Tag: statistics

Acta Neurol Scand. 2022 Jan 28. doi: 10.1111/ane.13584. Online ahead of print.

ABSTRACT

OBJECTIVE: Uncertainty exists for the absolute risk of ischemic and hemorrhagic stroke in users of oral contraceptives (OCs). Estimates greatly vary between countries. In Denmark, absolute risk of ischemic stroke (IS) is estimated to be 21 per 100,000 person-years. Risk of cerebral hemorrhage (CH) is unknown. Using the Danish Stroke Registry, we investigated absolute risk of IS and CH in users of OC.

MATERIAL AND METHODS: For the Danish female population aged 15-49 years during 2003-2011, we obtained information on hospital admission for IS and CH and current use of OC from Danish nationwide registries. We defined current use of OC as redeeming at least two OC prescriptions within the previous year.

RESULTS: The Danish female population years 2003-2011 consisted mean of 1,246,142 women per year. Of these, 29.6% were OC users. In the study period, OC users had 291 IS and 14 CH. Absolute risk of IS in OC users was 8.8 per 100,000 person-years and of CH it was 0.4 per 100,000 person-years.

CONCLUSIONS: In OC users, absolute risk of IS was 8.8 per 100,000 person-years. This is more than half that of the risk previously assumed in Denmark. Risk of CH in OC users was very low and 0.4 per 100,000 person-years.

PMID:35089604 | DOI:10.1111/ane.13584

Hum Psychopharmacol. 2022 Jan 28:e2833. doi: 10.1002/hup.2833. Online ahead of print.

ABSTRACT

OBJECTIVE: We examined the association of serotonin receptor transporter gene polymorphism in patients with MDD with the clinical efficacy of mirtazapine (MZ) and sertraline (ST).

METHOD: Newly diagnosed, treatment naïve, 80 MDD patients (aged 18-45) diagnosed using DSM-5 criteria and with Beck’s depression inventory score (BDI) score ≥21 were included and randomly divided into two groups of 40 participants and were administered MZ 15-45 mg/day or ST 25-200 mg/day respectively. Patients were followed up for 6 weeks for evaluation of BDI scores. Genotypic evaluation was done and three allele variants were identified based on the polymerase chain reaction fragment sizes: short (S; 486 bp), long (L; 529 bp), or extralong (XL; 612 or 654 bp) and classified into five genotypes: S/S,S/L, L/L, S/XL, and L/XL.

RESULT: We found that 32.5% patients belonged to the S/S genotype, suggesting that individuals with the SS genotype are at higher risk of developing MDD. No statistically significant association was seen with ST or MZ groups on the basis of genotypes. Clinically significant improvement was observed with a more than 50% reduction in BDI scores at 6 weeks of treatment with both drugs.

CONCLUSION: Identification of risk population can be carried out by genotype testing. Prior genotyping in MDD patients might help to predict a better clinical outcome with antidepressants.

PMID:35089613 | DOI:10.1002/hup.2833

J Racial Ethn Health Disparities. 2022 Jan 28. doi: 10.1007/s40615-022-01251-4. Online ahead of print.

ABSTRACT

BACKGROUND: Depression is an extremely common and widespread problem among university students. A better understanding of the magnitude and determinants of depressive symptoms is required to create appropriate interventions for those groups. This study aimed to assess the prevalence and predictors of depressive symptoms among Mizan-Tepi University students during the pandemic lockdown.

METHODS: From September 11th to September 25th, 2020, 779 Mizan-Tepi University students participated in this web-based cross-sectional study. The link was created with a Google Form, and the questionnaire was distributed to participants via e-mail, WhatsApp, Telegram, and other social media accounts. To determine the prevalence and determinants of depressive symptoms, both descriptive and inferential analyses were used. The chi-squared test of association and logistic regression were used to identify predictors of depressive symptoms among university students. We used (IBM) SPSS version 20 for all statistical analyses.

