Tag: statistics

Soc Sci Med. 2021 Jul 2;284:114196. doi: 10.1016/j.socscimed.2021.114196. Online ahead of print.

ABSTRACT

This paper examines the interrelationship between suicide, health, socioeconomic, and psychosocial factors in contributing to suicide in older adults in rural Australia. Drawing on a coronial dataset of suicide cases and a mixed methods sociological autopsy approach, our study integrated a quantitative analysis of 792 suicide cases with a qualitative analysis of medico-legal reports from 30 cases. The sociological autopsy provided novel insights into the entanglement of policy and service provision at the state-level with individual end-of-life decisions. Particular attention is drawn to age and gendered dimensions of suicide, especially in relation to health and social issues. The study showed a continuity between suicide and the patterning of an individual’s life course, including experiences and consequences of inequality and marginality; a desire to meet culturally-normative ideals of autonomy; and a fragmented, under-funded, and intimidating social care system that offered limited options.

PMID:34271402 | DOI:10.1016/j.socscimed.2021.114196

Sci Total Environ. 2021 Jul 10;796:148950. doi: 10.1016/j.scitotenv.2021.148950. Online ahead of print.

ABSTRACT

Boundary layer height (BLH) plays an important role in regulating global weather/climate, as well as the dispersion and transportation of pollutants. Until now, however, the attribution and contributions of different controlling factors to BLH long-term variability and trends have not been quantified on a global scale. The long-term radiosonde dataset was used in this study to retrieve global BLH climatology; seasonal, diurnal, long-term variation and trends were analyzed over a 39-year period (1980-2018). Statistical results show that the global distribution of the BLH and its trend have apparent day-night differences. BLH during daytime is deeper during clear-sky conditions compared to cloudy sky conditions, indicating a significant effect of clouds; BLH during nighttime is deeper under cloudy conditions. BLH was also found to vary over different land types; dry and hot soil exhibits a deeper BLH than those of wet and cool soil. The long-term variation and trend of BLH are highly influenced by near-surface meteorological parameters. In particular, based on multiple linear stepwise regression models and the contribution calculation method, this investigation initiatively quantifies the influences of meteorological parameters on global BLH long-term variation and trend. Our results emphasized that a 10 m wind speed (WS) and low tropospheric stability (LTS) have significant contributions to long-term BLH variation; WS and LTS anomalies alternately dominated the contribution of the diurnal cycle of the BLH anomaly. Annual BLH recorded an average increasing trend (38.9-42.1 m/decade), and LTS is more dominant than WS from a contribution perspective, especially for increased BLH anomaly. Contributions from near-surface temperature (T) and relative humidity (RH) also play important roles. However, a decreasing WS trend dominated the decreased trends of BLH anomaly, accounting for nearly 40% of the total contribution.

PMID:34271389 | DOI:10.1016/j.scitotenv.2021.148950

Vet Parasitol. 2021 Jul 3;298:109516. doi: 10.1016/j.vetpar.2021.109516. Online ahead of print.

ABSTRACT

On the Northern Tablelands of New South Wales, Australia, endemic Theileria orientalis infection of cattle has been reported on farms where no ticks have been observed, raising the question of how Theileria is transmitted in these areas. To investigate the potential role of mechanical transmission by insects, the present study investigated the seasonal dynamics of biting fly species trapped between December 2017 and May 2019 on six cattle farms in the region where the presence of Theileria was confirmed. These flies, sucking lice collected from these farms and pools of Culicoides species affecting cattle also trapped in the region were subjected to qPCR detection of T. orientalis. Eleven species from eight genera of biting flies were collected using unbaited Nzi traps. Tabanid species were present in all farms, with Dasybasis oculata (43.6 %) and D. circumdata (27.6 %) being the most abundant and widespread species. The effect of season on the mean count per trapping event was statistically significant and highest in the summer months for Lilaea fuliginosa and D. oculata, and the autumn months for D. circumdata, with no seasonal effect on the abundance of the undescribed Dasybasis spp. No biting flies were trapped during the winter months. Sucking (Linognathus vituli and Haematopinus eurysternus) and biting (Bovicola bovis) cattle lice were also collected from all farms with the latter detected in only one farm. PCR screening for T. orientalis of trapped hematophagous insects resulted in parasite detection in the tabanid and Stomoxyini flies, biting midges and sucking lice with the highest proportion of positive samples for Haematopinus eurysternus (4/4 pools) and H. irritans exigua (6/15 individuals). The detection of the parasite in these potential vectors indicates a possible role in the mechanical transmission of T. orientalis and may partly explain the ubiquitous presence of Theileria in areas where ticks are absent.

