Tag: statistics

J Cardiovasc Electrophysiol. 2022 Sep 30. doi: 10.1111/jce.15697. Online ahead of print.

ABSTRACT

AIM: We conducted a systematic review and meta-analysis of randomized and observational studies with a control group to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation (AF).

METHODS: Three electronic databases (MEDLINE, Cochrane Central Register of Controlled Trials and Embase) without language restrictions were searched. The intervention assessed was a TTI-based strategy of CBA in the treatment of AF. TTI was defined as the time from the start of freezing to the last recorded pulmonary veins’ potential. The comparison of interest was intended conventional protocol of CBA. The primary end point was freedom from atrial arrhythmia.

RESULTS: Nine studies were deemed eligible (N= 2289 patients). Eight studies reported freedom from atrial arrhythmia and pooled results showed a marginally similar success rate between two protocols (OR: 1.24; 95% CI: 0.98 – 1.56). A prespecified subgroup analysis verified that a high dose TTI strategy (with >120s duration of cryotherapy post TTI) compared to conventional protocol could significantly increase the patients without atrial arrhythmia during follow-up (OR: 1.39; 95% CI: 1.05 – 1.83). TTI strategy could also significantly decrease total procedure time (SMD: – 26.24 minutes; 95% CI: – 36.90 to – 15.57) and phrenic nerve palsy incidence (OR: 0.49; 95% CI 0.29 – 0.84).

CONCLUSION: Moderate confidence evidence suggests that an individualized CBA dosing strategy based on TTI and extended (> 2 minutes post TTI) duration of CBA is accompanied by fewer recurrences post AF ablation. This article is protected by copyright. All rights reserved.

PMID:36177697 | DOI:10.1111/jce.15697

J Exp Psychol Gen. 2022 Sep 29. doi: 10.1037/xge0001304. Online ahead of print.

ABSTRACT

Nonarbitrary phenomena in language, such as systematic association in the form-meaning interface, have been widely reported in the literature. Exploiting such systematic associations previous studies have demonstrated that pseudowords can be indicative of meaning. However, whether semantic activation from words and pseudowords is supported by the very same processes, activating a common semantic memory system, is currently not known. Here, we take advantage of recent progresses from computational linguistics models allowing to induce meaning representations for out-of-vocabulary strings of letters via domain-general associative-learning mechanisms applied to natural language. We combined these models with data from priming tasks, in which participants are showed two strings of letters presented sequentially one after the other and are then asked to indicate if the latter is a word or a pseudoword. In Experiment 1 we reanalyzed the data of the largest behavioral database on semantic priming, while in Experiment 2 we ran an independent replication on a new language, Italian, controlling for a series of possible confounds. Results were consistent across the two experiments and showed that the prime-word meaning interferes with the semantic pattern elicited by the target pseudoword (i.e., at increasing estimated semantic relatedness between prime word and target pseudoword, participants’ reaction times increased and accuracy decreased). These findings indicate that the same associative mechanisms governing word meaning also subserve the processing of pseudowords, suggesting in turn that human semantic memory can be conceived as a distributional system that builds upon a general-purpose capacity of extracting knowledge from complex statistical patterns. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

PMID:36174173 | DOI:10.1037/xge0001304

Psychol Assess. 2022 Sep 29. doi: 10.1037/pas0001167. Online ahead of print.

ABSTRACT

Increasing research uses intensive longitudinal designs to examine antecedents and consequences associated with dynamic affective processes. These studies often rely on the Positive and Negative Affect Schedule (PANAS) to measure affect. Studies assessing the structure of the PANAS are largely cross-sectional in nature and cannot always disentangle within-person variability from between-person differences in affect. A paucity of studies examines structural similarities and differences in affect at the between- and within-person levels, and few have done so with short-form versions of the PANAS. This study investigates the multilevel factor structure of the 10-item PANAS-short-form in a sample of young adults (n = 272) measured daily consecutively over 1 month. Additionally, dynamic relations between positive and negative affect, depressive symptoms, stress, and physical symptoms were examined. Results support a three factors within and two factors between multilevel structural model. Distinct dynamic relations were observed among positive affect, negative affect, stress, and physical symptoms at the within level. Positive and negative affect were correlated with depressive symptoms, stress, and physical symptoms at the between level. Findings indicate the need to disentangle structural components of positive and negative affect when conducting intensive longitudinal studies to examine correlates linked to dynamic affective processes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

PMID:36174167 | DOI:10.1037/pas0001167

Psychol Assess. 2022 Sep 29. doi: 10.1037/pas0001183. Online ahead of print.

