J Diabetes Investig. 2022 Apr 27. doi: 10.1111/jdi.13818. Online ahead of print.
ABSTRACT
AIM/INTRODUCTION: We investigated the associations between a combination of lifestyle factors and changes to these factors and the subsequent risk of severe hypoglycemia (SH) in type 2 diabetes (T2D).
MATERIALS AND METHODS: Subjects with adult T2D who underwent consecutive two-year interval health screening programs from 2009 to 2012 from the Korean National Health Insurance Service database were included and followed up until 2018. Information on history of smoking status, alcohol consumption, and physical activity as well as changes to these factors was obtained. The primary outcome was incident SH.
RESULTS: Of the 1,490,233 T2D subjects, 30,539 (2.1%) subjects developed SH. Current smokers and heavy drinkers had increased risk of SH, compared to nonsmokers and nondrinkers, respectively (hazard ratio (HR) 1.28 [1.23-1.34]; HR 1.22 [1.15-1.30]). However, regular physical activity was associated with reduced SH risk (HR 0.79 [0.77-0.82]). A combination of unhealthy lifestyle habits was associated with increased SH risk in a dose-dependent fashion (P for trend <0.001). Compared with subjects without changes in their unhealthy lifestyles, subjects who improved lifestyles had decreased risk of SH.
CONCLUSIONS: Greater adherence to healthy lifestyle factors and any improvement in unhealthy lifestyle habits were associated with a substantially lower risk of SH in individuals with T2D.
PMID:35474300 | DOI:10.1111/jdi.13818
