Nevin Manimala Statistics

Forensic efficacy evaluation and genetic structure exploration of Yunnan Miao group by a multiplex InDel panel

Electrophoresis. 2022 Jun 16. doi: 10.1002/elps.202100387. Online ahead of print.


The aim of the study was to better understand the genetic characteristics of the Miao group in China. Herein, genetic characteristics and forensic application values of 57 autosomal insertion-deletion (InDel) loci were investigated in 210 unrelated healthy individuals from the Chinese Yunnan Miao (YM) group. Meanwhile, the genetic differences at these InDels were compared among the YM group and 26 reference populations. The results of forensic statistical analyses showed that all 57 autosomal InDels were in accordance with Hardy-Weinberg equilibrium and linkage equilibrium of pairwise loci in the Chinese YM group. Moreover, the combined probability of discrimination and probability of exclusion in the YM group were 0.9999999999999999999999801 and 0.999928, respectively, which indicated that the multiplex amplification including 57 autosomal InDels was suitable for forensic individual identification and paternity testing in the Chinese YM group. In addition, the results of allelic frequency distribution differential analyses, principal component analysis, phylogenetic tree reconstruction and genetic structure analysis between the Chinese YM group and 26 reference populations revealed that the genetic similarities between the YM group and East Asian populations were more than that between the YM group and other geographical populations. This 57 autosomal InDels system can also effectively distinguish East Asian, European and African populations. This article is protected by copyright. All rights reserved.

PMID:35707881 | DOI:10.1002/elps.202100387

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