracerebral hemorrhage onset). A comprehensive database search on PubMed, Embase, Cochrane Library, and SCOPUS was conducted. The pooled estimate was acquired using correlation analysis between the diffusion tensor imaging parameters of fractional anisotropy and motor recovery based on the period of stroke onset. In the results, out of 511 retrieved articles, eight were finally included in the meta-analysis. In patients who underwent diffusion tensor imaging within 2 weeks of intracerebral hemorrhage onset, a random-effects model revealed that the ratio of fractional anisotropy is a significant predictor of motor recovery of the hemi-side extremity after intracerebral hemorrhage (p = 0.0015). In patients who underwent diffusion tensor imaging after 2 weeks of intracerebral hemorrhage onset, a fixed-effects model revealed that the ratio of fractional anisotropy was also a significant predictor of motor recovery of the hemi-side extremity after intracerebral hemorrhage (p < 0.0001). Our meta-analysis revealed that ratio of fractional anisotropy (rFa) calculated from diffusion tensor imaging (DTI) performed ≥2 weeks of intracerebral hemorrhage onset had a positive correlation with the motor outcomes after intracerebral hemorrhage (ICH). Also, although diffusion tensor imaging was performed <2 weeks after intracerebral hemorrhage onset, the ratio of fractional anisotropy calculated from diffusion tensor imaging helped predict the motor outcome. Further analyses, including a more significant number of studies focused on this topic, are warranted.

PMID:34997724 | DOI:10.31083/j.jin2004102

J Integr Neurosci. 2021 Dec 30;20(4):861-870. doi: 10.31083/j.jin2004088.

ABSTRACT

Cerebrospinal fluid neurofilament light and plasma neurofilament light concentrations are elevated in patients with mild cognitive impairment and Alzheimer’s disease. We investigated the clinical relevance of increased neurofilament light concentrations in mild cognitive impairment and Alzheimer’s disease patients. In this study, 244 subjects were divided into cognitively normal control (n = 67), stable mild cognitive impairment (n = 52), progressive mild cognitive impairment (n = 68), and Alzheimer’s disease (n = 57). Linear regression examined the relationships between neurofilament light levels in cerebrospinal fluid or plasma and the diagnostic group. The relationships between neurofilament light and other biomarkers were assessed by Spearman correlation. Linear mixed-effects models were used to test cerebrospinal fluid and plasma neurofilament light as predictors of Alzheimer’s disease characteristics, including cognition, cortical glucose metabolism, and brain structure. Cerebrospinal fluid and plasma neurofilament light levels were significantly elevated in Alzheimer’s disease. Still, the correlations between neurofilament light and other cerebrospinal fluid biomarkers within the diagnostic groups were often not statistically significant. In addition, the diagnostic accuracy of cerebrospinal fluid and plasma neurofilament light for progressive mild cognitive impairment and Alzheimer’s disease was almost the same as that of cerebrospinal fluid total tau (T-tau). It is phosphorylated tau (P-tau) and high cerebrospinal fluid. Neurofilament light predicted conversion from mild cognitive impairment to Alzheimer’s disease. A high neurofilament light is related to poor cognition, low cerebral metabolism, hippocampal atrophy, and ventricular enlargement caused by Alzheimer’s disease. Our work further identifies cerebrospinal fluid neurofilament light and plasma neurofilament light as biomarkers of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease.

PMID:34997710 | DOI:10.31083/j.jin2004088

Rev Med Virol. 2022 Jan;32(1):e2238. doi: 10.1002/rmv.2238. Epub 2021 Apr 21.

ABSTRACT

Salivirus (SaV) is a newly described member of the family Picornaviridae that has been associated with gastrointestinal (GI) symptoms, particularly in children. The aim of the present study was to evaluate the prevalence of SaV in symptomatic children and its potential association with GI complications. A systematic search was conducted from 01 December 2009 to 10 December 2020, in three major English databases, including Scopus, PubMed and Web of Science as well as Google scholar search engine. Random effect model-based overall prevalence and odds ratio (OR) were assessed in cross-sectional and case-control studies by STATA 14.1. The random effect model-based pooled prevalence of SaV was 1.6% (95% CI, 0.010-0.022%) and overall OR for all eight case-control studies indicated an association (3.19 with 95% confidence interval 1.35-7.57) that was not statistically significant, due to the small number of studies available. More comprehensive case-control studies in multiple geographies should be conducted on the prevalence of SaV in children.

PMID:34997675 | DOI:10.1002/rmv.2238

J Cachexia Sarcopenia Muscle. 2022 Jan 8. doi: 10.1002/jcsm.12908. Online ahead of print.

ABSTRACT

BACKGROUND: Depression may be the most common cause of emotional distress later in life and can significantly reduce the quality of life in elderly individuals. Sarcopenia is a syndrome characterized by the continuous loss of skeletal muscle mass and decreased strength and function. In recent years, many studies have shown a correlation between sarcopenia and depression. The present study aimed to investigate the prevalence of depression among individuals with sarcopenia and to ascertain whether sarcopenia is independently associated with depression.

METHODS: We systematically searched the PubMed, Embase, and Google Scholar databases for papers on sarcopenia published up to 31 August 2021. We reviewed the literature on the number of individuals with sarcopenia, the number of individuals with both sarcopenia and depression, and the odds ratio (OR) of sarcopenia to depression. Statistical analyses were performed using Meta-DiSc 1.4 software and Stata version 12.0.

