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Diagnostic Value of Ophthalmic Artery Doppler Indices for Prediction of Preeclampsia at 28-32 Weeks of Gestation

Int J Gynaecol Obstet. 2022 Jun 13. doi: 10.1002/ijgo.14305. Online ahead of print.


OBJECTIVE: The aim of this study is to examine the diagnostic value of ophthalmic arteries Doppler indices in prediction of preeclampsia along with other markers in the third trimester of pregnancy.

METHODS: Normotensive subjects were included during 28-32 weeks’ gestation to undergo uterine and ophthalmic artery Doppler ultrasound. Maternal and fetal characteristics were documented at the visit between the 28-32 weeks of gestation, and the pregnancy associated plasma protein-A (PAPP-A) values in the first trimester were collected to be integrated in a multiparametric prediction model.

RESULTS: Out of 795 included participants, 48 cases progressed to preeclampsia. All assessed ophthalmic Doppler parameters including first and second peak systolic velocities (1st and 2nd PSV), second to first PSV Ratio (PR) and pulsatility index (PI)) were statistically different in those developing preeclampsia later on. Average PR (sensitivity: 100%, (95%CI): 0.81-1.00, specificity: 90%, 0.86-0.93) and PI between the eyes, PAPP-A MoM and uterine arteries PI were determined to be the most important predictors of PE which were subsequently integrated in a multiple regression model (sensitivity: 94%, 0.70-1.00, specificity: 93%, 0.89-0.96).

CONCLUSION: This study provided a screening method for individuals at higher risk of progressing towards preeclampsia in the third trimester of pregnancy.

PMID:35696254 | DOI:10.1002/ijgo.14305

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