Int J Dent Hyg. 2022 Apr 29. doi: 10.1111/idh.12594. Online ahead of print.
ABSTRACT
BACKGROUND: Nicotine replacement therapy is the first choice pharmacotherapy for smoking cessation. Oral side effects caused due to NRT lead to discontinuation of treatment. The objective of this meta-analysis is to look for the certainty of evidence on the number of patients that reported oral side effects due to the use of NRT.
METHOD: Eligible studies were selected and data extraction was carried out independently into a pre-tested data extraction form. Risk of Bias was assessed using Cochrane Tool. The heterogeneity between the studies was assessed using Chi-square and I2 tests. Mean difference and Odds ratio at 95% confidence interval were the effect estimates. GRADE working group approach was used to assess the quality of evidence.
RESULTS: 28 studies were included with moderate to low risk of Bias. The pooled estimates revealed a statistically significant number of patients developed mouth or throat irritation (2.54[1.23,5.25]), or oral soreness (2.22[1.40,3.55]) or gastric reflux or vomiting (1.97[1.34,2.90]) due to NRT.
CONCLUSION: It is important to understand that significant implications are caused due to NRT, on oral health. All patients on NRT must adhere to their regular dentist visits and must check their oral mucosa before initiating NRT.
PMID:35485245 | DOI:10.1111/idh.12594