ABSTRACT

For decades, the Home Observation for Measurement of the Environment (HOME) has been the most widely used measure of children’s home environments. This report provides a revised version of the HOME-Short Form, the HOME-21, reflecting historical changes in family composition and caregiver roles, norms about the acceptability of different forms of discipline, and children’s digital environments. Using data from two samples of parents of children ages 0-17 (Fast Track [FT], N = 553, age = 33.8, 49.2% female, 48.1% Black, 51.9% White/other; Great Smoky Mountains Study [GSMS], N = 722, age = 37.2, 54.7% female, 67.6% White, 6.6% Black, 25.8% American Indian), we assess the utility of the HOME-21 with descriptive statistics and correlations with a range of demographic, family context, parenting, and child adjustment measures. Higher HOME-21 scores were correlated with obtaining a high school diploma or equivalency diploma (in GSMS only), having 4 or more years of college, and household income. HOME-21 was also correlated with having a more favorable family context indexed by fewer stressful life events (in FT only), less household food insecurity, lower household chaos, and more perceived social support. Higher HOME-21 scores were correlated with better parenting in the form of parental acceptance, positive parenting, warm involvement, appropriate and consistent discipline, verbal discussion, less physical aggression, and greater parental self-efficacy. Higher HOME-21 scores were correlated with better child adjustment in terms of fewer emotional and conduct problems, less hyperactivity, and more prosocial behavior. The HOME-21 has utility for use in future studies of children’s home environments in the 21st century. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

PMID:36174166 | DOI:10.1037/pas0001183

Exp Clin Psychopharmacol. 2022 Sep 29. doi: 10.1037/pha0000603. Online ahead of print.

ABSTRACT

Alcohol and tobacco use are interrelated. This study examined response to very low nicotine content (VLNC) and moderate nicotine content (MNC) cigarettes by problematic drinking. We utilized a double-blind, randomized, within-subjects crossover design of VLNC and MNC cigarettes in two groups of adult cigarette smokers: with at-risk drinking (ARD; n = 23) and without ARD (n = 24). Participants smoked only their assigned experimental cigarette in their home environment for 7 days, and completed laboratory visits, including ad libitum smoking of the assigned experimental cigarette, at the beginning and end of each experimental week. Participants smoked their usual cigarettes for 7 days between conditions. Participants provided daily reports of alcohol and cigarette consumption. Current Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) alcohol use disorder (AUD) was assessed at baseline and the end of each experimental week. Compliance with smoking of experimental cigarettes was good. Adjusting for baseline drinking, there was no significant effect of experimental cigarette or ARD group on drinks per day or alcohol urges. There was no effect of experimental cigarette or ARD group on cigarettes per day, or on any puff topography outcome or postsmoking exhaled carbon monoxide during laboratory smoking. No participant had a change in AUD status or AUD severity. After 7 days of exposure to VLNC cigarettes, adult cigarette smokers with ARD did not show compensatory drinking or compensatory smoking behavior. A future policy change in the United States to reduce nicotine content in cigarettes may not produce unintended compensatory drinking or smoking among this vulnerable and prevalent population of smokers. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

PMID:36174143 | DOI:10.1037/pha0000603

Rehabil Psychol. 2022 Sep 29. doi: 10.1037/rep0000471. Online ahead of print.

ABSTRACT

PURPOSE/OBJECTIVE: We sought to explore perspectives of the paralysis community about COVID-19 vaccine boosters.

RESEARCH METHOD/DESIGN: Data were collected through an online survey with multiple choice and open-ended questions from adult persons with paralysis (PWP), persons with other disabilities, and other members of the paralysis community (Christopher & Dana Reeve Foundation Supporters, FS). PWP and persons with other disabilities were grouped into one group (persons with disabilities, PWD) for most analyses. Multiple choice questions were analyzed using descriptive statistics and chi-square analyses were conducted to compare the PWD and FS groups; open-ended responses were coded using Hamilton’s rapid assessment process.

RESULTS: A total of 774 participants (740 PWD and 304 FS) responded to the survey. PWD were less likely to agree that they felt well-informed about boosters, that the boosters were safe, and that their state and federal governments provide transparent information about boosters. Of those who had not received a booster, PWP were less likely than the rest of the sample to plan to receive one. Both groups expressed similar concerns about the boosters, but distrust was a more common concern for PWD than for FS. Both groups expressed concerns about side effects and the boosters affecting a health condition, but PWP expressed concerns unique to paralysis and neurological difficulties.

