Dermatol Ther. 2022 Jul 28:e15739. doi: 10.1111/dth.15739. Online ahead of print.
BACKGROUND: Many modalities are used for treatment of facial wrinkles, such as micro-needling that enhances collagen production, and platelet-rich plasma (PRP) which contains concentrated levels of growth factors. The human amniotic membrane isolated from the placentae of donors (during elective cesarean sections) has high levels of growth factors that help in rejuvenation by improving the migration and proliferation of keratinocytes, fibroblasts and increased collagen synthesis.
AIM OF THE STUDY: was to confirm the efficacy of irradiated amniotic collagen matrix (IACM) versus platelet rich plasma (PRP) delivered via micro-needling in facial rejuvenation.
PATIENTS AND METHODS: The present study included 20 patients with facial wrinkles divided into 2 groups using split face technique: Group A subjected to micro-needling with topical IACM on the right side of the face. Group B subjected to micro-needling with topical PRP on the left side of the face. Patients received 6 sessions 2 weeks apart. Photos by Antera camera and skin biopsies were taken to assess the clinical results.
RESULTS: There were a statistically significant improvement in both sides after than before treatment; with better improvement in patients treated with IACM more than patients treated with PRP using micro-needling in both sides as proved clinically (assessed by WSRS and GAIS scale), pathologically (Orcein and Masson trichrome stain) and by Antera camera (texture and pigmentation).
CONCLUSION: Micro-needling using IACM is a new, safe and effective method for facial rejuvenation, more effective when compared to micro-needling using PRP; in need for further studies to evaluate the correct dose and number of sessions to get the best outcome. This article is protected by copyright. All rights reserved.