PMID:34271315 | DOI:10.1016/j.vetpar.2021.109516

Eur J Obstet Gynecol Reprod Biol. 2021 Jun 24;264:25-30. doi: 10.1016/j.ejogrb.2021.06.025. Online ahead of print.

ABSTRACT

OBJECTIVES: The aim of this study was to measure the impact of innovative pelvic floor muscle training (iPFMT) on Quality-Adjusted Life Years (QALYs) in women with stress urinary incontinence (SUI) treated by duloxetine.

STUDY DESIGN: This analysis is part of the DULOXING study conducted between February 2019 and 2020. The control group received oral duloxetine treatment (40 mg BID), and the experimental group received oral duloxetine treatment (40 mg BID) and iPFMT with lumbopelvic stabilization. SUI was analysed at baseline and in the final period according to the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF). The QALYs gained were calculated by multiplying life expectancy (LE) by a weighting factor (QALYs = LE * WF).

RESULTS: The study included 158 women, of whom 129 were fully analysed (81.6%). The mean life expectancy was 26.3 ± 11.8 years for the control group and 29.0 ± 11.7 years for the experimental group. The mean baseline ICIQ-UI SF scores were 15.2 ± 1.7 vs 15.1 ± 1.5, and the final ICIQ-UI SF scores were 9.8 ± 4.2 vs 8.3 ± 3.8, in the control vs the experimental group, respectively (p < 0.05). The mean baseline WF was 0.27 ± 0.08 vs 0.28 ± 0.07, and the final WF was 0.53 ± 0.20 vs 0.60 ± 0.18, in the control vs the experimental group, respectively (p < 0.05). Before treatment, the number of QALYs during life expectancy in the control vs the experimental group was 7.53 ± 4.24 vs 8.30 ± 4.01. The number of QALYs during life expectancy in control vs the experimental group increased following treatment: 15.03 ± 7.63 vs 17.90 ± 7.86 (p < 0.05).

CONCLUSIONS: Combination treatment with duloxetine and iPFMT statistically significantly increased the number of QALYs and reduced the degree of urinary incontinence in women with stress urinary incontinence.

PMID:34271362 | DOI:10.1016/j.ejogrb.2021.06.025

Psychiatry Res. 2021 Jul 9;303:114107. doi: 10.1016/j.psychres.2021.114107. Online ahead of print.

ABSTRACT

Disadvantaged populations have an increased risk of suicide and suicide attempts because of the Covid-19 pandemic. To date, few studies focused on people living in detention, who have a high burden of mental health problems and are exposed to severe control measures. Our study investigated whether there was an increase in suicide attempts in prison. Data were collected in the largest Swiss pre-trial prison (Champ-Dollon) for the pre-pandemic and the pandemic periods. We identified a statistically significant 57%-increase of suicide attempts. Mitigation measures, access to mental health care, and access to vaccination are needed to protect this vulnerable population.

PMID:34271371 | DOI:10.1016/j.psychres.2021.114107

ESMO Open. 2021 Jul 13;6(4):100217. doi: 10.1016/j.esmoop.2021.100217. Online ahead of print.

ABSTRACT

BACKGROUND: Patients with advanced gastrointestinal stromal tumours (GISTs) resistant to the tyrosine kinase inhibitors imatinib and sunitinib may be treated with regorafenib, which resulted in a median progression-free survival (PFS) of 4.8 months in the GRID trial. Also, pazopanib, another tyrosine kinase inhibitor, has been studied in a randomized, placebo-controlled trial (PAZOGIST) in the third line, which showed a PFS of 45.2% 4 months after study entry, but patients intolerant to sunitinib were also included. We designed another trial evaluating pazopanib, enrolling only patients with progression on both imatinib and sunitinib.