CONCLUSIONS: Although PWD shared concerns with the FS group, distrust is a larger issue and concerns unique to PWD that must be considered in public health efforts to ensure that the paralysis community is treated equitably. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

PMID:36174136 | DOI:10.1037/rep0000471

PLoS Negl Trop Dis. 2022 Sep 29;16(9):e0010278. doi: 10.1371/journal.pntd.0010278. Online ahead of print.

ABSTRACT

BACKGROUND: Scrub typhus has become a serious public health concern in the Asia-Pacific region including China. There were new natural foci continuously recognized and dramatically increased reported cases in mainland China. However, the epidemiological characteristics and spatiotemporal patterns of scrub typhus in Fujian province have yet to be investigated.

OBJECTIVE: This study proposes to explore demographic characteristics and spatiotemporal dynamics of scrub typhus cases in Fujian province, and to detect high-risk regions between January 2012 and December 2020 at county/district scale and thereby help in devising public health strategies to improve scrub typhus prevention and control measures.

METHOD: Monthly cases of scrub typhus reported at the county level in Fujian province during 2012-2020 were collected from the National Notifiable Disease Surveillance System. Time-series analyses, spatial autocorrelation analyses and space-time scan statistics were applied to identify and visualize the spatiotemporal patterns of scrub typhus cases in Fujian province. The demographic differences of scrub typhus cases from high-risk and low-risk counties in Fujian province were also compared.

RESULTS: A total of 11,859 scrub typhus cases reported in 87 counties from Fujian province were analyzed and the incidence showed an increasing trend from 2012 (2.31 per 100,000) to 2020 (3.20 per 100,000) with a peak in 2018 (4.59 per 100,000). There existed two seasonal peaks in June-July and September-October every year in Fujian province. A significant positive spatial autocorrelation of scrub typhus incidence in Fujian province was observed with Moran’s I values ranging from 0.258 to 0.471 (P<0.001). Several distinct spatiotemporal clusters mainly concentrated in north and southern parts of Fujian province. Compared to low-risk regions, a greater proportion of cases were female, farmer, and older residents in high-risk counties.

CONCLUSIONS: These results demonstrate a clear spatiotemporal heterogeneity of scrub typhus cases in Fujian province, and provide the evidence in directing future researches on risk factors and effectively assist local health authorities in the refinement of public health interventions against scrub typhus transmission in the high risk regions.

PMID:36174105 | DOI:10.1371/journal.pntd.0010278

PLoS One. 2022 Sep 29;17(9):e0275531. doi: 10.1371/journal.pone.0275531. eCollection 2022.

ABSTRACT

We propose a deep learning-assisted overscan decision algorithm in chest low-dose computed tomography (LDCT) applicable to the lung cancer screening. The algorithm reflects the radiologists’ subjective evaluation criteria according to the Korea institute for accreditation of medical imaging (KIAMI) guidelines, where it judges whether a scan range is beyond landmarks’ criterion. The algorithm consists of three stages: deep learning-based landmark segmentation, rule-based logical operations, and overscan determination. A total of 210 cases from a single institution (internal data) and 50 cases from 47 institutions (external data) were utilized for performance evaluation. Area under the receiver operating characteristic (AUROC), accuracy, sensitivity, specificity, and Cohen’s kappa were used as evaluation metrics. Fisher’s exact test was performed to present statistical significance for the overscan detectability, and univariate logistic regression analyses were performed for validation. Furthermore, an excessive effective dose was estimated by employing the amount of overscan and the absorbed dose to effective dose conversion factor. The algorithm presented AUROC values of 0.976 (95% confidence interval [CI]: 0.925-0.987) and 0.997 (95% CI: 0.800-0.999) for internal and external dataset, respectively. All metrics showed average performance scores greater than 90% in each evaluation dataset. The AI-assisted overscan decision and the radiologist’s manual evaluation showed a statistically significance showing a p-value less than 0.001 in Fisher’s exact test. In the logistic regression analysis, demographics (age and sex), data source, CT vendor, and slice thickness showed no statistical significance on the algorithm (each p-value > 0.05). Furthermore, the estimated excessive effective doses were 0.02 ± 0.01 mSv and 0.03 ± 0.05 mSv for each dataset, not a concern within slight deviations from an acceptable scan range. We hope that our proposed overscan decision algorithm enables the retrospective scan range monitoring in LDCT for lung cancer screening program, and follows an as low as reasonably achievable (ALARA) principle.