RESULTS: The prevalence of depressive symptoms among university students was 39.5%. According to results of multivariable binary logistic regression, being female (AOR = 0.339, 95%CI: 0.220-0.522), being an alcoholic (AOR = 2.101, 95%CI: 1.452-3.041), smoking (AOR = 2.088, 95%CI: 1.460-2.986), being quarantined for 14 days (AOR = 1.775, 95%CI: 1.231-2.560), frequently using social media (AOR = 1.510, 95%CI: 1.063-2.145), fearing COVID-19 (AOR = 5.058, 95%CI: 3.508-7.292), having sleeping problems (AOR = 1.703, 95%CI: 1.051-2.760), having a family member infected with COVID-19 (AOR = 1.829, 95%CI: 1.211-2.763), being exposed to COVID-19 (AOR = 1.748, 95%CI: 1.114-2.743), monthly disposable income ≥ 501 ETB (AOR = 0.531, 95%CI: 0.359-0.784), having a higher level of hope (AOR = 0.158, 95%CI:0.056-0.447), and having high social support (AOR = 0.546, 95%CI: 0.374-0.797) were significantly associated with depressive symptoms among students.

CONCLUSION: In this study, the prevalence of depressive symptoms was found to be high among university students. Being an alcoholic, smoking, quarantined for 14 days, frequently using social media, fearing COVID-19, having sleep problems, having a family member infected with COVID-19, and being exposed to COVID-19 were all associated with an increased risk of developing depressive symptoms, while being a female, having a high level of disposable monthly income, hope, and social support decreased the risk of depressive symptoms among university students. Interventions should be put in place to promote mental health among university students.

PMID:35089580 | DOI:10.1007/s40615-022-01251-4

Environ Sci Pollut Res Int. 2022 Jan 28. doi: 10.1007/s11356-021-18296-3. Online ahead of print.

ABSTRACT

Among alternative tillage practices, conservation tillage (CT) is a prominent greenhouse gas (GHG) mitigation strategy advocated in wheat cultivation, largely because of its low energy consumption and minimum soil disturbance during cultural operations. This paper examines the agricultural production and GHG emission trade-off of CT vis-à-vis traditional tillage (TT) on wheat farms of Bangladesh. Using a directional distance function approach, the maximum reduction in GHG emissions was searched for within all available tillage technology options, while increasing wheat production as much as possible. The underlying institutional, technical, and other socio-economic factors determining the efficient use of CT were analyzed using a fractional regression model. The average meta-efficiency score for permanent bed planting (PBP) and strip tillage (ST) was 0.89, while that achieved using power tiller operated seeders (PTOS) is 0.87. This indicates that with the given input sets, there is potential to reduce GHG emissions by about 11% for ST and PTOS; that potential is 13% for farmers using PTOS. The largest share of TT farmers cultivate wheat at lower meta-efficiency levels (0.65-0.70) compared to that observed with farmers practicing CT (0.75-0.80). Fractional regression model estimates indicate that an optimal, timely dose of fertilizers with a balanced dose of nutrients is required to reduce GHG emissions. To develop climate smart sustainable intensification strategies in wheat cultivation, it is important to educate farmers on efficient input management and CT together. Agricultural development programs should focus on addressing heterogeneities in nutrient management in addition to tillage options within CT.

PMID:35089510 | DOI:10.1007/s11356-021-18296-3

Environ Sci Pollut Res Int. 2022 Jan 28. doi: 10.1007/s11356-022-18816-9. Online ahead of print.

ABSTRACT

Reproduction plays an important role in fish population efficiency and its resiliency to fishing and environment changes. The present study described the comprehensive information on reproductive feature of stinging catfish, Heteropneustes fossilis (Bloch 1794), including size at sexual maturity, spawning season, and fecundity using 622 female individuals sampling by the use of gill net, cast net, and square lift net from January to December 2019 in the Ganges River. We calculated the influences of various environmental parameters which include temperature, dissolved oxygen, pH, and rainfall on the reproductive feature of H. fossilis in the Ganges River. For every specimen, total length (TL), standard length (SL), and body weight (BW) were estimated by measuring board and electronic weighing scale. With ventral dissection of fishes, female gonads were cautiously removed and measured to 0.01 g precision. The gonadosomatic index (GSI), modified gonadosomatic index (MGSI), and Dobriyal index (DI) were used to assess the size at sexual maturity (L_m) and spawning season. According to the results of these indices, L_m was obtained 15.5 cm in TL. Also, TL₅₀ was determined through logistic function as 15.5 cm in TL. Moreover, the highest GSI, MGSI, and DI values indicated the spawning season as of March-August, with peak in May-June. Total fecundity (F_T) varied from 2059 to 59,984 with a mean of 25,028 ± 15,048. Temperature and rainfall was statistically correlated with GSI. In addition, long climatic data series analysis denoted that yearly mean atmospheric temperature is rising in 0.028 °C/year and yearly mean rainfall is declining in 2.98 mm/year which may suggest a potential shift of the spawning period of the species in the future if this trend persists. The results of our study might be more useful in imposing particular management and conservation for H. fossilis in the Ganges River and the surroundings.

