Nevin Manimala Statistics

Accurate interval estimation for the risk difference in an incomplete correlated 2 × 2 table: Calf immunity analysis

PLoS One. 2022 Jul 22;17(7):e0272007. doi: 10.1371/journal.pone.0272007. eCollection 2022.


Interval estimation with accurate coverage for risk difference (RD) in a correlated 2 × 2 table with structural zero is a fundamental and important problem in biostatistics. The score test-based and Bayesian tail-based confidence intervals (CIs) have good coverage performance among the existing methods. However, as approximation approaches, they have coverage probabilities lower than the nominal confidence level for finite and moderate sample sizes. In this paper, we propose three new CIs for RD based on the fiducial, inferential model (IM) and modified IM (MIM) methods. The IM interval is proven to be valid. Moreover, simulation studies show that the CIs of fiducial and MIM methods can guarantee the preset coverage rate even for small sample sizes. More importantly, in terms of coverage probability and expected length, the MIM interval outperforms other intervals. Finally, a real example illustrates the application of the proposed methods.

PMID:35867721 | DOI:10.1371/journal.pone.0272007

By Nevin Manimala

Portfolio Website for Nevin Manimala