J Diabetes Investig. 2022 Jul 24. doi: 10.1111/jdi.13889. Online ahead of print.
OBJECTIVE: To explore the differences of serum fibroblast growth factors-21 (FGF-21) levels in pregnant women with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM), and to analyze the relationship between FGF-21 and glucose and lipid metabolic indicators, leptin, RBP-4 and adiponectin in GDM, in order to provide basis for the prevention and treatment of GDM.
METHODS: Total of 120 women were included,and divided into NGT group (58 cases) and GDM group (62 cases) according to the OGTT results. General information were recorded, height, weight and blood pressure, blood glucose, lipids, insulin, FGF-21, leptin, RBP-4 and adiponectin were measured, and body mass index (BMI),homeostasis model assessment-IR (HOMA-IR), homeostasis model assessment-β (HOMA-β), area under glucose curve (AUCG) were calculated. T test, person analysis and multiple linear regression analysis were used to evaluate the differences and related factors of FGF-21 in GDM.
RESULTS: The pre-pregnancy BMI, pregnancy BMI, weight gain during pregnancy and FGF-21 levels were higher in GDM group, while there were no statistically significant differences in Letptin, retinol binding protein 4 (RBP-4) and adiponectin. Correlation analysis suggested that FGF-21 level was correlated with age, pre-pregnancy BMI, weight gain during pregnancy, high density liptein cholesterol (HDL-c), Leptin, RBP-4 and adiponectin,and the results of multiple linear regression indicated that serum FGF-21 was related to pre-pregnancy BMI, weight gain during pregnancy, leptin, RBP-4 and adiponectin in GDM.
CONCLUSIONS: There were higher serum FGF-21 levels in GDM, which might be related to pre-pregnancy BMI, weight gain during pregnancy, Leptin, RBP-4 and adiponectin.