J Clin Sleep Med. 2022 Aug 1. doi: 10.5664/jcsm.10152. Online ahead of print.
ABSTRACT
STUDY OBJECTIVES: Initial reports of intravenous (IV) iron administration have been promising for children with restless legs syndrome (RLS), periodic limb movement disorder (PLMD), and restless sleep disorder (RSD). The aim of the current study was to further evaluate the clinical response to IV iron supplementation in children seen in a pediatric sleep clinic.
METHODS: We performed a retrospective chart review of children cared for in a single pediatric sleep clinic who also underwent IV iron infusion. Pre and post IV data regarding their sleep symptoms and ferritin levels were abstracted.
RESULTS: Overall, 63 pediatric sleep patients underwent IV iron infusion, mostly with ferric carboxymaltose (n=60), for RLS (n=30), PLMD (n=22), and RSD (n=17) Of the 59 patients with clinical follow-up, 39 (73%) noted improvement in at least one symptom, and 14 (26%) did not notice improvement or noticed worsening symptoms. Of the 59 patients with pre- and post-infusion labs, the average ferritin level increased from 21.7 (13.3) to 147.9 (120.9), p<0.001. Comparing patients who experienced clinical improvement versus those who did not, there were no statistically significant differences in change in ferritin levels (p=0.278), sex (p=0.452), or age (p=0.391). Ferritin change with infusion according to diagnostic subgroups (RLS/PLMD/RSD) was examined, and no significant differences were noted (F(2,56)=0.852, p=0.432). In terms of immediate adverse reactions to the IV infusion, 7 (11%) experienced at least 1 side effect, with the most common being behavior change (n=6) or gastrointestinal discomfort (n=4); no episodes of anaphylaxis or extravasation were noted.
CONCLUSIONS: These data provide additional support for the efficacy and safety of IV iron for pediatric RLS, PLMD, and RSD recalcitrant to oral iron.
PMID:35912699 | DOI:10.5664/jcsm.10152
