Physiology (Bethesda). 2022 Jul 26. doi: 10.1152/physiol.00015.2022. Online ahead of print.
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics we will address include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased clearance during sleep.