PMID:36174098 | DOI:10.1371/journal.pone.0275531

PLoS One. 2022 Sep 29;17(9):e0275530. doi: 10.1371/journal.pone.0275530. eCollection 2022.

ABSTRACT

STUDY OBJECTIVES: To investigate inter-scorer agreement and scoring time differences associated with visual and computer-assisted analysis of polysomnographic (PSG) recordings.

METHODS: A group of 12 expert scorers reviewed 5 PSGs that were independently selected in the context of each of the following tasks: (i) sleep staging, (ii) scoring of leg movements, (iii) detection of respiratory (apneic-related) events, and (iv) of electroencephalographic (EEG) arousals. All scorers independently reviewed the same recordings, hence resulting in 20 scoring exercises per scorer from an equal amount of different subjects. The procedure was repeated, separately, using the classical visual manual approach and a computer-assisted (semi-automatic) procedure. Resulting inter-scorer agreement and scoring times were examined and compared among the two methods.

RESULTS: Computer-assisted sleep scoring showed a consistent and statistically relevant effect toward less time required for the completion of each of the PSG scoring tasks. Gain factors ranged from 1.26 (EEG arousals) to 2.41 (leg movements). Inter-scorer kappa agreement was also consistently increased with the use of supervised semi-automatic scoring. Specifically, agreement increased from Κ = 0.76 to K = 0.80 (sleep stages), Κ = 0.72 to K = 0.91 (leg movements), Κ = 0.55 to K = 0.66 (respiratory events), and Κ = 0.58 to Κ = 0.65 (EEG arousals). Inter-scorer agreement on the examined set of diagnostic indices did also show a trend toward higher Interclass Correlation Coefficient scores when using the semi-automatic scoring approach.

CONCLUSIONS: Computer-assisted analysis can improve inter-scorer agreement and scoring times associated with the review of PSG studies resulting in higher efficiency and overall quality in the diagnosis sleep disorders.

PMID:36174095 | DOI:10.1371/journal.pone.0275530

J Perinat Med. 2022 Oct 3. doi: 10.1515/jpm-2022-0118. Online ahead of print.

ABSTRACT

OBJECTIVES: We conducted a systematic review and meta-analysis to quantitatively summarize the present data on the association of prenatally identified lateral placenta in singleton pregnancies with small for gestational age (SGA) neonates, preeclampsia and other perinatal outcomes.

METHODS: From inception to November 2021, we searched PubMed/Medline, Scopus and The Cochrane Library for papers comparing the risk of SGA and preeclampsia, as well as other perinatal outcomes in singleton pregnancies with a prenatally identified lateral placenta to those with non-lateral placentas. The revised Newcastle-Ottawa Scale was used to evaluate the quality of eligible papers. The I² test was employed to evaluate the heterogeneity of outcomes among the studies. To investigate the possibility of publication bias, funnel plots were constructed. Prospero RN: CRD42021251590.

RESULTS: The search yielded 5,420 articles, of which 16 were chosen, comprising of 15 cohort studies and one case control study with a total of 4,947 cases of lateral and 96,035 of non-lateral placenta (controls) reported. SGA neonates were more likely to be delivered in cases with a lateral placenta (OR: 1.74; 95% CI: 1.54-1.96; p<0.00001; I²=47%). Likewise, placental laterality was linked to a higher risk of fetal growth restriction (OR: 2.18; 95% CI: 1.54-3.06; p<0.00001; I2=0%), hypertensive disorders of pregnancy (OR: 2.39; 95% CI: 1.65-3.51; p=0.0001; I²=80%), preeclampsia (OR: 2.92; 95% CI: 1.92-4.44; p<0.0001; I²=82%) and preterm delivery (OR: 1.65; 95% CI: 1.46-1.87; p<0.00001; I²=0%).

CONCLUSIONS: The prenatal diagnosis of a lateral placenta appears to be associated with a higher incidence of preeclampsia, fetal growth restriction, preterm delivery and SGA. This may prove useful in screening for these conditions at the second trimester anomaly scan.

PMID:36174088 | DOI:10.1515/jpm-2022-0118