Tag: statistics

Cornea. 2022 Aug 25. doi: 10.1097/ICO.0000000000003119. Online ahead of print.

ABSTRACT

PURPOSE: The aim of this study was to evaluate the quality-of-life (QoL) status in keratoconus severity subgroups using the Keratoconus Outcomes Research Questionnaire (KORQ) and to determine the relationship between the QoL scores and the standard clinical variables.

METHODS: A cross-sectional study was conducted using prospective, web-based Save Sight Keratoconus Registry data. Rasch analysis was conducted on the KORQ data using the Andrich Rating Scale Model. Comparative analysis included Welch t test and 1-way ANOVA. Associations between visual acuity, corneal curvature, and minimum corneal thickness with KORQ scores were evaluated with Pearson correlation and multiple regression adjusted for age and sex.

RESULTS: The KORQ was completed by 542 patients with keratoconus (male, 67.7%; mean age, 31.6 years). Keratoconus severity, based on Kmax, was mild [<48 diopter (D)], moderate (48-55 D), and severe (>55 D) in 26.3%, 45.0%, and 28.7% of patients, respectively. Activity limitation (AL) and symptoms (SY) scales of the KORQ had robust psychometric properties including well-functioning response categories, unidimensionality, excellent measurement precision, and satisfactory fit statistics. In a group-wise analysis, the female patients had significantly lower AL and SY scores. Similarly, the severe keratoconus group had the worst AL and SY scores. Contact lens wearers had worse KORQ scores than the spectacles wearers. Overall, statistically significant but weak correlations between KORQ scores and visual acuity and corneal curvature (Kmax and K2) (Pearson r, 0.11-0.35) were observed. The correlations for SY were weaker than for AL scores.

CONCLUSIONS: Female sex, contact lens wear, reduced visual acuity, and higher disease severity were associated with worse AL and SY scores in keratoconus. Although the correlations between clinical and QoL scores were statistically significant, the low magnitudes suggested a complex relationship between clinical parameters and patient-reported outcomes.

PMID:36036705 | DOI:10.1097/ICO.0000000000003119

Cornea. 2022 Aug 25. doi: 10.1097/ICO.0000000000003060. Online ahead of print.

ABSTRACT

PURPOSE: Outcomes of Acanthamoeba keratitis are often worse in India than in the United States. The goal of this study was to determine whether antiamoebic susceptibility patterns were different when comparing Acanthamoeba isolates from India with those of the United States.

METHODS: Acanthamoeba isolates were obtained from corneal scrapings of 43 patients with infectious keratitis seen at the Francis I. Proctor Foundation (N = 23) and Aravind Eye Hospital (N = 20) from 2008 through 2012 and plated on growth media. A previously described minimum cysticidal concentration (MCC) assay was performed by a single laboratory technician to assess susceptibility to 5 antiamoebic agents for all isolates. Testing was conducted in triplicate, with the median MCC chosen for analyses.

RESULTS: The MCC (μg/mL) of polyhexamethylene biguanide was 6.25 [IQR 5.47-12.5] for Aravind isolates and 6.25 [IQR 6.25-9.375] for Proctor isolates (P = 0.75), corresponding values were 6.25 [IQR 3.125-6.25] and 3.125 [IQR 3.125-9.375] for chlorhexidine (P = 0.81), 2500 [IQR 2500-5000] and 5000 [IQR 1250-20,000] for voriconazole (P = 0.25), 15.6 [IQR 15.6-39.0625] and 15.6 [IQR 15.6-31.25] for hexamidine (P = 0.92), and 15.6 [IQR 7.81-15.6] and 15.6 [IQR 7.81-31.25] for propamidine (P = 0.42).

CONCLUSIONS: This study found no statistically significant differences in antiamoebic susceptibility of Indian versus US samples from Acanthamoeba keratitis clinical isolates. These findings suggest that differences in antiamoebic susceptibility are likely not responsible for differential outcomes in Acanthamoeba keratitis between the 2 locations.

PMID:36036669 | DOI:10.1097/ICO.0000000000003060

Nutr Clin Pract. 2022 Aug 29. doi: 10.1002/ncp.10905. Online ahead of print.

ABSTRACT

BACKGROUND: Home enteral nutrition (HEN) is frequently prescribed to individuals who cannot consume adequate food orally. Commercial blenderized enteral formulas (CBEF) containing real-food ingredients are becoming more popular and more widely available; however, the demographics of patients receiving these formulas have rarely been evaluated, and little data are available on patient tolerance in the community.

METHODS: US claims data were obtained for children and adolescents/adults who used the CBEF of interest as the sole source of nutrition via enteral feeding tube in the community setting following discharge from acute care. Demographics, concomitant medications, clinical diagnoses, and Charlson Comorbidity Index scores were tabulated using descriptive statistics. Gastrointestinal (GI) symptoms before and after hospital discharge were compared using significance tests.

