Nevin Manimala Statistics

Systemic sclerosis mortality trends in Spain from 1980 to 2019: age-period-cohort and Joinpoint analysis

Clin Exp Dermatol. 2022 Jul 25. doi: 10.1111/ced.15342. Online ahead of print.


BACKGROUND: Systemic sclerosis (SSc) is an autoimmune chronic rheumatic disease with notable mortality that continues to be a challenge for clinicians today.

OBJECTIVE: To assess changes in mortality trends in the Spanish SSc population between 1980 and 2019, considering the independent effect of sex, age, period and birth cohort.

PATIENTS AND METHODS: SSc death records and mid-year population data were collected from the National Statistics Institute. Age-standardized mortality rates were calculated for the overall population and for each sex and age group. Significant changes in mortality trends were identified by Joinpoint regressions. Similarly, an age-period-cohort (APC) and potential years of life lost (PYLL) analysis were performed to know the burden of SSc.

RESULTS: Age-standardized mortality rates due to SSc increased from 1.87 (95% CI: 1.00; 3.02) per 1,000,000 inhabitants between 1980 and 1984, to 2.47 (95% CI: 1.74; 3.02) per 1,000,000 inhabitants between 2015 and 2019. The relative risk of mortality fell in cohorts born after 1990 in all groups. The PYLL rates registered a gradual rise in both sexes.

CONCLUSIONS: Mortality due to SSc in Spain Spain experienced a rise in overall mortality trend during the 39 years of study evaluated, although the male group showed a progressive drop.

PMID:35875897 | DOI:10.1111/ced.15342

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