Nevin Manimala Statistics

Changes in the first anti-seizure medication prescribed for children and adolescents with epilepsy in a tertiary clinical center in Serbia over two decades

Int J Clin Pharmacol Ther. 2022 Aug 18. doi: 10.5414/CP204236. Online ahead of print.


OBJECTIVES: We assessed the prevalence of the use of new anti-seizure medications and valproate in the female population over two decades.

MATERIALS AND METHODS: We conducted a retrospective observational cross-sectional study of medical records of children and adolescents (4 – 19 years old) with newly diagnosed epilepsy in a tertiary clinical center in Serbia from 1997 to 1999 and 2017 to 2019.

RESULTS: The statistical analysis revealed significant changes in the treatment of generalized and focal seizures and all etiologies of epilepsy. Valproate use in the adolescent girl population decreased significantly from 2017 to 2019.

CONCLUSION: The prescription pattern of the initial anti-seizure medication changed significantly over the two decades. The results correspond to current guidelines and recommendations.

PMID:35979899 | DOI:10.5414/CP204236

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