Luminescence. 2021 May 13. doi: 10.1002/bio.4083. Online ahead of print.
ABSTRACT
A water-soluble and highly stable N,S-doped CQDs (N,S-CQDs) have been synthesized by a low-cost strategy using citric acid (CA) and thiosemicarbazide (TSC) in one-step as a fluorescent nanosensor. The achieved N, S-CQDs have strong emission at 446 nm upon excitation at 370 nm and a high quantum yield of 58.5%. The quenching effect on the prepared N,S-CQDs has been utilized for determination of Trimetazidine (TMZ) spectrofluorimetrically in a wide linear range of 0.04-0.5μM (0.0106-0.133 μg mL-1 ) and low limit of detection of 0.01μM (0.002 μg mL-1 ). Furtherer, CDs was used to determine TMZ in its pharmaceutical formulations as well as in human plasma as a simple and rapid fluorescent probe. The method was tested in compliance with the ICH guidelines. The results obtained were statistically compared to those given by a reported method showing no significant variations regards accuracy and precision.
PMID:33982840 | DOI:10.1002/bio.4083