RESULTS: The study included 231 participants (180 children, 51 adolescents/adults). CBEFs were prescribed to patients with a variety of diagnoses, of which the most common were digestive and respiratory disorders. Children experienced significantly lower rates of diarrhea, nausea, vomiting, constipation, and abdominal distension in the weeks following hospital discharge compared with the baseline (all P < 0.001). Adolescents/adults experienced significantly lower rates of constipation, nausea, and vomiting (all P < 0.05). Neither group increased their usage of GI medications following hospital discharge.

CONCLUSION: These CBEFs, based on real-food ingredients, were prescribed to diverse patients in the community and were well tolerated. These formulas offer an alternative to standard polymeric formulas and an alternative or adjunct to homemade blenderized formulas.

PMID:36036217 | DOI:10.1002/ncp.10905

Med Educ Online. 2022 Dec;27(1):2114851. doi: 10.1080/10872981.2022.2114851.

ABSTRACT

Digitalisation is changing all areas of our daily life. This changing environment requires new competences from physicians in all specialities. This study systematically surveyed the knowledge, attitude, and interests of medical students. These results will help further develop the medical curriculum, as well as increase our understanding of future physicians by other healthcare market players. A web-based survey consisting of four sections was developed: Section one queried demographic data, section two assessed the current digital health knowledge of medical students, section three queried their attitudes about the future impact of digital health in medicine and section four assessed the recommendations medical students have for the medical curriculum in terms of digital health. This survey was distributed to all (11,978) student at all public Austrian medical schools. A total of 8.4% of the medical student population started the survey. At the knowledge self-assessment section, the medical students reached mean of 11.74 points (SD 4.42) out of a possible maximum of 32 (female mean 10.66/ SD 3.87, male mean 13.34/SD 4.50). The attitude section showed that students see digitalisation as a threat, especially with respect to the patient-physician relationship. The curriculum recommendation section showed a high interest for topics related to AI, a per study year increasing interest in impact of digital health in communication, as well as a decreasing interest in robotic related topics. The attitude towards digital health can be described as sceptical. To ensure that future physicians keep pace with this development and fulfil their responsibility towards the society, medical schools need to be more proactive to foster the understanding of medical students that digital health will persistently alter the medical practice.

PMID:36036219 | DOI:10.1080/10872981.2022.2114851

Ethn Health. 2022 Aug 28:1-11. doi: 10.1080/13557858.2022.2116631. Online ahead of print.

ABSTRACT

OBJECTIVE: Racial disparities in care and outcome have been demonstrated for several cancers, but it is not clear that a similar discrepancy exists for pancreatic cancer. Furthermore, there are limited data describing the pancreatic cancer experience of Pacific Islanders. The primary objective of this study was to analyze the clinical characteristics, treatment, and outcomes of Pacific Islander patients with pancreatic cancer.

DESIGN: We obtained data for a consecutive sample of pancreatic adenocarcinoma patients who presented to the largest hospital in Hawaii from 1 January 2000, through 31 December 2019. Analyses were performed for the entire population and separately for patients who had their cancer resected. Overall survival was calculated by the Kaplan-Meier method. Cox proportional hazards regression models were constructed to determine the prognostic capacity of clinical and pathologic factors.

RESULTS: A total of 1040 patients were included in the final analysis. Pacific islanders presented at a significantly younger age compared to Whites or Asians and had the highest Medicaid rate. There were no statistically significant racial differences in stage at presentation or treatments. We did not demonstrate an association between race and survival on univariate analysis, nor after adjusting for demographic and tumor factors. Age, stage, and treatment were significantly associated with survival for both univariate and multivariate analyses.

CONCLUSION: We did not demonstrate disparate outcomes among Pacific Islanders with pancreatic cancer. This is likely due in part to the absence of a screening test and the notable poor prognosis of pancreatic adenocarcinoma. Furthermore, equity in treatment may have contributed to racial parity in survival.

PMID:36036201 | DOI:10.1080/13557858.2022.2116631

Int J Inj Contr Saf Promot. 2022 Aug 28:1-12. doi: 10.1080/17457300.2022.2109679. Online ahead of print.

ABSTRACT

This study aims to evaluate the perception of safety and security in informal transport in Tunisia. This research employs a questionnaire-based survey of passengers and drivers of informal transport in Tunisia. Interviews were conducted with 215 informal transport Tunisian drivers and 255 Tunisian passengers, all above 18 years of age. Analyses have been made by employing several multivariate statistical analyses. Results showed that personal attributes of informal transport drivers influence their decision to violate traffic laws and to display risky driving behaviors. It was also found that driver skills, personality, education, experience, quality of the car, and information about the road congestion are the main factors influencing safety and security in informal transport. Non-compliance with the law by informal drivers leads to aberrant habits and behaviors as well as to a driving style beyond recognized standards. Informal drivers, police and local authorities are the parties involved in the low safety and security aspects of informal transport. It can be concluded that this study underlines that improving safety and security in informal transport cannot be achieved without improving awareness of the role of traffic laws and the need for their enforcement.

PMID:36036198 | DOI:10.1080/17457300.2022.2109679

Omega (Westport). 2022 Aug 27:302228221124358. doi: 10.1177/00302228221124358. Online ahead of print.