PATIENTS AND METHODS: Since all eligible patients had progressive disease, we preferred a non-randomized, phase II multicentre trial so that all patients could receive a potentially active drug. Patients had a progressive metastatic or locally advanced GIST and were ≥18 years of age, with a performance status of 0-2, and sufficient organ functions. The primary endpoint was disease control rate (defined as complete remission + partial remission + stable disease) at 12 weeks on pazopanib. A Simon’s two-stage analysis was used with an interim analysis 12 weeks after enrollment of the first 22 patients, and if passed, there was a full enrolment of 72 patients. GIST mutational analysis was done, and most patients had pazopanib plasma concentration measured after 12 weeks.

RESULTS: Seventy-two patients were enrolled. The disease control rate after 12 weeks was 44%, and the median PFS was 19.6 weeks (95% confidence interval 12.6-23.4 weeks). Pazopanib-related toxicity was moderate and manageable. No statistically significant differences were found related to mutations. Plasma concentrations of pazopanib had a formal but weak correlation with outcome.

CONCLUSION: Pazopanib given in the third line to patients with GIST progressing on both imatinib and sunitinib was beneficial for about half of the patients. The PAGIST trial confirms the results from the PAZOGIST trial, and the median PFS achieved seems comparable to the PFS achieved with regorafenib in the third-line setting.

PMID:34271307 | DOI:10.1016/j.esmoop.2021.100217

Stat Med. 2021 Aug 15;40(18):4161-4163. doi: 10.1002/sim.9074.

NO ABSTRACT

PMID:34270811 | DOI:10.1002/sim.9074

Stat Med. 2021 Aug 15;40(18):4164-4165. doi: 10.1002/sim.9073.

NO ABSTRACT

PMID:34270812 | DOI:10.1002/sim.9073

Biom J. 2021 Jul 16. doi: 10.1002/bimj.202100046. Online ahead of print.

ABSTRACT

We analyze data from a clinical trial investigating the effect of an on-demand drug for women with low sexual desire. These data consist of a varying number of measurements/events across patients of when the drug was taken, including data on a patient-reported outcome consisting of five items measuring an unobserved construct (latent variable). Traditionally, these data are aggregated prior to analysis by composing one sum score per event and averaging this sum score over all observed events. In this paper, we explain the drawbacks of this aggregating approach. One drawback is that these averages have different standard errors because the variance of the underlying events differs between patients and because the number of events per patient differs. Another drawback is the implicit assumption that all items have equal weight in relation to the latent variable being measured. We propose a multilevel structural equation model, treating the events (level 1) as nested observations within patients (level 2), as alternative analysis method to overcome these drawbacks. The model we apply includes a factor model measuring a latent variable at the level of the event and at the level of the patient. Then, in the same model, the latent variables are regressed on covariates to assess the drug effect. We discuss the inferences obtained about the efficacy of the on-demand drug using our proposed model. We further illustrate how to test for measurement invariance across grouping covariates and levels using the same model.

PMID:34270801 | DOI:10.1002/bimj.202100046

Biom J. 2021 Jul 16. doi: 10.1002/bimj.202100089. Online ahead of print.

ABSTRACT

Our paper differs from previous literature in two ways: 1.We think in terms of clinical consequences, what benefits patients, what harms patients. Our main message is: using a not logic-respecting efficacy measure can potentially harm patients in a randomized controlled trial (RCT), as we prove analytically, and demonstrate with the OAK blood-based tumor mutational burden (bTMB) study. 2.We follow nature, which mixes effects within each treatment arm. Our secondary message is that following nature to mix within each treatment arm first before calculating any efficacy measure between treatments resolves issues. For example, following natural mixing to prove ratio of time is logic-respecting avoids the issue that weights of efficacy measures are implicit solution to an equation that depends on the unknown prognostic effect. More importantly, coding subgroup mixable estimation (SEM) by mixing within each treatment arm first and then calculating efficacy will make marginal and conditional efficacy agree, for logic-respecting efficacy measures (be it a ratio or a difference), no matter the outcome is continuous, binary, or time-to-event. One does not have to choose between marginal and conditional.

PMID:34270810 | DOI:10.1002/bimj.202100089