PMID:35089516 | DOI:10.1007/s11356-022-18816-9

J Neurooncol. 2022 Jan 28. doi: 10.1007/s11060-022-03948-2. Online ahead of print.

ABSTRACT

PURPOSE: Postoperative epilepsy is common in glioma patients and has been suggested to indicate disease progression, yet knowledge of its role as a prognostic factor is limited. This study investigates the association between postoperative epilepsy and survival amongst patients with gliomas.

METHODS: We included 3763 patients with histopathologically diagnosed grade II, III, and IV gliomas from 2009 to 2018 according to the Danish Neuro-Oncology Registry. Information on epilepsy diagnosis was redeemed from the Danish National Patient Registry, the National Prescription Registry and the Danish Neuro-Oncology Registry. We used Cox proportional hazards models with 95% confidence intervals (CIs) to examine hazard ratios (HRs) for the association between postoperative epilepsy and risk of death. We examined the role of the timing of epilepsy in three different samples: Firstly, in all glioma patients with postoperative epilepsy; secondly, in patients with postoperative de novo epilepsy; thirdly, exclusively in a homogeneous sub-group of grade IV patients with postoperative de novo epilepsy.

RESULTS: Glioma patients with postoperative epilepsy had an increased risk of death, regardless of prior epilepsy status (HR = 4.03; CI 2.69-6.03). A similar increase in the risk of death was also seen in patients with postoperative de novo epilepsy (HR = 2.08; CI 1.26-3.44) and in the sub-group of grade IV patients with postoperative de novo epilepsy (HR = 1.83; CI 1.05-3.21).

CONCLUSIONS: Postoperative epilepsy may negatively impact survival after glioma diagnosis, regardless of preoperative epilepsy status. Postoperative epilepsy may be an expression of a more invasive growth pattern of the gliomas following primary tumor treatment.

PMID:35089480 | DOI:10.1007/s11060-022-03948-2

Psychometrika. 2022 Jan 28. doi: 10.1007/s11336-021-09828-4. Online ahead of print.

ABSTRACT

Estimation of the large Q-matrix in cognitive diagnosis models (CDMs) with many items and latent attributes from observational data has been a huge challenge due to its high computational cost. Borrowing ideas from deep learning literature, we propose to learn the large Q-matrix by restricted Boltzmann machines (RBMs) to overcome the computational difficulties. In this paper, key relationships between RBMs and CDMs are identified. Consistent and robust learning of the Q-matrix in various CDMs is shown to be valid under certain conditions. Our simulation studies under different CDM settings show that RBMs not only outperform the existing methods in terms of learning speed, but also maintain good recovery accuracy of the Q-matrix. In the end, we illustrate the applicability and effectiveness of our method through a TIMSS mathematics data set.

PMID:35089496 | DOI:10.1007/s11336-021-09828-4

Clin Rheumatol. 2022 Jan 28. doi: 10.1007/s10067-021-06038-2. Online ahead of print.

ABSTRACT

OBJECTIVE: To investigate the value of ⁶⁸ Ga-PSMA-11 positron emission tomography/computerized tomography (PET/CT) in evaluating lacrimal and salivary glands function.

METHODS: Ten patients with pSS and 18 healthy volunteers were recruited in this study. All participants underwent ⁶⁸ Ga-PSMA-11 PET/CT, and the patients with pSS performed salivary gland scintigraphy the next day. The maximum standardized uptake value (SUVmax), average of the standard uptake value (SUVavg), the average CT value (CTavg), and volume (V) in the region of interest (ROI) of each lacrimal and salivary gland were analyzed in⁶⁸Ga-PSMA-11 PET/CT. The uptake ratio (UR) of the bilateral parotid gland and submandibular gland was calculated in salivary gland scintigraphy (SGS). Statistical analysis was processed by the SPSS software and the MedCalc software. A p-value of < 0.05 was considered as statistically significant.

