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Pro Inflammatory Versus Anti Inflammatory Cytokines in Psoriatic Patients (Case Control Study)

J Cosmet Dermatol. 2022 Jul 23. doi: 10.1111/jocd.15262. Online ahead of print.

ABSTRACT

Psoriasis (PsO) is a systemic autoimmune disease. Many pro-inflammatory and anti-inflammatory biomarkers have been associated with the pathogenetic process of psoriasis. IL-35 act as an anti-inflammatory cytokine through down regulation of TH-17 cell development and cytokine production. So, IL-35 might be utilized as potential future therapeutic agent for psoriasis.

AIMS: to investigate the association between Inflammatory (IL-17, TNF-α, IFN-γ) and anti-Inflammatory Cytokines (IL-35, TGF-β) in psoriasis patients.

PATIENTS AND METHODS: A case-control study enrolled two groups; (Group I: 40 patientswith psoriasis) and (Group II: 40 healthy age and sex matched subjects). Full history was taken from all cases along with full dermatologic examination. The assessment of psoriasis severity was conducted by using PASI score. Assessment of Inflammatory (IL-17, TNF-α, IFN-γ) and anti-Inflammatory Cytokines (IL-35, TGF-β) was performed by using ELISA technique.

RESULTS: There was a statistically significant increase of mean level of TNF-α, IL-17 and IFN-γ among psoriasis cases in comparison to controls. The mean level of TGF-β and IL-35 was statistically significantly reduced among the psoriasis cases in comparison to controls. TNF-α, IL-17 and IFN-γ showed a significant strong positive association in between and statistically significant strong negative relationship with IL-35 and TGF-β.

CONCLUSION: IL-35 has a significant role in the pathogenetic process of PsO, and it serves as a potential future therapeutic agent for psoriasis. The current results could be used as a clue for the utilization of inflammatory (IL-17, TNF-α, IFN-γ) versus anti-inflammatory Cytokines (IL-35, TGF-β) in psoriasis patients as a diagnostic biomarker for severity of cases with psoriasis.

PMID:35869799 | DOI:10.1111/jocd.15262

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