RESULTS: Nineteen articles met the inclusion criteria for review: nine reported both prevalence and ORs, four described prevalence only, and six detailed the ORs only. Regarding prevalence, there were 1476 cases of sarcopenia and 364 of depression in the selected studies; the mean age of the patients was 75.5 years, and the overall prevalence of depression was 0.28 [95% confidence interval (CI): 0.21-0.36]. Significant heterogeneity was noted (P < 0.001; I² = 92.2%). In the case of ORs, there were 16 869 subjects with a mean age of 73 years; the overall adjusted OR between sarcopenia and depression was 1.57 (95% CI: 1.32-1.86). Significant heterogeneity was noted in the adjusted ORs (P < 0.001; I² = 75.1%).

CONCLUSIONS: The prevalence of depression in patients with sarcopenia was high relatively, and there was a correlation between sarcopenia and depression.

PMID:34997702 | DOI:10.1002/jcsm.12908

Hum Brain Mapp. 2022 Jan 7. doi: 10.1002/hbm.25764. Online ahead of print.

ABSTRACT

Numerous brain stimulation studies have targeted the posterior parietal cortex, a key hub of the attention network, to manipulate attentional reorientation. However, the impact of stimulating brain regions earlier in the pathway, including early visual regions, is poorly understood. In this study, 28 healthy adults underwent three high-definition transcranial direct current stimulation (HD-tDCS) visits (i.e., anodal, cathodal, and sham). During each visit, they completed 20 min of occipital HD-tDCS and then a modified Posner task during magnetoencephalography (MEG). MEG data were transformed into the time-frequency domain and significant oscillatory events were imaged using a beamformer. Oscillatory response amplitude values were extracted from peak voxels in the whole-brain maps and were statistically compared. Behaviorally, we found that the participants responded slowly when attention reallocation was needed (i.e., the validity effect), irrespective of the stimulation condition. Our neural findings indicated that cathodal HD-tDCS was associated with significantly reduced theta validity effects in the occipital cortices, as well as reduced alpha validity effects in the left occipital and parietal cortices relative to anodal HD-tDCS. Additionally, anodal occipital stimulation significantly increased gamma amplitude in right occipital regions relative to cathodal and sham stimulation. Finally, we also found a negative correlation between the alpha validity effect and reaction time following anodal stimulation. Our findings suggest that HD-tDCS of the occipital cortices has a polarity dependent impact on the multispectral neural oscillations serving attentional reorientation in healthy adults, and that such effects may reflect altered local GABA concentrations in the neural circuitry serving attentional reorientation.

PMID:34997673 | DOI:10.1002/hbm.25764

Sci Rep. 2022 Jan 7;12(1):276. doi: 10.1038/s41598-021-04388-0.

ABSTRACT

Pearl millet is an important staple food crop of poor people and excels all other cereals due to its unique features of resilience to adverse climatic conditions. It is rich in micronutrients like iron and zinc and amenable for focused breeding for these micronutrients along with high yield. Hence, this is a key to alleviate malnutrition and ensure nutritional security. This study was conducted to identify and validate candidate genes governing grain iron and zinc content enabling the desired modifications in the genotypes. Transcriptome sequencing using ION S5 Next Generation Sequencer generated 43.5 million sequence reads resulting in 83,721 transcripts with N₅₀ of 597 bp and 84.35% of transcripts matched with the pearl millet genome assembly. The genotypes having high iron and zinc showed differential gene expression during different stages. Of which, 155 were up-regulated and 251 were down-regulated while during flowering stage and milking stage 349 and 378 transcripts were differentially expressed, respectively. Gene annotation and GO term showed the presence of transcripts involved in metabolic activities associated with uptake and transport of iron and zinc. Information generated will help in gaining insights into iron and zinc metabolism and develop genotypes with high yield, grain iron and zinc content.

PMID:34997160 | DOI:10.1038/s41598-021-04388-0

Sci Rep. 2022 Jan 7;12(1):242. doi: 10.1038/s41598-021-04366-6.

ABSTRACT

We aimed to investigate whether annual change in the extracellular fluid to intracellular fluid (ΔECF/ICF) ratio can accurately predict mortality in hemodialysis patients. Totally, 247 hemodialysis patients were divided into two groups according to the median baseline ECF/ICF ratio of 0.563 and ΔECF/ICF ≥ 0% or < 0% during the first year, respectively. Thereafter, they were divided into four groups according to each cutoff point and were followed up for mortality assessment. The ECF/ICF ratio increased from 0.566 ± 0.177 to 0.595 ± 0.202 in the first year (P = 0.0016). During the 3.4-year median follow-up, 93 patients died (42 cardiovascular-specific causes). The baseline ECF/ICF ≥ 0.563 and ΔECF/ICF ≥ 0% were independently associated with all-cause mortality (adjusted hazard ratio [aHR] 4.55, 95% confidence interval [CI] 2.60-7.98 and aHR 8.11, 95% CI 3.47-18.96, respectively). The aHR for ECF/ICF ≥ 0.563 and ΔECF/ICF ≥ 0% vs. ECF/ICF < 0.563 and ΔECF/ICF < 0% was 73.49 (95% CI 9.45-571.69). For model discrimination, adding the ΔECF/ICF (0.859) alone and both the baseline ECF/ICF and ΔECF/ICF (0.903) to the established risk model (0.746) significantly improved the C-index. Similar results were obtained for cardiovascular mortality. In conclusion, the ΔECF/ICF ratio could not only predict all-cause and cardiovascular mortality but also improve predictability of mortality in hemodialysis patients.

PMID:34997150 | DOI:10.1038/s41598-021-04366-6