RESULTS: Almost all the parameters of pSS were significantly lower than those of the control group (p < 0.05). The left parotid gland (PG) UR was positive correlation with left PG SUVmax (r = 0.758, p = 0.011) and left PG SUVavg (r = 0.770, p = 0.009); the right PGUR was positive correlation with right PG SUVmax (r = 0.721, p = 0.019) and right PG SUVavg (r = 0.721, p = 0.019). The SUVmax and SUVavg of both sides of acrimal and salivary glands had area under the receiver operating curve values greater than 0.5.

CONCLUSIONS: ⁶⁸ Ga-PSMA-11 PET/CT can simultaneously enable the visualization of lacrimal glands and salivary glands and be used to evaluate the lacrimal and salivary glands function. Key Points • We have firstly investigated the value of 68 Ga-PSMA-11 PET/CT in evaluating lacrimal and salivary glands function in patients with pSS 68 Ga-PSMA-11 PET/CT can simultaneously allow the visualization of lacrimal glands and salivary glands. • The results of the present study imply that 68 Ga-PSMA-11 PET/CT can be used to evaluate the lacrimal and salivary glands function in patients with pSS meanwhile.

PMID:35089469 | DOI:10.1007/s10067-021-06038-2

Arch Sex Behav. 2022 Jan 28. doi: 10.1007/s10508-021-02214-2. Online ahead of print.

ABSTRACT

In order to align with their inner sense of gender identity, adolescents suffering from gender dysphoria are increasingly being treated with cross-sex hormones and irreversible surgeries to alter their bodies. The present study is the first to examine attitudes about these recently emergent medical practices in a national population. We used data from the 2018 Post-Midterm Election Study, a survey representative of adults in the USA ages 20 to 65 years (N = 5285), to examine the social factors associated with approval or disapproval of hormonal and/or surgical interventions for adolescents seeking medical treatment for gender dysphoria. Higher fertility, race/ethnicity (in this case, black), sex (male), and heterosexual self-identity were each robustly associated with disapproval. Nested regression models revealed that a range of religion measures were statistically significant (toward disapproval). However, all but evangelical self-identification were no longer significant after accounting for support for abortion rights, the spectrum of political self-identification, and voting behavior. These findings, prompted by a high percentage of variance explained, led us to consider perspectives on medical transitions for adolescents as fitting the “culture war” framework, largely polarized between a “progressive” worldview of bodily autonomy and an “orthodox” worldview of bodily integrity.

PMID:35089461 | DOI:10.1007/s10508-021-02214-2

Neurol Sci. 2022 Jan 28. doi: 10.1007/s10072-022-05913-3. Online ahead of print.

ABSTRACT

INTRODUCTION: Stroke is one of the top 10 causes of death worldwide, and more than half of stroke patients face distal upper extremity dysfunction. Considering that robot-assisted training may be effective in improving distal upper extremity function, the review evaluated the effect of robot-assisted distal training on motor function, hand dexterity, and spasticity after stroke.

METHODS: Eleven databases were systematically searched for randomised controlled trials (RCTs) from inception until Aug 28, 2021. Meta-analysis and meta-regression were performed to investigate the overall effect and source of heterogeneity, respectively.

RESULTS: Twenty-two trials involving 758 participants were included in this systematic review. The overall effect of robot-assisted distal training on the motor function of the wrists and hands was significant improvement (MD = 3.92; 95% CI, 3.04-4.80; P < 0.001). The robot-assisted training had a significantly beneficial effect on other motor functions (MD = 2.84; 95% CI, 1.54-4.14; P < 0.001); dexterity (MD = 9.01; 95% CI, -12.07–5.95; P < 0.001), spasticity, upper extremity strength (SMD = 0.42; 95% CI, 0.07-0.78; P = 0.02) and activities of daily living (SMD = 0.70; 95% CI, 0.29-1.23; P < 0.001). A series of subgroup analyses showed preferable design and effective regime of training. Meta-regression indicated the statistically significant effect of the year of trial, country, and duration on the effectiveness of training.

CONCLUSION: Robot-assisted distal training has a significant effect on motor function, dexterity and spasticity of the upper extremity, compared to conventional therapy.

PMID:35089447 | DOI:10.1007/s10072-022-05913-3