ABSTRACT

The current study aimed to determine the relationship between fear of death and their caregiver roles in nurses during the COVID-19. The research data were collected with the personal information form, the Thanatophobia scale, the Scale of Nurses’ Attitudes to Their Caregiver Roles (SNACR), the Google Questionnaire Form. Of the nurses participating in the study, 16.1% were diagnosed with COVID-19. The current study found statistically significant differences among the thanatophobia mean scores of the groups composed according to the variables; age, gender, marital status, job position, voluntarily choosing the profession, satisfaction with the department, having had a COVID-19 diagnosis, personal assessments about their own COVID-19 knowledge, and evaluating the COVID-19 disease as fatal. In addition, there were statistically significant differences among the SNACR mean scores of the groups according to their evaluations about gender, income level, working experience as a nurse, being diagnosed with COVID-19, and their COVID-19 knowledge. The current study found no correlation between the nurses’ Thanatophobia scale score and SNACR score.

PMID:36036194 | DOI:10.1177/00302228221124358

Nurs Forum. 2022 Aug 29. doi: 10.1111/nuf.12795. Online ahead of print.

ABSTRACT

BACKGROUND: Communication and collaboration with colleagues are crucial for new graduate nurses (NGNs) because of the adaptation to both the healthcare system and professional role. Therefore, working units with effective collaboration among nurses may increase new graduates’ work readiness.

AIM: This study aimed to determine the relationship between the perceptions of nurse-nurse collaboration and the work readiness level among NGNs.

METHODOLOGY: This descriptive, cross-sectional study was carried out with 198 NGNs in four private hospitals affiliated with a university. A self-administered questionnaire, including a personal information form, the Nurse-Nurse Collaboration Scale, and Work Readiness Scale, was used to collect data. Data analysis was performed using descriptive tests, and Spearman’s rank correlation coefficients.

RESULTS: NGNs had moderate perceptions of nurse-nurse collaboration, with a median score of 2.46 (2.23-2.88) out of 4. Work readiness among NGNs was moderate, with a median score of 304 (270-332) out of 460. There was a statistically significant correlation between nurse-nurse collaboration and work readiness (r_s = 0.26; p < .001).

CONCLUSION: The results of this study demonstrated that improving nurse-nurse collaboration is an effective way to increase work readiness among NGNs.

PMID:36036181 | DOI:10.1111/nuf.12795

Indian Pediatr. 2022 Aug 26:S097475591600449. Online ahead of print.

ABSTRACT

OBJECTIVES: To determine the prevalence of delirium and its risk factors among children admitted to a Pediatric intensive care unit (PICU).

METHOD: A descriptive study in which consecutive patients admitted to the PICU over a period of 12 months were screened daily for delirium using the Cornell Assessment of Pediatric Delirium (CAPD) score. Treatment-related and demographic variables were collected and analyzed. The statistically significant risk factors for delirium were analyzed by multivariable logistic regression for independent associations.

RESULTS: Among the 476 screened patients, 96 (20.2%) developed delirium. The independent risk factors associated with the development of delirium were respiratory failure (P<0.001), administration of benzodiazepines during PICU stay (P<0.001), and presence of multiple (≥2) risk factors for delirium (P<0.001). The mean length of PICU stay was significantly higher among delirious subjects with P<0.001.

CONCLUSION: Delirium is a frequent complication in critically ill children, and recognition of associated factors may assist in early diagnosis and focussed management.

PMID:36036188

Int J Audiol. 2022 Aug 27:1-11. doi: 10.1080/14992027.2022.2114024. Online ahead of print.

ABSTRACT

OBJECTIVE: Subjective promontory stimulation is used to evaluate cochlear implant (CI) candidacy, but the test reliability is low. Electrically evoked auditory brainstem response (EABR) can verify the function of the auditory system objectively. This study’s procedure uses a trans-tympanic rounded bent-tip electrode to perform pre-operative EABR under local anaesthesia (LA-TT-EABR) using MED-EL Software and Hardware. This study aimed to determine usability and effectiveness for CI candidates.

DESIGN: We hypothesised that LA-TT-EABR waveforms of good quality would be related to successful hearing outcomes. We assumed that the duration of hearing loss/deafness was a confounding factor to study outcomes.

STUDY SAMPLE: 19 borderline CI candidates.

RESULTS: Positive LA-TT-EABR results were confirmed in 14 patients. LA-TT-EABR’s mean latency was 2.05 ± 0.31 ms (eII/eIII) and 4.24 ± 0.39 ms (eIV/eV). Latencies weren’t statistically different from intra-operative EABR elicited by basal CI contacts. All positive LA-TT-EABR patients benefitted from CI and speech performance improved one year after implantation. One patient with negative LA-TT-EABR was cochlear-implanted and had no hearing sensation.

CONCLUSIONS: LA-TT-EABR is a tool in the frame of pre-operative objective testing the auditory pathway. It seems useful for clinical testing CI candidacy. Based on this study’s outcomes, LA-TT-EABR should be recommended for uncertain CI candidates.

PMID:36036176 | DOI:10.1080/14992027.2022.2114024